Enhancing Oxygen Transfer in Bioreactors by Perfluorocarbon Emulsions
Identifieur interne : 002030 ( Istex/Corpus ); précédent : 002029; suivant : 002031Enhancing Oxygen Transfer in Bioreactors by Perfluorocarbon Emulsions
Auteurs : Lu Wang Ju ; Jaw Fang Lee ; William B. ArmigerSource :
- Biotechnology Progress [ 8756-7938 ] ; 1991-07.
Abstract
This work aims to investigate the capability of perfluorocarbon (PFC) emulsions in enhancing oxygen transfer in bioreactors. Based on the penetration theory, a model has been derived for evaluating the potential oxygen transfer enhancement effects of PFC emulsions with very fine PFC particles. Defined as the ratio between the maximum oxygen transfer rates in systems with and without the emulsions, the enhancement factor achievable with dilute PFC emulsions can be estimated as the square root of the product of ratios of oxygen permeability and solubility in media with and without the emulsions. The effect of PFC emulsions on oxygen transfer in low‐shear cultivation systems was further studied experimentally with direct measurements of volumetric oxygen transfer coefficients, 𝔨Lα, in bioreactors and with microbial fermentations conducted under low‐shear conditions. It was found that significantly higher cell populations could be maintained at an aerobic state by using systems supplemented with the investigated emulsions. The experimentally determined values of oxygen transfer enhancement factor compare well with the theoretical values for emulsions with up to 15% (v/v) PFC. The feasibility of enhancing oxygen transfer in bioreactors by introduction of adequate amounts of PFC emulsions was clearly demonstrated.
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DOI: 10.1021/bp00010a006
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Armiger, BioChem Technology, Inc., 100 Ross Road, King of Prussia, Pennsylvania 19406===</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Biotechnology Progress</title><title level="j" type="abbrev">Biotechnol Progress</title><idno type="ISSN">8756-7938</idno><idno type="eISSN">1520-6033</idno><imprint><publisher>American Chemical Society</publisher><pubPlace>USA</pubPlace><date type="published" when="1991-07">1991-07</date><biblScope unit="volume">7</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="323">323</biblScope><biblScope unit="page" to="329">329</biblScope></imprint><idno type="ISSN">8756-7938</idno></series><idno type="istex">A422DF6BF8ACCA2F00278BDAF58E2FCFF74A4507</idno><idno type="DOI">10.1021/bp00010a006</idno><idno type="ArticleID">BTPR5420070406</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">8756-7938</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This work aims to investigate the capability of perfluorocarbon (PFC) emulsions in enhancing oxygen transfer in bioreactors. Based on the penetration theory, a model has been derived for evaluating the potential oxygen transfer enhancement effects of PFC emulsions with very fine PFC particles. Defined as the ratio between the maximum oxygen transfer rates in systems with and without the emulsions, the enhancement factor achievable with dilute PFC emulsions can be estimated as the square root of the product of ratios of oxygen permeability and solubility in media with and without the emulsions. The effect of PFC emulsions on oxygen transfer in low‐shear cultivation systems was further studied experimentally with direct measurements of volumetric oxygen transfer coefficients, 𝔨Lα, in bioreactors and with microbial fermentations conducted under low‐shear conditions. It was found that significantly higher cell populations could be maintained at an aerobic state by using systems supplemented with the investigated emulsions. The experimentally determined values of oxygen transfer enhancement factor compare well with the theoretical values for emulsions with up to 15% (v/v) PFC. The feasibility of enhancing oxygen transfer in bioreactors by introduction of adequate amounts of PFC emulsions was clearly demonstrated.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Lu‐Kwang Ju</name><affiliations><json:string>Department of Chemical Engineering, The University of Akron, Akron, Ohio 44325</json:string><json:string>Lu‐Kwang Ju, Department of Chemical Engineering, The University of Akron, Akron, Ohio 44325===William B. Armiger, BioChem Technology, Inc., 100 Ross Road, King of Prussia, Pennsylvania 19406===</json:string></affiliations></json:item><json:item><name>Jaw Fang Lee</name><affiliations><json:string>BioChem Technology, Inc., 100 Ross Road, King of Prussia, Pennsylvania 19406</json:string></affiliations></json:item><json:item><name>William B. Armiger</name><affiliations><json:string>BioChem Technology, Inc., 100 Ross Road, King of Prussia, Pennsylvania 19406</json:string><json:string>Lu‐Kwang Ju, Department of Chemical Engineering, The University of Akron, Akron, Ohio 44325===William B. Armiger, BioChem Technology, Inc., 100 Ross Road, King of Prussia, Pennsylvania 19406===</json:string></affiliations></json:item></author><articleId><json:string>BTPR5420070406</json:string></articleId><language><json:string>eng</json:string></language><abstract>This work aims to investigate the capability of perfluorocarbon (PFC) emulsions in enhancing oxygen transfer in bioreactors. Based on the penetration theory, a model has been derived for evaluating the potential oxygen transfer enhancement effects of PFC emulsions with very fine PFC particles. Defined as the ratio between the maximum oxygen transfer rates in systems with and without the emulsions, the enhancement factor achievable with dilute PFC emulsions can be estimated as the square root of the product of ratios of oxygen permeability and solubility in media with and without the emulsions. The effect of PFC emulsions on oxygen transfer in low‐shear cultivation systems was further studied experimentally with direct measurements of volumetric oxygen transfer coefficients, 𝔨Lα, in bioreactors and with microbial fermentations conducted under low‐shear conditions. It was found that significantly higher cell populations could be maintained at an aerobic state by using systems supplemented with the investigated emulsions. The experimentally determined values of oxygen transfer enhancement factor compare well with the theoretical values for emulsions with up to 15% (v/v) PFC. 