OcrV1, Main, Curation, bibRecord, 001632

Functional outcomes of reduced hyaluronan in acute vocal fold scar

Identifieur interne : 001632 ( Main/Curation ); précédent : 001631; suivant : 001633

Functional outcomes of reduced hyaluronan in acute vocal fold scar

Auteurs : Bernard Rousseau [États-Unis] ; Jinho Sohn [États-Unis] ; Douglas W. Montequin [États-Unis] ; Ichiro Tateya [États-Unis] ; Diane M. Bless [États-Unis]

Source :

The Annals of otology, rhinology & laryngology [ 0003-4894 ] ; 2004.

RBID : Pascal:04-0572361

Descripteurs français

Pascal (Inist)
- Porc, Animal, Modèle, Hyaluronique acide, Collagène, Larynx, Pronostic, Evolution, Aigu, Corde vocale, Cicatrice, ORL.

English descriptors

KwdEn :
- Acute, Animal, Collagen, ENT, Evolution, Hyaluronic acid, Larynx, Models, Pig, Prognosis, Scar, Vocal cord.

Abstract

To examine the functional effects of hyaluronan and collagen alterations in acute vocal fold scar, we injured 15 pig larynges by vocal fold mucosa stripping. At 3, 10, and 15 days after operation, we performed excised larynx experiments to measure phonation threshold pressure (PTP) and vocal economy (an acoustic output-cost ratio; OCR), and then performed hyaluronan and collagen assays. Five uninjured larynges were used as excised controls. Hyaluronan was reduced in the scarred vocal folds through 15 days of wound healing. Collagen was increased at day 15. The PTP was increased and OCR was decreased in scarred larynges, indicating decreased vocal efficiency and ease of phonation. Thus, PTP and OCR were sensitive to the biomolecular changes in acute vocal fold scar. Hyaluronan was more susceptible than collagen to acute tissue ultrastructural alterations. These findings may provide a rationale for increasing hyaluronan in acute vocal fold scar to improve postoperative vocal outcomes.

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Pascal:04-0572361

Le document en format XML

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<term>Animal</term>
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<front><div type="abstract" xml:lang="en">To examine the functional effects of hyaluronan and collagen alterations in acute vocal fold scar, we injured 15 pig larynges by vocal fold mucosa stripping. At 3, 10, and 15 days after operation, we performed excised larynx experiments to measure phonation threshold pressure (PTP) and vocal economy (an acoustic output-cost ratio; OCR), and then performed hyaluronan and collagen assays. Five uninjured larynges were used as excised controls. Hyaluronan was reduced in the scarred vocal folds through 15 days of wound healing. Collagen was increased at day 15. The PTP was increased and OCR was decreased in scarred larynges, indicating decreased vocal efficiency and ease of phonation. Thus, PTP and OCR were sensitive to the biomolecular changes in acute vocal fold scar. Hyaluronan was more susceptible than collagen to acute tissue ultrastructural alterations. These findings may provide a rationale for increasing hyaluronan in acute vocal fold scar to improve postoperative vocal outcomes.</div>
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Functional outcomes of reduced hyaluronan in acute vocal fold scar

Functional outcomes of reduced hyaluronan in acute vocal fold scar

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri