Association of Killer Cell Immunoglobulin-Like Receptor Genes with Pandemic Influenza A (H1N1)pdm09 Infection in Critically III Macedonian Patients
Identifieur interne : 000C31 ( Istex/Corpus ); précédent : 000C30; suivant : 000C32Association of Killer Cell Immunoglobulin-Like Receptor Genes with Pandemic Influenza A (H1N1)pdm09 Infection in Critically III Macedonian Patients
Auteurs : Aleksandar Petlichkovski ; Zvonko Milenkovic ; Eli Djulejic ; Bisera Jefremovska ; Haris Babacic ; Ljubomir Ivanovski ; Irena Kondova Topuzovska ; Katerina Spasovska ; Mirko SpiroskiSource :
- Macedonian Journal of Medical Sciences [ 1857-5749 ] ; 2012-11-01.
Abstract
Background: Infection by the pandemic influenza A (H1N1)pdm09 virus results in significant pathology disease in many cases in different populations worldwide. The natural killer (NK) cells are among the major effectors important in early innate immune responses to viral infections, interacting with host cells through their activating or inhibiting receptors. Aim: The aim of this study was to analyze Killer Ig-Like Receptor (KIR) gene polymorphisms in critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection. Material and Methods: The studied sample consists of 63 critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection. The population genetics analysis package, Arlequin, was used for analysis of the data. Results: We found that all 16 KIR genes were observed in the studied individuals and framework genes (KIR3DL3, KIR3DP1, KIR2DL4, and KIR3DL2) were present in all individuals. The results of tested linkage disequilibrium (LD) among KIR genes demonstrated that KIR genes present a wide range of linkage disequilibrium. Comparison of KIR gene frequencies between critically ill H1N1/09 Macedonian patients and healthy subjects reveals statistically significant difference for frequency of KIR2DL1 (F=1 in the patients group, and 0.94 in the control group, p=0.045). Conclusion: We did not found any significant association of all 16 KIR genes or KIR genotypes with critically ill (H1N1)pdm09 Macedonian patients, except for the KIR2DL1.
Url:
DOI: 10.2478/mjms.1857-5773.2012.0265
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<front><div type="abstract" xml:lang="en">Background: Infection by the pandemic influenza A (H1N1)pdm09 virus results in significant pathology disease in many cases in different populations worldwide. The natural killer (NK) cells are among the major effectors important in early innate immune responses to viral infections, interacting with host cells through their activating or inhibiting receptors. Aim: The aim of this study was to analyze Killer Ig-Like Receptor (KIR) gene polymorphisms in critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection. Material and Methods: The studied sample consists of 63 critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection. The population genetics analysis package, Arlequin, was used for analysis of the data. Results: We found that all 16 KIR genes were observed in the studied individuals and framework genes (KIR3DL3, KIR3DP1, KIR2DL4, and KIR3DL2) were present in all individuals. The results of tested linkage disequilibrium (LD) among KIR genes demonstrated that KIR genes present a wide range of linkage disequilibrium. Comparison of KIR gene frequencies between critically ill H1N1/09 Macedonian patients and healthy subjects reveals statistically significant difference for frequency of KIR2DL1 (F=1 in the patients group, and 0.94 in the control group, p=0.045). Conclusion: We did not found any significant association of all 16 KIR genes or KIR genotypes with critically ill (H1N1)pdm09 Macedonian patients, except for the KIR2DL1.</div>
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<abstract xml:lang="en"><p>Background: Infection by the pandemic influenza A (H1N1)pdm09 virus results in significant pathology disease in many cases in different populations worldwide. The natural killer (NK) cells are among the major effectors important in early innate immune responses to viral infections, interacting with host cells through their activating or inhibiting receptors. Aim: The aim of this study was to analyze Killer Ig-Like Receptor (KIR) gene polymorphisms in critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection. Material and Methods: The studied sample consists of 63 critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection. The population genetics analysis package, Arlequin, was used for analysis of the data. Results: We found that all 16 KIR genes were observed in the studied individuals and framework genes (KIR3DL3, KIR3DP1, KIR2DL4, and KIR3DL2) were present in all individuals. The results of tested linkage disequilibrium (LD) among KIR genes demonstrated that KIR genes present a wide range of linkage disequilibrium. Comparison of KIR gene frequencies between critically ill H1N1/09 Macedonian patients and healthy subjects reveals statistically significant difference for frequency of KIR2DL1 (F=1 in the patients group, and 0.94 in the control group, p=0.045). Conclusion: We did not found any significant association of all 16 KIR genes or KIR genotypes with critically ill (H1N1)pdm09 Macedonian patients, except for the KIR2DL1.</p>
