Sensory integration across space and in time for decision making in the somatosensory system of rodents
Identifieur interne : 001562 ( Pmc/Curation ); précédent : 001561; suivant : 001563Sensory integration across space and in time for decision making in the somatosensory system of rodents
Auteurs : Tansu Celikel [Allemagne] ; Bert Sakmann [Allemagne]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2007.
Abstract
Environment is represented in the brain by a neural code that is a result of the spatiotemporal pattern of incoming sensory information. Sensory neurons encode inputs across space and in time such that activity of a given cell inhibits the ability of near-simultaneously arriving sensory stimuli to excite the cell. At the behavioral level, consequences of such suppression are unknown. We investigated the contribution of spatially distributed, near-simultaneous sensory inputs to decision making in a whisker-dependent learning task. Mice learned the task with a single whisker or multiple whiskers alike. Both groups of mice had similar learning curves and final success rates. However, multiple-whisker animals had faster response times than single-whisker mice, requiring only about half the time to perform the task successfully. The results show that spatially distributed sensory inputs in a highly redundant sensory environment improve speed but not accuracy of the decisions made during simple sensory detection. Suppression of the near-simultaneous sensory inputs could, therefore, act to reduce the sensory redundancy.
Url:
DOI: 10.1073/pnas.0610267104
PubMed: 17227858
PubMed Central: 1783091
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Proc Natl Acad Sci U S A</journal-id><journal-id journal-id-type="publisher-id">PNAS</journal-id><journal-title>Proceedings of the National Academy of Sciences of the United States of America</journal-title><issn pub-type="ppub">0027-8424</issn><issn pub-type="epub">1091-6490</issn><publisher><publisher-name>National Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17227858</article-id><article-id pub-id-type="pmc">1783091</article-id><article-id pub-id-type="publisher-id">4779</article-id><article-id pub-id-type="doi">10.1073/pnas.0610267104</article-id><article-categories><subj-group subj-group-type="heading"><subject>Biological Sciences</subject><subj-group><subject>Neuroscience</subject></subj-group></subj-group></article-categories><title-group><article-title>Sensory integration across space and in time for decision making in the somatosensory system of rodents</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Celikel</surname><given-names>Tansu</given-names></name><xref rid="aff1" ref-type="aff"></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Sakmann</surname><given-names>Bert</given-names></name><xref rid="aff1" ref-type="aff"></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><aff id="aff1">Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany</aff></contrib-group><author-notes><corresp id="cor1">*To whom correspondence may be addressed. E-mail:
<email>tansu.celikel@mpimf-heidelberg.mpg.de</email> or <email>bert.sakmann@mpimf-heidelberg.mpg.de</email></corresp><fn fn-type="con"><p>Contributed by Bert Sakmann, November 20, 2006</p></fn><fn fn-type="con"><p>Author contributions: T.C. and B.S. designed research; T.C. performed research; T.C. contributed new reagents/analytic tools; and T.C. and B.S. wrote the paper.</p></fn></author-notes><pub-date pub-type="ppub"><day>23</day><month>1</month><year>2007</year></pub-date><pub-date pub-type="epub"><day>16</day><month>1</month><year>2007</year></pub-date><volume>104</volume><issue>4</issue><fpage>1395</fpage><lpage>1400</lpage><history><date date-type="received"><day>13</day><month>9</month><year>2006</year></date></history><copyright-statement>© 2007 by The National Academy of Sciences of the USA</copyright-statement><copyright-year>2007</copyright-year><self-uri xlink:title="pdf" xlink:href="zpq00407001395.pdf"></self-uri><abstract><p>Environment is represented in the brain by a neural code that is a result of the spatiotemporal pattern of incoming sensory information. Sensory neurons encode inputs across space and in time such that activity of a given cell inhibits the ability of near-simultaneously arriving sensory stimuli to excite the cell. At the behavioral level, consequences of such suppression are unknown. We investigated the contribution of spatially distributed, near-simultaneous sensory inputs to decision making in a whisker-dependent learning task. Mice learned the task with a single whisker or multiple whiskers alike. Both groups of mice had similar learning curves and final success rates. However, multiple-whisker animals had faster response times than single-whisker mice, requiring only about half the time to perform the task successfully. The results show that spatially distributed sensory inputs in a highly redundant sensory environment improve speed but not accuracy of the decisions made during simple sensory detection. Suppression of the near-simultaneous sensory inputs could, therefore, act to reduce the sensory redundancy.</p></abstract><kwd-group><kwd>sensory deprivation</kwd><kwd>whiskers</kwd><kwd>tactile learning</kwd><kwd>cortex</kwd></kwd-group><custom-meta-wrap><custom-meta><meta-name>PDF</meta-name><meta-value><uri xlink:type="simple" xlink:href="zpq00407001395.pdf"></uri></meta-value></custom-meta></custom-meta-wrap></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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