Poorly differentiated loco-regionally advanced naso and oropharyngeal carcinoma: results of neoadjuvant chemotherapy followed by radiotherapy
Identifieur interne : 002424 ( Istex/Corpus ); précédent : 002423; suivant : 002425Poorly differentiated loco-regionally advanced naso and oropharyngeal carcinoma: results of neoadjuvant chemotherapy followed by radiotherapy
Auteurs : A. Radkowski ; M. Reinfuss ; J. SkoyszewskiSource :
- Reports of Practical Oncology & Radiotherapy [ 1507-1367 ] ; 1999.
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Abstract
Over the years 19861997, at the Centre of Oncology in Krakw, 82 patients (28 women, 54 men; mean age: 50.8 years) with poorly differentiatied naso- and oropharyngeal carcinoma with metastases to regional nodes (stage III and IV) received neoadjuvant chemotherapy followed by teleradiotherapy. The primary tumour was located in the nasopharynx in 57 patients (69.5%), in the tonsil in 24 (29.3%), and in the base of the tongue (one patient). Chemotherapy cycles consisted of cisplatin in a dose of 100 mg/m2 administered intravenously on the first day, and 5-f1uorouracil in a dose of 1000 mg/m2 over days 1 to 5. Forty-seven (57.3%) patients received 3 cycles, 25 (30.5%) patients 2 cycles, 8 (9.8%) patients 1 cycle. After chemotherapy, patients received conventionally fractionated (200 cGy 5x a week) radiotherapy to the primary tumour (5065 Gy) and regional nodes (5070 Gy). The therapy was generally well tolerated, however two patients developed fatal late complications. Improvement in therapy results was observed when comparised with a historical group. Five-year overall survival was 52%. The degree of regression (PR + CR), following neoadjuvant chemotherapy, which appeared to depend on the number of chemotherapy cycles, is the main prognostic factor for this group of patients.
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DOI: 10.1016/S1507-1367(98)70170-1
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Skoyszewski</name><affiliation><mods:affiliation>Department of Radiation Oncology, Centre of Oncology Marie Skodowska-Curie Memorial Institute, Krakw, Poland</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3A9AE859AC6793A6205C3EA1E90CB9C2363BE4CF</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1016/S1507-1367(98)70170-1</idno><idno type="url">https://api.istex.fr/document/3A9AE859AC6793A6205C3EA1E90CB9C2363BE4CF/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002424</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Poorly differentiated loco-regionally advanced naso and oropharyngeal carcinoma: results of neoadjuvant chemotherapy followed by radiotherapy</title><author><name sortKey="Radkowski, A" sort="Radkowski, A" uniqKey="Radkowski A" first="A." last="Radkowski">A. Radkowski</name><affiliation><mods:affiliation>Department of Radiation Oncology, Centre of Oncology Marie Skodowska-Curie Memorial Institute, Krakw, Poland</mods:affiliation></affiliation></author><author><name sortKey="Reinfuss, M" sort="Reinfuss, M" uniqKey="Reinfuss M" first="M." last="Reinfuss">M. Reinfuss</name><affiliation><mods:affiliation>Teleradiotherapy Unit, Centre of Oncology Marie Skodowska-Curie Memorial Institute, Krakw, Poland</mods:affiliation></affiliation></author><author><name sortKey="Skoyszewski, J" sort="Skoyszewski, J" uniqKey="Skoyszewski J" first="J." last="Skoyszewski">J. Skoyszewski</name><affiliation><mods:affiliation>Department of Radiation Oncology, Centre of Oncology Marie Skodowska-Curie Memorial Institute, Krakw, Poland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Reports of Practical Oncology & Radiotherapy</title><title level="j" type="abbrev">RPOR</title><idno type="ISSN">1507-1367</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">3</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="67">67</biblScope><biblScope unit="page" to="73">73</biblScope></imprint><idno type="ISSN">1507-1367</idno></series><idno type="istex">3A9AE859AC6793A6205C3EA1E90CB9C2363BE4CF</idno><idno type="DOI">10.1016/S1507-1367(98)70170-1</idno><idno type="PII">S1507-1367(98)70170-1</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1507-1367</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>naso - and oropharyngeal cancer</term><term>neoadjuvant chemotherapy</term><term>radiotherapy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Over the years 19861997, at the Centre of Oncology in Krakw, 82 patients (28 women, 54 men; mean age: 50.8 years) with poorly differentiatied naso- and oropharyngeal carcinoma with metastases to regional nodes (stage III and IV) received neoadjuvant chemotherapy followed by teleradiotherapy. The primary tumour was located in the nasopharynx in 57 patients (69.5%), in the tonsil in 24 (29.3%), and in the base of the tongue (one patient). Chemotherapy cycles consisted of