T1DBase, a community web-based resource for type 1 diabetes research
Identifieur interne : 000191 ( Istex/Corpus ); précédent : 000190; suivant : 000192T1DBase, a community web-based resource for type 1 diabetes research
Auteurs : Luc J. Smink ; Erin M. Helton ; Barry C. Healy ; Christopher C. Cavnor ; Alex C. Lam ; Daisy Flamez ; Oliver S. Burren ; Yang Wang ; Geoffrey E. Dolman ; David B. Burdick ; Vincent H. Everett ; Gustavo Glusman ; Davide Laneri ; Lee Rowen ; Helen Schuilenburg ; Neil M. Walker ; Josyf Mychaleckyj ; Linda S. Wicker ; Decio L. Eizirik ; John A. Todd ; Nathan GoodmanSource :
- Nucleic Acids Research [ 0305-1048 ] ; 2005-01-01.
Abstract
T1DBase (http://T1DBase.org) is a public website and database that supports the type 1 diabetes (T1D) research community. The site is currently focused on the molecular genetics and biology of T1D susceptibility and pathogenesis. It includes the following datasets: annotated genome sequence for human, rat and mouse; information on genetically identified T1D susceptibility regions in human, rat and mouse, and genetic linkage and association studies pertaining to T1D; descriptions of NOD mouse congenic strains; the Beta Cell Gene Expression Bank, which reports expression levels of genes in beta cells under various conditions, and annotations of gene function in beta cells; data on gene expression in a variety of tissues and organs; and biological pathways from KEGG and BioCarta. Tools on the site include the GBrowse genome browser, site-wide context dependent search, Connect-the-Dots for connecting gene and other identifiers from multiple data sources, Cytoscape for visualizing and analyzing biological networks, and the GESTALT workbench for genome annotation. All data are open access and all software is open source.
Url:
DOI: 10.1093/nar/gki095
Links to Exploration step
ISTEX:299F884DFB177EEF6C2892D9CC0662CE80B313F7Le document en format XML
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Todd</name><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Goodman, Nathan" sort="Goodman, Nathan" uniqKey="Goodman N" first="Nathan" last="Goodman">Nathan Goodman</name><affiliation><mods:affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:299F884DFB177EEF6C2892D9CC0662CE80B313F7</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1093/nar/gki095</idno><idno type="url">https://api.istex.fr/document/299F884DFB177EEF6C2892D9CC0662CE80B313F7/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000191</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">T1DBase, a community web-based resource for type 1 diabetes research</title><author><name sortKey="Smink, Luc J" sort="Smink, Luc J" uniqKey="Smink L" first="Luc J." last="Smink">Luc J. Smink</name><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Helton, Erin M" sort="Helton, Erin M" uniqKey="Helton E" first="Erin M." last="Helton">Erin M. Helton</name><affiliation><mods:affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</mods:affiliation></affiliation><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Healy, Barry C" sort="Healy, Barry C" uniqKey="Healy B" first="Barry C." last="Healy">Barry C. Healy</name><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Cavnor, Christopher C" sort="Cavnor, Christopher C" uniqKey="Cavnor C" first="Christopher C." last="Cavnor">Christopher C. Cavnor</name><affiliation><mods:affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</mods:affiliation></affiliation><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Lam, Alex C" sort="Lam, Alex C" uniqKey="Lam A" first="Alex C." last="Lam">Alex C. Lam</name><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Flamez, Daisy" sort="Flamez, Daisy" uniqKey="Flamez D" first="Daisy" last="Flamez">Daisy Flamez</name><affiliation><mods:affiliation>Laboratory of Experimental Medicine, Free University of Brussels (ULB), Brussels, Belgium and</mods:affiliation></affiliation><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Burren, Oliver S" sort="Burren, Oliver S" uniqKey="Burren O" first="Oliver S." last="Burren">Oliver S. Burren</name><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Wang, Yang" sort="Wang, Yang" uniqKey="Wang Y" first="Yang" last="Wang">Yang Wang</name><affiliation><mods:affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</mods:affiliation></affiliation><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Dolman, Geoffrey E" sort="Dolman, Geoffrey E" uniqKey="Dolman G" first="Geoffrey E." last="Dolman">Geoffrey E. Dolman</name><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Burdick, David B" sort="Burdick, David B" uniqKey="Burdick D" first="David B." last="Burdick">David B. Burdick</name><affiliation><mods:affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</mods:affiliation></affiliation><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Everett, Vincent H" sort="Everett, Vincent H" uniqKey="Everett V" first="Vincent H." last="Everett">Vincent H. Everett</name><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Glusman, Gustavo" sort="Glusman, Gustavo" uniqKey="Glusman G" first="Gustavo" last="Glusman">Gustavo Glusman</name><affiliation><mods:affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</mods:affiliation></affiliation><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Laneri, Davide" sort="Laneri, Davide" uniqKey="Laneri D" first="Davide" last="Laneri">Davide