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Armiger, BioChem Technology, Inc., 100 Ross Road, King of Prussia, Pennsylvania 19406===</affiliation></author></analytic><monogr><title level="j">Biotechnology Progress</title><title level="j" type="abbrev">Biotechnol Progress</title><idno type="pISSN">8756-7938</idno><idno type="eISSN">1520-6033</idno><idno type="DOI">10.1021/(ISSN)1520-6033</idno><imprint><publisher>American Chemical Society</publisher><pubPlace>USA</pubPlace><date type="published" when="1991-07"></date><biblScope unit="volume">7</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="323">323</biblScope><biblScope unit="page" to="329">329</biblScope></imprint></monogr><idno type="istex">A422DF6BF8ACCA2F00278BDAF58E2FCFF74A4507</idno><idno type="DOI">10.1021/bp00010a006</idno><idno type="ArticleID">BTPR5420070406</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1991</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>This work aims to investigate the capability of perfluorocarbon (PFC) emulsions in enhancing oxygen transfer in bioreactors. Based on the penetration theory, a model has been derived for evaluating the potential oxygen transfer enhancement effects of PFC emulsions with very fine PFC particles. Defined as the ratio between the maximum oxygen transfer rates in systems with and without the emulsions, the enhancement factor achievable with dilute PFC emulsions can be estimated as the square root of the product of ratios of oxygen permeability and solubility in media with and without the emulsions. The effect of PFC emulsions on oxygen transfer in low‐shear cultivation systems was further studied experimentally with direct measurements of volumetric oxygen transfer coefficients, 𝔨Lα, in bioreactors and with microbial fermentations conducted under low‐shear conditions. It was found that significantly higher cell populations could be maintained at an aerobic state by using systems supplemented with the investigated emulsions. The experimentally determined values of oxygen transfer enhancement factor compare well with the theoretical values for emulsions with up to 15% (v/v) PFC. The feasibility of enhancing oxygen transfer in bioreactors by introduction of adequate amounts of PFC emulsions was clearly demonstrated.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Articles</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1991-04-09">Registration</change><change when="1991-07">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/A422DF6BF8ACCA2F00278BDAF58E2FCFF74A4507/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>American Chemical Society</publisherName><publisherLoc>USA</publisherLoc></publisherInfo><doi registered="yes">10.1021/(ISSN)1520-6033</doi><issn type="print">8756-7938</issn><issn type="electronic">1520-6033</issn><idGroup><id type="product" value="BTPR"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="BIOTECHNOLOGY PROGRESS">Biotechnology Progress</title><title type="short">Biotechnol Progress</title></titleGroup></publicationMeta><publicationMeta level="part" position="40"><doi origin="wiley" registered="no">10.1002/btpr.v7:4</doi><numberingGroup><numbering type="journalVolume" number="7">7</numbering><numbering type="journalIssue">4</numbering></numberingGroup><coverDate startDate="1991-07">July/August 1991</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="6" status="forIssue"><doi origin="wiley" registered="yes">10.1021/bp00010a006</doi><idGroup><id type="unit" value="BTPR5420070406"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="articleCategory">Articles</title><title type="tocHeading1">Articles</title></titleGroup><copyright ownership="publisher">Copyright © 1991 American Institute of Chemical Engineers (AIChE)</copyright><eventGroup><event type="manuscriptAccepted" date="1991-04-09"></event><event type="firstOnline" date="2008-09-05"></event><event type="publishedOnlineFinalForm" date="2008-09-05"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-12"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-15"></event></eventGroup><numberingGroup><numbering type="pageFirst">323</numbering><numbering type="pageLast">329</numbering></numberingGroup><correspondenceTo><lineatedText><line>Lu‐Kwang Ju, Department of Chemical Engineering, The University of Akron, Akron, Ohio 44325===</line><line>William B. Armiger, BioChem Technology, Inc., 100 Ross Road, King of Prussia, Pennsylvania 19406===</line></lineatedText></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:BTPR.BTPR5420070406.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="5"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="34"></count></countGroup><titleGroup><title type="main" xml:lang="en">Enhancing Oxygen Transfer in Bioreactors by Perfluorocarbon Emulsions</title><title type="short" xml:lang="en">ENHANCING OXYGEN TRANSFER IN BIOREACTORS BY PERFLUOROCARBON EMULSIONS</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Lu‐Kwang</givenNames><familyName>Ju</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Jaw Fang</givenNames><familyName>Lee</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2" corresponding="yes"><personName><givenNames>William B.