Muscle Oxygen Supply Impairment during Exercise in Poorly Controlled Type 1 Diabetes
Identifieur interne : 000134 ( Main/Exploration ); précédent : 000133; suivant : 000135Muscle Oxygen Supply Impairment during Exercise in Poorly Controlled Type 1 Diabetes
Auteurs : Semah Tagougui [France] ; Erwan Leclair ; Pierre Fontaine [France] ; Régis Matran [France] ; Gaelle Marais [France] ; Julien Aucouturier [France] ; Aurélien Descatoire [France] ; Anne Vambergue [France] ; Kahina Oussaidene [France] ; Georges Baquet [France] ; Elsa Heyman [France]Source :
- Medicine and Science in Sports and Exercise [ 0195-9131 ] ; 2015.
Abstract
Aerobic fitness, as reflected by maximal oxygen (O2) uptake (V˙O2max), is impaired in poorly controlled patients with type 1 diabetes. The mechanisms underlying this impairment remain to be explored. This study sought to investigate whether type 1 diabetes and high levels of glycated hemoglobin (HbA1c) influence O2 supply including O2 delivery and release to active muscles during maximal exercise.
Two groups of patients with uncomplicated type 1 diabetes (T1D-A,
Arterial O2 content was comparable between groups. However, changes in total hemoglobin (i.e., muscle blood volume) was significantly lower in T1D-I compared with that in CON-I. T1D-I also had impaired changes in deoxyhemoglobin levels and increase during high-intensity exercise despite normal erythrocyte 2,3-diphosphoglycerate levels. Finally, V˙O2max was lower in T1D-I compared with that in CON-I. No differences were observed between T1D-A and CON-A.
Poorly controlled patients displayed lower V˙O2max and blunted muscle deoxyhemoglobin increase. The latter supports the hypotheses of increase in O2 affinity induced by hemoglobin glycation and/or of a disturbed balance between nutritive and nonnutritive muscle blood flow. Furthermore, reduced exercise muscle blood volume in poorly controlled patients may warn clinicians of microvascular dysfunction occurring even before overt microangiopathy.
Url:
DOI: 10.1249/MSS.0000000000000424
PubMed: 24983346
PubMed Central: 4323553
Affiliations:
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first="Semah" last="Tagougui">Semah Tagougui</name><affiliation wicri:level="1"><nlm:aff id="aff1">Physical Activity, Muscle and Health, Lille, EA 4488, University of Lille 2, FRANCE;</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Physical Activity, Muscle and Health, Lille, EA 4488, University of Lille 2</wicri:regionArea><wicri:noRegion>University of Lille 2</wicri:noRegion><wicri:noRegion>University of Lille 2</wicri:noRegion></affiliation></author><author><name sortKey="Leclair, Erwan" sort="Leclair, Erwan" uniqKey="Leclair E" first="Erwan" last="Leclair">Erwan Leclair</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Fontaine, Pierre" sort="Fontaine, Pierre" uniqKey="Fontaine P" first="Pierre" last="Fontaine">Pierre Fontaine</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Diabetology, Lille University Hospital, EA 4489, Lille, FRANCE;</nlm:aff><country xml:lang="fr" 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FRANCE;</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Physical Activity, Muscle and Health, Lille, EA 4488, University of Lille 2</wicri:regionArea><wicri:noRegion>University of Lille 2</wicri:noRegion><wicri:noRegion>University of Lille 2</wicri:noRegion></affiliation></author><author><name sortKey="Aucouturier, Julien" sort="Aucouturier, Julien" uniqKey="Aucouturier J" first="Julien" last="Aucouturier">Julien Aucouturier</name><affiliation wicri:level="1"><nlm:aff id="aff1">Physical Activity, Muscle and Health, Lille, EA 4488, University of Lille 2, FRANCE;</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Physical Activity, Muscle