Virologic, serologic, and biochemical outcomes through 2 years of treatment with entecavir and lamivudine in nucleoside-naïve Chinese patients with chronic hepatitis B: a randomized, multicenter study
Identifieur interne : 001268 ( Main/Exploration ); précédent : 001267; suivant : 001269Virologic, serologic, and biochemical outcomes through 2 years of treatment with entecavir and lamivudine in nucleoside-naïve Chinese patients with chronic hepatitis B: a randomized, multicenter study
Auteurs : Guangbi Yao [République populaire de Chine] ; Chengwei Chen [République populaire de Chine] ; Weilun Lu [République populaire de Chine] ; Hong Ren [République populaire de Chine] ; Deming Tan [République populaire de Chine] ; Yuming Wang [République populaire de Chine] ; Daozheng Xu [République populaire de Chine] ; Jessica Liu [Belgique] ; Dong Xu [États-Unis] ; Cyril Llamoso [États-Unis]Source :
- Hepatology International [ 1936-0533 ] ; 2008.
Abstract
Entecavir demonstrated superior virologic and biochemical benefits over lamivudine at 48 weeks in nucleoside-naïve Chinese patients with chronic hepatitis B (CHB). We evaluated the effect of continued entecavir and lamivudine treatment in patients who continued treatment in year 2 and the off-treatment durability of patients who achieved a protocol-defined
Chinese adults (
Among patients treated during year 2 (entecavir:
Through 96 weeks of treatment, entecavir resulted in continued clinical benefit in nucleoside-naïve Chinese patients with CHB, with a safety profile comparable with lamivudine.
Url:
DOI: 10.1007/s12072-008-9088-8
PubMed: 19669324
PubMed Central: 2716907
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000246
- to stream Pmc, to step Curation: 000246
- to stream Pmc, to step Checkpoint: 000413
- to stream Ncbi, to step Merge: 000056
- to stream Ncbi, to step Curation: 000056
- to stream Ncbi, to step Checkpoint: 000056
- to stream Main, to step Merge: 001270
- to stream Main, to step Curation: 001268
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Virologic, serologic, and biochemical outcomes through 2 years of treatment with entecavir and lamivudine in nucleoside-naïve Chinese patients with chronic hepatitis B: a randomized, multicenter study</title>
<author><name sortKey="Yao, Guangbi" sort="Yao, Guangbi" uniqKey="Yao G" first="Guangbi" last="Yao">Guangbi Yao</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Shanghai Jing An Qu Central Hospital, No. 259 Xikang Road, Shanghai, 200040 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Jing An Qu Central Hospital, No. 259 Xikang Road, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Chengwei" sort="Chen, Chengwei" uniqKey="Chen C" first="Chengwei" last="Chen">Chengwei Chen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Shanghai Liver Disease Research Center of the Nanjing Military Area, The 85th Hospital of PLA, Shanghai, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Liver Disease Research Center of the Nanjing Military Area, The 85th Hospital of PLA, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lu, Weilun" sort="Lu, Weilun" uniqKey="Lu W" first="Weilun" last="Lu">Weilun Lu</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">No. 3 Hospital, Zhongshan University, Guangzhou, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>No. 3 Hospital, Zhongshan University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ren, Hong" sort="Ren, Hong" uniqKey="Ren H" first="Hong" last="Ren">Hong Ren</name>
<affiliation wicri:level="1"><nlm:aff id="Aff4">2nd Hospital, Chongqing Medical University, Chongqing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>2nd Hospital, Chongqing Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tan, Deming" sort="Tan, Deming" uniqKey="Tan D" first="Deming" last="Tan">Deming Tan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5">Department of Infectious Diseases, Xiang Ya Hospital, Central South University, Changsha, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infectious Diseases, Xiang Ya Hospital, Central South University, Changsha</wicri:regionArea>
<wicri:noRegion>Changsha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Yuming" sort="Wang, Yuming" uniqKey="Wang Y" first="Yuming" last="Wang">Yuming Wang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff6">Southwest Hospital, 3rd Military Medical University, Chongqing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Southwest Hospital, 3rd Military Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Daozheng" sort="Xu, Daozheng" uniqKey="Xu D" first="Daozheng" last="Xu">Daozheng Xu</name>
<affiliation wicri:level="3"><nlm:aff id="Aff7">Beijing Di Tan Hospital, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Di Tan Hospital, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Jessica" sort="Liu, Jessica" uniqKey="Liu J" first="Jessica" last="Liu">Jessica Liu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff8">Bristol-Myers Squibb Company, Braine L’Alleud, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Bristol-Myers Squibb Company, Braine L’Alleud</wicri:regionArea>
