Biomechanical properties and associated collagen composition in vaginal tissue of women with pelvic organ prolapse.
Identifieur interne : 000B84 ( PubMed/Checkpoint ); précédent : 000B83; suivant : 000B85Biomechanical properties and associated collagen composition in vaginal tissue of women with pelvic organ prolapse.
Auteurs : Lu Zhou [États-Unis] ; Jung Han Lee ; Yan Wen ; Christos Constantinou ; Murayama Yoshinobu ; Sadao Omata ; Bertha ChenSource :
- The Journal of urology [ 1527-3792 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Collagen Type III.
- chemistry : Vagina.
- physiopathology : Vagina.
- Adult, Biomechanical Phenomena, Elasticity, Female, Humans, Middle Aged, Pelvic Organ Prolapse.
Abstract
The pelvic tissue of women with pelvic organ prolapse is stiffer than that of controls but there are scant data on the collagen composition that corresponds to these mechanical properties. We evaluated human vaginal wall stiffness using the novel scanning haptic microscope and correlated these measurements to collagen expression in women with and without pelvic organ prolapse. In this simultaneous biomechanical and biochemical assessment we evaluated the usefulness of this measurement technology for pelvic floor disorder research and confirmed an association between mechanical properties and composition.
DOI: 10.1016/j.juro.2012.05.017
PubMed: 22819408
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Biomechanical properties and associated collagen composition in vaginal tissue of women with pelvic organ prolapse.</title><author><name sortKey="Zhou, Lu" sort="Zhou, Lu" uniqKey="Zhou L" first="Lu" last="Zhou">Lu Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, Stanford University School of Medicine, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, Stanford University School of Medicine, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Jung Han" sort="Lee, Jung Han" uniqKey="Lee J" first="Jung Han" last="Lee">Jung Han Lee</name></author><author><name sortKey="Wen, Yan" sort="Wen, Yan" uniqKey="Wen Y" first="Yan" last="Wen">Yan Wen</name></author><author><name sortKey="Constantinou, Christos" sort="Constantinou, Christos" uniqKey="Constantinou C" first="Christos" last="Constantinou">Christos Constantinou</name></author><author><name sortKey="Yoshinobu, Murayama" sort="Yoshinobu, Murayama" uniqKey="Yoshinobu M" first="Murayama" last="Yoshinobu">Murayama Yoshinobu</name></author><author><name sortKey="Omata, Sadao" sort="Omata, Sadao" uniqKey="Omata S" first="Sadao" last="Omata">Sadao Omata</name></author><author><name sortKey="Chen, Bertha" sort="Chen, Bertha" uniqKey="Chen B" first="Bertha" last="Chen">Bertha Chen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1016/j.juro.2012.05.017</idno><idno type="RBID">pubmed:22819408</idno><idno type="pmid">22819408</idno><idno type="wicri:Area/PubMed/Corpus">000B58</idno><idno type="wicri:Area/PubMed/Curation">000B58</idno><idno type="wicri:Area/PubMed/Checkpoint">000B84</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Biomechanical properties and associated collagen composition in vaginal tissue of women with pelvic organ prolapse.</title><author><name sortKey="Zhou, Lu" sort="Zhou, Lu" uniqKey="Zhou L" first="Lu" last="Zhou">Lu Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, Stanford University School of Medicine, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, Stanford University School of Medicine, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Jung Han" sort="Lee, Jung Han" uniqKey="Lee J" first="Jung Han" last="Lee">Jung Han Lee</name></author><author><name sortKey="Wen, Yan" sort="Wen, Yan" uniqKey="Wen Y" first="Yan" last="Wen">Yan Wen</name></author><author><name sortKey="Constantinou, Christos" sort="Constantinou, Christos" uniqKey="Constantinou C" first="Christos" last="Constantinou">Christos Constantinou</name></author><author><name sortKey="Yoshinobu, Murayama" sort="Yoshinobu, Murayama" uniqKey="Yoshinobu M" first="Murayama" last="Yoshinobu">Murayama Yoshinobu</name></author><author><name sortKey="Omata, Sadao" sort="Omata, Sadao" uniqKey="Omata S" first="Sadao" last="Omata">Sadao Omata</name></author><author><name sortKey="Chen, Bertha" sort="Chen, Bertha" uniqKey="Chen B" first="Bertha" last="Chen">Bertha Chen</name></author></analytic><series><title level="j">The Journal of urology</title><idno type="eISSN">1527-3792</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Biomechanical Phenomena</term><term>Collagen Type III (analysis)</term><term>Elasticity</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Pelvic Organ Prolapse</term><term>Vagina (chemistry)</term><term>Vagina (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Collagen Type III</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Vagina</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Vagina</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Biomechanical Phenomena</term><term>Elasticity</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Pelvic Organ Prolapse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pelvic tissue of women with pelvic organ prolapse is stiffer than that of controls but there are scant data on the collagen composition that corresponds to these mechanical properties. We evaluated human vaginal wall stiffness using the novel scanning haptic microscope and correlated these measurements to collagen expression in women with and without pelvic organ prolapse. In this simultaneous biomechanical and biochemical assessment we evaluated the usefulness of this measurement technology for pelvic floor disorder research and confirmed an association between mechanical properties and composition.