and Health, Lille, EA 4488, University of Lille 2</wicri:regionArea><wicri:noRegion>University of Lille 2</wicri:noRegion><wicri:noRegion>University of Lille 2</wicri:noRegion></affiliation></author><author><name sortKey="Descatoire, Aurelien" sort="Descatoire, Aurelien" uniqKey="Descatoire A" first="Aurélien" last="Descatoire">Aurélien Descatoire</name><affiliation wicri:level="1"><nlm:aff id="aff1">Regional Hospital Centre of Roubaix, FRANCE</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Regional Hospital Centre of Roubaix</wicri:regionArea></affiliation></author><author><name sortKey="Vambergue, Anne" sort="Vambergue, Anne" uniqKey="Vambergue A" first="Anne" last="Vambergue">Anne Vambergue</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Diabetology, Lille University Hospital, EA 4489, Lille, FRANCE;</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Department of Diabetology, Lille University Hospital, EA 4489, Lille</wicri:regionArea><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Oussaidene, Kahina" sort="Oussaidene, Kahina" uniqKey="Oussaidene K" first="Kahina" last="Oussaidene">Kahina Oussaidene</name><affiliation wicri:level="1"><nlm:aff id="aff1">Physical Activity, Muscle and Health, Lille, EA 4488, University of Lille 2, FRANCE;</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Physical Activity, Muscle and Health, Lille, EA 4488, University of Lille 2</wicri:regionArea><wicri:noRegion>University of Lille 2</wicri:noRegion><wicri:noRegion>University of Lille 2</wicri:noRegion></affiliation></author><author><name sortKey="Baquet, Georges" sort="Baquet, Georges" uniqKey="Baquet G" first="Georges" last="Baquet">Georges Baquet</name><affiliation wicri:level="1"><nlm:aff id="aff1">Physical Activity, Muscle and Health, Lille, EA 4488, University of Lille 2, FRANCE;</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Physical Activity, Muscle and Health, Lille, EA 4488, University of Lille 2</wicri:regionArea><wicri:noRegion>University of Lille 2</wicri:noRegion><wicri:noRegion>University of Lille 2</wicri:noRegion></affiliation></author><author><name sortKey="Heyman, Elsa" sort="Heyman, Elsa" uniqKey="Heyman E" first="Elsa" last="Heyman">Elsa Heyman</name><affiliation wicri:level="1"><nlm:aff id="aff1">Physical Activity, Muscle and Health, Lille, EA 4488, University of Lille 2, FRANCE;</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Physical Activity, Muscle and Health, Lille, EA 4488, University of Lille 2</wicri:regionArea><wicri:noRegion>University of Lille 2</wicri:noRegion><wicri:noRegion>University of Lille 2</wicri:noRegion></affiliation></author></analytic><series><title level="j">Medicine and Science in Sports and Exercise</title><idno type="ISSN">0195-9131</idno><idno type="eISSN">1530-0315</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><sec><title>Purpose</title><p>Aerobic fitness, as reflected by maximal oxygen (O<sub>2</sub>) uptake (V˙O<sub>2max</sub>), is impaired in poorly controlled patients with type 1 diabetes. The mechanisms underlying this impairment remain to be explored. This study sought to investigate whether type 1 diabetes and high levels of glycated hemoglobin (HbA<sub>1c</sub>) influence O<sub>2</sub> supply including O<sub>2</sub> delivery and release to active muscles during maximal exercise.