Laneri</name><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Rowen, Lee" sort="Rowen, Lee" uniqKey="Rowen L" first="Lee" last="Rowen">Lee Rowen</name><affiliation><mods:affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</mods:affiliation></affiliation><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Schuilenburg, Helen" sort="Schuilenburg, Helen" uniqKey="Schuilenburg H" first="Helen" last="Schuilenburg">Helen Schuilenburg</name><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Walker, Neil M" sort="Walker, Neil M" uniqKey="Walker N" first="Neil M." last="Walker">Neil M. Walker</name><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Mychaleckyj, Josyf" sort="Mychaleckyj, Josyf" uniqKey="Mychaleckyj J" first="Josyf" last="Mychaleckyj">Josyf Mychaleckyj</name><affiliation><mods:affiliation>Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Wicker, Linda S" sort="Wicker, Linda S" uniqKey="Wicker L" first="Linda S." last="Wicker">Linda S. Wicker</name><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Eizirik, Decio L" sort="Eizirik, Decio L" uniqKey="Eizirik D" first="Decio L." last="Eizirik">Decio L. Eizirik</name><affiliation><mods:affiliation>Laboratory of Experimental Medicine, Free University of Brussels (ULB), Brussels, Belgium and</mods:affiliation></affiliation><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Todd, John A" sort="Todd, John A" uniqKey="Todd J" first="John A." last="Todd">John A. Todd</name><affiliation><mods:affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</mods:affiliation></affiliation></author><author><name sortKey="Goodman, Nathan" sort="Goodman, Nathan" uniqKey="Goodman N" first="Nathan" last="Goodman">Nathan Goodman</name><affiliation><mods:affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Nucleic Acids Research</title><title level="j" type="abbrev">Nucl. Acids Res.</title><idno type="ISSN">0305-1048</idno><idno type="eISSN">1362-4962</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2005-01-01">2005-01-01</date><biblScope unit="volume">33</biblScope><biblScope unit="supplement">suppl_1</biblScope><biblScope unit="page" from="D544">D544</biblScope><biblScope unit="page" to="D549">D549</biblScope></imprint><idno type="ISSN">0305-1048</idno></series><idno type="istex">299F884DFB177EEF6C2892D9CC0662CE80B313F7</idno><idno type="DOI">10.1093/nar/gki095</idno><idno type="local">gki095</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0305-1048</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">T1DBase (http://T1DBase.org) is a public website and database that supports the type 1 diabetes (T1D) research community. The site is currently focused on the molecular genetics and biology of T1D susceptibility and pathogenesis. It includes the following datasets: annotated genome sequence for human, rat and mouse; information on genetically identified T1D susceptibility regions in human, rat and mouse, and genetic linkage and association studies pertaining to T1D; descriptions of NOD mouse congenic strains; the Beta Cell Gene Expression Bank, which reports expression levels of genes in beta cells under various conditions, and annotations of gene function in beta cells; data on gene expression in a variety of tissues and organs; and biological pathways from KEGG and BioCarta. Tools on the site include the GBrowse genome browser, site-wide context dependent search, Connect-the-Dots for connecting gene and other identifiers from multiple data sources, Cytoscape for visualizing and analyzing biological networks, and the GESTALT workbench for genome annotation. All data are open access and all software is open source.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Luc J. Smink</name><affiliations><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string><json:string>E-mail: Luc.Smink@cimr.cam.ac.uk</json:string></affiliations></json:item><json:item><name>Erin M. Helton</name><affiliations><json:string>Institute for Systems Biology, Seattle, WA 98103, USA,</json:string><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>Barry C. Healy</name><affiliations><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>Christopher C. Cavnor</name><affiliations><json:string>Institute for Systems Biology, Seattle, WA 98103, USA,</json:string><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>Alex C. Lam</name><affiliations><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>Daisy Flamez</name><affiliations><json:string>Laboratory of Experimental Medicine, Free University of Brussels (ULB), Brussels, Belgium and</json:string><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>Oliver S. Burren</name><affiliations><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>Yang Wang</name><affiliations><json:string>Institute for Systems Biology, Seattle, WA 98103, USA,</json:string><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>Geoffrey E. Dolman</name><affiliations><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>David B. Burdick</name><affiliations><json:string>Institute for Systems Biology, Seattle, WA 98103, USA,</json:string><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>Vincent H. Everett</name><affiliations><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>Gustavo Glusman</name><affiliations><json:string>Institute for Systems Biology, Seattle, WA 98103, USA,</json:string><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>Davide