<wicri:noRegion>Braine L’Alleud</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Dong" sort="Xu, Dong" uniqKey="Xu D" first="Dong" last="Xu">Dong Xu</name>
<affiliation wicri:level="2"><nlm:aff id="Aff9">Bristol-Myers Squibb Company, Wallingford, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Bristol-Myers Squibb Company, Wallingford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Llamoso, Cyril" sort="Llamoso, Cyril" uniqKey="Llamoso C" first="Cyril" last="Llamoso">Cyril Llamoso</name>
<affiliation wicri:level="2"><nlm:aff id="Aff9">Bristol-Myers Squibb Company, Wallingford, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Bristol-Myers Squibb Company, Wallingford</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19669324</idno>
<idno type="pmc">2716907</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716907</idno>
<idno type="RBID">PMC:2716907</idno>
<idno type="doi">10.1007/s12072-008-9088-8</idno>
<date when="2008">2008</date>
<idno type="wicri:Area/Pmc/Corpus">000246</idno>
<idno type="wicri:Area/Pmc/Curation">000246</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000413</idno>
<idno type="wicri:Area/Ncbi/Merge">000056</idno>
<idno type="wicri:Area/Ncbi/Curation">000056</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000056</idno>
<idno type="wicri:doubleKey">1936-0533:2008:Yao G:virologic:serologic:and</idno>
<idno type="wicri:Area/Main/Merge">001270</idno>
<idno type="wicri:Area/Main/Curation">001268</idno>
<idno type="wicri:Area/Main/Exploration">001268</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Virologic, serologic, and biochemical outcomes through 2 years of treatment with entecavir and lamivudine in nucleoside-naïve Chinese patients with chronic hepatitis B: a randomized, multicenter study</title>
<author><name sortKey="Yao, Guangbi" sort="Yao, Guangbi" uniqKey="Yao G" first="Guangbi" last="Yao">Guangbi Yao</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Shanghai Jing An Qu Central Hospital, No. 259 Xikang Road, Shanghai, 200040 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Jing An Qu Central Hospital, No. 259 Xikang Road, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Chengwei" sort="Chen, Chengwei" uniqKey="Chen C" first="Chengwei" last="Chen">Chengwei Chen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Shanghai Liver Disease Research Center of the Nanjing Military Area, The 85th Hospital of PLA, Shanghai, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Liver Disease Research Center of the Nanjing Military Area, The 85th Hospital of PLA, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lu, Weilun" sort="Lu, Weilun" uniqKey="Lu W" first="Weilun" last="Lu">Weilun Lu</name>
<affiliation wicri:level="3"><nlm:aff id="Aff3">No. 3 Hospital, Zhongshan University, Guangzhou, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>No. 3 Hospital, Zhongshan University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ren, Hong" sort="Ren, Hong" uniqKey="Ren H" first="Hong" last="Ren">Hong Ren</name>
<affiliation wicri:level="1"><nlm:aff id="Aff4">2nd Hospital, Chongqing Medical University, Chongqing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>2nd Hospital, Chongqing Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tan, Deming" sort="Tan, Deming" uniqKey="Tan D" first="Deming" last="Tan">Deming Tan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5">Department of Infectious Diseases, Xiang Ya Hospital, Central South University, Changsha, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infectious Diseases, Xiang Ya Hospital, Central South University, Changsha</wicri:regionArea>
<wicri:noRegion>Changsha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Yuming" sort="Wang, Yuming" uniqKey="Wang Y" first="Yuming" last="Wang">Yuming Wang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff6">Southwest Hospital, 3rd Military Medical University, Chongqing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Southwest Hospital, 3rd Military Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Daozheng" sort="Xu, Daozheng" uniqKey="Xu D" first="Daozheng" last="Xu">Daozheng Xu</name>
<affiliation wicri:level="3"><nlm:aff id="Aff7">Beijing Di Tan Hospital, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Di Tan Hospital, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Jessica" sort="Liu, Jessica" uniqKey="Liu J" first="Jessica" last="Liu">Jessica Liu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff8">Bristol-Myers Squibb Company, Braine L’Alleud, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Bristol-Myers Squibb Company, Braine L’Alleud</wicri:regionArea>
<wicri:noRegion>Braine L’Alleud</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Dong" sort="Xu, Dong" uniqKey="Xu D" first="Dong" last="Xu">Dong Xu</name>
<affiliation wicri:level="2"><nlm:aff id="Aff9">Bristol-Myers Squibb Company, Wallingford, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Bristol-Myers Squibb Company, Wallingford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Llamoso, Cyril" sort="Llamoso, Cyril" uniqKey="Llamoso C" first="Cyril" last="Llamoso">Cyril Llamoso</name>