</p></sec><sec><title>Methods</title><p>Two groups of patients with uncomplicated type 1 diabetes (T1D-A, <italic>n</italic> = 11, with adequate glycemic control, HbA<sub>1c</sub> <7.0%; T1D-I, <italic>n</italic> = 12 with inadequate glycemic control, HbA<sub>1c</sub> >8%) were compared with healthy controls (CON-A, <italic>n</italic> = 11; CON-I, <italic>n</italic> = 12, respectively) matched for physical activity and body composition. Subjects performed exhaustive incremental exercise to determine V˙O<sub>2max</sub>. Throughout the exercise, near-infrared spectroscopy allowed investigation of changes in oxyhemoglobin, deoxyhemoglobin, and total hemoglobin in the vastus lateralis. Venous and arterialized capillary blood was sampled during exercise to assess arterial O<sub>2</sub> transport and factors able to shift the oxyhemoglobin dissociation curve.</p></sec><sec><title>Results</title><p>Arterial O<sub>2</sub> content was comparable between groups. However, changes in total hemoglobin (i.e., muscle blood volume) was significantly lower in T1D-I compared with that in CON-I. T1D-I also had impaired changes in deoxyhemoglobin levels and increase during high-intensity exercise despite normal erythrocyte 2,3-diphosphoglycerate levels. Finally, V˙O<sub>2max</sub> was lower in T1D-I compared with that in CON-I. No differences were observed between T1D-A and CON-A.</p></sec><sec><title>Conclusions</title><p>Poorly controlled patients displayed lower V˙O<sub>2max</sub> and blunted muscle deoxyhemoglobin increase. The latter supports the hypotheses of increase in O<sub>2</sub> affinity induced by hemoglobin glycation and/or of a disturbed balance between nutritive and nonnutritive muscle blood flow. Furthermore, reduced exercise muscle blood volume in poorly controlled patients may warn clinicians of microvascular dysfunction occurring even before overt microangiopathy.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Arturson, G" uniqKey="Arturson G">G Arturson</name></author><author><name sortKey="Garby, L" uniqKey="Garby L">L Garby</name></author><author><name sortKey="Robert, M" uniqKey="Robert M">M Robert</name></author><author><name sortKey="Zaar, B" uniqKey="Zaar B">B Zaar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aspenes, St" uniqKey="Aspenes S">ST Aspenes</name></author><author><name sortKey="Nilsen, Til" uniqKey="Nilsen T">TIL Nilsen</name></author><author><name sortKey="Skaug, Ea" uniqKey="Skaug E">EA Skaug</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Astorino, Ta" uniqKey="Astorino T">TA Astorino</name></author><author><name sortKey="White, Ac" uniqKey="White A">AC White</name></author><author><name sortKey="Dalleck, Lc" uniqKey="Dalleck L">LC Dalleck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Astrand, Po" uniqKey="Astrand P">PO Astrand</name></author><author><name sortKey="Rodahl, K" uniqKey="Rodahl K">K Rodahl</name></author><author><name sortKey="Dahl, Ha" uniqKey="Dahl H">HA Dahl</name></author><author><name sortKey="Stromme, Sb" uniqKey="Stromme S">SB Stromme</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baldi, Jc" uniqKey="Baldi J">JC Baldi</name></author><author><name sortKey="Cassuto, Na" uniqKey="Cassuto N">NA Cassuto</name></author><author><name sortKey="Foxx Lupo, Wt" uniqKey="Foxx Lupo W">WT Foxx-Lupo</name></author><author><name sortKey="Wheatley, Cm" uniqKey="Wheatley C">CM Wheatley</name></author><author><name sortKey="Snyder, Em" uniqKey="Snyder E">EM Snyder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bassett, Dr" uniqKey="Bassett D">DR Bassett</name></author><author><name sortKey="Howley, Et" uniqKey="Howley E">ET Howley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhambhani, Yn" uniqKey="Bhambhani Y">YN Bhambhani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bodnar, Pn" uniqKey="Bodnar P">PN Bodnar</name></author><author><name sortKey="Pristupiuk, Am" uniqKey="Pristupiuk A">AM Pristupiuk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brazeau, As" uniqKey="Brazeau A">AS Brazeau</name></author><author><name sortKey="Rabasa Lhoret, R" uniqKey="Rabasa Lhoret R">R Rabasa-Lhoret</name></author><author><name