Orthotopic and heterotopic ovarian tissue transplantation
Identifieur interne : 001529 ( Istex/Corpus ); précédent : 001528; suivant : 001530Orthotopic and heterotopic ovarian tissue transplantation
Auteurs : I. Demeestere ; P. Simon ; S. Emiliani ; A. Delbaere ; Y. EnglertSource :
- Human Reproduction Update [ 1355-4786 ] ; 2009.
Abstract
BACKGROUND Transplantation of ovarian tissue is, at present, the only clinical option available to restore fertility using cryopreserved ovarian tissue. More than 30 transplantations of cryopreserved tissue have been reported, and six babies have been born, worldwide, following this procedure. Despite these encouraging results, it is essential to optimize the procedure by improving the follicular survival, confirming safety and developing alternatives. Here, we review the different factors affecting follicular survival and growth after grafting. METHODS Relevant studies were identified by searching Pubmed up to January 2009 with English language limitation. The following key words were used: (ovarian tissue or whole ovary) AND (transplantation) AND (cryopreservation or pregnancy). Using the literature and personal experience, we examined relevant data on the different exogenous and clinical factors affecting follicular development after grafting. RESULTS Clinical factors such as the patient's age and the transplantation sites influenced the lifespan of the graft. A heterotopic transplantation site is not optimal but offers some advantages and it may also promote the hormonal environment after a combined heterotopic and orthotopic transplantation. Exogenous factors such as antioxidants, growth factors or hormones were tested to improve follicular survival; however, their efficiency regarding further follicular development and fertility potential remains to be established. CONCLUSION Additional evidence is required to define optimal conditions for ovarian tissue transplantation. Alternatives such as whole ovary or isolated follicles transplantations require further investigation but are likely to be successful in humans in the future.
Url:
DOI: 10.1093/humupd/dmp021
Links to Exploration step
ISTEX:150FB370851F64A081B8CE46DD0DCC06C9AE6017Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Orthotopic and heterotopic ovarian tissue transplantation</title><author><name sortKey="Demeestere, I" sort="Demeestere, I" uniqKey="Demeestere I" first="I." last="Demeestere">I. Demeestere</name><affiliation><mods:affiliation>Research Laboratory on Human Reproduction, Medicine Faculty, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: idemeest@ulb.ac.be</mods:affiliation></affiliation></author><author><name sortKey="Simon, P" sort="Simon, P" uniqKey="Simon P" first="P." last="Simon">P. Simon</name><affiliation><mods:affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Emiliani, S" sort="Emiliani, S" uniqKey="Emiliani S" first="S." last="Emiliani">S. Emiliani</name><affiliation><mods:affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Delbaere, A" sort="Delbaere, A" uniqKey="Delbaere A" first="A." last="Delbaere">A. Delbaere</name><affiliation><mods:affiliation>Research Laboratory on Human Reproduction, Medicine Faculty, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Englert, Y" sort="Englert, Y" uniqKey="Englert Y" first="Y." last="Englert">Y. Englert</name><affiliation><mods:affiliation>Research Laboratory on Human Reproduction, Medicine Faculty, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:150FB370851F64A081B8CE46DD0DCC06C9AE6017</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1093/humupd/dmp021</idno><idno type="url">https://api.istex.fr/document/150FB370851F64A081B8CE46DD0DCC06C9AE6017/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001529</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Orthotopic and heterotopic ovarian tissue transplantation</title><author><name sortKey="Demeestere, I" sort="Demeestere, I" uniqKey="Demeestere I" first="I." last="Demeestere">I. Demeestere</name><affiliation><mods:affiliation>Research Laboratory on Human Reproduction, Medicine Faculty, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: idemeest@ulb.ac.be</mods:affiliation></affiliation></author><author><name sortKey="Simon, P" sort="Simon, P" uniqKey="Simon P" first="P." last="Simon">P. Simon</name><affiliation><mods:affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Emiliani, S" sort="Emiliani, S" uniqKey="Emiliani S" first="S." last="Emiliani">S. Emiliani</name><affiliation><mods:affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Delbaere, A" sort="Delbaere, A" uniqKey="Delbaere A" first="A." last="Delbaere">A. Delbaere</name><affiliation><mods:affiliation>Research Laboratory on Human Reproduction, Medicine Faculty, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Englert, Y" sort="Englert, Y" uniqKey="Englert Y" first="Y." last="Englert">Y. Englert</name><affiliation><mods:affiliation>Research Laboratory on Human Reproduction, Medicine Faculty, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Human Reproduction Update</title><idno type="ISSN">1355-4786</idno><idno type="eISSN">1460-2369</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2009">2009</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="649">649</biblScope><biblScope unit="page" to="665">665</biblScope></imprint><idno type="ISSN">1355-4786</idno></series><idno type="istex">150FB370851F64A081B8CE46DD0DCC06C9AE6017</idno><idno type="DOI">10.1093/humupd/dmp021</idno><idno