Laneri</name><affiliations><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>Lee Rowen</name><affiliations><json:string>Institute for Systems Biology, Seattle, WA 98103, USA,</json:string><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>Helen Schuilenburg</name><affiliations><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>Neil M. Walker</name><affiliations><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>Josyf Mychaleckyj</name><affiliations><json:string>Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA</json:string><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>Linda S. Wicker</name><affiliations><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>Decio L. Eizirik</name><affiliations><json:string>Laboratory of Experimental Medicine, Free University of Brussels (ULB), Brussels, Belgium and</json:string><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>John A. Todd</name><affiliations><json:string>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</json:string></affiliations></json:item><json:item><name>Nathan Goodman</name><affiliations><json:string>Institute for Systems Biology, Seattle, WA 98103, USA,</json:string><json:string>E-mail: Luc.Smink@cimr.cam.ac.uk</json:string></affiliations></json:item></author><language><json:string>eng</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>T1DBase (http://T1DBase.org) is a public website and database that supports the type 1 diabetes (T1D) research community. The site is currently focused on the molecular genetics and biology of T1D susceptibility and pathogenesis. It includes the following datasets: annotated genome sequence for human, rat and mouse; information on genetically identified T1D susceptibility regions in human, rat and mouse, and genetic linkage and association studies pertaining to T1D; descriptions of NOD mouse congenic strains; the Beta Cell Gene Expression Bank, which reports expression levels of genes in beta cells under various conditions, and annotations of gene function in beta cells; data on gene expression in a variety of tissues and organs; and biological pathways from KEGG and BioCarta. Tools on the site include the GBrowse genome browser, site-wide context dependent search, Connect-the-Dots for connecting gene and other identifiers from multiple data sources, Cytoscape for visualizing and analyzing biological networks, and the GESTALT workbench for genome annotation. All data are open access and all software is open source.</abstract><qualityIndicators><score>6.435</score><pdfVersion>1.4</pdfVersion><pdfPageSize>612 x 794 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1132</abstractCharCount><pdfWordCount>3943</pdfWordCount><pdfCharCount>25384</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>166</abstractWordCount></qualityIndicators><title>T1DBase, a community web-based resource for type 1 diabetes research</title><genre><json:string>research-article</json:string></genre><host><volume>33</volume><publisherId><json:string>nar</json:string></publisherId><pages><last>D549</last><first>D544</first></pages><issn><json:string>0305-1048</json:string></issn><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1362-4962</json:string></eissn><title>Nucleic Acids Research</title></host><categories><wos><json:string>BIOCHEMISTRY & MOLECULAR BIOLOGY</json:string></wos></categories><publicationDate>2005</publicationDate><copyrightDate>2005</copyrightDate><doi><json:string>10.1093/nar/gki095</json:string></doi><id>299F884DFB177EEF6C2892D9CC0662CE80B313F7</id><score>0.33396137</score><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/299F884DFB177EEF6C2892D9CC0662CE80B313F7/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/299F884DFB177EEF6C2892D9CC0662CE80B313F7/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/299F884DFB177EEF6C2892D9CC0662CE80B313F7/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">T1DBase, a community web-based resource for type 1 diabetes research</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Oxford University Press</publisher><availability><p>© 2005, the authors
Nucleic Acids Research, Vol. 33, Database issue © Oxford University Press 2005; all rights reserved</p></availability><date>2005</date></publicationStmt><notesStmt><note>Received August 20, 2004; Revised and Accepted October 12, 2004</note><note>*To whom correspondence should be addressed. Tel: +44 1223 763211; Fax: +44 1223 762102; Email: Luc.Smink@cimr.cam.ac.uk
Correspondence may also be addressed to Nathan Goodman. Tel: +1 206 331 0077; Fax: +1 206 732 1299; Email: natg@shore.net</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">T1DBase, a community web-based resource for type 1 diabetes research</title><author xml:id="author-1"><persName><forename type="first">Luc J.</forename><surname>Smink</surname></persName><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-2"><persName><forename type="first">Erin M.</forename><surname>Helton</surname></persName><affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-3"><persName><forename type="first">Barry C.</forename><surname>Healy</surname></persName><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-4"><persName><forename type="first">Christopher C.</forename><surname>Cavnor</surname></persName><affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-5"><persName><forename type="first">Alex C.