</givenNames><familyName>Armiger</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Department of Chemical Engineering, The University of Akron, Akron, Ohio 44325</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>BioChem Technology, Inc., 100 Ross Road, King of Prussia, Pennsylvania 19406</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>This work aims to investigate the capability of perfluorocarbon (PFC) emulsions in enhancing oxygen transfer in bioreactors. Based on the penetration theory, a model has been derived for evaluating the potential oxygen transfer enhancement effects of PFC emulsions with very fine PFC particles. Defined as the ratio between the maximum oxygen transfer rates in systems with and without the emulsions, the enhancement factor achievable with dilute PFC emulsions can be estimated as the square root of the product of ratios of oxygen permeability and solubility in media with and without the emulsions. The effect of PFC emulsions on oxygen transfer in low‐shear cultivation systems was further studied experimentally with direct measurements of volumetric oxygen transfer coefficients, 𝔨<sub>L</sub>α, in bioreactors and with microbial fermentations conducted under low‐shear conditions. It was found that significantly higher cell populations could be maintained at an aerobic state by using systems supplemented with the investigated emulsions. The experimentally determined values of oxygen transfer enhancement factor compare well with the theoretical values for emulsions with up to 15% (v/v) PFC. The feasibility of enhancing oxygen transfer in bioreactors by introduction of adequate amounts of PFC emulsions was clearly demonstrated.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Enhancing Oxygen Transfer in Bioreactors by Perfluorocarbon Emulsions</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>ENHANCING OXYGEN TRANSFER IN BIOREACTORS BY PERFLUOROCARBON EMULSIONS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Enhancing Oxygen Transfer in Bioreactors by Perfluorocarbon Emulsions</title></titleInfo><name type="personal"><namePart type="given">Lu‐Kwang</namePart><namePart type="family">Ju</namePart><affiliation>Department of Chemical Engineering, The University of Akron, Akron, Ohio 44325</affiliation><affiliation>Lu‐Kwang Ju, Department of Chemical Engineering, The University of Akron, Akron, Ohio 44325===William B. Armiger, BioChem Technology, Inc., 100 Ross Road, King of Prussia, Pennsylvania 19406===</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jaw Fang</namePart><namePart type="family">Lee</namePart><affiliation>BioChem Technology, Inc., 100 Ross Road, King of Prussia, Pennsylvania 19406</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">William B.</namePart><namePart type="family">Armiger</namePart><affiliation>BioChem Technology, Inc., 100 Ross Road, King of Prussia, Pennsylvania 19406</affiliation><affiliation>Lu‐Kwang Ju, Department of Chemical Engineering, The University of Akron, Akron, Ohio 44325===William B. Armiger, BioChem Technology, Inc., 100 Ross Road, King of Prussia, Pennsylvania 19406===</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>American Chemical Society</publisher><place><placeTerm type="text">USA</placeTerm></place><dateIssued encoding="w3cdtf">1991-07</dateIssued><dateValid encoding="w3cdtf">1991-04-09</dateValid><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">5</extent><extent unit="tables">3</extent><extent unit="references">34</extent></physicalDescription><abstract lang="en">This work aims to investigate the capability of perfluorocarbon (PFC) emulsions in enhancing oxygen transfer in bioreactors. Based on the penetration theory, a model has been derived for evaluating the potential oxygen transfer enhancement effects of PFC emulsions with very fine PFC particles. Defined as the ratio between the maximum oxygen transfer rates in systems with and without the emulsions, the enhancement factor achievable with dilute PFC emulsions can be estimated as the square root of the product of ratios of oxygen permeability and solubility in media with and without the emulsions. The effect of PFC emulsions on oxygen transfer in low‐shear cultivation systems was further studied experimentally with direct measurements of volumetric oxygen transfer coefficients, 𝔨Lα, in bioreactors and with microbial fermentations conducted under low‐shear conditions. It was found that significantly higher cell populations could be maintained at an aerobic state by using systems supplemented with the investigated emulsions. The experimentally determined values of oxygen transfer enhancement factor compare well with the theoretical values for emulsions with up to 15% (v/v) PFC. The feasibility of enhancing oxygen transfer in bioreactors by introduction of adequate amounts of PFC emulsions was clearly demonstrated.</abstract><relatedItem type="host"><titleInfo><title>Biotechnology Progress</title></titleInfo><titleInfo type="abbreviated"><title>Biotechnol Progress</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Articles</topic></subject><identifier type="ISSN">8756-7938</identifier><identifier type="eISSN">1520-6033</identifier><identifier type="DOI">10.1021/(ISSN)1520-6033</identifier><identifier type="PublisherID">BTPR</identifier><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>323</start><end>329</end><total>7</total></extent></part></relatedItem><identifier type="istex">A422DF6BF8ACCA2F00278BDAF58E2FCFF74A4507</identifier><identifier type="DOI">10.1021/bp00010a006</identifier><identifier type="ArticleID">BTPR5420070406</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1991 American Institute of Chemical Engineers (AIChE)</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>American Chemical Society</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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