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Plasma from the second and third weeks after open colorectal resection for cancer stimulates in vitro endothelial cell growth, migration, and invasion

Identifieur interne : 000674 ( PascalFrancis/Curation ); précédent : 000673; suivant : 000675

Plasma from the second and third weeks after open colorectal resection for cancer stimulates in vitro endothelial cell growth, migration, and invasion

Auteurs : H. M. C. Shantha Kumara [États-Unis] ; Daniel Kirchoff [États-Unis] ; Samer Naffouje [États-Unis] ; Michael Grieco [États-Unis] ; Sonali A. C. Herath [États-Unis] ; Nadav Dujovny [États-Unis] ; Matthew F. Kalady [États-Unis] ; Neil Hyman [États-Unis] ; Linda Njoh [États-Unis] ; Richard L. Whelan [États-Unis]

Source :

RBID : Pascal:12-0151770

Descripteurs français

English descriptors

Abstract

Introduction Angiogenesis is central to wound healing and tumor growth. Postoperative (postop) plasma from weeks 2 and 3 after minimally invasive colorectal resection (MICR) stimulates endothelial cell (EC) migration (MIG), invasion (INV), and proliferation (all vital to angiogenesis) compared with preoperative (preop) plasma results and may promote postop tumor growth. The purpose of this study was to determine whether plasma from open colorectal resection (OCR) patients has similar proangiogenic EC effects in vitro. Methods OCR cancer patient plasma from institutional review board-approved banks was used; patients with preop and one postop sample from postoperative days (POD) 7-33 were eligible. Samples were bundled into 7- to 13-day periods and considered as single time points. In vitro cultures of human umbilical venous ECs were used for the EC proliferation (BPF, Branch Point Formation), INV, and MIG assays performed with preop, POD 7-13, POD 14-20, and POD 21-33 plasma. Data were analyzed by paired t test and were reported as mean ± standard deviation (significance, P < 0.05). Results Plasma from 53 cancer patients (25 rectal and 28 colon) was used. Because of limited postop samples, the number for each time point varies: POD 7-13, n = 30; POD 14-20, n = 26; and POD 21-33, n = 17. In vitro EC BPF was significantly greater at the POD 7-13 (P < 0.0001) and POD 14-20 (P < 0.0001) time points versus preop results. Significantly greater EC INV and MIG were noted on POD 7-13 and POD 14-20 versus the preop plasma results (P < 0.0001). In regards to POD 21-33, a significantly greater result was noted only for the INV assay versus preop. Conclusions Plasma from weeks 2 and 3 after OCR stimulates in vitro EC BPF, INV, and MIG. A significant difference from preop baseline was noted only for the INV assay in week 4. The OCR and previous MICR results were largely similar. Tumor angiogenesis may be stimulated after OCR and MICR for 3 weeks. Further studies are warranted.
pA  
A01 01  1    @0 0930-2794
A02 01      @0 SUREEX
A03   1    @0 Surg. endosc.
A05       @2 26
A06       @2 3