</forename><surname>Lam</surname></persName><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-6"><persName><forename type="first">Daisy</forename><surname>Flamez</surname></persName><affiliation>Laboratory of Experimental Medicine, Free University of Brussels (ULB), Brussels, Belgium and</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-7"><persName><forename type="first">Oliver S.</forename><surname>Burren</surname></persName><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-8"><persName><forename type="first">Yang</forename><surname>Wang</surname></persName><affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-9"><persName><forename type="first">Geoffrey E.</forename><surname>Dolman</surname></persName><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-10"><persName><forename type="first">David B.</forename><surname>Burdick</surname></persName><affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-11"><persName><forename type="first">Vincent H.</forename><surname>Everett</surname></persName><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-12"><persName><forename type="first">Gustavo</forename><surname>Glusman</surname></persName><affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-13"><persName><forename type="first">Davide</forename><surname>Laneri</surname></persName><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-14"><persName><forename type="first">Lee</forename><surname>Rowen</surname></persName><affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-15"><persName><forename type="first">Helen</forename><surname>Schuilenburg</surname></persName><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-16"><persName><forename type="first">Neil M.</forename><surname>Walker</surname></persName><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-17"><persName><forename type="first">Josyf</forename><surname>Mychaleckyj</surname></persName><affiliation>Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-18"><persName><forename type="first">Linda S.</forename><surname>Wicker</surname></persName><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-19"><persName><forename type="first">Decio L.</forename><surname>Eizirik</surname></persName><affiliation>Laboratory of Experimental Medicine, Free University of Brussels (ULB), Brussels, Belgium and</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-20"><persName><forename type="first">John A.</forename><surname>Todd</surname></persName><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation></author><author xml:id="author-21"><persName><forename type="first">Nathan</forename><surname>Goodman</surname></persName><affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</affiliation></author></analytic><monogr><title level="j">Nucleic Acids Research</title><title level="j" type="abbrev">Nucl. Acids Res.</title><idno type="pISSN">0305-1048</idno><idno type="eISSN">1362-4962</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2005-01-01"></date><biblScope unit="volume">33</biblScope><biblScope unit="supplement">suppl_1</biblScope><biblScope unit="page" from="D544">D544</biblScope><biblScope unit="page" to="D549">D549</biblScope></imprint></monogr><idno type="istex">299F884DFB177EEF6C2892D9CC0662CE80B313F7</idno><idno type="DOI">10.1093/nar/gki095</idno><idno type="local">gki095</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2005</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>T1DBase (http://T1DBase.org) is a public website and database that supports the type 1 diabetes (T1D) research community. The site is currently focused on the molecular genetics and biology of T1D susceptibility and pathogenesis. It includes the following datasets: annotated genome sequence for human, rat and mouse; information on genetically identified T1D susceptibility regions in human, rat and mouse, and genetic linkage and association studies pertaining to T1D; descriptions of NOD mouse congenic strains; the Beta Cell Gene Expression Bank, which reports expression levels of genes in beta cells under various conditions, and annotations of gene function in beta cells; data on gene expression in a variety of tissues and organs; and biological pathways from KEGG and BioCarta. Tools on the site include the GBrowse genome browser, site-wide context dependent search, Connect-the-Dots for connecting gene and other identifiers from multiple data sources, Cytoscape for visualizing and analyzing biological networks, and the GESTALT workbench for genome annotation. All data are open access and all software is open source.</p></abstract></profileDesc><revisionDesc><change when="2005-01-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-10-14">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/299F884DFB177EEF6C2892D9CC0662CE80B313F7/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="US-ASCII"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article xml:lang="en" article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">nar</journal-id><journal-id journal-id-type="nlm-ta">Nucleic Acids Res</journal-id><journal-id journal-id-type="publisher-id">nar</journal-id><journal-title>Nucleic Acids Research</journal-title><abbrev-journal-title abbrev-type="publisher">Nucl. Acids Res.</abbrev-journal-title><issn pub-type="ppub">0305-1048</issn><issn pub-type="epub">1362-4962</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="other">gki095</article-id><article-id pub-id-type="doi">10.1093/nar/gki095</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>T1DBase, a community web-based resource for type 1 diabetes research</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Smink</surname><given-names>Luc J.