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<journal-meta>
<journal-id journal-id-type="publisher-id">mjms</journal-id>
<journal-title-group>
<abbrev-journal-title abbrev-type="full">Macedonian Journal of Medical Sciences</abbrev-journal-title>
</journal-title-group>
<issn pub-type="epub">1857-5773</issn>
<issn pub-type="ppub">1857-5749</issn>
<publisher>
<publisher-name>Versita</publisher-name>
</publisher>
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<article-meta>
<article-id pub-id-type="publisher-id">mjms.1857-5773.2012.0265</article-id>
<article-id pub-id-type="doi">10.2478/mjms.1857-5773.2012.0265</article-id>
<article-categories></article-categories>
<title-group>
<article-title>Association of Killer Cell Immunoglobulin-Like Receptor Genes with Pandemic Influenza A (H1N1)pdm09 Infection in Critically III Macedonian Patients</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Petlichkovski</surname>
<given-names>Aleksandar</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Milenkovic</surname>
<given-names>Zvonko</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Djulejic</surname>
<given-names>Eli</given-names>
</name>
<xref ref-type="aff" rid="aff3">
<sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Jefremovska</surname>
<given-names>Bisera</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Babacic</surname>
<given-names>Haris</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ivanovski</surname>
<given-names>Ljubomir</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kondova Topuzovska</surname>
<given-names>Irena</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Spasovska</surname>
<given-names>Katerina</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Spiroski</surname>
<given-names>Mirko</given-names>
</name>
<email xlink:href="mailto:mspiroski@yahoo.com">mspiroski@yahoo.com</email>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
</contrib>
<aff id="aff1"><sup>1</sup>
Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, Republic of Macedonia</aff>
<aff id="aff2"><sup>2</sup>
University Clinic of Infective Diseases, Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, Republic of Macedonia</aff>
<aff id="aff3"><sup>3</sup>
Quintiles, Belgrade, Republic of Serbia</aff>
</contrib-group>
<pub-date pub-type="ppub">
<day>1</day>
<month>11</month>
<year>2012</year>
<string-date>1 November 2012</string-date>
</pub-date>
<pub-date pub-type="epub">
<day>23</day>
<month>11</month>
<year>2012</year>
<string-date>November 2012</string-date>
</pub-date>
<volume>5</volume>
<issue>3</issue>
<fpage>288</fpage>
<lpage>295</lpage>
<permissions>
<license license-type="open-access">
<license-p>This content is open access.</license-p>
</license>
</permissions>
<related-article related-article-type="pdf" xlink:href="mjms.1857-5773.2012.0265.pdf"></related-article>
<abstract>
<title>Abstract</title>
<p> Background: Infection by the pandemic influenza A (H1N1)pdm09 virus results in significant pathology disease in many cases in different populations worldwide. The natural killer (NK) cells are among the major effectors important in early innate immune responses to viral infections, interacting with host cells through their activating or inhibiting receptors.</p>
<p>Aim: The aim of this study was to analyze Killer Ig-Like Receptor (KIR) gene polymorphisms in critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection.</p>
<p>Material and Methods: The studied sample consists of 63 critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection. The population genetics analysis package, Arlequin, was used for analysis of the data.</p>
<p>Results: We found that all 16 KIR genes were observed in the studied individuals and framework genes (KIR3DL3, KIR3DP1, KIR2DL4, and KIR3DL2) were present in all individuals. The results of tested linkage disequilibrium (LD) among KIR genes demonstrated that KIR genes present a wide range of linkage disequilibrium. Comparison of KIR gene frequencies between critically ill H1N1/09 Macedonian patients and healthy subjects reveals statistically significant difference for frequency of KIR2DL1 (F=1 in the patients group, and 0.94 in the control group, p=0.045).</p>
<p>Conclusion: We did not found any significant association of all 16 KIR genes or KIR genotypes with critically ill (H1N1)pdm09 Macedonian patients, except for the KIR2DL1.</p>
</abstract>
<kwd-group>
<title>Keywords </title>
<kwd>Killer immunoglobulin-like receptor (KIR) gene polymorphism</kwd>
<kwd>KIR genotyping</kwd>
<kwd>PCRSSP</kwd>
<kwd>patients with (H1N1)pdm09 infection</kwd>
<kwd>Republic of Macedonia.</kwd>
</kwd-group>
</article-meta>
</front>
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<mods version="3.6"><titleInfo lang="en"><title>Association of Killer Cell Immunoglobulin-Like Receptor Genes with Pandemic Influenza A (H1N1)pdm09 Infection in Critically III Macedonian Patients</title>
