From genome to proteome: developing expression clone resources for the human genome
Identifieur interne : 001301 ( Istex/Corpus ); précédent : 001300; suivant : 001302From genome to proteome: developing expression clone resources for the human genome
Auteurs : Gary Temple ; Philippe Lamesch ; Stuart Milstein ; David E. Hill ; Lukas Wagner ; Troy Moore ; Marc VidalSource :
- Human Molecular Genetics [ 0964-6906 ] ; 2006-04-15.
Abstract
cDNA clones have long been valuable reagents for studying the structure and function of proteins. With recent access to the entire human genome sequence, it has become possible and highly productive to compare the sequences of mRNAs to their genes, in order to validate the sequences and protein-coding annotations of each (1,2). Thus, well-characterized collections of human cDNAs are now playing an essential role in defining the structure and function of human genes and proteins. In this review, we will summarize the major collections of human cDNA clones, discuss some limitations common to most of these collections and describe several noteworthy proteomics applications, focusing on the detection and analysis of protein–protein interactions (PPI). These human cDNA collections contain principally two types of cDNA clones. The largest collections comprise cDNAs with full-length protein coding sequences (FL-CDS). Some but not all of these cDNA clones may represent the entire mRNA sequence, but many are missing considerable non-coding UTR sequence, usually at the 5′ end. A second type of cDNA clone, a ‘full-ORF’ (F-ORF) expression clone, is one where the annotated protein-coding sequence, excised of 5′ UTR and 3′ UTR sequence, has been transferred to a vector designed to facilitate transfer to other vectors for protein expression.
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DOI: 10.1093/hmg/ddl048
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Mol. Genet.</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2006-04-15">2006-04-15</date><biblScope unit="volume">15</biblScope><biblScope unit="supplement">suppl_1</biblScope><biblScope unit="page" from="R31">R31</biblScope><biblScope unit="page" to="R43">R43</biblScope></imprint><idno type="ISSN">0964-6906</idno></series><idno type="istex">AE7BDE6846D5AEAEF9612C8453BDC3BAEC26AFDF</idno><idno type="DOI">10.1093/hmg/ddl048</idno><idno type="href">ddl048</idno><idno type="local">ddl048</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0964-6906</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">cDNA clones have long been valuable reagents for studying the structure and function of proteins. With recent access to the entire human genome sequence, it has become possible and highly productive to compare the sequences of mRNAs to their genes, in order to validate the sequences and protein-coding annotations of each (1,2). Thus, well-characterized collections of human cDNAs are now playing an essential role in defining the structure and function of human genes and proteins. In this review, we will summarize the major collections of human cDNA clones, discuss some limitations common to most of these collections and describe several noteworthy proteomics applications, focusing on the detection and analysis of protein–protein interactions (PPI). These human cDNA collections contain principally two types of cDNA clones. The largest collections comprise cDNAs with full-length protein coding sequences (FL-CDS). Some but not all of these cDNA clones may represent the entire mRNA sequence, but many are missing considerable non-coding UTR sequence, usually at the 5′ end. A second type of cDNA clone, a ‘full-ORF’ (F-ORF) expression clone, is one where the annotated protein-coding sequence, excised of 5′ UTR and 3′ UTR sequence, has been transferred to a vector designed to facilitate transfer to other vectors for protein expression.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Gary Temple</name><affiliations><json:string>Mammalian Gene Collection, National Human Genome Research Institute and</json:string><json:string>E-mail: gtemple@mail.nih.gov</json:string></affiliations></json:item><json:item><name>Philippe Lamesch</name><affiliations><json:string>Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA,</json:string><json:string>Unité de Recherche en Biologie Moléculaire, Facultés Universitaires Notre-Dame de la Paix, 5000 Namur, Belgium and</json:string></affiliations></json:item><json:item><name>Stuart Milstein</name><affiliations><json:string>Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA,</json:string></affiliations></json:item><json:item><name>David E. 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A second type of cDNA clone, a ‘full-ORF’ (F-ORF) expression clone, is one where the annotated protein-coding sequence, excised of 5′ UTR and 3′ UTR sequence, has been transferred to a vector designed to facilitate transfer to other vectors for protein expression.