Combined coronary and late-enhanced multidetector-computed tomography for delineation of the etiology of left ventricular dysfunction: comparison with coronary angiography and contrast-enhanced cardiac magnetic resonance imaging
Identifieur interne : 000993 ( Istex/Corpus ); précédent : 000992; suivant : 000994Combined coronary and late-enhanced multidetector-computed tomography for delineation of the etiology of left ventricular dysfunction: comparison with coronary angiography and contrast-enhanced cardiac magnetic resonance imaging
Auteurs : Jean-Benot Le Polain De Waroux ; Anne-Catherine Pouleur ; Cline Goffinet ; Agns Pasquet ; Jean-Louis Vanoverschelde ; Bernhard L. GerberSource :
- European Heart Journal [ 0195-668X ] ; 2008-10.
Abstract
Aims To evaluate whether comprehensive evaluation of coronary anatomy and delayed enhancement (DE) by multidetector-computed tomography (MDCT) would allow determination of etiology of left ventricular dysfunction (LVD) as compared with coronary angiography (CA) and DE-magnetic resonance (CMR). Methods and results Seventy-one consecutive patients (50 males, 59 16 years) with LVD (ejection fraction: 26 11) of unknown etiology underwent MDCT, LGE (late Gd-DTPA-enhanced)-CMR and CA. Patients were classified into four groups according to coronary artery disease (CAD) by CA and LGE-CMR patterns. Patients (n 24) with CAD and transmural or sub-endocardial DE by CMR were considered having definite ischaemic LVD (group 1). Patients (n 36) without CAD by CA and with no/atypical LGE-CMR were considered non-ischaemic LVD (group 2). Further we identified four patients with transmural DE but no CAD (group 3) and seven patients with CAD but no DE (group 4). On per-patient basis, combined coronary and DE-MDCT had excellent agreement ( 0.89; P < 0.001) with CA/LGE-CMR to classify patients into the same four groups. Sensitivity, specificity and accuracy of MDCT were 97, 92 and 94, respectively for detecting patients with definite (group 1) or likely (groups 3 and 4) ischaemic LVD. Conclusion Combined coronary and DE-MDCT can accurately differentiate ischaemic vs. non-ischaemic etiology of LVD.
Url:
DOI: 10.1093/eurheartj/ehn381
Links to Exploration step
ISTEX:8186013D21C42C5B5687C2184CCE5D1E636E65B2Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Combined coronary and late-enhanced multidetector-computed tomography for delineation of the etiology of left ventricular dysfunction: comparison with coronary angiography and contrast-enhanced cardiac magnetic resonance imaging</title><author><name sortKey="Le Polain De Waroux, Jean Benot" sort="Le Polain De Waroux, Jean Benot" uniqKey="Le Polain De Waroux J" first="Jean-Benot" last="Le Polain De Waroux">Jean-Benot Le Polain De Waroux</name><affiliation><mods:affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Pouleur, Anne Catherine" sort="Pouleur, Anne Catherine" uniqKey="Pouleur A" first="Anne-Catherine" last="Pouleur">Anne-Catherine Pouleur</name><affiliation><mods:affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Goffinet, Cline" sort="Goffinet, Cline" uniqKey="Goffinet C" first="Cline" last="Goffinet">Cline Goffinet</name><affiliation><mods:affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Pasquet, Agns" sort="Pasquet, Agns" uniqKey="Pasquet A" first="Agns" last="Pasquet">Agns Pasquet</name><affiliation><mods:affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Vanoverschelde, Jean Louis" sort="Vanoverschelde, Jean Louis" uniqKey="Vanoverschelde J" first="Jean-Louis" last="Vanoverschelde">Jean-Louis Vanoverschelde</name><affiliation><mods:affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Gerber, Bernhard L" sort="Gerber, Bernhard L" uniqKey="Gerber B" first="Bernhard L." last="Gerber">Bernhard L. Gerber</name><affiliation><mods:affiliation>E-mail: bernhard.gerber@uclouvain.be</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8186013D21C42C5B5687C2184CCE5D1E636E65B2</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1093/eurheartj/ehn381</idno><idno type="url">https://api.istex.fr/document/8186013D21C42C5B5687C2184CCE5D1E636E65B2/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000993</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Combined coronary and late-enhanced multidetector-computed tomography for delineation of the etiology of left ventricular dysfunction: comparison with coronary angiography and contrast-enhanced cardiac magnetic resonance imaging</title><author><name sortKey="Le Polain De Waroux, Jean Benot" sort="Le Polain De Waroux, Jean Benot" uniqKey="Le Polain De Waroux J" first="Jean-Benot" last="Le Polain De