type="ArticleID">dmp021</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1355-4786</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">BACKGROUND Transplantation of ovarian tissue is, at present, the only clinical option available to restore fertility using cryopreserved ovarian tissue. More than 30 transplantations of cryopreserved tissue have been reported, and six babies have been born, worldwide, following this procedure. Despite these encouraging results, it is essential to optimize the procedure by improving the follicular survival, confirming safety and developing alternatives. Here, we review the different factors affecting follicular survival and growth after grafting. METHODS Relevant studies were identified by searching Pubmed up to January 2009 with English language limitation. The following key words were used: (ovarian tissue or whole ovary) AND (transplantation) AND (cryopreservation or pregnancy). Using the literature and personal experience, we examined relevant data on the different exogenous and clinical factors affecting follicular development after grafting. RESULTS Clinical factors such as the patient's age and the transplantation sites influenced the lifespan of the graft. A heterotopic transplantation site is not optimal but offers some advantages and it may also promote the hormonal environment after a combined heterotopic and orthotopic transplantation. Exogenous factors such as antioxidants, growth factors or hormones were tested to improve follicular survival; however, their efficiency regarding further follicular development and fertility potential remains to be established. CONCLUSION Additional evidence is required to define optimal conditions for ovarian tissue transplantation. Alternatives such as whole ovary or isolated follicles transplantations require further investigation but are likely to be successful in humans in the future.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>I. Demeestere</name><affiliations><json:string>Research Laboratory on Human Reproduction, Medicine Faculty, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</json:string><json:string>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</json:string><json:string>E-mail: idemeest@ulb.ac.be</json:string></affiliations></json:item><json:item><name>P. Simon</name><affiliations><json:string>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</json:string></affiliations></json:item><json:item><name>S. Emiliani</name><affiliations><json:string>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</json:string></affiliations></json:item><json:item><name>A. Delbaere</name><affiliations><json:string>Research Laboratory on Human Reproduction, Medicine Faculty, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</json:string><json:string>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</json:string></affiliations></json:item><json:item><name>Y. Englert</name><affiliations><json:string>Research Laboratory on Human Reproduction, Medicine Faculty, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</json:string><json:string>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>ovarian tissue</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>transplantation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pregnancy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>sites</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>vascularization</value></json:item></subject><articleId><json:string>dmp021</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>review-article</json:string></originalGenre><abstract>BACKGROUND Transplantation of ovarian tissue is, at present, the only clinical option available to restore fertility using cryopreserved ovarian tissue. More than 30 transplantations of cryopreserved tissue have been reported, and six babies have been born, worldwide, following this procedure. Despite these encouraging results, it is essential to optimize the procedure by improving the follicular survival, confirming safety and developing alternatives. Here, we review the different factors affecting follicular survival and growth after grafting. METHODS Relevant studies were identified by searching Pubmed up to January 2009 with English language limitation. The following key words were used: (ovarian tissue or whole ovary) AND (transplantation) AND (cryopreservation or pregnancy). Using the literature and personal experience, we examined relevant data on the different exogenous and clinical factors affecting follicular development after grafting. RESULTS Clinical factors such as the patient's age and the transplantation sites influenced the lifespan of the graft. A heterotopic transplantation site is not optimal but offers some advantages and it may also promote the hormonal environment after a combined heterotopic and orthotopic transplantation. Exogenous factors such as antioxidants, growth factors or hormones were tested to improve follicular survival; however, their efficiency regarding further follicular development and fertility potential remains to be established. CONCLUSION Additional evidence is required to define optimal conditions for ovarian tissue transplantation. Alternatives such as whole ovary or isolated follicles transplantations require further investigation but are likely to be successful in humans in the future.</abstract><qualityIndicators><score>8.856</score><pdfVersion>1.5</pdfVersion><pdfPageSize>612.283 x 790.866 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1762</abstractCharCount><pdfWordCount>11959</pdfWordCount><pdfCharCount>80771</pdfCharCount><pdfPageCount>17</pdfPageCount><abstractWordCount>238</abstractWordCount></qualityIndicators><title>Orthotopic and heterotopic ovarian tissue transplantation</title><genre><json:string>review-article</json:string></genre><host><volume>15</volume><publisherId><json:string>humupd</json:string></publisherId><pages><last>665</last><first>649</first></pages><issn><json:string>1355-4786</json:string></issn><issue>6</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1460-2369</json:string></eissn><title>Human Reproduction Update</title></host><categories><wos><json:string>OBSTETRICS & GYNECOLOGY</json:string><json:string>REPRODUCTIVE BIOLOGY</json:string></wos></categories><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1093/humupd/dmp021</json:string></doi><id>150FB370851F64A081B8CE46DD0DCC06C9AE6017</id><score>0.22585043</score><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/150FB370851F64A081B8CE46DD0DCC06C9AE6017/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/150FB370851F64A081B8CE46DD0DCC06C9AE6017/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/150FB370851F64A081B8CE46DD0DCC06C9AE6017/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Orthotopic and heterotopic ovarian tissue transplantation</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Oxford University Press</publisher><availability><p>The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissionsoxfordjournals.org</p></availability><date>2009-05-27</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Orthotopic and heterotopic ovarian tissue transplantation</title><author xml:id="author-1"><persName><forename type="first">I.</forename><surname>Demeestere</surname></persName><email>idemeest@ulb.ac.be</email><affiliation>Research Laboratory on Human Reproduction, Medicine Faculty, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</affiliation><affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</affiliation></author><author xml:id="author-2"><persName><forename type="first">P.</forename><surname>Simon</surname></persName><affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</affiliation></author><author xml:id="author-3"><persName><forename type="first">S.</forename><surname>Emiliani</surname></persName><affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</affiliation></author><author xml:id="author-4"><persName><forename type="first">A.</forename><surname>Delbaere</surname></persName><affiliation>Research Laboratory on Human Reproduction, Medicine Faculty, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</affiliation><affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</affiliation></author><author xml:id="author-5"><persName><forename type="first">Y.</forename><surname>Englert</surname></persName><affiliation>Research Laboratory on Human Reproduction, Medicine Faculty, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</affiliation><affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</affiliation></author></analytic><monogr><title level="j">Human Reproduction Update</title><idno type="pISSN">1355-4786</idno><idno type="eISSN">1460-2369</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2009"></date><biblScope unit="volume">15</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="649">649</biblScope><biblScope unit="page" to="665">665</biblScope></imprint></monogr><idno type="istex">150FB370851F64A081B8CE46DD0DCC06C9AE6017</idno><idno type="DOI">10.1093/humupd/dmp021</idno><idno type="ArticleID">dmp021</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009-05-27</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>BACKGROUND Transplantation of ovarian tissue is, at present, the only clinical option available to restore fertility using cryopreserved ovarian tissue. More than 30 transplantations of cryopreserved tissue have been reported, and six babies have been born, worldwide, following this procedure. Despite these encouraging results, it is essential to optimize the procedure by improving the follicular survival, confirming safety and developing alternatives. Here, we review the different factors affecting follicular survival and growth after grafting. METHODS Relevant studies were identified by searching Pubmed up to January 2009 with English language limitation. The following key words were used: (ovarian tissue or whole ovary) AND (transplantation) AND (cryopreservation or pregnancy). Using the literature and personal experience, we examined relevant data on the different exogenous and clinical factors affecting follicular development after grafting. RESULTS Clinical factors such as the patient's age and the transplantation sites influenced the lifespan of the graft. A heterotopic transplantation site is not optimal but offers some advantages and it may also promote the hormonal environment after a combined heterotopic and orthotopic transplantation. Exogenous factors such as antioxidants, growth factors or hormones were tested to improve follicular survival; however, their efficiency regarding further follicular development and fertility potential remains to be established. CONCLUSION Additional evidence is required to define optimal conditions for ovarian tissue transplantation. Alternatives such as whole ovary or isolated follicles transplantations require further investigation but are likely to be successful in humans in the future.