cisplatin in a dose of 100 mg/m2 administered intravenously on the first day, and 5-f1uorouracil in a dose of 1000 mg/m2 over days 1 to 5. Forty-seven (57.3%) patients received 3 cycles, 25 (30.5%) patients 2 cycles, 8 (9.8%) patients 1 cycle. After chemotherapy, patients received conventionally fractionated (200 cGy 5x a week) radiotherapy to the primary tumour (5065 Gy) and regional nodes (5070 Gy). The therapy was generally well tolerated, however two patients developed fatal late complications. Improvement in therapy results was observed when comparised with a historical group. Five-year overall survival was 52%. The degree of regression (PR + CR), following neoadjuvant chemotherapy, which appeared to depend on the number of chemotherapy cycles, is the main prognostic factor for this group of patients.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>A. Radkowski</name><affiliations><json:string>Department of Radiation Oncology, Centre of Oncology Marie Skodowska-Curie Memorial Institute, Krakw, Poland</json:string></affiliations></json:item><json:item><name>M. Reinfuss</name><affiliations><json:string>Teleradiotherapy Unit, Centre of Oncology Marie Skodowska-Curie Memorial Institute, Krakw, Poland</json:string></affiliations></json:item><json:item><name>J. Skoyszewski</name><affiliations><json:string>Department of Radiation Oncology, Centre of Oncology Marie Skodowska-Curie Memorial Institute, Krakw, Poland</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>neoadjuvant chemotherapy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>radiotherapy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>naso - and oropharyngeal cancer</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Over the years 19861997, at the Centre of Oncology in Krakw, 82 patients (28 women, 54 men; mean age: 50.8 years) with poorly differentiatied naso- and oropharyngeal carcinoma with metastases to regional nodes (stage III and IV) received neoadjuvant chemotherapy followed by teleradiotherapy. The primary tumour was located in the nasopharynx in 57 patients (69.5%), in the tonsil in 24 (29.3%), and in the base of the tongue (one patient). Chemotherapy cycles consisted of cisplatin in a dose of 100 mg/m2 administered intravenously on the first day, and 5-f1uorouracil in a dose of 1000 mg/m2 over days 1 to 5. Forty-seven (57.3%) patients received 3 cycles, 25 (30.5%) patients 2 cycles, 8 (9.8%) patients 1 cycle. After chemotherapy, patients received conventionally fractionated (200 cGy 5x a week) radiotherapy to the primary tumour (5065 Gy) and regional nodes (5070 Gy). The therapy was generally well tolerated, however two patients developed fatal late complications. Improvement in therapy results was observed when comparised with a historical group. Five-year overall survival was 52%. The degree of regression (PR + CR), following neoadjuvant chemotherapy, which appeared to depend on the number of chemotherapy cycles, is the main prognostic factor for this group of patients.</abstract><qualityIndicators><score>7.299</score><pdfVersion>1.7</pdfVersion><pdfPageSize>601.92 x 828 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>3</keywordCount><abstractCharCount>1291</abstractCharCount><pdfWordCount>2911</pdfWordCount><pdfCharCount>19790</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>199</abstractWordCount></qualityIndicators><title>Poorly differentiated loco-regionally advanced naso and oropharyngeal carcinoma: results of neoadjuvant chemotherapy followed by radiotherapy</title><pii><json:string>S1507-1367(98)70170-1</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>3</volume><pii><json:string>S1507-1367(98)X7010-0</json:string></pii><pages><last>73</last><first>67</first></pages><issn><json:string>1507-1367</json:string></issn><issue>4</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Reports of Practical Oncology & Radiotherapy</title><publicationDate>1998</publicationDate></host><categories><wos><json:string>ONCOLOGY</json:string><json:string>RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING</json:string></wos></categories><publicationDate>1999</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1016/S1507-1367(98)70170-1</json:string></doi><id>3A9AE859AC6793A6205C3EA1E90CB9C2363BE4CF</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/3A9AE859AC6793A6205C3EA1E90CB9C2363BE4CF/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/3A9AE859AC6793A6205C3EA1E90CB9C2363BE4CF/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/3A9AE859AC6793A6205C3EA1E90CB9C2363BE4CF/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/3A9AE859AC6793A6205C3EA1E90CB9C2363BE4CF/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Poorly differentiated loco-regionally advanced naso and oropharyngeal carcinoma: results of neoadjuvant chemotherapy followed by radiotherapy</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">Section title: Original papers</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Poorly differentiated loco-regionally advanced naso and oropharyngeal carcinoma: results of neoadjuvant chemotherapy followed by radiotherapy</title><author><persName><forename type="first">A.