<affiliation wicri:level="2"><nlm:aff id="Aff9">Bristol-Myers Squibb Company, Wallingford, CT USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Bristol-Myers Squibb Company, Wallingford</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Hepatology International</title>
<idno type="ISSN">1936-0533</idno>
<idno type="eISSN">1936-0541</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Purpose</title>
<p>Entecavir demonstrated superior virologic and biochemical benefits over lamivudine at 48 weeks in nucleoside-naïve Chinese patients with chronic hepatitis B (CHB). We evaluated the effect of continued entecavir and lamivudine treatment in patients who continued treatment in year 2 and the off-treatment durability of patients who achieved a protocol-defined <italic>consolidated response</italic>
at week 48.</p>
</sec>
<sec><title>Methods</title>
<p>Chinese adults (<italic>n</italic>
= 519) with CHB were randomized to a minimum of 52 weeks of treatment with entecavir 0.5 mg/day or lamivudine 100 mg/day. Patients with a <italic>consolidated response</italic>
at week 48 (HBV DNA <0.7 MEq/ml for ≥24 weeks, ALT <1.25 times ULN, and, if HBeAg(+) at baseline, loss of HBeAg for at least 24 weeks) stopped treatment at week 52 and were followed off-treatment. Patients with a <italic>partial response</italic>
at week 48 (HBV DNA <0.7 MEq/ml in the absence of other criteria for a consolidated response) could continue blinded treatment for up to 96 weeks. Patients were assessed for HBV DNA, ALT normalization, safety, and, if HBeAg(+) at baseline, for HBe seroconversion. Cumulative proportions of all treated patients who ever achieved these responses were also analyzed.</p>
</sec>
<sec><title>Results</title>
<p>Among patients treated during year 2 (entecavir: <italic>n</italic>
= 193; lamivudine: <italic>n</italic>
= 145), 74% of entecavir-treated and 41% of lamivudine-treated patients had HBV DNA <300 copies/ml by PCR at end of dosing and 96% of entecavir-treated and 82% of lamivudine-treated patients normalized ALT. Eleven percent of entecavir-treated versus 19% of lamivudine-treated patients underwent HBe seroconversion during year 2. Cumulative confirmed analysis for all treated patients through 96 weeks showed that 79% of entecavir-treated versus 46% of lamivudine-treated patients (<italic>p</italic>
< 0.0001) achieved HBV DNA <300 copies/ml by PCR. Similar proportions of entecavir- and lamivudine-treated patients achieved confirmed ALT normalization and HBe seroconversion. Safety profile was comparable for both treatment groups.</p>
</sec>
<sec><title>Conclusions</title>
<p>Through 96 weeks of treatment, entecavir resulted in continued clinical benefit in nucleoside-naïve Chinese patients with CHB, with a safety profile comparable with lamivudine.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Belgique</li>
<li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region><li>Connecticut</li>
<li>Guangdong</li>
</region>
<settlement><li>Jiangmen</li>
<li>Pékin</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Yao, Guangbi" sort="Yao, Guangbi" uniqKey="Yao G" first="Guangbi" last="Yao">Guangbi Yao</name>
</noRegion>
<name sortKey="Chen, Chengwei" sort="Chen, Chengwei" uniqKey="Chen C" first="Chengwei" last="Chen">Chengwei Chen</name>
<name sortKey="Lu, Weilun" sort="Lu, Weilun" uniqKey="Lu W" first="Weilun" last="Lu">Weilun Lu</name>
<name sortKey="Ren, Hong" sort="Ren, Hong" uniqKey="Ren H" first="Hong" last="Ren">Hong Ren</name>
<name sortKey="Tan, Deming" sort="Tan, Deming" uniqKey="Tan D" first="Deming" last="Tan">Deming Tan</name>
<name sortKey="Wang, Yuming" sort="Wang, Yuming" uniqKey="Wang Y" first="Yuming" last="Wang">Yuming Wang</name>
<name sortKey="Xu, Daozheng" sort="Xu, Daozheng" uniqKey="Xu D" first="Daozheng" last="Xu">Daozheng Xu</name>
</country>
<country name="Belgique"><noRegion><name sortKey="Liu, Jessica" sort="Liu, Jessica" uniqKey="Liu J" first="Jessica" last="Liu">Jessica Liu</name>
</noRegion>
</country>
<country name="États-Unis"><region name="Connecticut"><name sortKey="Xu, Dong" sort="Xu, Dong" uniqKey="Xu D" first="Dong" last="Xu">Dong Xu</name>
</region>
<name sortKey="Llamoso, Cyril" sort="Llamoso, Cyril" uniqKey="Llamoso C" first="Cyril" last="Llamoso">Cyril Llamoso</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Belgique/explor/OpenAccessBelV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001268 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001268 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Belgique |area= OpenAccessBelV2 |flux= Main |étape= Exploration |type= RBID |clé= PMC:2716907 |texte= Virologic, serologic, and biochemical outcomes through 2 years of treatment with entecavir and lamivudine in nucleoside-naïve Chinese patients with chronic hepatitis B: a randomized, multicenter study }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:19669324" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a OpenAccessBelV2
This area was generated with Dilib version V0.6.25. |