THz and mm-Wave Sensing of Corneal Tissue Water Content: Electromagnetic Modeling and Analysis
Identifieur interne : 001872 ( Pmc/Corpus ); précédent : 001871; suivant : 001873THz and mm-Wave Sensing of Corneal Tissue Water Content: Electromagnetic Modeling and Analysis
Auteurs : Zachary D. Taylor ; James Garritano ; Shijun Sung ; Neha Bajwa ; David B. Bennett ; Bryan Nowroozi ; Priyamvada Tewari ; James Sayre ; Jean-Pierre Hubschman ; Sophie Deng ; Elliott R. Brown ; Warren S. GrundfestSource :
- IEEE transactions on terahertz science and technology [ 2156-342X ] ; 2015.
Abstract
Terahertz (THz) spectral properties of human cornea are explored as a function of central corneal thickness (CCT) and corneal water content, and the clinical utility of THz-based corneal water content sensing is discussed. Three candidate corneal tissue water content (CTWC) perturbations, based on corneal physiology, are investigated that affect the axial water distribution and total thickness. The THz frequency reflectivity properties of the three CTWC perturbations were simulated and explored with varying system center frequency and bandwidths (Q-factors). The modeling showed that at effective optical path lengths on the order of a wavelength the cornea presents a lossy etalon bordered by air at the anterior and the aqueous humor at the posterior. The simulated standing wave peak-to-valley ratio is pronounced at lower frequencies and its effect on acquired data can be modulated by adjusting the bandwidth of the sensing system. These observations are supported with experimental spectroscopic data. The results suggest that
Url:
DOI: 10.1109/TTHZ.2015.2392619
PubMed: 26322247
PubMed Central: 4551413
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