</titleInfo>
<titleInfo type="alternative" lang="en" contentType="CDATA"><title>Association of Killer Cell Immunoglobulin-Like Receptor Genes with Pandemic Influenza A (H1N1)pdm09 Infection in Critically III Macedonian Patients</title>
</titleInfo>
<name type="personal"><namePart type="given">Aleksandar</namePart>
<namePart type="family">Petlichkovski</namePart>
<affiliation>Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, Republic of Macedonia</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Zvonko</namePart>
<namePart type="family">Milenkovic</namePart>
<affiliation>University Clinic of Infective Diseases, Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, Republic of Macedonia</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Eli</namePart>
<namePart type="family">Djulejic</namePart>
<affiliation>Quintiles, Belgrade, Republic of Serbia</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Bisera</namePart>
<namePart type="family">Jefremovska</namePart>
<affiliation>Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, Republic of Macedonia</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Haris</namePart>
<namePart type="family">Babacic</namePart>
<affiliation>Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, Republic of Macedonia</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Ljubomir</namePart>
<namePart type="family">Ivanovski</namePart>
<affiliation>University Clinic of Infective Diseases, Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, Republic of Macedonia</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Irena</namePart>
<namePart type="family">Kondova Topuzovska</namePart>
<affiliation>University Clinic of Infective Diseases, Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, Republic of Macedonia</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Katerina</namePart>
<namePart type="family">Spasovska</namePart>
<affiliation>University Clinic of Infective Diseases, Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, Republic of Macedonia</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal" displayLabel="corresp"><namePart type="given">Mirko</namePart>
<namePart type="family">Spiroski</namePart>
<affiliation>Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, Republic of Macedonia</affiliation>
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<originInfo><publisher>Versita</publisher>
<dateIssued encoding="w3cdtf">2012-11-01</dateIssued>
<dateCreated encoding="w3cdtf">2012-11-23</dateCreated>
<copyrightDate encoding="w3cdtf">2012</copyrightDate>
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<language><languageTerm type="code" authority="iso639-2b">eng</languageTerm>
<languageTerm type="code" authority="rfc3066">en</languageTerm>
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<abstract lang="en">Background: Infection by the pandemic influenza A (H1N1)pdm09 virus results in significant pathology disease in many cases in different populations worldwide. The natural killer (NK) cells are among the major effectors important in early innate immune responses to viral infections, interacting with host cells through their activating or inhibiting receptors. Aim: The aim of this study was to analyze Killer Ig-Like Receptor (KIR) gene polymorphisms in critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection. Material and Methods: The studied sample consists of 63 critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection. The population genetics analysis package, Arlequin, was used for analysis of the data. Results: We found that all 16 KIR genes were observed in the studied individuals and framework genes (KIR3DL3, KIR3DP1, KIR2DL4, and KIR3DL2) were present in all individuals. The results of tested linkage disequilibrium (LD) among KIR genes demonstrated that KIR genes present a wide range of linkage disequilibrium. Comparison of KIR gene frequencies between critically ill H1N1/09 Macedonian patients and healthy subjects reveals statistically significant difference for frequency of KIR2DL1 (F=1 in the patients group, and 0.94 in the control group, p=0.045). Conclusion: We did not found any significant association of all 16 KIR genes or KIR genotypes with critically ill (H1N1)pdm09 Macedonian patients, except for the KIR2DL1.</abstract>
<subject><genre>Keywords</genre>
<topic>Killer immunoglobulin-like receptor (KIR) gene polymorphism</topic>
<topic>KIR genotyping</topic>
<topic>PCRSSP</topic>
<topic>patients with (H1N1)pdm09 infection</topic>
<topic>Republic of Macedonia.</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Macedonian Journal of Medical Sciences</title>
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<genre type="journal">journal</genre>
<identifier type="ISSN">1857-5749</identifier>
<identifier type="eISSN">1857-5773</identifier>
<identifier type="PublisherID">mjms</identifier>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>5</number>
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<detail type="issue"><caption>no.</caption>
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