Trigeminothalamic barrelette neurons: natural structural side asymmetries and sensory input-dependent plasticity in adult rats.
Identifieur interne : 001239 ( PubMed/Corpus ); précédent : 001238; suivant : 001240Trigeminothalamic barrelette neurons: natural structural side asymmetries and sensory input-dependent plasticity in adult rats.
Auteurs : P. Negredo ; Y B Martin ; A. Lagares ; J. Castro ; J A Villacorta ; C. Avenda OSource :
- Neuroscience [ 1873-7544 ] ; 2009.
English descriptors
- KwdEn :
- Animals, Dendrites (physiology), Functional Laterality, Image Processing, Computer-Assisted, Male, Neural Pathways (cytology), Neural Pathways (physiology), Neuronal Plasticity (physiology), Neuronal Tract-Tracers, Neurons (cytology), Neurons (physiology), Rats, Rats, Sprague-Dawley, Sensory Deprivation (physiology), Thalamus (cytology), Thalamus (physiology), Touch Perception (physiology), Trigeminal Nuclei (cytology), Trigeminal Nuclei (physiology).
- MESH :
- chemical : Neuronal Tract-Tracers.
- cytology : Neural Pathways, Neurons, Thalamus, Trigeminal Nuclei.
- physiology : Dendrites, Neural Pathways, Neuronal Plasticity, Neurons, Sensory Deprivation, Thalamus, Touch Perception, Trigeminal Nuclei.
- Animals, Functional Laterality, Image Processing, Computer-Assisted, Male, Rats, Rats, Sprague-Dawley.
Abstract
In the rodent trigeminal principal nucleus (Pr5) the barrelette thalamic-projecting neurons relay information from individual whiskers to corresponding contralateral thalamic barreloids. Here we investigated the presence of lateral asymmetries in the dendritic trees of these neurons, and the morphometric changes resulting from input-dependent plasticity in young adult rats. After retrograde labeling with dextran amines from the thalamus, neurons were digitally reconstructed with Neurolucida, and metrically and topologically analyzed with NeuroExplorer. The most unexpected and remarkable result was the observation of side-to-side asymmetries in the barrelette neurons of control rats. These asymmetries more significantly involved the number of low-grade trees and the total dendritic length, which were greater on the left side. Chronic global input loss resulting from infraorbital nerve (IoN) transection, or loss of active touch resulting from whisker clipping in the right neutralized, or even reversed, the observed lateral differences. While results after IoN transection have to be interpreted in the context of partial neuron death in this model, profound bilateral changes were found after haptic loss, which is achieved without inflicting any nerve damage. After whisker trimming, neurons on the left side closely resembled neurons on the right in controls, the natural dendritic length asymmetry being reversed mainly by a shortening of the left trees and a more moderate elongation of the right trees. These results demonstrate that dendritic morphometry is both side- and input-dependent, and that unilateral manipulation of the sensory periphery leads to bilateral morphometric changes in second order neurons of the whisker-barrel system. The presence of anatomical asymmetries in neural structures involved in early stages of somatosensory processing could help explain the expression of sensory input-dependent behavioral asymmetries.
DOI: 10.1016/j.neuroscience.2009.07.065
PubMed: 19664693
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Castro</name></author><author><name sortKey="Villacorta, J A" sort="Villacorta, J A" uniqKey="Villacorta J" first="J A" last="Villacorta">J A Villacorta</name></author><author><name sortKey="Avenda O, C" sort="Avenda O, C" uniqKey="Avenda O C" first="C" last="Avenda O">C. Avenda O</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1016/j.neuroscience.2009.07.065</idno><idno type="RBID">pubmed:19664693</idno><idno type="pmid">19664693</idno><idno type="wicri:Area/PubMed/Corpus">001239</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Trigeminothalamic barrelette neurons: natural structural side asymmetries and sensory input-dependent plasticity in adult rats.</title><author><name sortKey="Negredo, P" sort="Negredo, P" uniqKey="Negredo P" first="P" last="Negredo">P. Negredo</name><affiliation><nlm:affiliation>Department of Anatomy, Histology, and Neuroscience, Medical School, Autonoma University of Madrid, c/ Arzobispo Morcillo 2, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Martin, Y B" sort="Martin, Y B" uniqKey="Martin Y" first="Y B" last="Martin">Y B Martin</name></author><author><name sortKey="Lagares, A" sort="Lagares, A" uniqKey="Lagares A" first="A" last="Lagares">A. Lagares</name></author><author><name sortKey="Castro, J" sort="Castro, J" uniqKey="Castro J" first="J" last="Castro">J. Castro</name></author><author><name sortKey="Villacorta, J A" sort="Villacorta, J A" uniqKey="Villacorta J" first="J A" last="Villacorta">J A Villacorta</name></author><author><name sortKey="Avenda O, C" sort="Avenda O, C" uniqKey="Avenda O C" first="C" last="Avenda O">C. Avenda O</name></author></analytic><series><title level="j">Neuroscience</title><idno type="eISSN">1873-7544</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Dendrites (physiology)</term><term>Functional Laterality</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Neural Pathways (cytology)</term><term>Neural Pathways (physiology)</term><term>Neuronal Plasticity (physiology)</term><term>Neuronal Tract-Tracers</term><term>Neurons (cytology)</term><term>Neurons (physiology)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Sensory Deprivation (physiology)</term><term>Thalamus (cytology)</term><term>Thalamus (physiology)</term><term>Touch Perception (physiology)</term><term>Trigeminal Nuclei (cytology)</term><term>Trigeminal Nuclei (physiology)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Neuronal Tract-Tracers</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Neural Pathways</term><term>Neurons</term><term>Thalamus</term><term>Trigeminal Nuclei</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dendrites</term><term>Neural Pathways</term><term>Neuronal Plasticity</term><term>Neurons</term><term>Sensory Deprivation</term><term>Thalamus</term><term>Touch Perception</term><term>Trigeminal Nuclei</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Functional Laterality</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the rodent trigeminal principal nucleus (Pr5) the barrelette thalamic-projecting neurons relay information from individual whiskers to corresponding contralateral thalamic barreloids. Here we investigated the presence of lateral asymmetries in the dendritic trees of these neurons, and the morphometric changes resulting from input-dependent plasticity in young adult rats. After retrograde labeling with dextran amines from the thalamus, neurons were digitally reconstructed with Neurolucida, and metrically and topologically analyzed with NeuroExplorer. The most unexpected and remarkable result was the observation of side-to-side asymmetries in the barrelette neurons of control rats. These asymmetries more significantly involved the number of low-grade trees and the total dendritic length, which were greater on the left side. Chronic global input loss resulting from infraorbital nerve (IoN) transection, or loss of active touch resulting from whisker clipping in the right neutralized, or even reversed, the observed lateral differences. While results after IoN transection have to be interpreted in the context of partial neuron death in this model, profound bilateral changes were found after haptic loss, which is achieved without inflicting any nerve damage. After whisker trimming, neurons on the left side closely resembled neurons on the right in controls, the natural dendritic length asymmetry being reversed mainly by a shortening of the left trees and a more moderate elongation of the right trees. These results demonstrate that dendritic morphometry is both side- and input-dependent, and that unilateral manipulation of the sensory periphery leads to bilateral morphometric changes in second order neurons of the whisker-barrel system. The presence of anatomical asymmetries in neural structures involved in early stages of somatosensory processing could help explain the expression of sensory input-dependent behavioral asymmetries.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19664693</PMID><DateCreated><Year>2009</Year><Month>10</Month><Day>12</Day></DateCreated><DateCompleted><Year>2010</Year><Month>02</Month><Day>12</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-7544</ISSN><JournalIssue CitedMedium="Internet"><Volume>163</Volume><Issue>4</Issue><PubDate><Year>2009</Year><Month>Nov</Month><Day>10</Day></PubDate></JournalIssue><Title>Neuroscience</Title><ISOAbbreviation>Neuroscience</ISOAbbreviation></Journal><ArticleTitle>Trigeminothalamic barrelette neurons: natural structural side asymmetries and sensory input-dependent plasticity in adult rats.</ArticleTitle><Pagination><MedlinePgn>1242-54</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neuroscience.2009.07.065</ELocationID><Abstract><AbstractText>In the rodent trigeminal principal nucleus (Pr5) the barrelette thalamic-projecting neurons relay information from individual whiskers to corresponding contralateral thalamic barreloids. Here we investigated the presence of lateral asymmetries in the dendritic trees of these neurons, and the morphometric changes resulting from input-dependent plasticity in young adult rats. After retrograde labeling with dextran amines from the thalamus, neurons were digitally reconstructed with Neurolucida, and metrically and topologically analyzed with NeuroExplorer. The most unexpected and remarkable result was the observation of side-to-side asymmetries in the barrelette neurons of control rats. These asymmetries more significantly involved the number of low-grade trees and the total dendritic length, which were greater on the left side. Chronic global input loss resulting from infraorbital nerve (IoN) transection, or loss of active touch resulting from whisker clipping in the right neutralized, or even reversed, the observed lateral differences. While results after IoN transection have to be interpreted in the context of partial neuron death in this model, profound bilateral changes were found after haptic loss, which is achieved without inflicting any nerve damage. After whisker trimming, neurons on the left side closely resembled neurons on the right in controls, the natural dendritic length asymmetry being reversed mainly by a shortening of the left trees and a more moderate elongation of the right trees. These results demonstrate that dendritic morphometry is both side- and input-dependent, and that unilateral manipulation of the sensory periphery leads to bilateral morphometric changes in second order neurons of the whisker-barrel system. 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