Amplitude and timing of somatosensory cortex activity in Task Specific Focal Hand Dystonia
Identifieur interne : 001685 ( Pmc/Curation ); précédent : 001684; suivant : 001686Amplitude and timing of somatosensory cortex activity in Task Specific Focal Hand Dystonia
Auteurs : Rebecca Dolberg ; Leighton B. N. Hinkley ; Susanne Honma ; Zhao Zhu ; Anne M. Findlay ; Nancy N. Byl ; Srikantan S. NagarjanSource :
- Clinical Neurophysiology [ 1388-2457 ] ; 2011.
Abstract
Task-specific focal hand dystonia (tspFHD) is a movement disorder diagnosed in individuals performing repetitive hand behaviors. The extent to which processing anomalies in primary sensory cortex extend to other regions or across the two hemispheres is presently unclear.
In response to low/high rate and novel tactile stimuli on the affected and unaffected hands, magnetoencephalography (MEG) was used to elaborate activity timing and amplitude in the primary somatosensory (S1) and secondary somatosensory/parietal ventral (S2/PV) cortices. MEG and clinical performance measures were collected from thirteen patients and matched controls.
Compared to controls, subjects with tspFHD had increased response amplitude in S2/PV bilaterally in response to high rate and novel stimuli. Subjects with tspFHD also showed increased response latency (low rate, novel) of the affected digits in contralateral S1. For high rate, subjects with tspFHD showed increased response latency in ipsilateral S1 and S2/PV bilaterally. Activation differences correlated with functional sensory deficits (predicting a latency shift in S1), motor speed and muscle strength.
There are objective differences in the amplitude and timing of activity for both hands across contralateral and ipsilateral somatosensory cortex in patients with tspFHD.
Knowledge of cortical processing abnormalities across S1 and S2/PV in dystonia should be applied towards the development of learning based sensorimotor interventions.
Url:
DOI: 10.1016/j.clinph.2011.05.020
PubMed: 21802357
PubMed Central: 3327722
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Rebecca Dolberg<affiliation><nlm:aff id="A1">Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, School of Medicine</nlm:aff>
<wicri:noCountry code="subfield">School of Medicine</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Radiology, University of California, San Francisco, School of Medicine</nlm:aff>
<wicri:noCountry code="subfield">School of Medicine</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Radiology, University of California, San Francisco, School of Medicine</nlm:aff>
<wicri:noCountry code="subfield">School of Medicine</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Radiology, University of California, San Francisco, School of Medicine</nlm:aff>
<wicri:noCountry code="subfield">School of Medicine</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Radiology, University of California, San Francisco, School of Medicine</nlm:aff>
<wicri:noCountry code="subfield">School of Medicine</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A1">Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, School of Medicine</nlm:aff>
<wicri:noCountry code="subfield">School of Medicine</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Radiology, University of California, San Francisco, School of Medicine</nlm:aff>
<wicri:noCountry code="subfield">School of Medicine</wicri:noCountry>
</affiliation>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">Task-specific focal hand dystonia (tspFHD) is a movement disorder diagnosed in individuals performing repetitive hand behaviors. The extent to which processing anomalies in primary sensory cortex extend to other regions or across the two hemispheres is presently unclear.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">In response to low/high rate and novel tactile stimuli on the affected and unaffected hands, magnetoencephalography (MEG) was used to elaborate activity timing and amplitude in the primary somatosensory (S1) and secondary somatosensory/parietal ventral (S2/PV) cortices. MEG and clinical performance measures were collected from thirteen patients and matched controls.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Compared to controls, subjects with tspFHD had increased response amplitude in S2/PV bilaterally in response to high rate and novel stimuli. Subjects with tspFHD also showed increased response latency (low rate, novel) of the affected digits in contralateral S1. For high rate, subjects with tspFHD showed increased response latency in ipsilateral S1 and S2/PV bilaterally. Activation differences correlated with functional sensory deficits (predicting a latency shift in S1), motor speed and muscle strength.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">There are objective differences in the amplitude and timing of activity for both hands across contralateral and ipsilateral somatosensory cortex in patients with tspFHD.</p>
</sec>
<sec id="S5"><title>Significance</title>
<p id="P5">Knowledge of cortical processing abnormalities across S1 and S2/PV in dystonia should be applied towards the development of learning based sensorimotor interventions.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100883319</journal-id>
<journal-id journal-id-type="pubmed-jr-id">21365</journal-id>
