Long-Term Outcomes of the Australasian Randomized Clinical Trial Comparing Laparoscopic and Conventional Open Surgical Treatments for Colon Cancer: The Australasian Laparoscopic Colon Cancer Study Trial
Identifieur interne : 000309 ( Main/Exploration ); précédent : 000308; suivant : 000310Long-Term Outcomes of the Australasian Randomized Clinical Trial Comparing Laparoscopic and Conventional Open Surgical Treatments for Colon Cancer: The Australasian Laparoscopic Colon Cancer Study Trial
Auteurs : Philip F. Bagshaw [Nouvelle-Zélande] ; Randall A. Allardyce [Nouvelle-Zélande] ; Christopher M. Frampton [Nouvelle-Zélande] ; Francis A. Frizelle [Nouvelle-Zélande] ; Peter J. Hewett [Australie] ; Paul J. Mcmurrick [Australie] ; Nicholas A. Rieger [Australie] ; J. Shona Smith [Nouvelle-Zélande] ; Michael J. Solomon [Australie] ; Andrew Rl. Stevenson [Australie]Source :
- Annals of surgery [ 0003-4932 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
Abstract
Objective: We report a multicentered randomized controlled trial across Australia and New Zealand comparing laparoscopic-assisted colon resection (LCR) with open colon resection (OCR) for colon cancer. Background: Colon cancer is a significant worldwide health issue. This trial investigated whether the short-term benefits associated with LCR for colon cancer could be achieved safely, without survival disadvantages, in our region. Methods: A total of 601 patients with potentially curable colon cancer were randomized to receive LCR or OCR. Primary endpoints were 5-year overall survival, recurrence-free survival, and freedom from recurrence rates, compared using an intention-to-treat analysis. Results: On April 5, 2010, 587 eligible patients were followed for a median of 5.2 years (range, 1 week-11.4 years) with 5-year confirmed follow-up data for survival and recurrence on 567 (96.6%). Significant differences between the 2 trial groups were as follows: LCR patients were older at randomization, and their pathology specimens showed smaller distal resection margins; OCR patients had some worse pathology parameters, but there were no differences in disease stages. There were no significant differences between the LCR and OCR groups in 5-year follow-up of overall survival (77.7% vs 76.0%, P = 0.64), recurrence-free survival (72.7% vs 71.2%, P = 0.70), or freedom from recurrence (86.2% vs 85.6%, P = 0.85). Conclusions: In spite of some differences in short-term surrogate oncological markers, LCR was not inferior to OCR in direct measures of survival and disease recurrence. These findings emphasize the importance of long-term data in formulating evidence-based practice guidelines.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000065
- to stream PascalFrancis, to step Curation: 000703
- to stream PascalFrancis, to step Checkpoint: 000071
- to stream Main, to step Merge: 000312
- to stream Main, to step Curation: 000309
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Long-Term Outcomes of the Australasian Randomized Clinical Trial Comparing Laparoscopic and Conventional Open Surgical Treatments for Colon Cancer: The Australasian Laparoscopic Colon Cancer Study Trial</title>
<author><name sortKey="Bagshaw, Philip F" sort="Bagshaw, Philip F" uniqKey="Bagshaw P" first="Philip F." last="Bagshaw">Philip F. Bagshaw</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgery, University of Otago</s1>
<s3>NZL</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Nouvelle-Zélande</country>
<wicri:noRegion>Department of Surgery, University of Otago</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Allardyce, Randall A" sort="Allardyce, Randall A" uniqKey="Allardyce R" first="Randall A." last="Allardyce">Randall A. Allardyce</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgery, University of Otago</s1>
<s3>NZL</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Nouvelle-Zélande</country>
<wicri:noRegion>Department of Surgery, University of Otago</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Frampton, Christopher M" sort="Frampton, Christopher M" uniqKey="Frampton C" first="Christopher M." last="Frampton">Christopher M. Frampton</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, University of Otago</s1>
<s3>NZL</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Nouvelle-Zélande</country>