</given-names></name><xref rid="COR1">*</xref></contrib><contrib contrib-type="author"><name><surname>Helton</surname><given-names>Erin M.</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author"><name><surname>Healy</surname><given-names>Barry C.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Cavnor</surname><given-names>Christopher C.</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lam</surname><given-names>Alex C.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Flamez</surname><given-names>Daisy</given-names></name><xref rid="AFF2">2</xref></contrib><contrib contrib-type="author"><name><surname>Burren</surname><given-names>Oliver S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Yang</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author"><name><surname>Dolman</surname><given-names>Geoffrey E.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Burdick</surname><given-names>David B.</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author"><name><surname>Everett</surname><given-names>Vincent H.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Glusman</surname><given-names>Gustavo</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author"><name><surname>Laneri</surname><given-names>Davide</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rowen</surname><given-names>Lee</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author"><name><surname>Schuilenburg</surname><given-names>Helen</given-names></name></contrib><contrib contrib-type="author"><name><surname>Walker</surname><given-names>Neil M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Mychaleckyj</surname><given-names>Josyf</given-names></name><xref rid="AFF3">3</xref></contrib><contrib contrib-type="author"><name><surname>Wicker</surname><given-names>Linda S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Eizirik</surname><given-names>Decio L.</given-names></name><xref rid="AFF2">2</xref></contrib><contrib contrib-type="author"><name><surname>Todd</surname><given-names>John A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Goodman</surname><given-names>Nathan</given-names></name><xref rid="AFF1">1</xref><xref rid="COR1">*</xref></contrib><aff>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK, <target target-type="aff" id="AFF1"></target><label>1</label>Institute for Systems Biology, Seattle, WA 98103, USA, <target target-type="aff" id="AFF2"></target><label>2</label>Laboratory of Experimental Medicine, Free University of Brussels (ULB), Brussels, Belgium and <target target-type="aff" id="AFF3"></target><label>3</label>Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA</aff></contrib-group><author-notes><corresp id="COR1"><label>*</label>To whom correspondence should be addressed. Tel: +44 1223 763211; Fax: +44 1223 762102; Email: <ext-link xlink:href="Luc.Smink@cimr.cam.ac.uk" ext-link-type="email">Luc.Smink@cimr.cam.ac.uk</ext-link>
Correspondence may also be addressed to Nathan Goodman. Tel: +1 206 331 0077; Fax: +1 206 732 1299; Email: <ext-link xlink:href="natg@shore.net" ext-link-type="email">natg@shore.net</ext-link></corresp></author-notes><pub-date pub-type="ppub"><day>1</day><month>1</month><year>2005</year></pub-date><volume>33</volume><issue>suppl_1</issue><fpage>D544</fpage><lpage>D549</lpage><permissions><copyright-statement>© 2005, the authors
<italic>Nucleic Acids Research, Vol. 33, Database issue © Oxford University Press 2005; all rights reserved</italic></copyright-statement><copyright-year>2005</copyright-year><license license-type="open-access"><p></p></license></permissions><abstract xml:lang="en"><p>T1DBase (<ext-link xlink:href="http://T1DBase.org" ext-link-type="url">http://T1DBase.org</ext-link>) is a public website and database that supports the type 1 diabetes (T1D) research community. The site is currently focused on the molecular genetics and biology of T1D susceptibility and pathogenesis. It includes the following datasets: annotated genome sequence for human, rat and mouse; information on genetically identified T1D susceptibility regions in human, rat and mouse, and genetic linkage and association studies pertaining to T1D; descriptions of NOD mouse congenic strains; the Beta Cell Gene Expression Bank, which reports expression levels of genes in beta cells under various conditions, and annotations of gene function in beta cells; data on gene expression in a variety of tissues and organs; and biological pathways from KEGG and BioCarta. Tools on the site include the GBrowse genome browser, site-wide context dependent search, Connect-the-Dots for connecting gene and other identifiers from multiple data sources, Cytoscape for visualizing and analyzing biological networks, and the GESTALT workbench for genome annotation. All data are open access and all software is open source.</p></abstract><custom-meta-wrap><custom-meta><meta-name>hwp-legacy-fpage</meta-name><meta-value>D544</meta-value></custom-meta><custom-meta><meta-name>hwp-legacy-dochead</meta-name><meta-value>Article</meta-value></custom-meta></custom-meta-wrap></article-meta><notes><p content-type="arthw-misc">Received August 20, 2004; Revised and Accepted October 12, 2004