</forename><surname>Radkowski</surname></persName><affiliation>Department of Radiation Oncology, Centre of Oncology Marie Skodowska-Curie Memorial Institute, Krakw, Poland</affiliation></author><author><persName><forename type="first">M.</forename><surname>Reinfuss</surname></persName><affiliation>Teleradiotherapy Unit, Centre of Oncology Marie Skodowska-Curie Memorial Institute, Krakw, Poland</affiliation></author><author><persName><forename type="first">J.</forename><surname>Skoyszewski</surname></persName><affiliation>Department of Radiation Oncology, Centre of Oncology Marie Skodowska-Curie Memorial Institute, Krakw, Poland</affiliation></author></analytic><monogr><title level="j">Reports of Practical Oncology & Radiotherapy</title><title level="j" type="abbrev">RPOR</title><idno type="pISSN">1507-1367</idno><idno type="PII">S1507-1367(98)X7010-0</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999"></date><biblScope unit="volume">3</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="67">67</biblScope><biblScope unit="page" to="73">73</biblScope></imprint></monogr><idno type="istex">3A9AE859AC6793A6205C3EA1E90CB9C2363BE4CF</idno><idno type="DOI">10.1016/S1507-1367(98)70170-1</idno><idno type="PII">S1507-1367(98)70170-1</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Over the years 19861997, at the Centre of Oncology in Krakw, 82 patients (28 women, 54 men; mean age: 50.8 years) with poorly differentiatied naso- and oropharyngeal carcinoma with metastases to regional nodes (stage III and IV) received neoadjuvant chemotherapy followed by teleradiotherapy. The primary tumour was located in the nasopharynx in 57 patients (69.5%), in the tonsil in 24 (29.3%), and in the base of the tongue (one patient). Chemotherapy cycles consisted of cisplatin in a dose of 100 mg/m2 administered intravenously on the first day, and 5-f1uorouracil in a dose of 1000 mg/m2 over days 1 to 5. Forty-seven (57.3%) patients received 3 cycles, 25 (30.5%) patients 2 cycles, 8 (9.8%) patients 1 cycle. After chemotherapy, patients received conventionally fractionated (200 cGy 5x a week) radiotherapy to the primary tumour (5065 Gy) and regional nodes (5070 Gy). The therapy was generally well tolerated, however two patients developed fatal late complications. Improvement in therapy results was observed when comparised with a historical group. Five-year overall survival was 52%. The degree of regression (PR + CR), following neoadjuvant chemotherapy, which appeared to depend on the number of chemotherapy cycles, is the main prognostic factor for this group of patients.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key words</head><item><term>neoadjuvant chemotherapy</term></item><item><term>radiotherapy</term></item><item><term>naso - and oropharyngeal cancer</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999-05-21">Registration</change><change when="1999-04-13">Modified</change><change when="1999">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.1.0//EN//XML" URI="art510.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.1" xml:lang="en" docsubtype="fla"><item-info><jid>RPOR</jid><aid>70170</aid><ce:pii>S1507-1367(98)70170-1</ce:pii><ce:doi>10.1016/S1507-1367(98)70170-1</ce:doi><ce:copyright type="society" year="2009">Greater Poland Oncology Center</ce:copyright></item-info><head><ce:dochead><ce:textfn>Original papers</ce:textfn></ce:dochead><ce:title>Poorly differentiated loco-regionally advanced naso – and oropharyngeal carcinoma: results of neoadjuvant chemotherapy followed by radiotherapy</ce:title><ce:author-group><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Radkowski</ce:surname><ce:cross-ref refid="aff0005"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.</ce:given-name><ce:surname>Reinfuss</ce:surname><ce:cross-ref refid="aff0010"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.