A08 01  1  ENG  @1 Plasma from the second and third weeks after open colorectal resection for cancer stimulates in vitro endothelial cell growth, migration, and invasion
A11 01  1    @1 SHANTHA KUMARA (H. M. C.)
A11 02  1    @1 KIRCHOFF (Daniel)
A11 03  1    @1 NAFFOUJE (Samer)
A11 04  1    @1 GRIECO (Michael)
A11 05  1    @1 HERATH (Sonali A. C.)
A11 06  1    @1 DUJOVNY (Nadav)
A11 07  1    @1 KALADY (Matthew F.)
A11 08  1    @1 HYMAN (Neil)
A11 09  1    @1 NJOH (Linda)
A11 10  1    @1 WHELAN (Richard L.)
A14 01      @1 Division of Colon and Rectal Surgery. Department of Surgery, St Luke-Roosevelt Hospital Center, Suite 7B, 425 West, 59th Street @2 New York, NY 10019 @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 9 aut. @Z 10 aut.
A14 02      @1 Ferguson Clinic, Spectrum Health Medical Group. 4100 Lake Drive 205 @2 Grand Rapids, MI 49546 @3 USA @Z 6 aut.
A14 03      @1 Department of Colorectal Surgery, Digestive Disease Institute, 9500, Euclid Avenue, A 30 @2 Cleveland, OH 44195 @3 USA @Z 7 aut.
A14 04      @1 Department of Surgery, University of Vermont, College of Medicine, Fletcher 465 @2 Burlington, VT 05401 @3 USA @Z 8 aut.
A20       @1 790-795
A21       @1 2012
A23 01      @0 ENG
A43 01      @1 INIST @2 21220 @5 354000502864350280
A44       @0 0000 @1 © 2012 INIST-CNRS. All rights reserved.
A45       @0 10 ref.
A47 01  1    @0 12-0151770
A60       @1 P
A61       @0 A
A64 01  1    @0 Surgical endoscopy
A66 01      @0 USA
C01 01    ENG  @0 Introduction Angiogenesis is central to wound healing and tumor growth. Postoperative (postop) plasma from weeks 2 and 3 after minimally invasive colorectal resection (MICR) stimulates endothelial cell (EC) migration (MIG), invasion (INV), and proliferation (all vital to angiogenesis) compared with preoperative (preop) plasma results and may promote postop tumor growth. The purpose of this study was to determine whether plasma from open colorectal resection (OCR) patients has similar proangiogenic EC effects in vitro. Methods OCR cancer patient plasma from institutional review board-approved banks was used; patients with preop and one postop sample from postoperative days (POD) 7-33 were eligible. Samples were bundled into 7- to 13-day periods and considered as single time points. In vitro cultures of human umbilical venous ECs were used for the EC proliferation (BPF, Branch Point Formation), INV, and MIG assays performed with preop, POD 7-13, POD 14-20, and POD 21-33 plasma. Data were analyzed by paired t test and were reported as mean ± standard deviation (significance, P < 0.05). Results Plasma from 53 cancer patients (25 rectal and 28 colon) was used. Because of limited postop samples, the number for each time point varies: POD 7-13, n = 30; POD 14-20, n = 26; and POD 21-33, n = 17. In vitro EC BPF was significantly greater at the POD 7-13 (P < 0.0001) and POD 14-20 (P < 0.0001) time points versus preop results. Significantly greater EC INV and MIG were noted on POD 7-13 and POD 14-20 versus the preop plasma results (P < 0.0001). In regards to POD 21-33, a significantly greater result was noted only for the INV assay versus preop. Conclusions Plasma from weeks 2 and 3 after OCR stimulates in vitro EC BPF, INV, and MIG. A significant difference from preop baseline was noted only for the INV assay in week 4. The OCR and previous MICR results were largely similar. Tumor angiogenesis may be stimulated after OCR and MICR for 3 weeks. Further studies are warranted.
