Histological criteria for atypical pituitary adenomas – data from the German pituitary adenoma registry suggests modifications
Identifieur interne : 000160 ( Main/Exploration ); précédent : 000159; suivant : 000161Histological criteria for atypical pituitary adenomas – data from the German pituitary adenoma registry suggests modifications
Auteurs : Christian P. Miermeister [Allemagne] ; Stephan Petersenn [Allemagne] ; Michael Buchfelder [Allemagne] ; Rudolf Fahlbusch [Allemagne] ; Dieter K. Lüdecke [Allemagne] ; Annett Hölsken [Allemagne] ; Markus Bergmann [Allemagne] ; Hans Ulrich Knappe [Allemagne] ; Volkmar H. Hans [Allemagne] ; Jörg Flitsch [Allemagne] ; Wolfgang Saeger [Allemagne] ; Rolf Buslei [Allemagne]Source :
- Acta Neuropathologica Communications [ 2051-5960 ] ; 2015.
Abstract
The term
Of the 308 patients included in the study, 98 were diagnosed as APAs (incidence 2.9 %) and 10 patients suffered from a pituitary carcinoma (incidence 0.2 %). As a control group, we selected 200 group matched patients with typical pituitary adenomas (TPAs). Cut-off values were attained using ROC analysis.
We determined significant threshold values for p53 (≥2 %; AUC: 0.94) and the mitotic index (≥2 mitosis within 10 high power fields; AUC: 0.89). The most reliable individual marker for differentiating TPAs and APAs was a Ki-67-labeling index ≥ 4 % (AUC: 0.98). Using logistic regression analysis (LRA) we were able to show that all four criteria (Ki-67 (
Here we present a proposed rectification of the current WHO classification of pituitary tumors describing an additional marker for TPA and specific threshold values for p53 and the mitotic index. This will greatly help in the reliable diagnosis of APAs and facilitate further studies to ascertain the prognostic relevance of this categorization.
The online version of this article (doi:10.1186/s40478-015-0229-8) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s40478-015-0229-8
PubMed: 26285571
PubMed Central: 4545559
Affiliations:
- Allemagne
- Basse-Saxe, Bavière, Brême (Land), District de Moyenne-Franconie, Hambourg
- Brême, Erlangen, Hambourg, Hanovre
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Le document en format XML
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<author><name sortKey="Ludecke, Dieter K" sort="Ludecke, Dieter K" uniqKey="Ludecke D" first="Dieter K." last="Lüdecke">Dieter K. Lüdecke</name>
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<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
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<author><name sortKey="Holsken, Annett" sort="Holsken, Annett" uniqKey="Holsken A" first="Annett" last="Hölsken">Annett Hölsken</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Departments of Neuropathology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Schwabachanlage 6, 91054 Erlangen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Departments of Neuropathology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Schwabachanlage 6, 91054 Erlangen</wicri:regionArea>
<wicri:noRegion>91054 Erlangen</wicri:noRegion>
<placeName><settlement type="city">Erlangen</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Moyenne-Franconie</region>
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<author><name sortKey="Bergmann, Markus" sort="Bergmann, Markus" uniqKey="Bergmann M" first="Markus" last="Bergmann">Markus Bergmann</name>
<affiliation wicri:level="3"><nlm:aff id="Aff6">Department of Neuropathology, Klinikum Bremen Mitte, Bremen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neuropathology, Klinikum Bremen Mitte, Bremen</wicri:regionArea>
<placeName><region type="land" nuts="3">Brême (Land)</region>
<settlement type="city">Brême</settlement>
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<author><name sortKey="Knappe, Hans Ulrich" sort="Knappe, Hans Ulrich" uniqKey="Knappe H" first="Hans Ulrich" last="Knappe">Hans Ulrich Knappe</name>
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<author><name sortKey="Hans, Volkmar H" sort="Hans, Volkmar H" uniqKey="Hans V" first="Volkmar H." last="Hans">Volkmar H. Hans</name>
<affiliation wicri:level="1"><nlm:aff id="Aff8">Department of Pathology, Ruhr University Bochum, Bochum, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, Ruhr University Bochum, Bochum</wicri:regionArea>
<wicri:noRegion>Bochum</wicri:noRegion>
<wicri:noRegion>Bochum</wicri:noRegion>
<wicri:noRegion>Bochum</wicri:noRegion>