Waroux">Jean-Benot Le Polain De Waroux</name><affiliation><mods:affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Pouleur, Anne Catherine" sort="Pouleur, Anne Catherine" uniqKey="Pouleur A" first="Anne-Catherine" last="Pouleur">Anne-Catherine Pouleur</name><affiliation><mods:affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Goffinet, Cline" sort="Goffinet, Cline" uniqKey="Goffinet C" first="Cline" last="Goffinet">Cline Goffinet</name><affiliation><mods:affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Pasquet, Agns" sort="Pasquet, Agns" uniqKey="Pasquet A" first="Agns" last="Pasquet">Agns Pasquet</name><affiliation><mods:affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Vanoverschelde, Jean Louis" sort="Vanoverschelde, Jean Louis" uniqKey="Vanoverschelde J" first="Jean-Louis" last="Vanoverschelde">Jean-Louis Vanoverschelde</name><affiliation><mods:affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Gerber, Bernhard L" sort="Gerber, Bernhard L" uniqKey="Gerber B" first="Bernhard L." last="Gerber">Bernhard L. Gerber</name><affiliation><mods:affiliation>E-mail: bernhard.gerber@uclouvain.be</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Heart Journal</title><idno type="ISSN">0195-668X</idno><idno type="eISSN">1522-9645</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2008-10">2008-10</date><biblScope unit="volume">29</biblScope><biblScope unit="issue">20</biblScope><biblScope unit="page" from="2544">2544</biblScope><biblScope unit="page" to="2551">2551</biblScope></imprint><idno type="ISSN">0195-668X</idno></series><idno type="istex">8186013D21C42C5B5687C2184CCE5D1E636E65B2</idno><idno type="DOI">10.1093/eurheartj/ehn381</idno><idno type="ArticleID">ehn381</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0195-668X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Aims To evaluate whether comprehensive evaluation of coronary anatomy and delayed enhancement (DE) by multidetector-computed tomography (MDCT) would allow determination of etiology of left ventricular dysfunction (LVD) as compared with coronary angiography (CA) and DE-magnetic resonance (CMR). Methods and results Seventy-one consecutive patients (50 males, 59 16 years) with LVD (ejection fraction: 26 11) of unknown etiology underwent MDCT, LGE (late Gd-DTPA-enhanced)-CMR and CA. Patients were classified into four groups according to coronary artery disease (CAD) by CA and LGE-CMR patterns. Patients (n 24) with CAD and transmural or sub-endocardial DE by CMR were considered having definite ischaemic LVD (group 1). Patients (n 36) without CAD by CA and with no/atypical LGE-CMR were considered non-ischaemic LVD (group 2). Further we identified four patients with transmural DE but no CAD (group 3) and seven patients with CAD but no DE (group 4). On per-patient basis, combined coronary and DE-MDCT had excellent agreement ( 0.89; P < 0.001) with CA/LGE-CMR to classify patients into the same four groups. Sensitivity, specificity and accuracy of MDCT were 97, 92 and 94, respectively for detecting patients with definite (group 1) or likely (groups 3 and 4) ischaemic LVD. Conclusion Combined coronary and DE-MDCT can accurately differentiate ischaemic vs. non-ischaemic etiology of LVD.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Jean-Benot le Polain de Waroux</name><affiliations><json:string>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</json:string></affiliations></json:item><json:item><name>Anne-Catherine Pouleur</name><affiliations><json:string>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</json:string></affiliations></json:item><json:item><name>Cline Goffinet</name><affiliations><json:string>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</json:string></affiliations></json:item><json:item><name>Agns Pasquet</name><affiliations><json:string>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</json:string></affiliations></json:item><json:item><name>Jean-Louis Vanoverschelde</name><affiliations><json:string>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</json:string></affiliations></json:item><json:item><name>Bernhard L. Gerber</name><affiliations><json:string>E-mail: bernhard.gerber@uclouvain.be</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Computed tomography</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Left ventricular dysfunction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Magnetic resonance imaging</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Coronary angiography</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Dilated