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22819408</PMID><DateCreated><Year>2012</Year><Month>08</Month><Day>13</Day></DateCreated><DateCompleted><Year>2012</Year><Month>10</Month><Day>29</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1527-3792</ISSN><JournalIssue CitedMedium="Internet"><Volume>188</Volume><Issue>3</Issue><PubDate><Year>2012</Year><Month>Sep</Month></PubDate></JournalIssue><Title>The Journal of urology</Title><ISOAbbreviation>J. Urol.</ISOAbbreviation></Journal><ArticleTitle>Biomechanical properties and associated collagen composition in vaginal tissue of women with pelvic organ prolapse.</ArticleTitle><Pagination><MedlinePgn>875-80</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.juro.2012.05.017</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">The pelvic tissue of women with pelvic organ prolapse is stiffer than that of controls but there are scant data on the collagen composition that corresponds to these mechanical properties. We evaluated human vaginal wall stiffness using the novel scanning haptic microscope and correlated these measurements to collagen expression in women with and without pelvic organ prolapse. In this simultaneous biomechanical and biochemical assessment we evaluated the usefulness of this measurement technology for pelvic floor disorder research and confirmed an association between mechanical properties and composition.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">The elastic constant (a measure of stiffness) of vaginal wall tissue was measured with the scanning haptic microscope. Protein expression of collagen types I and III of the same tissues were determined by Western blot. The Student t test was used for comparisons between groups.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The anterior and posterior vaginal walls of premenopausal and postmenopausal women with pelvic organ prolapse were significantly stiffer than those of controls (p <0.05). Collagen III protein expression in the anterior vaginal wall in the control group was higher than in menopausal women. Collagen I expression was not significantly different between controls and cases.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The scanning haptic microscope produced reliable mechanical measurements in small tissue samples without tissue destruction. Vaginal wall tissues are stiffer in women with pelvic organ prolapse than in controls. This vaginal wall stiffness was associated with lower protein expression of collagen III in the vaginal wall compared to that in asymptomatic controls.</AbstractText><CopyrightInformation>Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Lu</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, Stanford University School of Medicine, California 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Jung Han</ForeName><Initials>JH</Initials></Author><Author ValidYN="Y"><LastName>Wen</LastName><ForeName>Yan</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Constantinou</LastName><ForeName>Christos</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Yoshinobu</LastName><ForeName>Murayama</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Omata</LastName><ForeName>Sadao</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Bertha</ForeName><Initials>B</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>1R01 EB006170</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG01790</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>07</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Urol</MedlineTA><NlmUniqueID>0376374</NlmUniqueID><ISSNLinking>0022-5347</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D024061">Collagen Type III</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001696">Biomechanical Phenomena</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D024061">Collagen Type III</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000032">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004548">Elasticity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D056887">Pelvic Organ Prolapse</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014621">Vagina</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>1</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2012</Year><Month>7</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>7</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>7</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>10</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">S0022-5347(12)03715-9</ArticleId><ArticleId IdType="doi">10.1016/j.juro.2012.05.017</ArticleId><ArticleId IdType="pubmed">22819408</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Chen, Bertha" sort="Chen, Bertha" uniqKey="Chen B" first="Bertha" last="Chen">Bertha Chen</name><name sortKey="Constantinou, Christos" sort="Constantinou, Christos" uniqKey="Constantinou C" first="Christos" last="Constantinou">Christos Constantinou</name><name sortKey="Lee, Jung Han" sort="Lee, Jung Han" uniqKey="Lee J" first="Jung Han" last="Lee">Jung Han Lee</name><name sortKey="Omata, Sadao" sort="Omata, Sadao" uniqKey="Omata S" first="Sadao" last="Omata">Sadao Omata</name><name sortKey="Wen, Yan" sort="Wen, Yan" uniqKey="Wen Y" first="Yan" last="Wen">Yan Wen</name><name sortKey="Yoshinobu, Murayama" sort="Yoshinobu, Murayama" uniqKey="Yoshinobu M" first="Murayama" last="Yoshinobu">Murayama Yoshinobu</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Zhou, Lu" sort="Zhou, Lu" uniqKey="Zhou L" first="Lu" last="Zhou">Lu Zhou</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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