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<author><name sortKey="Flitsch, Jorg" sort="Flitsch, Jorg" uniqKey="Flitsch J" first="Jörg" last="Flitsch">Jörg Flitsch</name>
<affiliation wicri:level="3"><nlm:aff id="Aff5">Departments of Neurosurgery, University Clinic Hamburg-Eppendorf, Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Departments of Neurosurgery, University Clinic Hamburg-Eppendorf, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
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<author><name sortKey="Saeger, Wolfgang" sort="Saeger, Wolfgang" uniqKey="Saeger W" first="Wolfgang" last="Saeger">Wolfgang Saeger</name>
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<country xml:lang="fr">Allemagne</country>
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<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
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<author><name sortKey="Buslei, Rolf" sort="Buslei, Rolf" uniqKey="Buslei R" first="Rolf" last="Buslei">Rolf Buslei</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Departments of Neuropathology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Schwabachanlage 6, 91054 Erlangen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Departments of Neuropathology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Schwabachanlage 6, 91054 Erlangen</wicri:regionArea>
<wicri:noRegion>91054 Erlangen</wicri:noRegion>
<placeName><settlement type="city">Erlangen</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Moyenne-Franconie</region>
</placeName>
</affiliation>
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<series><title level="j">Acta Neuropathologica Communications</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Introduction</title>
<p>The term <italic>atypical pituitary adenoma</italic>
(APA) was revised in the 2004 World Health Organization (WHO) classification of pituitary tumors. However, two of the four parameters required for the diagnosis of APAs were formulated rather vaguely (i.e., <italic>“extensive”</italic>
nuclear staining for p53; <italic>“elevated”</italic>
mitotic index). Based on a case-control study using a representative cohort of typical pituitary adenomas and APAs selected from the German Pituitary Tumor Registry, we aimed to obtain reliable cut-off values for both p53 and the mitotic index. In addition, we analyzed the impact of all four individual parameters (invasiveness, Ki67-index, p53, mitotic index) on the selectivity for differentiating both adenoma subtypes.</p>
</sec>
<sec><title>Methods</title>
<p>Of the 308 patients included in the study, 98 were diagnosed as APAs (incidence 2.9 %) and 10 patients suffered from a pituitary carcinoma (incidence 0.2 %). As a control group, we selected 200 group matched patients with typical pituitary adenomas (TPAs). Cut-off values were attained using ROC analysis.</p>
</sec>
<sec><title>Results</title>
<p>We determined significant threshold values for p53 (≥2 %; AUC: 0.94) and the mitotic index (≥2 mitosis within 10 high power fields; AUC: 0.89). The most reliable individual marker for differentiating TPAs and APAs was a Ki-67-labeling index ≥ 4 % (AUC: 0.98). Using logistic regression analysis (LRA) we were able to show that all four criteria (Ki-67 (<italic>p</italic>
< 0.001); OR 5.2// p53 (<italic>p</italic>
< 0.001); OR 3.1// mitotic index (<italic>p</italic>
< 0.001); OR 2.1// invasiveness (<italic>p</italic>
< 0.001); OR 8.2)) were significant for the group of APAs. Furthermore, we describe the presence of nucleoli as a new favorable parameter for TPAs (<italic>p</italic>
= 0.008; OR: 0.4; CI95 %: 0.18; 0.77).</p>
</sec>
<sec><title>Conclusions</title>
<p>Here we present a proposed rectification of the current WHO classification of pituitary tumors describing an additional marker for TPA and specific threshold values for p53 and the mitotic index. This will greatly help in the reliable diagnosis of APAs and facilitate further studies to ascertain the prognostic relevance of this categorization.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s40478-015-0229-8) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Buurman, H" uniqKey="Buurman H">H Buurman</name>
</author>
<author><name sortKey="Saeger, W" uniqKey="Saeger W">W Saeger</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Daly, Af" uniqKey="Daly A">AF Daly</name>
</author>
<author><name sortKey="Rixhon, M" uniqKey="Rixhon M">M Rixhon</name>
</author>
<author><name sortKey="Adam, C" uniqKey="Adam C">C Adam</name>
</author>