</p></abstract><textClass><keywords scheme="keyword"><list><head>keywords</head><item><term>ovarian tissue</term></item><item><term>transplantation</term></item><item><term>pregnancy</term></item><item><term>sites</term></item><item><term>vascularization</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-05-27">Created</change><change when="2009">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/150FB370851F64A081B8CE46DD0DCC06C9AE6017/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="review-article"><front><journal-meta><journal-id journal-id-type="publisher-id">humupd</journal-id><journal-id journal-id-type="hwp">humupd</journal-id><journal-title>Human Reproduction Update</journal-title><issn pub-type="ppub">1355-4786</issn><issn pub-type="epub">1460-2369</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1093/humupd/dmp021</article-id><article-id pub-id-type="publisher-id">dmp021</article-id><article-categories><subj-group subj-group-type="heading"><subject>Reviews</subject></subj-group></article-categories><title-group><article-title>Orthotopic and heterotopic ovarian tissue transplantation</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Demeestere</surname><given-names>I.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="corresp" rid="cor1">3</xref></contrib><contrib contrib-type="author"><name><surname>Simon</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Emiliani</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Delbaere</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Englert</surname><given-names>Y.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>Research Laboratory on Human Reproduction, Medicine Faculty</addr-line>, <institution>Université Libre de Bruxelles (ULB), Erasme Hospital</institution>, <addr-line>808 Route de Lennik, 1070 Brussels</addr-line>, <country>Belgium</country></aff><aff id="af2"><label>2</label><addr-line>Fertility Clinic, Department of Gynaecology and Obstetrics</addr-line>, <institution>Université Libre de Bruxelles (ULB), Erasme Hospital</institution>, <addr-line>808 Route de Lennik, 1070 Brussels</addr-line>, <country>Belgium</country></aff><author-notes><corresp id="cor1"><label>3</label>Correspondence address. Tel: <phone>+32-2-5556358</phone>; Fax: <fax>+32-2-5556205</fax>; E-mail: <email>idemeest@ulb.ac.be</email></corresp></author-notes><pub-date pub-type="ppub"><season>November-December</season><year>2009</year></pub-date><pub-date pub-type="epub"><day>27</day><month>5</month><year>2009</year></pub-date><volume>15</volume><issue>6</issue><fpage>649</fpage><lpage>665</lpage><history><date date-type="received"><day>15</day><month>1</month><year>2009</year></date><date date-type="rev-recd"><day>20</day><month>4</month><year>2009</year></date><date date-type="accepted"><day>24</day><month>4</month><year>2009</year></date></history><copyright-statement>© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org</copyright-statement><copyright-year>2009</copyright-year><license license-type="creative-commons" xlink:href="http://creativecommons.org/licenses/by-nc/2.0/uk/"><p>The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org</p></license><abstract><sec><title>BACKGROUND</title><p>Transplantation of ovarian tissue is, at present, the only clinical option available to restore fertility using cryopreserved ovarian tissue. More than 30 transplantations of cryopreserved tissue have been reported, and six babies have been born, worldwide, following this procedure. Despite these encouraging results, it is essential to optimize the procedure by improving the follicular survival, confirming safety and developing alternatives. Here, we review the different factors affecting follicular survival and growth after grafting.</p></sec><sec><title>METHODS</title><p>Relevant studies were identified by searching Pubmed up to January 2009 with English language limitation. The following key words were used: (ovarian tissue or whole ovary) AND (transplantation) AND (cryopreservation or pregnancy). Using the literature and personal experience, we examined relevant data on the different exogenous and clinical factors affecting follicular development after grafting.</p></sec><sec><title>RESULTS</title><p>Clinical factors such as the patient's age and the transplantation sites influenced the lifespan of the graft. A heterotopic transplantation site is not optimal but offers some advantages and it may also promote the hormonal environment after a combined heterotopic and orthotopic transplantation. Exogenous factors such as antioxidants, growth factors or hormones were tested to improve follicular survival; however, their efficiency regarding further follicular development and fertility potential remains to be established.</p></sec><sec><title>CONCLUSION</title><p>Additional evidence is required to define optimal conditions for ovarian tissue transplantation. Alternatives such as whole ovary or isolated follicles transplantations require further investigation but are likely to be successful in humans in the future.