C02 01  X    @0 002B25G02
C02 02  X    @0 002B13B01
C03 01  X  FRE  @0 Cancer colorectal @2 NM @5 01
C03 01  X  ENG  @0 Colorectal cancer @2 NM @5 01
C03 01  X  SPA  @0 Cancer de colon y recto @2 NM @5 01
C03 02  X  FRE  @0 Résection chirurgicale @5 04
C03 02  X  ENG  @0 Surgical resection @5 04
C03 02  X  SPA  @0 Resección quirúrgica @5 04
C03 03  X  FRE  @0 Plasma sanguin @5 07
C03 03  X  ENG  @0 Blood plasma @5 07
C03 03  X  SPA  @0 Plasma sanguíneo @5 07
C03 04  X  FRE  @0 In vitro @5 08
C03 04  X  ENG  @0 In vitro @5 08
C03 04  X  SPA  @0 In vitro @5 08
C03 05  X  FRE  @0 Mouvement cellulaire @5 09
C03 05  X  ENG  @0 Cell motility @5 09
C03 05  X  SPA  @0 Movimiento celular @5 09
C03 06  X  FRE  @0 Cellule endothéliale @5 13
C03 06  X  ENG  @0 Endothelial cell @5 13
C03 06  X  SPA  @0 Célula endotelial @5 13
C03 07  X  FRE  @0 Migration cellulaire @5 14
C03 07  X  ENG  @0 Cell migration @5 14
C03 07  X  SPA  @0 Migración celular @5 14
C03 08  X  FRE  @0 Multiplication cellulaire @5 15
C03 08  X  ENG  @0 Cell proliferation @5 15
C03 08  X  SPA  @0 Multiplicación celular @5 15
C03 09  X  FRE  @0 Postopératoire @5 16
C03 09  X  ENG  @0 Postoperative @5 16
C03 09  X  SPA  @0 Postoperatorio @5 16
C03 10  X  FRE  @0 Homme @5 17
C03 10  X  ENG  @0 Human @5 17
C03 10  X  SPA  @0 Hombre @5 17
C03 11  X  FRE  @0 Angiogenèse @5 18
C03 11  X  ENG  @0 Angiogenesis @5 18
C03 11  X  SPA  @0 Angiogénesis @5 18
C03 12  X  FRE  @0 Médecine @5 19
C03 12  X  ENG  @0 Medicine @5 19
C03 12  X  SPA  @0 Medicina @5 19
C03 13  X  FRE  @0 Chirurgie endoscopique @5 30
C03 13  X  ENG  @0 Endoscopic surgery @5 30
C03 13  X  SPA  @0 Cirugía endoscópica @5 30
C03 14  X  FRE  @0 Traitement @5 31
C03 14  X  ENG  @0 Treatment @5 31
C03 14  X  SPA  @0 Tratamiento @5 31
C07 01  X  FRE  @0 Pathologie de l'appareil digestif @5 37
C07 01  X  ENG  @0 Digestive diseases @5 37
C07 01  X  SPA  @0 Aparato digestivo patología @5 37
C07 02  X  FRE  @0 Pathologie du côlon @5 38
C07 02  X  ENG  @0 Colonic disease @5 38
C07 02  X  SPA  @0 Colón patología @5 38
C07 03  X  FRE  @0 Pathologie de l'intestin @5 39
C07 03  X  ENG  @0 Intestinal disease @5 39
C07 03  X  SPA  @0 Intestino patología @5 39
C07 04  X  FRE  @0 Tumeur maligne @2 NM @5 40
C07 04  X  ENG  @0 Malignant tumor @2 NM @5 40
C07 04  X  SPA  @0 Tumor maligno @2 NM @5 40
C07 05  X  FRE  @0 Cancer @2 NM
C07 05  X  ENG  @0 Cancer @2 NM
C07 05  X  SPA  @0 Cáncer @2 NM
C07 06  X  FRE  @0 Pathologie du rectum @5 41
C07 06  X  ENG  @0 Rectal disease @5 41
C07 06  X  SPA  @0 Recto patología @5 41
C07 07  X  FRE  @0 Chirurgie @5 44
C07 07  X  ENG  @0 Surgery @5 44
C07 07  X  SPA  @0 Cirugía @5 44
N21       @1 114