<author><name sortKey="Dempegioti, A" uniqKey="Dempegioti A">A Dempegioti</name>
</author>
<author><name sortKey="Tichomirowa, Ma" uniqKey="Tichomirowa M">MA Tichomirowa</name>
</author>
<author><name sortKey="Beckers, A" uniqKey="Beckers A">A Beckers</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Ezzat, S" uniqKey="Ezzat S">S Ezzat</name>
</author>
<author><name sortKey="Asa, Sl" uniqKey="Asa S">SL Asa</name>
</author>
<author><name sortKey="Couldwell, Wt" uniqKey="Couldwell W">WT Couldwell</name>
</author>
<author><name sortKey="Barr, Ce" uniqKey="Barr C">CE Barr</name>
</author>
<author><name sortKey="Dodge, We" uniqKey="Dodge W">WE Dodge</name>
</author>
<author><name sortKey="Vance, Ml" uniqKey="Vance M">ML Vance</name>
</author>
<author><name sortKey="Mccutcheon, Ie" uniqKey="Mccutcheon I">IE McCutcheon</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Al Shraim, M" uniqKey="Al Shraim M">M Al-Shraim</name>
</author>
<author><name sortKey="Asa, Sl" uniqKey="Asa S">SL Asa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zada, G" uniqKey="Zada G">G Zada</name>
</author>
<author><name sortKey="Woodmansee, Ww" uniqKey="Woodmansee W">WW Woodmansee</name>
</author>
<author><name sortKey="Ramkissoon, S" uniqKey="Ramkissoon S">S Ramkissoon</name>
</author>
<author><name sortKey="Amadio, J" uniqKey="Amadio J">J Amadio</name>
</author>
<author><name sortKey="Nose, V" uniqKey="Nose V">V Nose</name>
</author>
<author><name sortKey="Laws, Er" uniqKey="Laws E">ER Laws</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yildirim, Ae" uniqKey="Yildirim A">AE Yildirim</name>
</author>
<author><name sortKey="Divanlioglu, D" uniqKey="Divanlioglu D">D Divanlioglu</name>
</author>
<author><name sortKey="Nacar, Oa" uniqKey="Nacar O">OA Nacar</name>
</author>
<author><name sortKey="Dursun, E" uniqKey="Dursun E">E Dursun</name>
</author>
<author><name sortKey="Sahinoglu, M" uniqKey="Sahinoglu M">M Sahinoglu</name>
</author>
<author><name sortKey="Unal, T" uniqKey="Unal T">T Unal</name>
</author>
<author><name sortKey="Belen, Ad" uniqKey="Belen A">AD Belen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Breslow, Ne" uniqKey="Breslow N">NE Breslow</name>
</author>
<author><name sortKey="Day, Ne" uniqKey="Day N">NE Day</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Youden, Wj" uniqKey="Youden W">WJ Youden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hanley, Ja" uniqKey="Hanley J">JA Hanley</name>
</author>
<author><name sortKey="Mcneil, Bj" uniqKey="Mcneil B">BJ McNeil</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Swets, Ja" uniqKey="Swets J">JA Swets</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Szumilas, M" uniqKey="Szumilas M">M Szumilas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nagelkerke, Nj" uniqKey="Nagelkerke N">NJ Nagelkerke</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Metz, Ce" uniqKey="Metz C">CE Metz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Figarella Branger, D" uniqKey="Figarella Branger D">D Figarella-Branger</name>
</author>
<author><name sortKey="Trouillas, J" uniqKey="Trouillas J">J Trouillas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kontogeorgos, G" uniqKey="Kontogeorgos G">G Kontogeorgos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kontogeorgos, G" uniqKey="Kontogeorgos G">G Kontogeorgos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Laws, Er" uniqKey="Laws E">ER Laws</name>
</author>
<author><name sortKey="Lopes, Mb" uniqKey="Lopes M">MB Lopes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perry, A" uniqKey="Perry A">A Perry</name>
</author>
<author><name sortKey="Scheithauer, Bw" uniqKey="Scheithauer B">BW Scheithauer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wolfsberger, S" uniqKey="Wolfsberger S">S Wolfsberger</name>
</author>
<author><name sortKey="Knosp, E" uniqKey="Knosp E">E Knosp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sumi, T" uniqKey="Sumi T">T Sumi</name>
</author>
<author><name sortKey="Stefaneanu, L" uniqKey="Stefaneanu L">L Stefaneanu</name>
</author>
<author><name sortKey="Kovacs, K" uniqKey="Kovacs K">K Kovacs</name>
</author>
<author><name sortKey="Asa, S" uniqKey="Asa S">S Asa</name>
</author>
<author><name sortKey="Rindi, G" uniqKey="Rindi G">G Rindi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gandour Edwards, R" uniqKey="Gandour Edwards R">R Gandour-Edwards</name>
</author>
<author><name sortKey="Kapadia, Sb" uniqKey="Kapadia S">SB Kapadia</name>
</author>
<author><name sortKey="Janecka, Ip" uniqKey="Janecka I">IP Janecka</name>
