Sensory integration across space and in time for decision making in the somatosensory system of rodents
Identifieur interne : 001562 ( Pmc/Curation ); précédent : 001561; suivant : 001563Sensory integration across space and in time for decision making in the somatosensory system of rodents
Auteurs : Tansu Celikel [Allemagne] ; Bert Sakmann [Allemagne]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2007.
Abstract
Environment is represented in the brain by a neural code that is a result of the spatiotemporal pattern of incoming sensory information. Sensory neurons encode inputs across space and in time such that activity of a given cell inhibits the ability of near-simultaneously arriving sensory stimuli to excite the cell. At the behavioral level, consequences of such suppression are unknown. We investigated the contribution of spatially distributed, near-simultaneous sensory inputs to decision making in a whisker-dependent learning task. Mice learned the task with a single whisker or multiple whiskers alike. Both groups of mice had similar learning curves and final success rates. However, multiple-whisker animals had faster response times than single-whisker mice, requiring only about half the time to perform the task successfully. The results show that spatially distributed sensory inputs in a highly redundant sensory environment improve speed but not accuracy of the decisions made during simple sensory detection. Suppression of the near-simultaneous sensory inputs could, therefore, act to reduce the sensory redundancy.
Url:
DOI: 10.1073/pnas.0610267104
PubMed: 17227858
PubMed Central: 1783091
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PMC:1783091Le document en format XML
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<author><name sortKey="Celikel, Tansu" sort="Celikel, Tansu" uniqKey="Celikel T" first="Tansu" last="Celikel">Tansu Celikel</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany</nlm:aff>
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<wicri:regionArea>Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany</nlm:aff>
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<front><div type="abstract" xml:lang="en"><p>Environment is represented in the brain by a neural code that is a result of the spatiotemporal pattern of incoming sensory information. Sensory neurons encode inputs across space and in time such that activity of a given cell inhibits the ability of near-simultaneously arriving sensory stimuli to excite the cell. At the behavioral level, consequences of such suppression are unknown. We investigated the contribution of spatially distributed, near-simultaneous sensory inputs to decision making in a whisker-dependent learning task. Mice learned the task with a single whisker or multiple whiskers alike. Both groups of mice had similar learning curves and final success rates. However, multiple-whisker animals had faster response times than single-whisker mice, requiring only about half the time to perform the task successfully. The results show that spatially distributed sensory inputs in a highly redundant sensory environment improve speed but not accuracy of the decisions made during simple sensory detection. Suppression of the near-simultaneous sensory inputs could, therefore, act to reduce the sensory redundancy.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Proc Natl Acad Sci U S A</journal-id>
<journal-id journal-id-type="publisher-id">PNAS</journal-id>
<journal-title>Proceedings of the National Academy of Sciences of the United States of America</journal-title>
<issn pub-type="ppub">0027-8424</issn>
<issn pub-type="epub">1091-6490</issn>
<publisher><publisher-name>National Academy of Sciences</publisher-name>
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<article-id pub-id-type="doi">10.1073/pnas.0610267104</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Biological Sciences</subject>
<subj-group><subject>Neuroscience</subject>
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<title-group><article-title>Sensory integration across space and in time for decision making in the somatosensory system of rodents</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Celikel</surname>
<given-names>Tansu</given-names>
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<xref rid="aff1" ref-type="aff"></xref>
<xref ref-type="corresp" rid="cor1">*</xref>
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<contrib contrib-type="author"><name><surname>Sakmann</surname>
<given-names>Bert</given-names>
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<xref rid="aff1" ref-type="aff"></xref>
<xref ref-type="corresp" rid="cor1">*</xref>
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<aff id="aff1">Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany</aff>
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<author-notes><corresp id="cor1">*To whom correspondence may be addressed. E-mail:
<email>tansu.celikel@mpimf-heidelberg.mpg.de</email>
or <email>bert.sakmann@mpimf-heidelberg.mpg.de</email>
</corresp>
<fn fn-type="con"><p>Contributed by Bert Sakmann, November 20, 2006</p>
</fn>
<fn fn-type="con"><p>Author contributions: T.C. and B.S. designed research; T.C. performed research; T.C. contributed new reagents/analytic tools; and T.C. and B.S. wrote the paper.</p>
</fn>
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<pub-date pub-type="ppub"><day>23</day>
<month>1</month>
<year>2007</year>
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<pub-date pub-type="epub"><day>16</day>
<month>1</month>
<year>2007</year>
</pub-date>
<volume>104</volume>
<issue>4</issue>
<fpage>1395</fpage>
<lpage>1400</lpage>
<history><date date-type="received"><day>13</day>
<month>9</month>
<year>2006</year>
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<copyright-statement>© 2007 by The National Academy of Sciences of the USA</copyright-statement>
<copyright-year>2007</copyright-year>
<self-uri xlink:title="pdf" xlink:href="zpq00407001395.pdf"></self-uri>
<abstract><p>Environment is represented in the brain by a neural code that is a result of the spatiotemporal pattern of incoming sensory information. Sensory neurons encode inputs across space and in time such that activity of a given cell inhibits the ability of near-simultaneously arriving sensory stimuli to excite the cell. At the behavioral level, consequences of such suppression are unknown. We investigated the contribution of spatially distributed, near-simultaneous sensory inputs to decision making in a whisker-dependent learning task. Mice learned the task with a single whisker or multiple whiskers alike. Both groups of mice had similar learning curves and final success rates. However, multiple-whisker animals had faster response times than single-whisker mice, requiring only about half the time to perform the task successfully. The results show that spatially distributed sensory inputs in a highly redundant sensory environment improve speed but not accuracy of the decisions made during simple sensory detection. Suppression of the near-simultaneous sensory inputs could, therefore, act to reduce the sensory redundancy.</p>
</abstract>
<kwd-group><kwd>sensory deprivation</kwd>
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<kwd>tactile learning</kwd>
<kwd>cortex</kwd>
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