sortKey="Strychar, I" uniqKey="Strychar I">I Strychar</name></author><author><name sortKey="Mircescu, H" uniqKey="Mircescu H">H Mircescu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bunn, Hf" uniqKey="Bunn H">HF Bunn</name></author><author><name sortKey="Briehl, Rw" uniqKey="Briehl R">RW Briehl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chance, Ww" uniqKey="Chance W">WW Chance</name></author><author><name sortKey="Rhee, C" uniqKey="Rhee C">C Rhee</name></author><author><name sortKey="Yilmaz, C" uniqKey="Yilmaz C">C Yilmaz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clark, Mg" uniqKey="Clark M">MG Clark</name></author><author><name sortKey="Rattigan, S" uniqKey="Rattigan S">S Rattigan</name></author><author><name sortKey="Clerk, Lh" uniqKey="Clerk L">LH Clerk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delorey, Ds" uniqKey="Delorey D">DS DeLorey</name></author><author><name sortKey="Kowalchuk, Jm" uniqKey="Kowalchuk J">JM Kowalchuk</name></author><author><name sortKey="Paterson, Dh" uniqKey="Paterson D">DH Paterson</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ditzel, J" uniqKey="Ditzel J">J Ditzel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ditzel, J" uniqKey="Ditzel J">J Ditzel</name></author><author><name sortKey="Kjaergaard, Jj" uniqKey="Kjaergaard J">JJ Kjaergaard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Esposito, F" uniqKey="Esposito F">F Esposito</name></author><author><name sortKey="Mathieu Costello, O" uniqKey="Mathieu Costello O">O Mathieu-Costello</name></author><author><name sortKey="Shabetai, R" uniqKey="Shabetai R">R Shabetai</name></author><author><name sortKey="Wagner, Pd" uniqKey="Wagner P">PD Wagner</name></author><author><name sortKey="Richardson, Rs" uniqKey="Richardson R">RS Richardson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferrari, M" uniqKey="Ferrari M">M Ferrari</name></author><author><name sortKey="Muthalib, M" uniqKey="Muthalib M">M Muthalib</name></author><author><name sortKey="Quaresima, V" uniqKey="Quaresima V">V Quaresima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grassi, B" uniqKey="Grassi B">B Grassi</name></author><author><name sortKey="Pogliaghi, S" uniqKey="Pogliaghi S">S Pogliaghi</name></author><author><name sortKey="Rampichini, S" uniqKey="Rampichini S">S Rampichini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, Md" uniqKey="Jones M">MD Jones</name></author><author><name sortKey="Booth, J" uniqKey="Booth J">J Booth</name></author><author><name sortKey="Taylor, Jl" uniqKey="Taylor J">JL Taylor</name></author><author><name sortKey="Barry, Bk" uniqKey="Barry B">BK Barry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Komatsu, Wr" uniqKey="Komatsu W">WR Komatsu</name></author><author><name sortKey="Barros Neto, Tl" uniqKey="Barros Neto T">TL Barros Neto</name></author><author><name sortKey="Chacra, Ar" uniqKey="Chacra A">AR Chacra</name></author><author><name sortKey="Dib, Sa" uniqKey="Dib S">SA Dib</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lakoski, Sg" uniqKey="Lakoski S">SG Lakoski</name></author><author><name sortKey="Barlow, Ce" uniqKey="Barlow C">CE Barlow</name></author><author><name sortKey="Farrell, Sw" uniqKey="Farrell S">SW Farrell</name></author><author><name sortKey="Berry, Jd" uniqKey="Berry J">JD Berry</name></author><author><name sortKey="Morrow, Jr" uniqKey="Morrow J">JR Morrow</name></author><author><name sortKey="Haskell, Wl" uniqKey="Haskell W">WL Haskell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laplaud, D" uniqKey="Laplaud D">D Laplaud</name></author><author><name sortKey="Hug, F" uniqKey="Hug F">F Hug</name></author><author><name sortKey="Grelot, L" uniqKey="Grelot L">L Grélot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lukacs, A" uniqKey="Lukacs