</ce:given-name><ce:surname>Skołyszewski</ce:surname><ce:cross-ref refid="aff0005"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff0005"><ce:label>1</ce:label><ce:textfn>Department of Radiation Oncology, Centre of Oncology – Marie Skłodowska-Curie Memorial Institute, Kraków, Poland</ce:textfn></ce:affiliation><ce:affiliation id="aff0010"><ce:label>2</ce:label><ce:textfn>Teleradiotherapy Unit, Centre of Oncology – Marie Skłodowska-Curie Memorial Institute, Kraków, Poland</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="11" month="3" year="1999"></ce:date-received><ce:date-revised day="13" month="4" year="1999"></ce:date-revised><ce:date-accepted day="21" month="5" year="1999"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para id="spar0005">Over the years 1986–1997, at the Centre of Oncology in Kraków, 82 patients (28 women, 54 men; mean age: 50.8 years) with poorly differentiatied naso- and oropharyngeal carcinoma with metastases to regional nodes (stage III and IV) received neoadjuvant chemotherapy followed by teleradiotherapy. The primary tumour was located in the nasopharynx in 57 patients (69.5%), in the tonsil – in 24 (29.3%), and in the base of the tongue (one patient). Chemotherapy cycles consisted of cisplatin in a dose of 100 mg/m<ce:sup>2</ce:sup> administered intravenously on the first day, and 5-f1uorouracil in a dose of 1000 mg/m<ce:sup>2</ce:sup> over days 1 to 5. Forty-seven (57.3%) patients received 3 cycles, 25 (30.5%) patients – 2 cycles, 8 (9.8%) patients – 1 cycle. After chemotherapy, patients received conventionally fractionated (200 cGy 5x a week) radiotherapy to the primary tumour (50–65 Gy) and regional nodes (50–70 Gy). The therapy was generally well tolerated, however two patients developed fatal late complications. Improvement in therapy results was observed when comparised with a historical group. Five-year overall survival was 52%. The degree of regression (PR + CR), following neoadjuvant chemotherapy, which appeared to depend on the number of chemotherapy cycles, is the main prognostic factor for this group of patients.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Key words</ce:section-title><ce:keyword><ce:text>neoadjuvant chemotherapy</ce:text></ce:keyword><ce:keyword><ce:text>radiotherapy</ce:text></ce:keyword><ce:keyword><ce:text>naso - and oropharyngeal cancer</ce:text></ce:keyword></ce:keywords></head><tail><ce:bibliography id="bibl0005"><ce:section-title>References</ce:section-title><ce:bibliography-sec id="bibs0005"><ce:bib-reference id="bib1"><ce:label>Al-Sarraf and McLaughlin, 1995</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:given-name>M.</ce:given-name><ce:surname>Al-Sarraf</ce:surname></sb:author><sb:author><ce:given-name>P.W.</ce:given-name><ce:surname>McLaughlin</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>Nasopharynx carcinoma: choice of treatment</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Int. 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The primary tumour was located in the nasopharynx in 57 patients (69.5%), in the tonsil in 24 (29.3%), and in the base of the tongue (one patient). Chemotherapy cycles consisted of cisplatin in a dose of 100 mg/m2 administered intravenously on the first day, and 5-f1uorouracil in a dose of 1000 mg/m2 over days 1 to 5. Forty-seven (57.3%) patients received 3 cycles, 25 (30.5%) patients 2 cycles, 8 (9.8%) patients 1 cycle. After chemotherapy, patients received conventionally fractionated (200 cGy 5x a week) radiotherapy to the primary tumour (5065 Gy) and regional nodes (5070 Gy). The therapy was generally well tolerated, however two patients developed fatal late complications. Improvement in therapy results was observed when comparised with a historical group. Five-year overall survival was 52%. The degree of regression (PR + CR), following neoadjuvant chemotherapy, which appeared to depend on the number of chemotherapy cycles, is the main prognostic factor for this group of patients.</abstract><note type="content">Section title: Original papers</note><subject lang="en"><genre>Key words</genre><topic>neoadjuvant chemotherapy</topic><topic>radiotherapy</topic><topic>naso - and oropharyngeal cancer</topic></subject><relatedItem type="host"><titleInfo><title>Reports of Practical Oncology & Radiotherapy</title></titleInfo><titleInfo type="abbreviated"><title>RPOR</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">1998</dateIssued></originInfo><identifier type="ISSN">1507-1367</identifier><identifier type="PII">S1507-1367(98)X7010-0</identifier><part><date>1998</date><detail type="volume"><number>3</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="issue pages"><start>67</start><end>90</end></extent><extent unit="pages"><start>67</start><end>73</end></extent></part></relatedItem><identifier type="istex">3A9AE859AC6793A6205C3EA1E90CB9C2363BE4CF</identifier><identifier type="DOI">10.1016/S1507-1367(98)70170-1</identifier><identifier type="PII">S1507-1367(98)70170-1</identifier><accessCondition type="use and reproduction" contentType="">© 2009Greater Poland Oncology Center</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Greater Poland Oncology Center, ©2009</recordOrigin></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/3A9AE859AC6793A6205C3EA1E90CB9C2363BE4CF/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">ONCOLOGY</classCode><classCode scheme="WOS">RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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