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Pascal:12-0151770

Le document en format XML

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<name sortKey="Kalady, Matthew F" sort="Kalady, Matthew F" uniqKey="Kalady M" first="Matthew F." last="Kalady">Matthew F. Kalady</name>
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<title xml:lang="en" level="a">Plasma from the second and third weeks after open colorectal resection for cancer stimulates in vitro endothelial cell growth, migration, and invasion</title>
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<name sortKey="Shantha Kumara, H M C" sort="Shantha Kumara, H M C" uniqKey="Shantha Kumara H" first="H. M. C." last="Shantha Kumara">H. M. C. Shantha Kumara</name>
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<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<name sortKey="Naffouje, Samer" sort="Naffouje, Samer" uniqKey="Naffouje S" first="Samer" last="Naffouje">Samer Naffouje</name>
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<s1>Division of Colon and Rectal Surgery. Department of Surgery, St Luke-Roosevelt Hospital Center, Suite 7B, 425 West, 59th Street</s1>
<s2>New York, NY 10019</s2>
<s3>USA</s3>
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<sZ>3 aut.</sZ>
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<name sortKey="Grieco, Michael" sort="Grieco, Michael" uniqKey="Grieco M" first="Michael" last="Grieco">Michael Grieco</name>
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<s1>Division of Colon and Rectal Surgery. Department of Surgery, St Luke-Roosevelt Hospital Center, Suite 7B, 425 West, 59th Street</s1>
<s2>New York, NY 10019</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
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<sZ>3 aut.</sZ>
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<author>
<name sortKey="Herath, Sonali A C" sort="Herath, Sonali A C" uniqKey="Herath S" first="Sonali A. C." last="Herath">Sonali A. C. Herath</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Division of Colon and Rectal Surgery. Department of Surgery, St Luke-Roosevelt Hospital Center, Suite 7B, 425 West, 59th Street</s1>
<s2>New York, NY 10019</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
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<sZ>10 aut.</sZ>
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<author>
<name sortKey="Dujovny, Nadav" sort="Dujovny, Nadav" uniqKey="Dujovny N" first="Nadav" last="Dujovny">Nadav Dujovny</name>
<affiliation wicri:level="1">
<inist:fA14 i1="02">
<s1>Ferguson Clinic, Spectrum Health Medical Group. 4100 Lake Drive 205</s1>
<s2>Grand Rapids, MI 49546</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author>
<name sortKey="Kalady, Matthew F" sort="Kalady, Matthew F" uniqKey="Kalady M" first="Matthew F." last="Kalady">Matthew F. Kalady</name>
<affiliation wicri:level="1">
<inist:fA14 i1="03">
<s1>Department of Colorectal Surgery, Digestive Disease Institute, 9500, Euclid Avenue, A 30</s1>
<s2>Cleveland, OH 44195</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author>
<name sortKey="Hyman, Neil" sort="Hyman, Neil" uniqKey="Hyman N" first="Neil" last="Hyman">Neil Hyman</name>
<affiliation wicri:level="1">
<inist:fA14 i1="04">
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<author>
<name sortKey="Njoh, Linda" sort="Njoh, Linda" uniqKey="Njoh L" first="Linda" last="Njoh">Linda Njoh</name>
<affiliation wicri:level="1">
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<s1>Division of Colon and Rectal Surgery. Department of Surgery, St Luke-Roosevelt Hospital Center, Suite 7B, 425 West, 59th Street</s1>
<s2>New York, NY 10019</s2>
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<name sortKey="Whelan, Richard L" sort="Whelan, Richard L" uniqKey="Whelan R" first="Richard L." last="Whelan">Richard L. Whelan</name>
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<s1>Division of Colon and Rectal Surgery. Department of Surgery, St Luke-Roosevelt Hospital Center, Suite 7B, 425 West, 59th Street</s1>
<s2>New York, NY 10019</s2>
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<sZ>1 aut.</sZ>
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<country>États-Unis</country>
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</analytic>
<series>
<title level="j" type="main">Surgical endoscopy</title>
<title level="j" type="abbreviated">Surg. endosc.</title>
<idno type="ISSN">0930-2794</idno>
<imprint>
<date when="2012">2012</date>
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<title level="j" type="main">Surgical endoscopy</title>
<title level="j" type="abbreviated">Surg. endosc.</title>
<idno type="ISSN">0930-2794</idno>
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<term>Angiogenesis</term>
<term>Blood plasma</term>
<term>Cell migration</term>
<term>Cell motility</term>
<term>Cell proliferation</term>
<term>Colorectal cancer</term>