A">A Lukács</name></author><author><name sortKey="Mayer, K" uniqKey="Mayer K">K Mayer</name></author><author><name sortKey="Juhasz, E" uniqKey="Juhasz E">E Juhász</name></author><author><name sortKey="Varga, B" uniqKey="Varga B">B Varga</name></author><author><name sortKey="Fodor, B" uniqKey="Fodor B">B Fodor</name></author><author><name sortKey="Barkai, L" uniqKey="Barkai L">L Barkai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marschner, Jp" uniqKey="Marschner J">JP Marschner</name></author><author><name sortKey="Seidlitz, T" uniqKey="Seidlitz T">T Seidlitz</name></author><author><name sortKey="Rietbrock, N" uniqKey="Rietbrock N">N Rietbrock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcdonald, Mj" uniqKey="Mcdonald M">MJ McDonald</name></author><author><name sortKey="Bleichman, M" uniqKey="Bleichman M">M Bleichman</name></author><author><name sortKey="Bunn, Hf" uniqKey="Bunn H">HF Bunn</name></author><author><name sortKey="Noble, Rw" uniqKey="Noble R">RW Noble</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mollard, P" uniqKey="Mollard P">P Mollard</name></author><author><name sortKey="Bourdillon, N" uniqKey="Bourdillon N">N Bourdillon</name></author><author><name sortKey="Letournel, M" uniqKey="Letournel M">M Letournel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nadeau, Kj" uniqKey="Nadeau K">KJ Nadeau</name></author><author><name sortKey="Regensteiner, Jg" uniqKey="Regensteiner J">JG Regensteiner</name></author><author><name sortKey="Bauer, Ta" uniqKey="Bauer T">TA Bauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nielsen, Hb" uniqKey="Nielsen H">HB Nielsen</name></author><author><name sortKey="Madsen, P" uniqKey="Madsen P">P Madsen</name></author><author><name sortKey="Svendsen, Lb" uniqKey="Svendsen L">LB Svendsen</name></author><author><name sortKey="Roach, Rc" uniqKey="Roach R">RC Roach</name></author><author><name sortKey="Secher, Nh" uniqKey="Secher N">NH Secher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niranjan, V" uniqKey="Niranjan V">V Niranjan</name></author><author><name sortKey="Mcbrayer, Dg" uniqKey="Mcbrayer D">DG McBrayer</name></author><author><name sortKey="Ramirez, Lc" uniqKey="Ramirez L">LC Ramirez</name></author><author><name sortKey="Raskin, P" uniqKey="Raskin P">P Raskin</name></author><author><name sortKey="Hsia, Cc" uniqKey="Hsia C">CC Hsia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Padilla, Dj" uniqKey="Padilla D">DJ Padilla</name></author><author><name sortKey="Mcdonough, P" uniqKey="Mcdonough P">P McDonough</name></author><author><name sortKey="Behnke, Bj" uniqKey="Behnke B">BJ Behnke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peltonen, Je" uniqKey="Peltonen J">JE Peltonen</name></author><author><name sortKey="Koponen, As" uniqKey="Koponen A">AS Koponen</name></author><author><name sortKey="Pullinen, K" uniqKey="Pullinen K">K Pullinen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pichler, G" uniqKey="Pichler G">G Pichler</name></author><author><name sortKey="Urlesberger, B" uniqKey="Urlesberger B">B Urlesberger</name></author><author><name sortKey="Jirak, P" uniqKey="Jirak P">P Jirak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Plasqui, G" uniqKey="Plasqui G">G Plasqui</name></author><author><name sortKey="Westerterp, Kr" uniqKey="Westerterp K">KR Westerterp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poortmans, Jr" uniqKey="Poortmans J">JR Poortmans</name></author><author><name sortKey="Saerens, P" uniqKey="Saerens P">P Saerens</name></author><author><name sortKey="Edelman, R" uniqKey="Edelman R">R Edelman</name></author><author><name sortKey="Vertongen, F" uniqKey="Vertongen F">F Vertongen</name></author><author><name sortKey="Dorchy, H" uniqKey="Dorchy