</author>
<author><name sortKey="Martinez, Aj" uniqKey="Martinez A">AJ Martinez</name>
</author>
<author><name sortKey="Barnes, L" uniqKey="Barnes L">L Barnes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Buckley, N" uniqKey="Buckley N">N Buckley</name>
</author>
<author><name sortKey="Bates, As" uniqKey="Bates A">AS Bates</name>
</author>
<author><name sortKey="Broome, Jc" uniqKey="Broome J">JC Broome</name>
</author>
<author><name sortKey="Strange, Rc" uniqKey="Strange R">RC Strange</name>
</author>
<author><name sortKey="Perrett, Cw" uniqKey="Perrett C">CW Perrett</name>
</author>
<author><name sortKey="Burke, Cw" uniqKey="Burke C">CW Burke</name>
</author>
<author><name sortKey="Clayton, Rn" uniqKey="Clayton R">RN Clayton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thapar, K" uniqKey="Thapar K">K Thapar</name>
</author>
<author><name sortKey="Scheithauer, Bw" uniqKey="Scheithauer B">BW Scheithauer</name>
</author>
<author><name sortKey="Kovacs, K" uniqKey="Kovacs K">K Kovacs</name>
</author>
<author><name sortKey="Pernicone, Pj" uniqKey="Pernicone P">PJ Pernicone</name>
</author>
<author><name sortKey="Laws, Er" uniqKey="Laws E">ER Laws</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Levy, A" uniqKey="Levy A">A Levy</name>
</author>
<author><name sortKey="Hall, L" uniqKey="Hall L">L Hall</name>
</author>
<author><name sortKey="Yeudall, Wa" uniqKey="Yeudall W">WA Yeudall</name>
</author>
<author><name sortKey="Lightman, Sl" uniqKey="Lightman S">SL Lightman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, W" uniqKey="Muller W">W Muller</name>
</author>
<author><name sortKey="Saeger, W" uniqKey="Saeger W">W Saeger</name>
</author>
<author><name sortKey="Wellhausen, L" uniqKey="Wellhausen L">L Wellhausen</name>
</author>
<author><name sortKey="Derwahl, Km" uniqKey="Derwahl K">KM Derwahl</name>
</author>
<author><name sortKey="Hamacher, C" uniqKey="Hamacher C">C Hamacher</name>
</author>
<author><name sortKey="Ludecke, Dk" uniqKey="Ludecke D">DK Ludecke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lubke, D" uniqKey="Lubke D">D Lubke</name>
</author>
<author><name sortKey="Saeger, W" uniqKey="Saeger W">W Saeger</name>
</author>
<author><name sortKey="Ludecke, Dk" uniqKey="Ludecke D">DK Ludecke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oliveira, Mc" uniqKey="Oliveira M">MC Oliveira</name>
</author>
<author><name sortKey="Marroni, Cp" uniqKey="Marroni C">CP Marroni</name>
</author>
<author><name sortKey="Pizarro, Cb" uniqKey="Pizarro C">CB Pizarro</name>
</author>
<author><name sortKey="Pereira Lima, Jf" uniqKey="Pereira Lima J">JF Pereira-Lima</name>
</author>
<author><name sortKey="Barbosa Coutinho, Lm" uniqKey="Barbosa Coutinho L">LM Barbosa-Coutinho</name>
</author>
<author><name sortKey="Ferreira, Np" uniqKey="Ferreira N">NP Ferreira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saeger, W" uniqKey="Saeger W">W Saeger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Madsen, H" uniqKey="Madsen H">H Madsen</name>
</author>
<author><name sortKey="Borges, Tm" uniqKey="Borges T">TM Borges</name>
</author>
<author><name sortKey="Knox, Aj" uniqKey="Knox A">AJ Knox</name>
</author>
<author><name sortKey="Michaelis, Ka" uniqKey="Michaelis K">KA Michaelis</name>
</author>
<author><name sortKey="Xu, M" uniqKey="Xu M">M Xu</name>
</author>
<author><name sortKey="Lillehei, Ko" uniqKey="Lillehei K">KO Lillehei</name>
</author>
<author><name sortKey="Wierman, Me" uniqKey="Wierman M">ME Wierman</name>
</author>
<author><name sortKey="Kleinschmidt Demasters, Bk" uniqKey="Kleinschmidt Demasters B">BK Kleinschmidt-DeMasters</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hentschel, Sj" uniqKey="Hentschel S">SJ Hentschel</name>
</author>
<author><name sortKey="Mccutcheon, Ie" uniqKey="Mccutcheon I">IE McCutcheon</name>
</author>
<author><name sortKey="Moore, W" uniqKey="Moore W">W Moore</name>
</author>
<author><name sortKey="Durity, Fa" uniqKey="Durity F">FA Durity</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bassarova, Av" uniqKey="Bassarova A">AV Bassarova</name>
</author>
<author><name sortKey="Popov, Aa" uniqKey="Popov A">AA Popov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salehi, F" uniqKey="Salehi F">F Salehi</name>
</author>
<author><name sortKey="Agur, A" uniqKey="Agur A">A Agur</name>
</author>
<author><name sortKey="Scheithauer, Bw" uniqKey="Scheithauer B">BW Scheithauer</name>
</author>
<author><name sortKey="Kovacs, K" uniqKey="Kovacs K">K Kovacs</name>
