High-Resolution Mechanical Imaging of Glioblastoma by Multifrequency Magnetic Resonance Elastography
Identifieur interne : 000352 ( Pmc/Corpus ); précédent : 000351; suivant : 000353High-Resolution Mechanical Imaging of Glioblastoma by Multifrequency Magnetic Resonance Elastography
Auteurs : Kaspar-Josche Streitberger ; Martin Reiss-Zimmermann ; Florian Baptist Freimann ; Simon Bayerl ; Jing Guo ; Felix Arlt ; Jens Wuerfel ; Jürgen Braun ; Karl-Titus Hoffmann ; Ingolf SackSource :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
To generate high-resolution maps of the viscoelastic properties of human brain parenchyma for presurgical quantitative assessment in glioblastoma (GB).
Twenty-two GB patients underwent routine presurgical work-up supplemented by additional multifrequency magnetic resonance elastography. Two three-dimensional viscoelastic parameter maps, magnitude
Mechanical brain maps confirmed that GB are composed of stiff and soft compartments, resulting in high intratumor heterogeneity. GB could be easily differentiated from healthy reference tissue by their reduced viscous behavior quantified by φ (0.37±0.08 vs. 0.58±0.07).
GB are generally less viscous and softer than healthy brain parenchyma. Unrelated to the morphology-based contrast of standard magnetic resonance imaging, elastography provides an entirely new neuroradiological marker and contrast related to the biomechanical properties of tumors.
Url:
DOI: 10.1371/journal.pone.0110588
PubMed: 25338072
PubMed Central: 4206430
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