</abstract><qualityIndicators><score>7.448</score><pdfVersion>1.3</pdfVersion><pdfPageSize>610 x 795 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1348</abstractCharCount><pdfWordCount>8538</pdfWordCount><pdfCharCount>56424</pdfCharCount><pdfPageCount>13</pdfPageCount><abstractWordCount>204</abstractWordCount></qualityIndicators><title>From genome to proteome: developing expression clone resources for the human genome</title><genre><json:string>review-article</json:string></genre><host><volume>15</volume><publisherId><json:string>hmg</json:string></publisherId><pages><last>R43</last><first>R31</first></pages><issn><json:string>0964-6906</json:string></issn><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1460-2083</json:string></eissn><title>Human Molecular Genetics</title></host><categories><wos><json:string>BIOCHEMISTRY & MOLECULAR BIOLOGY</json:string><json:string>GENETICS & HEREDITY</json:string></wos></categories><publicationDate>2006</publicationDate><copyrightDate>2006</copyrightDate><doi><json:string>10.1093/hmg/ddl048</json:string></doi><id>AE7BDE6846D5AEAEF9612C8453BDC3BAEC26AFDF</id><score>0.23362571</score><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/AE7BDE6846D5AEAEF9612C8453BDC3BAEC26AFDF/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/AE7BDE6846D5AEAEF9612C8453BDC3BAEC26AFDF/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/AE7BDE6846D5AEAEF9612C8453BDC3BAEC26AFDF/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">From genome to proteome: developing expression clone resources for the human genome</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Oxford University Press</publisher><availability><p>Published by Oxford University Press 2006.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact: journals.permissions@oxfordjournals.org</p></availability><date>2006</date></publicationStmt><notesStmt><note>*To whom correspondence should be addressed. Tel: +1 3015945951; Fax: +1 3014802770; Email: gtemple@mail.nih.gov</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">From genome to proteome: developing expression clone resources for the human genome</title><author xml:id="author-1"><persName><forename type="first">Gary</forename><surname>Temple</surname></persName><affiliation>Mammalian Gene Collection, National Human Genome Research Institute and</affiliation></author><author xml:id="author-2"><persName><forename type="first">Philippe</forename><surname>Lamesch</surname></persName><affiliation>Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA,</affiliation><affiliation>Unité de Recherche en Biologie Moléculaire, Facultés Universitaires Notre-Dame de la Paix, 5000 Namur, Belgium and</affiliation></author><author xml:id="author-3"><persName><forename type="first">Stuart</forename><surname>Milstein</surname></persName><affiliation>Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA,</affiliation></author><author xml:id="author-4"><persName><forename type="first">David E.</forename><surname>Hill</surname></persName><affiliation>Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA,</affiliation></author><author xml:id="author-5"><persName><forename type="first">Lukas</forename><surname>Wagner</surname></persName><affiliation>National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, USA,</affiliation></author><author xml:id="author-6"><persName><forename type="first">Troy</forename><surname>Moore</surname></persName><affiliation>Open Biosystems, Huntsville, AL 35806, USA</affiliation></author><author xml:id="author-7"><persName><forename type="first">Marc</forename><surname>Vidal</surname></persName><affiliation>Unité de Recherche en Biologie Moléculaire, Facultés Universitaires Notre-Dame de la Paix, 5000 Namur, Belgium and</affiliation></author></analytic><monogr><title level="j">Human Molecular Genetics</title><title level="j" type="abbrev">Hum. Mol. Genet.</title><idno type="pISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2006-04-15"></date><biblScope unit="volume">15</biblScope><biblScope unit="supplement">suppl_1</biblScope><biblScope unit="page" from="R31">R31</biblScope><biblScope unit="page" to="R43">R43</biblScope></imprint></monogr><idno type="istex">AE7BDE6846D5AEAEF9612C8453BDC3BAEC26AFDF</idno><idno type="DOI">10.1093/hmg/ddl048</idno><idno type="href">ddl048</idno><idno type="local">ddl048</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2006</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>cDNA clones have long been valuable reagents for studying the structure and function of proteins. With recent access to the entire human genome sequence, it has become possible and highly productive to compare the sequences of mRNAs to their genes, in order to validate the sequences and protein-coding annotations of each (1,2). Thus, well-characterized collections of human cDNAs are now playing an essential role in defining the structure and function of human genes and proteins. In this review, we will summarize the major collections of human cDNA clones, discuss some limitations common to most of these collections and describe several noteworthy proteomics applications, focusing on the detection and analysis of protein–protein interactions (PPI). These human cDNA collections contain principally two types of cDNA clones. The largest collections comprise cDNAs with full-length protein coding sequences (FL-CDS). Some but not all of these cDNA clones may represent the entire mRNA sequence, but many are missing considerable non-coding UTR sequence, usually at the 5′ end. A second type of cDNA clone, a ‘full-ORF’ (F-ORF) expression clone, is one where the annotated protein-coding sequence, excised of 5′ UTR and 3′ UTR sequence, has been transferred to a vector designed to facilitate transfer to other vectors for protein expression.