</author>
<author><name sortKey="Lloyd, Rv" uniqKey="Lloyd R">RV Lloyd</name>
</author>
<author><name sortKey="Cusimano, M" uniqKey="Cusimano M">M Cusimano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scheithauer, Bw" uniqKey="Scheithauer B">BW Scheithauer</name>
</author>
<author><name sortKey="Gaffey, Ta" uniqKey="Gaffey T">TA Gaffey</name>
</author>
<author><name sortKey="Lloyd, Rv" uniqKey="Lloyd R">RV Lloyd</name>
</author>
<author><name sortKey="Sebo, Tj" uniqKey="Sebo T">TJ Sebo</name>
</author>
<author><name sortKey="Kovacs, Kt" uniqKey="Kovacs K">KT Kovacs</name>
</author>
<author><name sortKey="Horvath, E" uniqKey="Horvath E">E Horvath</name>
</author>
<author><name sortKey="Yapicier, O" uniqKey="Yapicier O">O Yapicier</name>
</author>
<author><name sortKey="Young, Wf" uniqKey="Young W">WF Young</name>
</author>
<author><name sortKey="Meyer, Fb" uniqKey="Meyer F">FB Meyer</name>
</author>
<author><name sortKey="Kuroki, T" uniqKey="Kuroki T">T Kuroki</name>
</author>
<author><name sortKey="Riehle, Dl" uniqKey="Riehle D">DL Riehle</name>
</author>
<author><name sortKey="Laws, Er" uniqKey="Laws E">ER Laws</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dubois, S" uniqKey="Dubois S">S Dubois</name>
</author>
<author><name sortKey="Guyetant, S" uniqKey="Guyetant S">S Guyetant</name>
</author>
<author><name sortKey="Menei, P" uniqKey="Menei P">P Menei</name>
</author>
<author><name sortKey="Rodien, P" uniqKey="Rodien P">P Rodien</name>
</author>
<author><name sortKey="Illouz, F" uniqKey="Illouz F">F Illouz</name>
</author>
<author><name sortKey="Vielle, B" uniqKey="Vielle B">B Vielle</name>
</author>
<author><name sortKey="Rohmer, V" uniqKey="Rohmer V">V Rohmer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hsu, Cy" uniqKey="Hsu C">CY Hsu</name>
</author>
<author><name sortKey="Guo, Wy" uniqKey="Guo W">WY Guo</name>
</author>
<author><name sortKey="Chien, Cp" uniqKey="Chien C">CP Chien</name>
</author>
<author><name sortKey="Ho, Dm" uniqKey="Ho D">DM Ho</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gejman, R" uniqKey="Gejman R">R Gejman</name>
</author>
<author><name sortKey="Swearingen, B" uniqKey="Swearingen B">B Swearingen</name>
</author>
<author><name sortKey="Hedley Whyte, Et" uniqKey="Hedley Whyte E">ET Hedley-Whyte</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Honegger, J" uniqKey="Honegger J">J Honegger</name>
</author>
<author><name sortKey="Prettin, C" uniqKey="Prettin C">C Prettin</name>
</author>
<author><name sortKey="Feuerhake, F" uniqKey="Feuerhake F">F Feuerhake</name>
</author>
<author><name sortKey="Petrick, M" uniqKey="Petrick M">M Petrick</name>
</author>
<author><name sortKey="Schulte Monting, J" uniqKey="Schulte Monting J">J Schulte-Monting</name>
</author>
<author><name sortKey="Reincke, M" uniqKey="Reincke M">M Reincke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mastronardi, L" uniqKey="Mastronardi L">L Mastronardi</name>
</author>
<author><name sortKey="Guiducci, A" uniqKey="Guiducci A">A Guiducci</name>
</author>
<author><name sortKey="Spera, C" uniqKey="Spera C">C Spera</name>
</author>
<author><name sortKey="Puzzilli, F" uniqKey="Puzzilli F">F Puzzilli</name>
</author>
<author><name sortKey="Liberati, F" uniqKey="Liberati F">F Liberati</name>
</author>
<author><name sortKey="Maira, G" uniqKey="Maira G">G Maira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Losa, M" uniqKey="Losa M">M Losa</name>
</author>
<author><name sortKey="Franzin, A" uniqKey="Franzin A">A Franzin</name>
</author>
<author><name sortKey="Mangili, F" uniqKey="Mangili F">F Mangili</name>
</author>
<author><name sortKey="Terreni, Mr" uniqKey="Terreni M">MR Terreni</name>
</author>
<author><name sortKey="Barzaghi, R" uniqKey="Barzaghi R">R Barzaghi</name>
</author>
<author><name sortKey="Veglia, F" uniqKey="Veglia F">F Veglia</name>
</author>
<author><name sortKey="Mortini, P" uniqKey="Mortini P">P Mortini</name>
</author>
<author><name sortKey="Giovanelli, M" uniqKey="Giovanelli M">M Giovanelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paek, Ki" uniqKey="Paek K">KI Paek</name>
</author>
<author><name sortKey="Kim, Sh" uniqKey="Kim S">SH Kim</name>
</author>
<author><name sortKey="Song, Sh" uniqKey="Song S">SH Song</name>
</author>
<author><name sortKey="Choi, Sw" uniqKey="Choi S">SW Choi</name>
</author>
<author><name sortKey="Koh, Hs" uniqKey="Koh H">HS Koh</name>
</author>
<author><name sortKey="Youm, Jy" uniqKey="Youm J">JY Youm</name>
</author>