cardiomyopathy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Infarct</value></json:item></subject><articleId><json:string>ehn381</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>Aims To evaluate whether comprehensive evaluation of coronary anatomy and delayed enhancement (DE) by multidetector-computed tomography (MDCT) would allow determination of etiology of left ventricular dysfunction (LVD) as compared with coronary angiography (CA) and DE-magnetic resonance (CMR). Methods and results Seventy-one consecutive patients (50 males, 59 16 years) with LVD (ejection fraction: 26 11) of unknown etiology underwent MDCT, LGE (late Gd-DTPA-enhanced)-CMR and CA. Patients were classified into four groups according to coronary artery disease (CAD) by CA and LGE-CMR patterns. Patients (n 24) with CAD and transmural or sub-endocardial DE by CMR were considered having definite ischaemic LVD (group 1). Patients (n 36) without CAD by CA and with no/atypical LGE-CMR were considered non-ischaemic LVD (group 2). Further we identified four patients with transmural DE but no CAD (group 3) and seven patients with CAD but no DE (group 4). On per-patient basis, combined coronary and DE-MDCT had excellent agreement ( 0.89; P > 0.001) with CA/LGE-CMR to classify patients into the same four groups. Sensitivity, specificity and accuracy of MDCT were 97, 92 and 94, respectively for detecting patients with definite (group 1) or likely (groups 3 and 4) ischaemic LVD. Conclusion Combined coronary and DE-MDCT can accurately differentiate ischaemic vs. non-ischaemic etiology of LVD.</abstract><qualityIndicators><score>7.484</score><pdfVersion>1.2</pdfVersion><pdfPageSize>664.214 x 862.639 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1397</abstractCharCount><pdfWordCount>5555</pdfWordCount><pdfCharCount>36484</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>207</abstractWordCount></qualityIndicators><title>Combined coronary and late-enhanced multidetector-computed tomography for delineation of the etiology of left ventricular dysfunction: comparison with coronary angiography and contrast-enhanced cardiac magnetic resonance imaging</title><genre><json:string>research-article</json:string></genre><host><volume>29</volume><publisherId><json:string>eurheartj</json:string></publisherId><pages><last>2551</last><first>2544</first></pages><issn><json:string>0195-668X</json:string></issn><issue>20</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1522-9645</json:string></eissn><title>European Heart Journal</title></host><categories><wos><json:string>CARDIAC & CARDIOVASCULAR SYSTEMS</json:string></wos></categories><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1093/eurheartj/ehn381</json:string></doi><id>8186013D21C42C5B5687C2184CCE5D1E636E65B2</id><score>0.26701373</score><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/8186013D21C42C5B5687C2184CCE5D1E636E65B2/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/8186013D21C42C5B5687C2184CCE5D1E636E65B2/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/8186013D21C42C5B5687C2184CCE5D1E636E65B2/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Combined coronary and late-enhanced multidetector-computed tomography for delineation of the etiology of left ventricular dysfunction: comparison with coronary angiography and contrast-enhanced cardiac magnetic resonance imaging</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Oxford University Press</publisher><availability><p>Published on behalf of the European Society of Cardiology. All rights reserved. The Author 2008. For permissions please email: journals.permissionsoxfordjournals.org</p></availability><date>2008-09-01</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Combined coronary and late-enhanced multidetector-computed tomography for delineation of the etiology of left ventricular dysfunction: comparison with coronary angiography and contrast-enhanced cardiac magnetic resonance imaging</title><author xml:id="author-1"><persName><forename type="first">Jean-Benot</forename><surname>le Polain de Waroux</surname></persName><affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</affiliation></author><author xml:id="author-2"><persName><forename type="first">Anne-Catherine</forename><surname>Pouleur</surname></persName><affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</affiliation></author><author xml:id="author-3"><persName><forename type="first">Cline</forename><surname>Goffinet</surname></persName><affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</affiliation></author><author xml:id="author-4"><persName><forename type="first">Agns</forename><surname>Pasquet</surname></persName><affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</affiliation></author><author xml:id="author-5"><persName><forename type="first">Jean-Louis</forename><surname>Vanoverschelde</surname></persName><affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</affiliation></author><author xml:id="author-6"><persName><forename type="first">Bernhard L.