<journal-id journal-id-type="nlm-ta">Clin Neurophysiol</journal-id>
<journal-id journal-id-type="iso-abbrev">Clin Neurophysiol</journal-id>
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<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Amplitude and timing of somatosensory cortex activity in Task Specific Focal Hand Dystonia</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Dolberg</surname>
<given-names>Rebecca</given-names>
</name>
<degrees>MS, DPTSc</degrees>
<xref rid="FN2" ref-type="author-notes">@</xref>
<xref ref-type="aff" rid="A1">1</xref>
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<contrib contrib-type="author"><name><surname>Hinkley</surname>
<given-names>Leighton B. N.</given-names>
</name>
<degrees>PhD</degrees>
<xref rid="FN2" ref-type="author-notes">@</xref>
<xref ref-type="aff" rid="A2">2</xref>
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<contrib contrib-type="author"><name><surname>Honma</surname>
<given-names>Susanne</given-names>
</name>
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</contrib>
<contrib contrib-type="author"><name><surname>Zhu</surname>
<given-names>Zhao</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Findlay</surname>
<given-names>Anne M.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Byl</surname>
<given-names>Nancy N.</given-names>
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<degrees>PT, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
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<contrib contrib-type="author"><name><surname>Nagarjan</surname>
<given-names>Srikantan S.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, School of Medicine</aff>
<aff id="A2"><label>2</label>
Department of Radiology, University of California, San Francisco, School of Medicine</aff>
<author-notes><corresp id="FN1">Corresponding Author: Leighton B. Hinkley, Ph.D., Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94143-0628, <email>leighton.hinkley@radiology.ucsf.edu</email>
, (415) 476-4124</corresp>
<fn id="FN2" fn-type="equal"><label>@</label>
<p>These authors contributed equally to this work.</p>
</fn>
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<pub-date pub-type="nihms-submitted"><day>8</day>
<month>8</month>
<year>2011</year>
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<month>7</month>
<year>2011</year>
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<year>2011</year>
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<pub-date pub-type="pmc-release"><day>01</day>
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<volume>122</volume>
<issue>12</issue>
<fpage>2441</fpage>
<lpage>2451</lpage>
<permissions><copyright-statement>© 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract><sec id="S1"><title>Objective</title>
<p id="P1">Task-specific focal hand dystonia (tspFHD) is a movement disorder diagnosed in individuals performing repetitive hand behaviors. The extent to which processing anomalies in primary sensory cortex extend to other regions or across the two hemispheres is presently unclear.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">In response to low/high rate and novel tactile stimuli on the affected and unaffected hands, magnetoencephalography (MEG) was used to elaborate activity timing and amplitude in the primary somatosensory (S1) and secondary somatosensory/parietal ventral (S2/PV) cortices. MEG and clinical performance measures were collected from thirteen patients and matched controls.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Compared to controls, subjects with tspFHD had increased response amplitude in S2/PV bilaterally in response to high rate and novel stimuli. Subjects with tspFHD also showed increased response latency (low rate, novel) of the affected digits in contralateral S1. For high rate, subjects with tspFHD showed increased response latency in ipsilateral S1 and S2/PV bilaterally. Activation differences correlated with functional sensory deficits (predicting a latency shift in S1), motor speed and muscle strength.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">There are objective differences in the amplitude and timing of activity for both hands across contralateral and ipsilateral somatosensory cortex in patients with tspFHD.</p>
</sec>
<sec id="S5"><title>Significance</title>
<p id="P5">Knowledge of cortical processing abnormalities across S1 and S2/PV in dystonia should be applied towards the development of learning based sensorimotor interventions.</p>
</sec>
</abstract>
<kwd-group><kwd>Focal hand dystonia</kwd>
<kwd>neuroimaging</kwd>
<kwd>magnetoencephalography</kwd>
<kwd>aberrant evoked sensory responses</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source>
<award-id>R21 NS076171-01A1 || NS</award-id>
</award-group>
<award-group><funding-source country="United States">National Institute on Deafness and Other Communication Disorders : NIDCD</funding-source>
<award-id>R01 DC006435-05 || DC</award-id>
</award-group>
<award-group><funding-source country="United States">National Institute on Deafness and Other Communication Disorders : NIDCD</funding-source>
<award-id>R01 DC004855-09 || DC</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
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