H">H Dorchy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, Ap" uniqKey="Roberts A">AP Roberts</name></author><author><name sortKey="Story, Cj" uniqKey="Story C">CJ Story</name></author><author><name sortKey="Ryall, Rg" uniqKey="Ryall R">RG Ryall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roca, J" uniqKey="Roca J">J Roca</name></author><author><name sortKey="Agusti, Ag" uniqKey="Agusti A">AG Agusti</name></author><author><name sortKey="Alonso, A" uniqKey="Alonso A">A Alonso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wanke, T" uniqKey="Wanke T">T Wanke</name></author><author><name sortKey="Formanek, D" uniqKey="Formanek D">D Formanek</name></author><author><name sortKey="Auinger, M" uniqKey="Auinger M">M Auinger</name></author><author><name sortKey="Zwick, H" uniqKey="Zwick H">H Zwick</name></author><author><name sortKey="Irsigler, K" uniqKey="Irsigler K">K Irsigler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wheatley, Cm" uniqKey="Wheatley C">CM Wheatley</name></author><author><name sortKey="Baldi, Jc" uniqKey="Baldi J">JC Baldi</name></author><author><name sortKey="Cassuto, Na" uniqKey="Cassuto N">NA Cassuto</name></author><author><name sortKey="Foxx Lupo, Wt" uniqKey="Foxx Lupo W">WT Foxx-Lupo</name></author><author><name sortKey="Snyder, Em" uniqKey="Snyder E">EM Snyder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whipp, Bj" uniqKey="Whipp B">BJ Whipp</name></author><author><name sortKey="Higgenbotham, Mb" uniqKey="Higgenbotham M">MB Higgenbotham</name></author><author><name sortKey="Cobb, Fc" uniqKey="Cobb F">FC Cobb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Womack, L" uniqKey="Womack L">L Womack</name></author><author><name sortKey="Peters, D" uniqKey="Peters D">D Peters</name></author><author><name sortKey="Barrett, Ej" uniqKey="Barrett E">EJ Barrett</name></author><author><name sortKey="Kaul, S" uniqKey="Kaul S">S Kaul</name></author><author><name sortKey="Price, W" uniqKey="Price W">W Price</name></author><author><name sortKey="Lindner, Jr" uniqKey="Lindner J">JR Lindner</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><settlement><li>Lille</li></settlement></list><tree><noCountry><name sortKey="Leclair, Erwan" sort="Leclair, Erwan" uniqKey="Leclair E" first="Erwan" last="Leclair">Erwan Leclair</name></noCountry><country name="France"><noRegion><name sortKey="Tagougui, Semah" sort="Tagougui, Semah" uniqKey="Tagougui S" first="Semah" last="Tagougui">Semah Tagougui</name></noRegion><name sortKey="Aucouturier, Julien" sort="Aucouturier, Julien" uniqKey="Aucouturier J" first="Julien" last="Aucouturier">Julien Aucouturier</name><name sortKey="Baquet, Georges" sort="Baquet, Georges" uniqKey="Baquet G" first="Georges" last="Baquet">Georges Baquet</name><name sortKey="Descatoire, Aurelien" sort="Descatoire, Aurelien" uniqKey="Descatoire A" first="Aurélien" last="Descatoire">Aurélien Descatoire</name><name sortKey="Fontaine, Pierre" sort="Fontaine, Pierre" uniqKey="Fontaine P" first="Pierre" last="Fontaine">Pierre Fontaine</name><name sortKey="Heyman, Elsa" sort="Heyman, Elsa" uniqKey="Heyman E" first="Elsa" last="Heyman">Elsa Heyman</name><name sortKey="Marais, Gaelle" sort="Marais, Gaelle" uniqKey="Marais G" first="Gaelle" last="Marais">Gaelle Marais</name><name sortKey="Matran, Regis" sort="Matran, Regis" uniqKey="Matran R" first="Régis" last="Matran">Régis Matran</name><name sortKey="Oussaidene, Kahina" sort="Oussaidene, Kahina" uniqKey="Oussaidene K" first="Kahina" last="Oussaidene">Kahina Oussaidene</name><name sortKey="Vambergue, Anne" sort="Vambergue, Anne" uniqKey="Vambergue A" first="Anne" last="Vambergue">Anne Vambergue</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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