Haptic breakage following neonatal IOL implantation in a nonhuman primate model.
Identifieur interne : 002103 ( PubMed/Curation ); précédent : 002102; suivant : 002104Haptic breakage following neonatal IOL implantation in a nonhuman primate model.
Auteurs : S R Lambert [États-Unis] ; A. Fernandes ; H E GrossniklausSource :
- Journal of pediatric ophthalmology and strabismus [ 0191-3913 ]
English descriptors
- KwdEn :
- Animals, Animals, Newborn, Anterior Eye Segment (pathology), Cataract Extraction, Foreign-Body Migration (etiology), Foreign-Body Migration (pathology), Lens, Crystalline (surgery), Lenses, Intraocular (adverse effects), Macaca mulatta, Methylmethacrylates, Prosthesis Failure, Reoperation, Vitrectomy.
- MESH :
- chemical : Methylmethacrylates.
- adverse effects : Lenses, Intraocular.
- etiology : Foreign-Body Migration.
- pathology : Anterior Eye Segment, Foreign-Body Migration.
- surgery : Lens, Crystalline.
- Animals, Animals, Newborn, Cataract Extraction, Macaca mulatta, Prosthesis Failure, Reoperation, Vitrectomy.
Abstract
To evaluate the long-term safety of implanting intraocular lenses (IOLs) in neonatal eyes using a nonhuman primate model, a one-piece all-polymethylmethacrylate (PMMA) IOL was implanted into the posterior chamber of 21 neonatal Rhesus monkey eyes following a lensectomy and anterior vitrectomy. These monkeys then were monitored for 26 to 40 months for complications. The eyes from seven monkeys were studied histopathologically. One or both haptics broke on 7 of the 21 (33%) IOLs in a mean of 21 months (range 6 to 31 months) after their implantation. Only one of the haptics from these seven eyes was found to be in the capsular bag when these eyes were studied histopathologically. Nine haptics had eroded into the iris leaflets, two into the ciliary body, and one into the anterior chamber. One additional haptic was in the sulcus. The haptics of one-piece all-PMMA IOLs may break if implanted in neonatal eyes. A number of factors likely contributed to haptic breakage in these eyes, including an increased number of reoperations, malpositioning of IOL haptics, rapid circumferential and axial growth, and the formation of large Soemmerring's rings.
PubMed: 7494156
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Fernandes</name></author><author><name sortKey="Grossniklaus, H E" sort="Grossniklaus, H E" uniqKey="Grossniklaus H" first="H E" last="Grossniklaus">H E Grossniklaus</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>1995 Jul-Aug</MedlineDate></PubDate></date><idno type="RBID">pubmed:7494156</idno><idno type="pmid">7494156</idno><idno type="wicri:Area/PubMed/Corpus">002103</idno><idno type="wicri:Area/PubMed/Curation">002103</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Haptic breakage following neonatal IOL implantation in a nonhuman primate model.</title><author><name sortKey="Lambert, S R" sort="Lambert, S R" uniqKey="Lambert S" first="S R" last="Lambert">S R Lambert</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Emory University, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Emory University, Atlanta, Georgia</wicri:regionArea></affiliation></author><author><name sortKey="Fernandes, A" sort="Fernandes, A" uniqKey="Fernandes A" first="A" last="Fernandes">A. Fernandes</name></author><author><name sortKey="Grossniklaus, H E" sort="Grossniklaus, H E" uniqKey="Grossniklaus H" first="H E" last="Grossniklaus">H E Grossniklaus</name></author></analytic><series><title level="j">Journal of pediatric ophthalmology and strabismus</title><idno type="ISSN">0191-3913</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Animals, Newborn</term><term>Anterior Eye Segment (pathology)</term><term>Cataract Extraction</term><term>Foreign-Body Migration (etiology)</term><term>Foreign-Body Migration (pathology)</term><term>Lens, Crystalline (surgery)</term><term>Lenses, Intraocular (adverse effects)</term><term>Macaca mulatta</term><term>Methylmethacrylates</term><term>Prosthesis Failure</term><term>Reoperation</term><term>Vitrectomy</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Methylmethacrylates</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Lenses, Intraocular</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Foreign-Body Migration</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Anterior Eye Segment</term><term>Foreign-Body Migration</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Lens, Crystalline</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Animals, Newborn</term><term>Cataract Extraction</term><term>Macaca mulatta</term><term>Prosthesis Failure</term><term>Reoperation</term><term>Vitrectomy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate the long-term safety of implanting intraocular lenses (IOLs) in neonatal eyes using a nonhuman primate model, a one-piece all-polymethylmethacrylate (PMMA) IOL was implanted into the posterior chamber of 21 neonatal Rhesus monkey