Microsecond-Scale Timing Precision in Rodent Trigeminal Primary Afferents
Identifieur interne : 000050 ( Pmc/Curation ); précédent : 000049; suivant : 000051Microsecond-Scale Timing Precision in Rodent Trigeminal Primary Afferents
Auteurs : Michael R. Bale [Royaume-Uni, Espagne] ; Dario Campagner [Royaume-Uni] ; Andrew Erskine [Royaume-Uni] ; Rasmus S. Petersen [Royaume-Uni]Source :
- The Journal of Neuroscience [ 0270-6474 ] ; 2015.
Abstract
Communication in the nervous system occurs by spikes: the timing precision with which spikes are fired is a fundamental limit on neural information processing. In sensory systems, spike-timing precision is constrained by first-order neurons. We found that spike-timing precision of trigeminal primary afferents in rats and mice is limited both by stimulus speed and by electrophysiological sampling rate. High-speed video of behaving mice revealed whisker velocities of at least 17,000°/s, so we delivered an ultrafast “ping” (>50,000°/s) to single whiskers and sampled primary afferent activity at 500 kHz. Median spike jitter was 17.4 μs; 29% of neurons had spike jitter < 10 μs. These results indicate that the input stage of the trigeminal pathway has extraordinary spike-timing precision and very high potential information capacity. This timing precision ranks among the highest in biology.
Url:
DOI: 10.1523/JNEUROSCI.3876-14.2015
PubMed: 25878266
PubMed Central: 4397594
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000050
Links to Exploration step
PMC:4397594Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Microsecond-Scale Timing Precision in Rodent Trigeminal Primary Afferents</title><author><name sortKey="Bale, Michael R" sort="Bale, Michael R" uniqKey="Bale M" first="Michael R." last="Bale">Michael R. Bale</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="aff1">Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Life Sciences, University of Manchester, Manchester M13 9PT</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Instituto de Neurociencias de Alicante UMH-CSIC, Sant Joan d'Alacant, 03550 Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Neurociencias de Alicante UMH-CSIC, Sant Joan d'Alacant</wicri:regionArea></affiliation></author><author><name sortKey="Campagner, Dario" sort="Campagner, Dario" uniqKey="Campagner D" first="Dario" last="Campagner">Dario Campagner</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="aff1">Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Life Sciences, University of Manchester, Manchester M13 9PT</wicri:regionArea></affiliation></author><author><name sortKey="Erskine, Andrew" sort="Erskine, Andrew" uniqKey="Erskine A" first="Andrew" last="Erskine">Andrew Erskine</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="aff1">Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Life Sciences, University of Manchester, Manchester M13 9PT</wicri:regionArea></affiliation></author><author><name sortKey="Petersen, Rasmus S" sort="Petersen, Rasmus S" uniqKey="Petersen R" first="Rasmus S." last="Petersen">Rasmus S. Petersen</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="aff1">Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Life Sciences, University of Manchester, Manchester M13 9PT</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25878266</idno><idno type="pmc">4397594</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397594</idno><idno type="RBID">PMC:4397594</idno><idno type="doi">10.1523/JNEUROSCI.3876-14.2015</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000050</idno><idno type="wicri:Area/Pmc/Curation">000050</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Microsecond-Scale Timing Precision in Rodent Trigeminal Primary Afferents</title><author><name sortKey="Bale, Michael R" sort="Bale, Michael R" uniqKey="Bale M" first="Michael R." last="Bale">Michael R. Bale</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="aff1">Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Life Sciences, University of Manchester, Manchester M13 9PT</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Instituto de Neurociencias de Alicante UMH-CSIC, Sant Joan d'Alacant, 03550 Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Neurociencias de Alicante UMH-CSIC, Sant Joan d'Alacant</wicri:regionArea></affiliation></author><author><name sortKey="Campagner, Dario" sort="Campagner, Dario" uniqKey="Campagner D" first="Dario" last="Campagner">Dario Campagner</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="aff1">Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Life Sciences, University of Manchester, Manchester M13 9PT</wicri:regionArea></affiliation></author><author><name sortKey="Erskine, Andrew" sort="Erskine, Andrew" uniqKey="Erskine A" first="Andrew" last="Erskine">Andrew Erskine</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="aff1">Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Life Sciences, University of Manchester, Manchester M13 9PT</wicri:regionArea></affiliation></author><author><name sortKey="Petersen, Rasmus S" sort="Petersen, Rasmus S" uniqKey="Petersen R" first="Rasmus S." last="Petersen">Rasmus S. Petersen</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="aff1">Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Life Sciences, University of Manchester, Manchester M13 9PT</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of Neuroscience</title><idno type="ISSN">0270-6474</idno><idno type="eISSN">1529-2401</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Communication in the nervous system occurs by spikes: the timing precision with which spikes are fired is a fundamental limit on neural information processing. In sensory systems, spike-timing precision is constrained by first-order neurons. We found that spike-timing precision of trigeminal primary afferents in rats and mice is limited both by stimulus speed and by electrophysiological sampling rate. High-speed video of behaving mice revealed whisker velocities of at least 17,000°/s, so we delivered an ultrafast “ping” (>50,000°/s) to single whiskers and sampled primary afferent activity at 500 kHz. Median spike jitter was 17.4 μs; 29% of neurons had spike jitter < 10 μs. These results indicate that the input stage of the trigeminal pathway has extraordinary spike-timing precision and very high potential information capacity. This timing precision ranks among the highest in biology.