</p></abstract></profileDesc><revisionDesc><change when="2006-04-15">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-10-14">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/AE7BDE6846D5AEAEF9612C8453BDC3BAEC26AFDF/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="US-ASCII"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article xml:lang="en" article-type="review-article"><front><journal-meta><journal-id journal-id-type="hwp">hmg</journal-id><journal-id journal-id-type="nlm-ta">Hum Mol Genet</journal-id><journal-id journal-id-type="publisher-id">hmg</journal-id><journal-title>Human Molecular Genetics</journal-title><abbrev-journal-title abbrev-type="publisher">Hum. Mol. Genet.</abbrev-journal-title><issn pub-type="ppub">0964-6906</issn><issn pub-type="epub">1460-2083</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="other">ddl048</article-id><article-id pub-id-type="doi">10.1093/hmg/ddl048</article-id><article-categories><subj-group subj-group-type="heading"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>From genome to proteome: developing expression clone resources for the human genome</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Temple</surname><given-names>Gary</given-names></name><xref rid="AF1">1</xref><xref rid="COR1">*</xref></contrib><contrib contrib-type="author"><name><surname>Lamesch</surname><given-names>Philippe</given-names></name><xref rid="AF3">3</xref><xref rid="AF4">4</xref></contrib><contrib contrib-type="author"><name><surname>Milstein</surname><given-names>Stuart</given-names></name><xref rid="AF3">3</xref></contrib><contrib contrib-type="author"><name><surname>Hill</surname><given-names>David E.</given-names></name><xref rid="AF3">3</xref></contrib><contrib contrib-type="author"><name><surname>Wagner</surname><given-names>Lukas</given-names></name><xref rid="AF2">2</xref></contrib><contrib contrib-type="author"><name><surname>Moore</surname><given-names>Troy</given-names></name><xref rid="AF5">5</xref></contrib><contrib contrib-type="author"><name><surname>Vidal</surname><given-names>Marc</given-names></name><xref rid="AF4">4</xref></contrib><aff id="AF1"><sup>1</sup>Mammalian Gene Collection, National Human Genome Research Institute and</aff><aff id="AF2"><sup>2</sup>National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, USA,</aff><aff id="AF3"><sup>3</sup>Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA,</aff><aff id="AF4"><sup>4</sup>Unité de Recherche en Biologie Moléculaire, Facultés Universitaires Notre-Dame de la Paix, 5000 Namur, Belgium and</aff><aff id="AF5"><sup>5</sup>Open Biosystems, Huntsville, AL 35806, USA</aff></contrib-group><author-notes><corresp id="COR1"><label>*</label>To whom correspondence should be addressed. Tel: +1 3015945951; Fax: +1 3014802770; Email: <ext-link xlink:href="gtemple@mail.nih.gov" ext-link-type="email">gtemple@mail.nih.gov</ext-link></corresp></author-notes><pub-date pub-type="ppub"><day>15</day><month>April</month><year>2006</year></pub-date><volume>15</volume><issue>suppl_1</issue><issue-title>Genomics</issue-title><fpage>R31</fpage><lpage>R43</lpage><history><date date-type="accepted"><day>2</day><month>03</month><year>2006</year></date><date date-type="received"><day>20</day><month>02</month><year>2006</year></date></history><permissions><copyright-statement>Published by Oxford University Press 2006.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact: journals.permissions@oxfordjournals.org</copyright-statement><copyright-year>2006</copyright-year><license license-type="open-access"><p></p></license></permissions><self-uri content-type="arthw-pdf" xlink:href="ddl048"></self-uri><abstract xml:lang="en"><p>cDNA clones have long been valuable reagents for studying the structure and function of proteins. With recent access to the entire human genome sequence, it has become possible and highly productive to compare the sequences of mRNAs to their genes, in order to validate the sequences and protein-coding annotations of each (1,2). Thus, well-characterized collections of human cDNAs are now playing an essential role in defining the structure and function of human genes and proteins. In this review, we will summarize the major collections of human cDNA clones, discuss some limitations common to most of these collections and describe several noteworthy proteomics applications, focusing on the detection and analysis of protein–protein interactions (PPI). These human cDNA collections contain principally two types of cDNA clones. The largest collections comprise cDNAs with full-length protein coding sequences (FL-CDS). Some but not all of these cDNA clones may represent the entire mRNA sequence, but many are missing considerable non-coding UTR sequence, usually at the 5′ end. A second type of cDNA clone, a ‘full-ORF’ (F-ORF) expression clone, is one where the annotated protein-coding sequence, excised of 5′ UTR and 3′ UTR sequence, has been transferred to a vector designed to facilitate transfer to other vectors for protein expression.