Molecular modelling and drug design.
Identifieur interne : 001E43 ( PubMed/Corpus ); précédent : 001E42; suivant : 001E44Molecular modelling and drug design.
Auteurs : E F Meyer ; S M Swanson ; J A WilliamsSource :
- Pharmacology & therapeutics [ 0163-7258 ] ; 2000.
English descriptors
- KwdEn :
- MESH :
Abstract
Drug design is a creative act of the same magnitude as composing, sculpting, or writing. The results can touch the lives of millions, but the creator is rarely one scientist and the rewards are distributed differently in the arts than in the sciences. The mechanisms of creativity are the same, i.e., incremental (plodding from darkness to dawn) or sudden (the "Eureka" effect) realization, but both are poorly understood. Creativity remains a human characteristic, but it is directly related to the tools available, especially computer software and hardware. While modelling software continues to mature, very little new has evolved in terms of hardware. Here, we discuss the history of molecular modelling and describe two novel modelling tools, a haptic device and a program, SCULPT, to generate solid molecular models at atomic resolution.
PubMed: 10739866
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E-Meyer@tamu.edu</nlm:affiliation></affiliation></author><author><name sortKey="Swanson, S M" sort="Swanson, S M" uniqKey="Swanson S" first="S M" last="Swanson">S M Swanson</name></author><author><name sortKey="Williams, J A" sort="Williams, J A" uniqKey="Williams J" first="J A" last="Williams">J A Williams</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:10739866</idno><idno type="pmid">10739866</idno><idno type="wicri:Area/PubMed/Corpus">001E43</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Molecular modelling and drug design.</title><author><name sortKey="Meyer, E F" sort="Meyer, E F" uniqKey="Meyer E" first="E F" last="Meyer">E F Meyer</name><affiliation><nlm:affiliation>Biographics Laboratory, Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX, USA. 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