</forename><surname>Gerber</surname></persName><email>bernhard.gerber@uclouvain.be</email></author></analytic><monogr><title level="j">European Heart Journal</title><idno type="pISSN">0195-668X</idno><idno type="eISSN">1522-9645</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2008-10"></date><biblScope unit="volume">29</biblScope><biblScope unit="issue">20</biblScope><biblScope unit="page" from="2544">2544</biblScope><biblScope unit="page" to="2551">2551</biblScope></imprint></monogr><idno type="istex">8186013D21C42C5B5687C2184CCE5D1E636E65B2</idno><idno type="DOI">10.1093/eurheartj/ehn381</idno><idno type="ArticleID">ehn381</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008-09-01</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Aims To evaluate whether comprehensive evaluation of coronary anatomy and delayed enhancement (DE) by multidetector-computed tomography (MDCT) would allow determination of etiology of left ventricular dysfunction (LVD) as compared with coronary angiography (CA) and DE-magnetic resonance (CMR). Methods and results Seventy-one consecutive patients (50 males, 59 16 years) with LVD (ejection fraction: 26 11) of unknown etiology underwent MDCT, LGE (late Gd-DTPA-enhanced)-CMR and CA. Patients were classified into four groups according to coronary artery disease (CAD) by CA and LGE-CMR patterns. Patients (n 24) with CAD and transmural or sub-endocardial DE by CMR were considered having definite ischaemic LVD (group 1). Patients (n 36) without CAD by CA and with no/atypical LGE-CMR were considered non-ischaemic LVD (group 2). Further we identified four patients with transmural DE but no CAD (group 3) and seven patients with CAD but no DE (group 4). On per-patient basis, combined coronary and DE-MDCT had excellent agreement ( 0.89; P < 0.001) with CA/LGE-CMR to classify patients into the same four groups. Sensitivity, specificity and accuracy of MDCT were 97, 92 and 94, respectively for detecting patients with definite (group 1) or likely (groups 3 and 4) ischaemic LVD. Conclusion Combined coronary and DE-MDCT can accurately differentiate ischaemic vs. non-ischaemic etiology of LVD.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Computed tomography</term></item><item><term>Left ventricular dysfunction</term></item><item><term>Magnetic resonance imaging</term></item><item><term>Coronary angiography</term></item><item><term>Dilated cardiomyopathy</term></item><item><term>Infarct</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-09-01">Created</change><change when="2008-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/8186013D21C42C5B5687C2184CCE5D1E636E65B2/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">ehj</journal-id><journal-id journal-id-type="publisher-id">eurheartj</journal-id><journal-title>European Heart Journal</journal-title><issn pub-type="ppub">0195-668X</issn><issn pub-type="epub">1522-9645</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1093/eurheartj/ehn381</article-id><article-id pub-id-type="publisher-id">ehn381</article-id><article-categories><subj-group subj-group-type="heading"><subject>CLINICAL RESEARCH</subject><subj-group subj-group-type="heading"><subject>Imaging</subject></subj-group></subj-group></article-categories><title-group><article-title>Combined coronary and late-enhanced multidetector-computed tomography for delineation of the etiology of left ventricular dysfunction: comparison with coronary angiography and contrast-enhanced cardiac magnetic resonance imaging</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>le Polain de Waroux</surname><given-names>Jean-Benoît</given-names></name></contrib><contrib contrib-type="author"><name><surname>Pouleur</surname><given-names>Anne-Catherine</given-names></name></contrib><contrib contrib-type="author"><name><surname>Goffinet</surname><given-names>Céline</given-names></name></contrib><contrib contrib-type="author"><name><surname>Pasquet</surname><given-names>Agnès</given-names></name></contrib><contrib contrib-type="author"><name><surname>Vanoverschelde</surname><given-names>Jean-Louis</given-names></name></contrib><contrib contrib-type="author"><name><surname>Gerber</surname><given-names>Bernhard L.