<term>Endoscopic surgery</term>
<term>Endothelial cell</term>
<term>Human</term>
<term>In vitro</term>
<term>Medicine</term>
<term>Postoperative</term>
<term>Surgical resection</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Cancer colorectal</term>
<term>Résection chirurgicale</term>
<term>Plasma sanguin</term>
<term>In vitro</term>
<term>Mouvement cellulaire</term>
<term>Cellule endothéliale</term>
<term>Migration cellulaire</term>
<term>Multiplication cellulaire</term>
<term>Postopératoire</term>
<term>Homme</term>
<term>Angiogenèse</term>
<term>Médecine</term>
<term>Chirurgie endoscopique</term>
<term>Traitement</term>
</keywords>
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<term>Homme</term>
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<div type="abstract" xml:lang="en">Introduction Angiogenesis is central to wound healing and tumor growth. Postoperative (postop) plasma from weeks 2 and 3 after minimally invasive colorectal resection (MICR) stimulates endothelial cell (EC) migration (MIG), invasion (INV), and proliferation (all vital to angiogenesis) compared with preoperative (preop) plasma results and may promote postop tumor growth. The purpose of this study was to determine whether plasma from open colorectal resection (OCR) patients has similar proangiogenic EC effects in vitro. Methods OCR cancer patient plasma from institutional review board-approved banks was used; patients with preop and one postop sample from postoperative days (POD) 7-33 were eligible. Samples were bundled into 7- to 13-day periods and considered as single time points. In vitro cultures of human umbilical venous ECs were used for the EC proliferation (BPF, Branch Point Formation), INV, and MIG assays performed with preop, POD 7-13, POD 14-20, and POD 21-33 plasma. Data were analyzed by paired t test and were reported as mean ± standard deviation (significance, P < 0.05). Results Plasma from 53 cancer patients (25 rectal and 28 colon) was used. Because of limited postop samples, the number for each time point varies: POD 7-13, n = 30; POD 14-20, n = 26; and POD 21-33, n = 17. In vitro EC BPF was significantly greater at the POD 7-13 (P < 0.0001) and POD 14-20 (P < 0.0001) time points versus preop results. Significantly greater EC INV and MIG were noted on POD 7-13 and POD 14-20 versus the preop plasma results (P < 0.0001). In regards to POD 21-33, a significantly greater result was noted only for the INV assay versus preop. Conclusions Plasma from weeks 2 and 3 after OCR stimulates in vitro EC BPF, INV, and MIG. A significant difference from preop baseline was noted only for the INV assay in week 4. The OCR and previous MICR results were largely similar. Tumor angiogenesis may be stimulated after OCR and MICR for 3 weeks. Further studies are warranted.</div>
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<s0>Introduction Angiogenesis is central to wound healing and tumor growth. Postoperative (postop) plasma from weeks 2 and 3 after minimally invasive colorectal resection (MICR) stimulates endothelial cell (EC) migration (MIG), invasion (INV), and proliferation (all vital to angiogenesis) compared with preoperative (preop) plasma results and may promote postop tumor growth. The purpose of this study was to determine whether plasma from open colorectal resection (OCR) patients has similar proangiogenic EC effects in vitro. Methods OCR cancer patient plasma from institutional review board-approved banks was used; patients with preop and one postop sample from postoperative days (POD) 7-33 were eligible. Samples were bundled into 7- to 13-day periods and considered as single time points. In vitro cultures of human umbilical venous ECs were used for the EC proliferation (BPF, Branch Point Formation), INV, and MIG assays performed with preop, POD 7-13, POD 14-20, and POD 21-33 plasma. Data were analyzed by paired t test and were reported as mean ± standard deviation (significance, P < 0.05). Results Plasma from 53 cancer patients (25 rectal and 28 colon) was used. Because of limited postop samples, the number for each time point varies: POD 7-13, n = 30; POD 14-20, n = 26; and POD 21-33, n = 17. In vitro EC BPF was significantly greater at the POD 7-13 (P < 0.0001) and POD 14-20 (P < 0.0001) time points versus preop results. Significantly greater EC INV and MIG were noted on POD 7-13 and POD 14-20 versus the preop plasma results (P < 0.0001). In regards to POD 21-33, a significantly greater result was noted only for the INV assay versus preop. Conclusions Plasma from weeks 2 and 3 after OCR stimulates in vitro EC BPF, INV, and MIG. A significant difference from preop baseline was noted only for the INV assay in week 4. The OCR and previous MICR results were largely similar. Tumor angiogenesis may be stimulated after OCR and MICR for 3 weeks. Further studies are warranted.</s0>
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