Predicting the FSH threshold dose in women with WHO Group II anovulatory infertility failing to ovulate or conceive on clomiphene citrate
Identifieur interne : 001302 ( Main/Curation ); précédent : 001301; suivant : 001303Predicting the FSH threshold dose in women with WHO Group II anovulatory infertility failing to ovulate or conceive on clomiphene citrate
Auteurs : Anders Nyboe Andersen [Danemark] ; Adam Balen [Royaume-Uni] ; Peter Platteau [Belgique] ; Paul Devroey [Belgique] ; Lisbeth Helmgaard [Danemark] ; Joan-Carles Arce [Danemark]Source :
- Human Reproduction [ 0268-1161 ] ; 2008-06.
Abstract
BACKGROUND The objective of this investigation was to establish independent predictors of follicle-stimulating hormone (FSH) threshold dose in anovulatory women undergoing ovulation induction with FSH preparations. METHODS One hundred and fifty-one patients with WHO Group II anovulatory infertility failing to ovulate or conceive on clomiphene citrate underwent ovarian stimulation with FSH-only preparations following a low-dose step-up protocol. The individual FSH threshold dose was defined as the FSH dose when meeting the human chorionic gonadotrophin criteria (one follicle 17 mm, or 23 follicles 15 mm). The influence of demographics, physical characteristics, obstetric and infertility and menstrual cycle history, ovarian ultrasonography, endocrine parameters and type of gonadotrophin preparation on the FSH threshold dose was assessed through multiple regression analysis. RESULTS In the univariate analysis, age, body mass index (BMI), failure to ovulate with clomiphene citrate, menstrual cycle history (amenorrhea, oligomenorrhea or anovulatory cycles of 2135 days), mean ovarian volume, LH/FSH ratio, testosterone and free androgen index were significant (P < 0.05) predictors of FSH threshold dose. In the multivariate analysis, menstrual cycle history, mean ovarian volume and BMI remained significant (P < 0.001). CONCLUSIONS The individual FSH threshold dose for ovulation induction in anovulatory women can be predicted based on three variables easily determined in clinical practice: menstrual cycle history, mean ovarian volume and BMI. A FSH dosage nomogram was constructed based on these parameters.
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DOI: 10.1093/humrep/den089
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Joan Carles" sort="Arce, Joan Carles" uniqKey="Arce J" first="Joan-Carles" last="Arce">Joan-Carles Arce</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:41DBB7293CD2E5E6FF19DC21AA82F02F8C3313C2</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1093/humrep/den089</idno><idno type="url">https://api.istex.fr/document/41DBB7293CD2E5E6FF19DC21AA82F02F8C3313C2/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000570</idno><idno type="wicri:Area/Istex/Curation">000570</idno><idno type="wicri:Area/Istex/Checkpoint">000D88</idno><idno type="wicri:doubleKey">0268-1161:2008:Nyboe Andersen A:predicting:the:fsh</idno><idno type="wicri:Area/Main/Merge">001305</idno><idno type="wicri:Area/Main/Curation">001302</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Predicting the FSH threshold dose in women with WHO Group II anovulatory infertility failing to ovulate or conceive on clomiphene citrate</title><author><name sortKey="Nyboe Andersen, Anders" sort="Nyboe Andersen, Anders" uniqKey="Nyboe Andersen A" first="Anders" last="Nyboe Andersen">Anders Nyboe Andersen</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Fertility Clinic, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Danemark</country></affiliation></author><author><name sortKey="Balen, Adam" sort="Balen, Adam" uniqKey="Balen A" first="Adam" last="Balen">Adam Balen</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Leeds General Infirmary, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Platteau, Peter" sort="Platteau, Peter" uniqKey="Platteau P" first="Peter" last="Platteau">Peter Platteau</name><affiliation wicri:level="3"><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Reproductive Medicine, Universitair Ziekenhuis (UZ) Brussel, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Devroey, Paul" sort="Devroey, Paul" uniqKey="Devroey P" first="Paul" last="Devroey">Paul Devroey</name><affiliation wicri:level="3"><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Reproductive Medicine, Universitair Ziekenhuis (UZ) Brussel, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Helmgaard, Lisbeth" sort="Helmgaard, Lisbeth" uniqKey="Helmgaard 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type="ISSN">0268-1161</idno><idno type="eISSN">1460-2350</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2008-06">2008-06</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1424">1424</biblScope><biblScope unit="page" to="1430">1430</biblScope></imprint><idno type="ISSN">0268-1161</idno></series><idno type="istex">41DBB7293CD2E5E6FF19DC21AA82F02F8C3313C2</idno><idno type="DOI">10.1093/humrep/den089</idno><idno type="ArticleID">den089</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0268-1161</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">BACKGROUND The objective of this investigation was to establish independent predictors of follicle-stimulating hormone (FSH) threshold dose in anovulatory women undergoing ovulation induction with FSH preparations. METHODS One hundred and fifty-one patients with WHO Group II anovulatory infertility failing to ovulate or conceive on clomiphene citrate underwent ovarian stimulation with FSH-only preparations following a low-dose step-up protocol. The individual FSH threshold dose was defined as the FSH dose when meeting the human chorionic gonadotrophin criteria (one follicle 17 mm, or 23 follicles 15 mm). The influence of demographics, physical characteristics, obstetric and infertility and menstrual cycle history, ovarian ultrasonography, endocrine parameters and type of gonadotrophin preparation on the FSH threshold dose was assessed through multiple regression analysis. RESULTS In the univariate analysis, age, body mass index (BMI), failure to ovulate with clomiphene citrate, menstrual cycle history (amenorrhea, oligomenorrhea or anovulatory cycles of 2135 days), mean ovarian volume, LH/FSH ratio, testosterone and free androgen index were significant (P < 0.05) predictors of FSH threshold dose. In the multivariate analysis, menstrual cycle history, mean ovarian volume and BMI remained significant (P < 0.001). CONCLUSIONS The individual FSH threshold dose for ovulation induction in anovulatory women can be predicted based on three variables easily determined in clinical practice: menstrual cycle history, mean ovarian volume and BMI. A FSH dosage nomogram was constructed based on these parameters.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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