<author><name sortKey="Kim, Y" uniqKey="Kim Y">Y Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Righi, A" uniqKey="Righi A">A Righi</name>
</author>
<author><name sortKey="Agati, P" uniqKey="Agati P">P Agati</name>
</author>
<author><name sortKey="Sisto, A" uniqKey="Sisto A">A Sisto</name>
</author>
<author><name sortKey="Frank, G" uniqKey="Frank G">G Frank</name>
</author>
<author><name sortKey="Faustini Fustini, M" uniqKey="Faustini Fustini M">M Faustini-Fustini</name>
</author>
<author><name sortKey="Agati, R" uniqKey="Agati R">R Agati</name>
</author>
<author><name sortKey="Mazzatenta, D" uniqKey="Mazzatenta D">D Mazzatenta</name>
</author>
<author><name sortKey="Farnedi, A" uniqKey="Farnedi A">A Farnedi</name>
</author>
<author><name sortKey="Menetti, F" uniqKey="Menetti F">F Menetti</name>
</author>
<author><name sortKey="Marucci, G" uniqKey="Marucci G">G Marucci</name>
</author>
<author><name sortKey="Foschini, Mp" uniqKey="Foschini M">MP Foschini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thapar, K" uniqKey="Thapar K">K Thapar</name>
</author>
<author><name sortKey="Kovacs, K" uniqKey="Kovacs K">K Kovacs</name>
</author>
<author><name sortKey="Scheithauer, Bw" uniqKey="Scheithauer B">BW Scheithauer</name>
</author>
<author><name sortKey="Stefaneanu, L" uniqKey="Stefaneanu L">L Stefaneanu</name>
</author>
<author><name sortKey="Horvath, E" uniqKey="Horvath E">E Horvath</name>
</author>
<author><name sortKey="Pernicone, Pj" uniqKey="Pernicone P">PJ Pernicone</name>
</author>
<author><name sortKey="Murray, D" uniqKey="Murray D">D Murray</name>
</author>
<author><name sortKey="Laws, Er" uniqKey="Laws E">ER Laws</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Trouillas, J" uniqKey="Trouillas J">J Trouillas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Raverot, G" uniqKey="Raverot G">G Raverot</name>
</author>
<author><name sortKey="Jouanneau, E" uniqKey="Jouanneau E">E Jouanneau</name>
</author>
<author><name sortKey="Trouillas, J" uniqKey="Trouillas J">J Trouillas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Buchfelder, M" uniqKey="Buchfelder M">M Buchfelder</name>
</author>
<author><name sortKey="Fahlbusch, R" uniqKey="Fahlbusch R">R Fahlbusch</name>
</author>
<author><name sortKey="Adams, Ef" uniqKey="Adams E">EF Adams</name>
</author>
<author><name sortKey="Kiesewetter, F" uniqKey="Kiesewetter F">F Kiesewetter</name>
</author>
<author><name sortKey="Thierauf, P" uniqKey="Thierauf P">P Thierauf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meij, Bp" uniqKey="Meij B">BP Meij</name>
</author>
<author><name sortKey="Lopes, Mb" uniqKey="Lopes M">MB Lopes</name>
</author>
<author><name sortKey="Ellegala, Db" uniqKey="Ellegala D">DB Ellegala</name>
</author>
<author><name sortKey="Alden, Td" uniqKey="Alden T">TD Alden</name>
</author>
<author><name sortKey="Laws, Er" uniqKey="Laws E">ER Laws</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shakespeare, Tp" uniqKey="Shakespeare T">TP Shakespeare</name>
</author>
<author><name sortKey="Gebski, Vj" uniqKey="Gebski V">VJ Gebski</name>
</author>
<author><name sortKey="Veness, Mj" uniqKey="Veness M">MJ Veness</name>
</author>
<author><name sortKey="Simes, J" uniqKey="Simes J">J Simes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De La Monte, Sm" uniqKey="De La Monte S">SM de la Monte</name>
</author>
<author><name sortKey="Flickinger, J" uniqKey="Flickinger J">J Flickinger</name>
</author>
<author><name sortKey="Linggood, Rm" uniqKey="Linggood R">RM Linggood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heaney, Ap" uniqKey="Heaney A">AP Heaney</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pernicone, Pj" uniqKey="Pernicone P">PJ Pernicone</name>
</author>
<author><name sortKey="Scheithauer, Bw" uniqKey="Scheithauer B">BW Scheithauer</name>
</author>
<author><name sortKey="Sebo, Tj" uniqKey="Sebo T">TJ Sebo</name>
</author>
<author><name sortKey="Kovacs, Kt" uniqKey="Kovacs K">KT Kovacs</name>
</author>
<author><name sortKey="Horvath, E" uniqKey="Horvath E">E Horvath</name>
</author>
<author><name sortKey="Young, Wf" uniqKey="Young W">WF Young</name>
</author>
<author><name sortKey="Lloyd, Rv" uniqKey="Lloyd R">RV Lloyd</name>
</author>
<author><name sortKey="Davis, Dh" uniqKey="Davis D">DH Davis</name>
</author>
<author><name sortKey="Guthrie, Bl" uniqKey="Guthrie B">BL Guthrie</name>
</author>
<author><name sortKey="Schoene, Wc" uniqKey="Schoene W">WC Schoene</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ragel, Bt" uniqKey="Ragel B">BT Ragel</name>