</p></abstract><custom-meta-wrap><custom-meta><meta-name>hwp-legacy-fpage</meta-name><meta-value>R31</meta-value></custom-meta><custom-meta><meta-name>cover-date</meta-name><meta-value>15 April 2006</meta-value></custom-meta><custom-meta><meta-name>hwp-legacy-dochead</meta-name><meta-value>Review</meta-value></custom-meta></custom-meta-wrap></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>From genome to proteome: developing expression clone resources for the human genome</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>From genome to proteome: developing expression clone resources for the human genome</title></titleInfo><name type="personal"><namePart type="given">Gary</namePart><namePart type="family">Temple</namePart><affiliation>Mammalian Gene Collection, National Human Genome Research Institute and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Philippe</namePart><namePart type="family">Lamesch</namePart><affiliation>Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA,</affiliation><affiliation>Unité de Recherche en Biologie Moléculaire, Facultés Universitaires Notre-Dame de la Paix, 5000 Namur, Belgium and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stuart</namePart><namePart type="family">Milstein</namePart><affiliation>Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David E.</namePart><namePart type="family">Hill</namePart><affiliation>Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lukas</namePart><namePart type="family">Wagner</namePart><affiliation>National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, USA,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Troy</namePart><namePart type="family">Moore</namePart><affiliation>Open Biosystems, Huntsville, AL 35806, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marc</namePart><namePart type="family">Vidal</namePart><affiliation>Unité de Recherche en Biologie Moléculaire, Facultés Universitaires Notre-Dame de la Paix, 5000 Namur, Belgium and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="review-article"></genre><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">2006-04-15</dateIssued><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">cDNA clones have long been valuable reagents for studying the structure and function of proteins. With recent access to the entire human genome sequence, it has become possible and highly productive to compare the sequences of mRNAs to their genes, in order to validate the sequences and protein-coding annotations of each (1,2). Thus, well-characterized collections of human cDNAs are now playing an essential role in defining the structure and function of human genes and proteins. In this review, we will summarize the major collections of human cDNA clones, discuss some limitations common to most of these collections and describe several noteworthy proteomics applications, focusing on the detection and analysis of protein–protein interactions (PPI). These human cDNA collections contain principally two types of cDNA clones. The largest collections comprise cDNAs with full-length protein coding sequences (FL-CDS). Some but not all of these cDNA clones may represent the entire mRNA sequence, but many are missing considerable non-coding UTR sequence, usually at the 5′ end. A second type of cDNA clone, a ‘full-ORF’ (F-ORF) expression clone, is one where the annotated protein-coding sequence, excised of 5′ UTR and 3′ UTR sequence, has been transferred to a vector designed to facilitate transfer to other vectors for protein expression.</abstract><note type="author-notes">*To whom correspondence should be addressed. Tel: +1 3015945951; Fax: +1 3014802770; Email: gtemple@mail.nih.gov</note><relatedItem type="host"><titleInfo><title>Human Molecular Genetics</title></titleInfo><titleInfo type="abbreviated"><title>Hum. Mol. Genet.</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0964-6906</identifier><identifier type="eISSN">1460-2083</identifier><identifier type="PublisherID">hmg</identifier><identifier type="PublisherID-hwp">hmg</identifier><identifier type="PublisherID-nlm-ta">Hum Mol Genet</identifier><part><date>2006</date><detail type="title"><title>Genomics</title></detail><detail type="volume"><caption>vol.</caption><number>15</number></detail><detail type="supplement"><number>suppl_1</number></detail><extent unit="pages"><start>R31</start><end>R43</end></extent></part></relatedItem><identifier type="istex">AE7BDE6846D5AEAEF9612C8453BDC3BAEC26AFDF</identifier><identifier type="DOI">10.1093/hmg/ddl048</identifier><identifier type="href">ddl048</identifier><identifier type="local">ddl048</identifier><accessCondition type="use and reproduction" contentType="copyright">Published by Oxford University Press 2006.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact: journals.permissions@oxfordjournals.org</accessCondition><recordInfo><recordContentSource>OUP</recordContentSource></recordInfo></mods></metadata><annexes><json:item><original>true</original><mimetype>image/jpeg</mimetype><extension>jpeg</extension><uri>https://api.istex.fr/document/AE7BDE6846D5AEAEF9612C8453BDC3BAEC26AFDF/annexes/jpeg</uri></json:item><json:item><original>true</original><mimetype>image/gif</mimetype><extension>gif</extension><uri>https://api.istex.fr/document/AE7BDE6846D5AEAEF9612C8453BDC3BAEC26AFDF/annexes/gif</uri></json:item></annexes><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/AE7BDE6846D5AEAEF9612C8453BDC3BAEC26AFDF/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">BIOCHEMISTRY & MOLECULAR BIOLOGY</classCode><classCode scheme="WOS">GENETICS & HEREDITY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI><json:item><type>refBibs</type><uri>https://api.istex.fr/document/AE7BDE6846D5AEAEF9612C8453BDC3BAEC26AFDF/enrichments/refBibs</uri></json:item></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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