</given-names></name><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff><addr-line>Division of Cardiology, Department of Cardiovascular Diseases</addr-line>, <institution>Cliniques Universitaires St Luc UCL</institution>, <addr-line>Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels</addr-line>, <country>Belgium</country></aff><author-notes><corresp id="cor1"><label>*</label>Corresponding author. Tel: <phone>+32 2 7642803</phone>, Fax: <fax>+32 2 7648980</fax>, Email: <email>bernhard.gerber@uclouvain.be</email></corresp></author-notes><pub-date pub-type="ppub"><month>10</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>1</day><month>9</month><year>2008</year></pub-date><volume>29</volume><issue>20</issue><fpage>2544</fpage><lpage>2551</lpage><history><date date-type="received"><day>18</day><month>2</month><year>2008</year></date><date date-type="rev-recd"><day>27</day><month>6</month><year>2008</year></date><date date-type="accepted"><day>25</day><month>7</month><year>2008</year></date></history><copyright-statement>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org</copyright-statement><copyright-year>2008</copyright-year><license license-type="creative-commons" xlink:href="http://creativecommons.org/licenses/by-nc/2.0/uk/"><p>The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org.</p></license><abstract><sec><title>Aims</title><p>To evaluate whether comprehensive evaluation of coronary anatomy and delayed enhancement (DE) by multidetector-computed tomography (MDCT) would allow determination of etiology of left ventricular dysfunction (LVD) as compared with coronary angiography (CA) and DE-magnetic resonance (CMR).</p></sec><sec><title>Methods and results</title><p>Seventy-one consecutive patients (50 males, 59 ± 16 years) with LVD (ejection fraction: 26 ± 11%) of unknown etiology underwent MDCT, LGE (late Gd-DTPA-enhanced)-CMR and CA. Patients were classified into four groups according to coronary artery disease (CAD) by CA and LGE-CMR patterns. Patients (<italic>n</italic> = 24) with CAD and transmural or sub-endocardial DE by CMR were considered having definite ischaemic LVD (group 1). Patients (<italic>n</italic> = 36) without CAD by CA and with no/atypical LGE-CMR were considered non-ischaemic LVD (group 2). Further we identified four patients with transmural DE but no CAD (group 3) and seven patients with CAD but no DE (group 4). On per-patient basis, combined coronary and DE-MDCT had excellent agreement (<italic>κ</italic> = 0.89; <italic>P</italic> < 0.001) with CA/LGE-CMR to classify patients into the same four groups. Sensitivity, specificity and accuracy of MDCT were 97, 92 and 94%, respectively for detecting patients with definite (group 1) or likely (groups 3 and 4) ischaemic LVD.</p></sec><sec><title>Conclusion</title><p>Combined coronary and DE-MDCT can accurately differentiate ischaemic vs. non-ischaemic etiology of LVD.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>Computed tomography</kwd><kwd>Left ventricular dysfunction</kwd><kwd>Magnetic resonance imaging</kwd><kwd>Coronary angiography</kwd><kwd>Dilated cardiomyopathy</kwd><kwd>Infarct</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Combined coronary and late-enhanced multidetector-computed tomography for delineation of the etiology of left ventricular dysfunction: comparison with coronary angiography and contrast-enhanced cardiac magnetic resonance imaging</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Combined coronary and late-enhanced multidetector-computed tomography for delineation of the etiology of left ventricular dysfunction: comparison with coronary angiography and contrast-enhanced cardiac magnetic resonance imaging</title></titleInfo><name type="personal"><namePart type="given">Jean-Benot</namePart><namePart type="family">le Polain de Waroux</namePart><affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anne-Catherine</namePart><namePart type="family">Pouleur</namePart><affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Cline</namePart><namePart type="family">Goffinet</namePart><affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Agns</namePart><namePart type="family">Pasquet</namePart><affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean-Louis</namePart><namePart type="family">Vanoverschelde</namePart><affiliation>Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St Luc UCL, Av Hippocrate 10/2806, B-1200 Woluwe St Lambert, Brussels, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bernhard L.