</p></div></front></TEI><pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurosci</journal-id><journal-id journal-id-type="iso-abbrev">J. Neurosci</journal-id><journal-id journal-id-type="hwp">jneuro</journal-id><journal-id journal-id-type="pmc">jneurosci</journal-id><journal-id journal-id-type="publisher-id">J. Neurosci</journal-id><journal-title-group><journal-title>The Journal of Neuroscience</journal-title></journal-title-group><issn pub-type="ppub">0270-6474</issn><issn pub-type="epub">1529-2401</issn><publisher><publisher-name>Society for Neuroscience</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25878266</article-id><article-id pub-id-type="pmc">4397594</article-id><article-id pub-id-type="publisher-id">3876-14</article-id><article-id pub-id-type="doi">10.1523/JNEUROSCI.3876-14.2015</article-id><article-categories><subj-group subj-group-type="heading"><subject>Brief Communications</subject></subj-group></article-categories><title-group><article-title>Microsecond-Scale Timing Precision in Rodent Trigeminal Primary Afferents</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bale</surname><given-names>Michael R.</given-names></name><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-8562-962X</contrib-id><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Campagner</surname><given-names>Dario</given-names></name><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-9016-4575</contrib-id><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Erskine</surname><given-names>Andrew</given-names></name><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0003-4392-1873</contrib-id><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Petersen</surname><given-names>Rasmus S.</given-names></name><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-5607-977X</contrib-id><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><aff id="aff1"><sup>1</sup>Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom and</aff><aff id="aff2"><sup>2</sup>Instituto de Neurociencias de Alicante UMH-CSIC, Sant Joan d'Alacant, 03550 Spain</aff></contrib-group><author-notes><corresp>Correspondence should be addressed to Rasmus S. Petersen,
<addr-line>Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.</addr-line><email>r.petersen@manchester.ac.uk</email></corresp><fn fn-type="con"><p>Author contributions: M.R.B. and R.S.P. designed research; M.R.B., D.C., and A.E. performed research; M.R.B. and D.C. analyzed data; M.R.B. and R.S.P. wrote the paper.</p></fn><fn fn-type="present-address"><p>A. Erskine's present address: National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK.</p></fn></author-notes><pub-date pub-type="ppub"><day>15</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>4</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>35</volume><issue>15</issue><fpage>5935</fpage><lpage>5940</lpage><history><date date-type="received"><day>17</day><month>9</month><year>2014</year></date><date date-type="rev-recd"><day>6</day><month>2</month><year>2015</year></date><date date-type="accepted"><day>15</day><month>2</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015 the authors 0270-6474/15/355935-06$15.00/0</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access"><license-p>This article is freely available online through the <ext-link ext-link-type="uri" xlink:href="http://www.jneurosci.org/cgi/content/full/35/15/5935"><italic>J Neurosci</italic></ext-link> Author Open Choice option.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zns01515005935.pdf"></self-uri><abstract><p>Communication in the nervous system occurs by spikes: the timing precision with which spikes are fired is a fundamental limit on neural information processing. In sensory systems, spike-timing precision is constrained by first-order neurons. We found that spike-timing precision of trigeminal primary afferents in rats and mice is limited both by stimulus speed and by electrophysiological sampling rate. High-speed video of behaving mice revealed whisker velocities of at least 17,000°/s, so we delivered an ultrafast “ping” (>50,000°/s) to single whiskers and sampled primary afferent activity at 500 kHz. Median spike jitter was 17.4 μs; 29% of neurons had spike jitter < 10 μs. These results indicate that the input stage of the trigeminal pathway has extraordinary spike-timing precision and very high potential information capacity. This timing precision ranks among the highest in biology.</p></abstract><kwd-group><kwd>neural coding</kwd><kwd>trigeminal ganglion</kwd><kwd>vibrissa</kwd><kwd>whisker</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000050 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000050 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Ticri/CIDE
|area= HapticV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:4397594
|texte= Microsecond-Scale Timing Precision in Rodent Trigeminal Primary Afferents
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:25878266" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a HapticV1
| This area was generated with Dilib version V0.6.23. |  |