</author>
<author><name sortKey="Couldwell, Wt" uniqKey="Couldwell W">WT Couldwell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scheithauer, Bw" uniqKey="Scheithauer B">BW Scheithauer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Branch, Cl" uniqKey="Branch C">CL Branch</name>
</author>
<author><name sortKey="Laws, Er" uniqKey="Laws E">ER Laws</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morita, A" uniqKey="Morita A">A Morita</name>
</author>
<author><name sortKey="Meyer, Fb" uniqKey="Meyer F">FB Meyer</name>
</author>
<author><name sortKey="Laws, Er" uniqKey="Laws E">ER Laws</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Doniach, I" uniqKey="Doniach I">I Doniach</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaltsas, Ga" uniqKey="Kaltsas G">GA Kaltsas</name>
</author>
<author><name sortKey="Grossman, Ab" uniqKey="Grossman A">AB Grossman</name>
</author>
</analytic>
</biblStruct>
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<biblStruct><analytic><author><name sortKey="Kaltsas, Ga" uniqKey="Kaltsas G">GA Kaltsas</name>
</author>
<author><name sortKey="Nomikos, P" uniqKey="Nomikos P">P Nomikos</name>
</author>
<author><name sortKey="Kontogeorgos, G" uniqKey="Kontogeorgos G">G Kontogeorgos</name>
</author>
<author><name sortKey="Buchfelder, M" uniqKey="Buchfelder M">M Buchfelder</name>
</author>
<author><name sortKey="Grossman, Ab" uniqKey="Grossman A">AB Grossman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ironside, Jw" uniqKey="Ironside J">JW Ironside</name>
</author>
</analytic>
</biblStruct>
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</author>
<author><name sortKey="Kovacs, K" uniqKey="Kovacs K">K Kovacs</name>
</author>
<author><name sortKey="Rutka, J" uniqKey="Rutka J">J Rutka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tanizaki, Y" uniqKey="Tanizaki Y">Y Tanizaki</name>
</author>
<author><name sortKey="Jin, L" uniqKey="Jin L">L Jin</name>
</author>
<author><name sortKey="Scheithauer, Bw" uniqKey="Scheithauer B">BW Scheithauer</name>
</author>
<author><name sortKey="Kovacs, K" uniqKey="Kovacs K">K Kovacs</name>
</author>
<author><name sortKey="Roncaroli, F" uniqKey="Roncaroli F">F Roncaroli</name>
</author>
<author><name sortKey="Lloyd, Rv" uniqKey="Lloyd R">RV Lloyd</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pei, L" uniqKey="Pei L">L Pei</name>
</author>
<author><name sortKey="Melmed, S" uniqKey="Melmed S">S Melmed</name>
</author>
<author><name sortKey="Scheithauer, B" uniqKey="Scheithauer B">B Scheithauer</name>
</author>
<author><name sortKey="Kovacs, K" uniqKey="Kovacs K">K Kovacs</name>
</author>
<author><name sortKey="Benedict, Wf" uniqKey="Benedict W">WF Benedict</name>
</author>
<author><name sortKey="Prager, D" uniqKey="Prager D">D Prager</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pei, L" uniqKey="Pei L">L Pei</name>
</author>
<author><name sortKey="Melmed, S" uniqKey="Melmed S">S Melmed</name>
</author>
<author><name sortKey="Scheithauer, B" uniqKey="Scheithauer B">B Scheithauer</name>
</author>
<author><name sortKey="Kovacs, K" uniqKey="Kovacs K">K Kovacs</name>
</author>
<author><name sortKey="Prager, D" uniqKey="Prager D">D Prager</name>
</author>
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</biblStruct>
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</author>
<author><name sortKey="Yamada, Y" uniqKey="Yamada Y">Y Yamada</name>
</author>
<author><name sortKey="Scheithauer, B" uniqKey="Scheithauer B">B Scheithauer</name>
</author>
<author><name sortKey="Kovacs, K" uniqKey="Kovacs K">K Kovacs</name>
</author>
<author><name sortKey="Yamada, S" uniqKey="Yamada S">S Yamada</name>
</author>
<author><name sortKey="Stefaneanu, L" uniqKey="Stefaneanu L">L Stefaneanu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sanno, N" uniqKey="Sanno N">N Sanno</name>
</author>
<author><name sortKey="Teramoto, A" uniqKey="Teramoto A">A Teramoto</name>
</author>
<author><name sortKey="Osamura, Ry" uniqKey="Osamura R">RY Osamura</name>
</author>
<author><name sortKey="Horvath, E" uniqKey="Horvath E">E Horvath</name>
</author>
<author><name sortKey="Kovacs, K" uniqKey="Kovacs K">K Kovacs</name>
</author>
<author><name sortKey="Lloyd, Rv" uniqKey="Lloyd R">RV Lloyd</name>
</author>
<author><name sortKey="Scheithauer, Bw" uniqKey="Scheithauer B">BW Scheithauer</name>
</author>
</analytic>
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</author>
<author><name sortKey="Nose, V" uniqKey="Nose V">V Nose</name>
</author>