<wicri:noRegion>Department of Medicine, University of Otago</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Frizelle, Francis A" sort="Frizelle, Francis A" uniqKey="Frizelle F" first="Francis A." last="Frizelle">Francis A. Frizelle</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgery, University of Otago</s1>
<s3>NZL</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Nouvelle-Zélande</country>
<wicri:noRegion>Department of Surgery, University of Otago</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hewett, Peter J" sort="Hewett, Peter J" uniqKey="Hewett P" first="Peter J." last="Hewett">Peter J. Hewett</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Division of Surgery, The Queen Elizabeth Hospital, Woodville and the University of Adelaide</s1>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Division of Surgery, The Queen Elizabeth Hospital, Woodville and the University of Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcmurrick, Paul J" sort="Mcmurrick, Paul J" uniqKey="Mcmurrick P" first="Paul J." last="Mcmurrick">Paul J. Mcmurrick</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Surgery, Monash University and Cabrini Hospital, Malvern</s1>
<s2>Victoria</s2>
<s3>AUS</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rieger, Nicholas A" sort="Rieger, Nicholas A" uniqKey="Rieger N" first="Nicholas A." last="Rieger">Nicholas A. Rieger</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Division of Surgery, The Queen Elizabeth Hospital, Woodville and the University of Adelaide</s1>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Division of Surgery, The Queen Elizabeth Hospital, Woodville and the University of Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shona Smith, J" sort="Shona Smith, J" uniqKey="Shona Smith J" first="J." last="Shona Smith">J. Shona Smith</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Academy of Endosurgery</s1>
<s2>Christchurch</s2>
<s3>NZL</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Nouvelle-Zélande</country>
<wicri:noRegion>Academy of Endosurgery</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Solomon, Michael J" sort="Solomon, Michael J" uniqKey="Solomon M" first="Michael J." last="Solomon">Michael J. Solomon</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Colon & Rectal Surgery, Royal Prince Alfred Hospital and Surgical Outcomes Research Centre (SOuRCe), University of Sydney</s1>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Department of Colon & Rectal Surgery, Royal Prince Alfred Hospital and Surgical Outcomes Research Centre (SOuRCe), University of Sydney</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stevenson, Andrew Rl" sort="Stevenson, Andrew Rl" uniqKey="Stevenson A" first="Andrew Rl." last="Stevenson">Andrew Rl. Stevenson</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Colon and Rectal Surgery, Royal Brisbane & Women's Hospital</s1>
<s2>Herston</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Herston</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">13-0048936</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 13-0048936 INIST</idno>
<idno type="RBID">Pascal:13-0048936</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000065</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000703</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000071</idno>
<idno type="wicri:doubleKey">0003-4932:2012:Bagshaw P:long:term:outcomes</idno>
<idno type="wicri:Area/Main/Merge">000312</idno>
<idno type="wicri:Area/Main/Curation">000309</idno>
<idno type="wicri:Area/Main/Exploration">000309</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Long-Term Outcomes of the Australasian Randomized Clinical Trial Comparing Laparoscopic and Conventional Open Surgical Treatments for Colon Cancer: The Australasian Laparoscopic Colon Cancer Study Trial</title>
<author><name sortKey="Bagshaw, Philip F" sort="Bagshaw, Philip F" uniqKey="Bagshaw P" first="Philip F." last="Bagshaw">Philip F. Bagshaw</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgery, University of Otago</s1>
<s3>NZL</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Nouvelle-Zélande</country>