</p></sec></abstract><kwd-group><kwd>ovarian tissue</kwd><kwd>transplantation</kwd><kwd>pregnancy</kwd><kwd>sites</kwd><kwd>vascularization</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Orthotopic and heterotopic ovarian tissue transplantation</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Orthotopic and heterotopic ovarian tissue transplantation</title></titleInfo><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Demeestere</namePart><affiliation>Research Laboratory on Human Reproduction, Medicine Faculty, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</affiliation><affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</affiliation><affiliation>E-mail: idemeest@ulb.ac.be</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Simon</namePart><affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Emiliani</namePart><affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Delbaere</namePart><affiliation>Research Laboratory on Human Reproduction, Medicine Faculty, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</affiliation><affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Englert</namePart><affiliation>Research Laboratory on Human Reproduction, Medicine Faculty, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</affiliation><affiliation>Fertility Clinic, Department of Gynaecology and Obstetrics, Universit Libre de Bruxelles (ULB), Erasme Hospital, 808 Route de Lennik, 1070 Brussels, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="review-article"></genre><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">2009</dateIssued><dateCreated encoding="w3cdtf">2009-05-27</dateCreated><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>BACKGROUND Transplantation of ovarian tissue is, at present, the only clinical option available to restore fertility using cryopreserved ovarian tissue. More than 30 transplantations of cryopreserved tissue have been reported, and six babies have been born, worldwide, following this procedure. Despite these encouraging results, it is essential to optimize the procedure by improving the follicular survival, confirming safety and developing alternatives. Here, we review the different factors affecting follicular survival and growth after grafting. METHODS Relevant studies were identified by searching Pubmed up to January 2009 with English language limitation. The following key words were used: (ovarian tissue or whole ovary) AND (transplantation) AND (cryopreservation or pregnancy). Using the literature and personal experience, we examined relevant data on the different exogenous and clinical factors affecting follicular development after grafting. RESULTS Clinical factors such as the patient's age and the transplantation sites influenced the lifespan of the graft. A heterotopic transplantation site is not optimal but offers some advantages and it may also promote the hormonal environment after a combined heterotopic and orthotopic transplantation. Exogenous factors such as antioxidants, growth factors or hormones were tested to improve follicular survival; however, their efficiency regarding further follicular development and fertility potential remains to be established. CONCLUSION Additional evidence is required to define optimal conditions for ovarian tissue transplantation. Alternatives such as whole ovary or isolated follicles transplantations require further investigation but are likely to be successful in humans in the future.</abstract><subject><genre>keywords</genre><topic>ovarian tissue</topic><topic>transplantation</topic><topic>pregnancy</topic><topic>sites</topic><topic>vascularization</topic></subject><relatedItem type="host"><titleInfo><title>Human Reproduction Update</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">1355-4786</identifier><identifier type="eISSN">1460-2369</identifier><identifier type="PublisherID">humupd</identifier><identifier type="PublisherID-hwp">humupd</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>649</start><end>665</end></extent></part></relatedItem><identifier type="istex">150FB370851F64A081B8CE46DD0DCC06C9AE6017</identifier><identifier type="DOI">10.1093/humupd/dmp021</identifier><identifier type="ArticleID">dmp021</identifier><accessCondition type="use and reproduction" contentType="copyright">The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissionsoxfordjournals.org</accessCondition><recordInfo><recordContentSource>OUP</recordContentSource></recordInfo></mods></metadata><covers><json:item><original>true</original><mimetype>image/tiff</mimetype><extension>tiff</extension><uri>https://api.istex.fr/document/150FB370851F64A081B8CE46DD0DCC06C9AE6017/covers/tiff</uri></json:item><json:item><original>true</original><mimetype>text/html</mimetype><extension>html</extension><uri>https://api.istex.fr/document/150FB370851F64A081B8CE46DD0DCC06C9AE6017/covers/html</uri></json:item></covers><annexes><json:item><original>true</original><mimetype>image/jpeg</mimetype><extension>jpeg</extension><uri>https://api.istex.fr/document/150FB370851F64A081B8CE46DD0DCC06C9AE6017/annexes/jpeg</uri></json:item><json:item><original>true</original><mimetype>image/gif</mimetype><extension>gif</extension><uri>https://api.istex.fr/document/150FB370851F64A081B8CE46DD0DCC06C9AE6017/annexes/gif</uri></json:item><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/150FB370851F64A081B8CE46DD0DCC06C9AE6017/annexes/pdf</uri></json:item></annexes><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/150FB370851F64A081B8CE46DD0DCC06C9AE6017/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">OBSTETRICS & GYNECOLOGY</classCode><classCode scheme="WOS">REPRODUCTIVE BIOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Belgique/explor/OpenAccessBelV2/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001529 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001529 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Belgique
|area= OpenAccessBelV2
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:150FB370851F64A081B8CE46DD0DCC06C9AE6017
|texte= Orthotopic and heterotopic ovarian tissue transplantation
}}
| This area was generated with Dilib version V0.6.25. |  |