eyes following a lensectomy and anterior vitrectomy. These monkeys then were monitored for 26 to 40 months for complications. The eyes from seven monkeys were studied histopathologically. One or both haptics broke on 7 of the 21 (33%) IOLs in a mean of 21 months (range 6 to 31 months) after their implantation. Only one of the haptics from these seven eyes was found to be in the capsular bag when these eyes were studied histopathologically. Nine haptics had eroded into the iris leaflets, two into the ciliary body, and one into the anterior chamber. One additional haptic was in the sulcus. The haptics of one-piece all-PMMA IOLs may break if implanted in neonatal eyes. A number of factors likely contributed to haptic breakage in these eyes, including an increased number of reoperations, malpositioning of IOL haptics, rapid circumferential and axial growth, and the formation of large Soemmerring's rings.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">7494156</PMID><DateCreated><Year>1996</Year><Month>01</Month><Day>11</Day></DateCreated><DateCompleted><Year>1996</Year><Month>01</Month><Day>11</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0191-3913</ISSN><JournalIssue CitedMedium="Print"><Volume>32</Volume><Issue>4</Issue><PubDate><MedlineDate>1995 Jul-Aug</MedlineDate></PubDate></JournalIssue><Title>Journal of pediatric ophthalmology and strabismus</Title><ISOAbbreviation>J Pediatr Ophthalmol Strabismus</ISOAbbreviation></Journal><ArticleTitle>Haptic breakage following neonatal IOL implantation in a nonhuman primate model.</ArticleTitle><Pagination><MedlinePgn>219-24</MedlinePgn></Pagination><Abstract><AbstractText>To evaluate the long-term safety of implanting intraocular lenses (IOLs) in neonatal eyes using a nonhuman primate model, a one-piece all-polymethylmethacrylate (PMMA) IOL was implanted into the posterior chamber of 21 neonatal Rhesus monkey eyes following a lensectomy and anterior vitrectomy. These monkeys then were monitored for 26 to 40 months for complications. The eyes from seven monkeys were studied histopathologically. One or both haptics broke on 7 of the 21 (33%) IOLs in a mean of 21 months (range 6 to 31 months) after their implantation. Only one of the haptics from these seven eyes was found to be in the capsular bag when these eyes were studied histopathologically. Nine haptics had eroded into the iris leaflets, two into the ciliary body, and one into the anterior chamber. One additional haptic was in the sulcus. The haptics of one-piece all-PMMA IOLs may break if implanted in neonatal eyes. A number of factors likely contributed to haptic breakage in these eyes, including an increased number of reoperations, malpositioning of IOL haptics, rapid circumferential and axial growth, and the formation of large Soemmerring's rings.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lambert</LastName><ForeName>S R</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Emory University, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernandes</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Grossniklaus</LastName><ForeName>H E</ForeName><Initials>HE</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>EY08544</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 EY06360</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>RR00165</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>J Pediatr Ophthalmol Strabismus</MedlineTA><NlmUniqueID>7901143</NlmUniqueID><ISSNLinking>0191-3913</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008768">Methylmethacrylates</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000831">Animals, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000869">Anterior Eye Segment</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002387">Cataract Extraction</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005548">Foreign-Body Migration</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007908">Lens, Crystalline</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000601">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007910">Lenses, Intraocular</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000009">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008253">Macaca mulatta</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008768">Methylmethacrylates</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011475">Prosthesis Failure</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012086">Reoperation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014821">Vitrectomy</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1995</Year><Month>7</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1995</Year><Month>7</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1995</Year><Month>7</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">7494156</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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