<wicri:noRegion>Department of Surgery, University of Otago</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Allardyce, Randall A" sort="Allardyce, Randall A" uniqKey="Allardyce R" first="Randall A." last="Allardyce">Randall A. Allardyce</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgery, University of Otago</s1>
<s3>NZL</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Nouvelle-Zélande</country>
<wicri:noRegion>Department of Surgery, University of Otago</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Frampton, Christopher M" sort="Frampton, Christopher M" uniqKey="Frampton C" first="Christopher M." last="Frampton">Christopher M. Frampton</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, University of Otago</s1>
<s3>NZL</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Nouvelle-Zélande</country>
<wicri:noRegion>Department of Medicine, University of Otago</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Frizelle, Francis A" sort="Frizelle, Francis A" uniqKey="Frizelle F" first="Francis A." last="Frizelle">Francis A. Frizelle</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgery, University of Otago</s1>
<s3>NZL</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Nouvelle-Zélande</country>
<wicri:noRegion>Department of Surgery, University of Otago</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hewett, Peter J" sort="Hewett, Peter J" uniqKey="Hewett P" first="Peter J." last="Hewett">Peter J. Hewett</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Division of Surgery, The Queen Elizabeth Hospital, Woodville and the University of Adelaide</s1>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Division of Surgery, The Queen Elizabeth Hospital, Woodville and the University of Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcmurrick, Paul J" sort="Mcmurrick, Paul J" uniqKey="Mcmurrick P" first="Paul J." last="Mcmurrick">Paul J. Mcmurrick</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Surgery, Monash University and Cabrini Hospital, Malvern</s1>
<s2>Victoria</s2>
<s3>AUS</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rieger, Nicholas A" sort="Rieger, Nicholas A" uniqKey="Rieger N" first="Nicholas A." last="Rieger">Nicholas A. Rieger</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Division of Surgery, The Queen Elizabeth Hospital, Woodville and the University of Adelaide</s1>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Division of Surgery, The Queen Elizabeth Hospital, Woodville and the University of Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shona Smith, J" sort="Shona Smith, J" uniqKey="Shona Smith J" first="J." last="Shona Smith">J. Shona Smith</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Academy of Endosurgery</s1>
<s2>Christchurch</s2>
<s3>NZL</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Nouvelle-Zélande</country>
<wicri:noRegion>Academy of Endosurgery</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Solomon, Michael J" sort="Solomon, Michael J" uniqKey="Solomon M" first="Michael J." last="Solomon">Michael J. Solomon</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Colon & Rectal Surgery, Royal Prince Alfred Hospital and Surgical Outcomes Research Centre (SOuRCe), University of Sydney</s1>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Department of Colon & Rectal Surgery, Royal Prince Alfred Hospital and Surgical Outcomes Research Centre (SOuRCe), University of Sydney</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stevenson, Andrew Rl" sort="Stevenson, Andrew Rl" uniqKey="Stevenson A" first="Andrew Rl." last="Stevenson">Andrew Rl. Stevenson</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Colon and Rectal Surgery, Royal Brisbane & Women's Hospital</s1>
<s2>Herston</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Herston</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Annals of surgery</title>
<title level="j" type="abbreviated">Ann. surg.</title>
<idno type="ISSN">0003-4932</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Annals of surgery</title>
<title level="j" type="abbreviated">Ann. surg.</title>
<idno type="ISSN">0003-4932</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Australasia</term>
<term>Clinical trial</term>
<term>Colon cancer</term>
<term>Comparative study</term>
<term>Evolution</term>
<term>Laparoscopy</term>
<term>Long term</term>
<term>Medicine</term>
<term>Prognosis</term>
<term>Surgery</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Chirurgie</term>