</namePart><namePart type="family">Gerber</namePart><affiliation>E-mail: bernhard.gerber@uclouvain.be</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">2008-10</dateIssued><dateCreated encoding="w3cdtf">2008-09-01</dateCreated><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Aims To evaluate whether comprehensive evaluation of coronary anatomy and delayed enhancement (DE) by multidetector-computed tomography (MDCT) would allow determination of etiology of left ventricular dysfunction (LVD) as compared with coronary angiography (CA) and DE-magnetic resonance (CMR). Methods and results Seventy-one consecutive patients (50 males, 59 16 years) with LVD (ejection fraction: 26 11) of unknown etiology underwent MDCT, LGE (late Gd-DTPA-enhanced)-CMR and CA. Patients were classified into four groups according to coronary artery disease (CAD) by CA and LGE-CMR patterns. Patients (n 24) with CAD and transmural or sub-endocardial DE by CMR were considered having definite ischaemic LVD (group 1). Patients (n 36) without CAD by CA and with no/atypical LGE-CMR were considered non-ischaemic LVD (group 2). Further we identified four patients with transmural DE but no CAD (group 3) and seven patients with CAD but no DE (group 4). On per-patient basis, combined coronary and DE-MDCT had excellent agreement ( 0.89; P < 0.001) with CA/LGE-CMR to classify patients into the same four groups. Sensitivity, specificity and accuracy of MDCT were 97, 92 and 94, respectively for detecting patients with definite (group 1) or likely (groups 3 and 4) ischaemic LVD. Conclusion Combined coronary and DE-MDCT can accurately differentiate ischaemic vs. non-ischaemic etiology of LVD.</abstract><subject><genre>Keywords</genre><topic>Computed tomography</topic><topic>Left ventricular dysfunction</topic><topic>Magnetic resonance imaging</topic><topic>Coronary angiography</topic><topic>Dilated cardiomyopathy</topic><topic>Infarct</topic></subject><relatedItem type="host"><titleInfo><title>European Heart Journal</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0195-668X</identifier><identifier type="eISSN">1522-9645</identifier><identifier type="PublisherID">eurheartj</identifier><identifier type="PublisherID-hwp">ehj</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><detail type="issue"><caption>no.</caption><number>20</number></detail><extent unit="pages"><start>2544</start><end>2551</end></extent></part></relatedItem><identifier type="istex">8186013D21C42C5B5687C2184CCE5D1E636E65B2</identifier><identifier type="DOI">10.1093/eurheartj/ehn381</identifier><identifier type="ArticleID">ehn381</identifier><accessCondition type="use and reproduction" contentType="copyright">Published on behalf of the European Society of Cardiology. All rights reserved. The Author 2008. For permissions please email: journals.permissionsoxfordjournals.org</accessCondition><recordInfo><recordContentSource>OUP</recordContentSource></recordInfo></mods></metadata><covers><json:item><original>true</original><mimetype>image/tiff</mimetype><extension>tiff</extension><uri>https://api.istex.fr/document/8186013D21C42C5B5687C2184CCE5D1E636E65B2/covers/tiff</uri></json:item><json:item><original>true</original><mimetype>text/html</mimetype><extension>html</extension><uri>https://api.istex.fr/document/8186013D21C42C5B5687C2184CCE5D1E636E65B2/covers/html</uri></json:item></covers><annexes><json:item><original>true</original><mimetype>image/jpeg</mimetype><extension>jpeg</extension><uri>https://api.istex.fr/document/8186013D21C42C5B5687C2184CCE5D1E636E65B2/annexes/jpeg</uri></json:item><json:item><original>true</original><mimetype>image/gif</mimetype><extension>gif</extension><uri>https://api.istex.fr/document/8186013D21C42C5B5687C2184CCE5D1E636E65B2/annexes/gif</uri></json:item><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/8186013D21C42C5B5687C2184CCE5D1E636E65B2/annexes/pdf</uri></json:item></annexes><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/8186013D21C42C5B5687C2184CCE5D1E636E65B2/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">CARDIAC & CARDIOVASCULAR SYSTEMS</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Belgique/explor/OpenAccessBelV2/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000993 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000993 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Belgique
|area= OpenAccessBelV2
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:8186013D21C42C5B5687C2184CCE5D1E636E65B2
|texte= Combined coronary and late-enhanced multidetector-computed tomography for delineation of the etiology of left ventricular dysfunction: comparison with coronary angiography and contrast-enhanced cardiac magnetic resonance imaging
}}
| This area was generated with Dilib version V0.6.25. |  |