<author><name sortKey="Scheithauer, Bw" uniqKey="Scheithauer B">BW Scheithauer</name>
</author>
<author><name sortKey="Kovacs, K" uniqKey="Kovacs K">K Kovacs</name>
</author>
<author><name sortKey="Horvath, E" uniqKey="Horvath E">E Horvath</name>
</author>
<author><name sortKey="Young, Wf" uniqKey="Young W">WF Young</name>
</author>
<author><name sortKey="Lloyd, Rv" uniqKey="Lloyd R">RV Lloyd</name>
</author>
<author><name sortKey="Bishop, Mc" uniqKey="Bishop M">MC Bishop</name>
</author>
<author><name sortKey="Hsi, B" uniqKey="Hsi B">B Hsi</name>
</author>
<author><name sortKey="Fletcher, Ja" uniqKey="Fletcher J">JA Fletcher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Losa, M" uniqKey="Losa M">M Losa</name>
</author>
<author><name sortKey="Mazza, E" uniqKey="Mazza E">E Mazza</name>
</author>
<author><name sortKey="Terreni, Mr" uniqKey="Terreni M">MR Terreni</name>
</author>
<author><name sortKey="Mccormack, A" uniqKey="Mccormack A">A McCormack</name>
</author>
<author><name sortKey="Gill, Aj" uniqKey="Gill A">AJ Gill</name>
</author>
<author><name sortKey="Motta, M" uniqKey="Motta M">M Motta</name>
</author>
<author><name sortKey="Cangi, Mg" uniqKey="Cangi M">MG Cangi</name>
</author>
<author><name sortKey="Talarico, A" uniqKey="Talarico A">A Talarico</name>
</author>
<author><name sortKey="Mortini, P" uniqKey="Mortini P">P Mortini</name>
</author>
<author><name sortKey="Reni, M" uniqKey="Reni M">M Reni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaltsas, Ga" uniqKey="Kaltsas G">GA Kaltsas</name>
</author>
<author><name sortKey="Mukherjee, Jj" uniqKey="Mukherjee J">JJ Mukherjee</name>
</author>
<author><name sortKey="Plowman, Pn" uniqKey="Plowman P">PN Plowman</name>
</author>
<author><name sortKey="Monson, Jp" uniqKey="Monson J">JP Monson</name>
</author>
<author><name sortKey="Grossman, Ab" uniqKey="Grossman A">AB Grossman</name>
</author>
<author><name sortKey="Besser, Gm" uniqKey="Besser G">GM Besser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Colao, A" uniqKey="Colao A">A Colao</name>
</author>
<author><name sortKey="Grasso, Lf" uniqKey="Grasso L">LF Grasso</name>
</author>
<author><name sortKey="Pivonello, R" uniqKey="Pivonello R">R Pivonello</name>
</author>
<author><name sortKey="Lombardi, G" uniqKey="Lombardi G">G Lombardi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grossman, Ab" uniqKey="Grossman A">AB Grossman</name>
</author>
</analytic>
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</div1>
</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Basse-Saxe</li>
<li>Bavière</li>
<li>Brême (Land)</li>
<li>District de Moyenne-Franconie</li>
<li>Hambourg</li>
</region>
<settlement><li>Brême</li>
<li>Erlangen</li>
<li>Hambourg</li>
<li>Hanovre</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Bavière"><name sortKey="Miermeister, Christian P" sort="Miermeister, Christian P" uniqKey="Miermeister C" first="Christian P." last="Miermeister">Christian P. Miermeister</name>
</region>
<name sortKey="Bergmann, Markus" sort="Bergmann, Markus" uniqKey="Bergmann M" first="Markus" last="Bergmann">Markus Bergmann</name>
<name sortKey="Buchfelder, Michael" sort="Buchfelder, Michael" uniqKey="Buchfelder M" first="Michael" last="Buchfelder">Michael Buchfelder</name>
<name sortKey="Buslei, Rolf" sort="Buslei, Rolf" uniqKey="Buslei R" first="Rolf" last="Buslei">Rolf Buslei</name>
<name sortKey="Fahlbusch, Rudolf" sort="Fahlbusch, Rudolf" uniqKey="Fahlbusch R" first="Rudolf" last="Fahlbusch">Rudolf Fahlbusch</name>
<name sortKey="Flitsch, Jorg" sort="Flitsch, Jorg" uniqKey="Flitsch J" first="Jörg" last="Flitsch">Jörg Flitsch</name>
<name sortKey="Hans, Volkmar H" sort="Hans, Volkmar H" uniqKey="Hans V" first="Volkmar H." last="Hans">Volkmar H. Hans</name>
<name sortKey="Holsken, Annett" sort="Holsken, Annett" uniqKey="Holsken A" first="Annett" last="Hölsken">Annett Hölsken</name>
<name sortKey="Knappe, Hans Ulrich" sort="Knappe, Hans Ulrich" uniqKey="Knappe H" first="Hans Ulrich" last="Knappe">Hans Ulrich Knappe</name>
<name sortKey="Ludecke, Dieter K" sort="Ludecke, Dieter K" uniqKey="Ludecke D" first="Dieter K." last="Lüdecke">Dieter K. Lüdecke</name>
<name sortKey="Petersenn, Stephan" sort="Petersenn, Stephan" uniqKey="Petersenn S" first="Stephan" last="Petersenn">Stephan Petersenn</name>
<name sortKey="Saeger, Wolfgang" sort="Saeger, Wolfgang" uniqKey="Saeger W" first="Wolfgang" last="Saeger">Wolfgang Saeger</name>
</country>
</tree>
</affiliations>
</record>
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