<term>Long terme</term>
<term>Evolution</term>
<term>Cancer du côlon</term>
<term>Pronostic</term>
<term>Essai clinique</term>
<term>Australasie</term>
<term>Etude comparative</term>
<term>Laparoscopie</term>
<term>Traitement</term>
<term>Médecine</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chirurgie</term>
<term>Médecine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: We report a multicentered randomized controlled trial across Australia and New Zealand comparing laparoscopic-assisted colon resection (LCR) with open colon resection (OCR) for colon cancer. Background: Colon cancer is a significant worldwide health issue. This trial investigated whether the short-term benefits associated with LCR for colon cancer could be achieved safely, without survival disadvantages, in our region. Methods: A total of 601 patients with potentially curable colon cancer were randomized to receive LCR or OCR. Primary endpoints were 5-year overall survival, recurrence-free survival, and freedom from recurrence rates, compared using an intention-to-treat analysis. Results: On April 5, 2010, 587 eligible patients were followed for a median of 5.2 years (range, 1 week-11.4 years) with 5-year confirmed follow-up data for survival and recurrence on 567 (96.6%). Significant differences between the 2 trial groups were as follows: LCR patients were older at randomization, and their pathology specimens showed smaller distal resection margins; OCR patients had some worse pathology parameters, but there were no differences in disease stages. There were no significant differences between the LCR and OCR groups in 5-year follow-up of overall survival (77.7% vs 76.0%, P = 0.64), recurrence-free survival (72.7% vs 71.2%, P = 0.70), or freedom from recurrence (86.2% vs 85.6%, P = 0.85). Conclusions: In spite of some differences in short-term surrogate oncological markers, LCR was not inferior to OCR in direct measures of survival and disease recurrence. These findings emphasize the importance of long-term data in formulating evidence-based practice guidelines.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Nouvelle-Zélande</li>
</country>
</list>
<tree><country name="Nouvelle-Zélande"><noRegion><name sortKey="Bagshaw, Philip F" sort="Bagshaw, Philip F" uniqKey="Bagshaw P" first="Philip F." last="Bagshaw">Philip F. Bagshaw</name>
</noRegion>
<name sortKey="Allardyce, Randall A" sort="Allardyce, Randall A" uniqKey="Allardyce R" first="Randall A." last="Allardyce">Randall A. Allardyce</name>
<name sortKey="Frampton, Christopher M" sort="Frampton, Christopher M" uniqKey="Frampton C" first="Christopher M." last="Frampton">Christopher M. Frampton</name>
<name sortKey="Frizelle, Francis A" sort="Frizelle, Francis A" uniqKey="Frizelle F" first="Francis A." last="Frizelle">Francis A. Frizelle</name>
<name sortKey="Shona Smith, J" sort="Shona Smith, J" uniqKey="Shona Smith J" first="J." last="Shona Smith">J. Shona Smith</name>
</country>
<country name="Australie"><noRegion><name sortKey="Hewett, Peter J" sort="Hewett, Peter J" uniqKey="Hewett P" first="Peter J." last="Hewett">Peter J. Hewett</name>
</noRegion>
<name sortKey="Mcmurrick, Paul J" sort="Mcmurrick, Paul J" uniqKey="Mcmurrick P" first="Paul J." last="Mcmurrick">Paul J. Mcmurrick</name>
<name sortKey="Rieger, Nicholas A" sort="Rieger, Nicholas A" uniqKey="Rieger N" first="Nicholas A." last="Rieger">Nicholas A. Rieger</name>
<name sortKey="Solomon, Michael J" sort="Solomon, Michael J" uniqKey="Solomon M" first="Michael J." last="Solomon">Michael J. Solomon</name>
<name sortKey="Stevenson, Andrew Rl" sort="Stevenson, Andrew Rl" uniqKey="Stevenson A" first="Andrew Rl." last="Stevenson">Andrew Rl. Stevenson</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/OcrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000309 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000309 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Ticri/CIDE |area= OcrV1 |flux= Main |étape= Exploration |type= RBID |clé= Pascal:13-0048936 |texte= Long-Term Outcomes of the Australasian Randomized Clinical Trial Comparing Laparoscopic and Conventional Open Surgical Treatments for Colon Cancer: The Australasian Laparoscopic Colon Cancer Study Trial }}
This area was generated with Dilib version V0.6.32. |