</p></notes></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>T1DBase, a community web-based resource for type 1 diabetes research</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>T1DBase, a community web-based resource for type 1 diabetes research</title></titleInfo><name type="personal"><namePart type="given">Luc J.</namePart><namePart type="family">Smink</namePart><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Erin M.</namePart><namePart type="family">Helton</namePart><affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Barry C.</namePart><namePart type="family">Healy</namePart><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christopher C.</namePart><namePart type="family">Cavnor</namePart><affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alex C.</namePart><namePart type="family">Lam</namePart><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Daisy</namePart><namePart type="family">Flamez</namePart><affiliation>Laboratory of Experimental Medicine, Free University of Brussels (ULB), Brussels, Belgium and</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Oliver S.</namePart><namePart type="family">Burren</namePart><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yang</namePart><namePart type="family">Wang</namePart><affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Geoffrey E.</namePart><namePart type="family">Dolman</namePart><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David B.</namePart><namePart type="family">Burdick</namePart><affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vincent H.</namePart><namePart type="family">Everett</namePart><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gustavo</namePart><namePart type="family">Glusman</namePart><affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Davide</namePart><namePart type="family">Laneri</namePart><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lee</namePart><namePart type="family">Rowen</namePart><affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Helen</namePart><namePart type="family">Schuilenburg</namePart><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Neil M.</namePart><namePart type="family">Walker</namePart><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Josyf</namePart><namePart type="family">Mychaleckyj</namePart><affiliation>Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Linda S.</namePart><namePart type="family">Wicker</namePart><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Decio L.</namePart><namePart type="family">Eizirik</namePart><affiliation>Laboratory of Experimental Medicine, Free University of Brussels (ULB), Brussels, Belgium and</affiliation><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John A.</namePart><namePart type="family">Todd</namePart><affiliation>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nathan</namePart><namePart type="family">Goodman</namePart><affiliation>Institute for Systems Biology, Seattle, WA 98103, USA,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">2005-01-01</dateIssued><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">T1DBase (http://T1DBase.org) is a public website and database that supports the type 1 diabetes (T1D) research community. The site is currently focused on the molecular genetics and biology of T1D susceptibility and pathogenesis. It includes the following datasets: annotated genome sequence for human, rat and mouse; information on genetically identified T1D susceptibility regions in human, rat and mouse, and genetic linkage and association studies pertaining to T1D; descriptions of NOD mouse congenic strains; the Beta Cell Gene Expression Bank, which reports expression levels of genes in beta cells under various conditions, and annotations of gene function in beta cells; data on gene expression in a variety of tissues and organs; and biological pathways from KEGG and BioCarta. Tools on the site include the GBrowse genome browser, site-wide context dependent search, Connect-the-Dots for connecting gene and other identifiers from multiple data sources, Cytoscape for visualizing and analyzing biological networks, and the GESTALT workbench for genome annotation. All data are open access and all software is open source.</abstract><note>Received August 20, 2004; Revised and Accepted October 12, 2004</note><note type="author-notes">*To whom correspondence should be addressed. Tel: +44 1223 763211; Fax: +44 1223 762102; Email: Luc.Smink@cimr.cam.ac.uk
Correspondence may also be addressed to Nathan Goodman. Tel: +1 206 331 0077; Fax: +1 206 732 1299; Email: natg@shore.net</note><relatedItem type="host"><titleInfo><title>Nucleic Acids Research</title></titleInfo><titleInfo type="abbreviated"><title>Nucl. Acids Res.</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0305-1048</identifier><identifier type="eISSN">1362-4962</identifier><identifier type="PublisherID">nar</identifier><identifier type="PublisherID-hwp">nar</identifier><identifier type="PublisherID-nlm-ta">Nucleic Acids Res</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><detail type="supplement"><number>suppl_1</number></detail><extent unit="pages"><start>D544</start><end>D549</end></extent></part></relatedItem><identifier type="istex">299F884DFB177EEF6C2892D9CC0662CE80B313F7</identifier><identifier type="DOI">10.1093/nar/gki095</identifier><identifier type="local">gki095</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2005, the authors
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