Visuomotor discordance during visually-guided hand movement in Virtual Reality modulates sensorimotor cortical activity in healthy and hemiparetic subjects
Identifieur interne : 000E94 ( Pmc/Checkpoint ); précédent : 000E93; suivant : 000E95Visuomotor discordance during visually-guided hand movement in Virtual Reality modulates sensorimotor cortical activity in healthy and hemiparetic subjects
Auteurs : Eugene Tunik ; Soha Saleh ; Sergei V. AdamovichSource :
- IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society [ 1534-4320 ] ; 2013.
Abstract
We investigated neural effects of visuo-motor discordances during visually-guided finger movements. An fMRI-compatible data glove was used to actuate (in real-time) virtual hand models shown on a display in 1st person perspective. In experiment 1, we manipulated virtual hand motion to simulate either hypometric or unintentional (actuation of a mismatched finger) feedback of sequential finger flexion in healthy subjects. Analysis of finger motion revealed no significant differences in movement behavior across conditions, suggesting that between-condition differences in brain activity could only be attributed to varying modes of visual feedback rather than motor output. Activation in the veridical relative to either altered feedback conditions was localized to the ipsilateral motor cortex. Hypometric feedback and mismatched finger feedback (relative to veridical) were associated with distinct activation. Hypometric feedback was associated with activation in the contralateral motor cortex. Mismatched feedback was associated with activation in bilateral ventral premotor, left dorsal premotor and left occipitotemporal cortex. The time it took the subject to evaluate visuomotor discordance was positively correlated with activation in bilateral supplementary motor area, bilateral insula, right postcentral gyrus, bilateral dorsal premotor areas and bilateral posterior parietal lobe. In Experiment 2, we investigated the effects of hypo- and hypermetric visual feedback in three stroke subjects. We observed increased activation of ipsilesional motor cortex in both hypometric and hypermetric feedback conditions. Our data suggest that manipulation of visual feedback of one’s own hand movement may be used to facilitate activity in select brain networks. We suggest that these effects can be exploited in neurorehabilition to enhance the processes of brain reorganization after injury and, specifically, might be useful in aiding recovery of hand function in patients during virtual reality-based training.
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DOI: 10.1109/TNSRE.2013.2238250
PubMed: 23314780
PubMed Central: 3762883
Affiliations:
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<front><div type="abstract" xml:lang="en"><p id="P1">We investigated neural effects of visuo-motor discordances during visually-guided finger movements. An fMRI-compatible data glove was used to actuate (in real-time) virtual hand models shown on a display in 1<sup>st</sup>
person perspective. In experiment 1, we manipulated virtual hand motion to simulate either hypometric or unintentional (actuation of a mismatched finger) feedback of sequential finger flexion in healthy subjects. Analysis of finger motion revealed no significant differences in movement behavior across conditions, suggesting that between-condition differences in brain activity could only be attributed to varying modes of visual feedback rather than motor output. Activation in the veridical relative to either altered feedback conditions was localized to the ipsilateral motor cortex. Hypometric feedback and mismatched finger feedback (relative to veridical) were associated with distinct activation. Hypometric feedback was associated with activation in the contralateral motor cortex. Mismatched feedback was associated with activation in bilateral ventral premotor, left dorsal premotor and left occipitotemporal cortex. The time it took the subject to evaluate visuomotor discordance was positively correlated with activation in bilateral supplementary motor area, bilateral insula, right postcentral gyrus, bilateral dorsal premotor areas and bilateral posterior parietal lobe. In Experiment 2, we investigated the effects of hypo- and hypermetric visual feedback in three stroke subjects. We observed increased activation of ipsilesional motor cortex in both hypometric and hypermetric feedback conditions. Our data suggest that manipulation of visual feedback of one’s own hand movement may be used to facilitate activity in select brain networks. We suggest that these effects can be exploited in neurorehabilition to enhance the processes of brain reorganization after injury and, specifically, might be useful in aiding recovery of hand function in patients during virtual reality-based training.</p>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101097023</journal-id>
<journal-id journal-id-type="pubmed-jr-id">22433</journal-id>
<journal-id journal-id-type="nlm-ta">IEEE Trans Neural Syst Rehabil Eng</journal-id>
<journal-id journal-id-type="iso-abbrev">IEEE Trans Neural Syst Rehabil Eng</journal-id>
<journal-title-group><journal-title>IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society</journal-title>
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<issn pub-type="ppub">1534-4320</issn>
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<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Visuomotor discordance during visually-guided hand movement in Virtual Reality modulates sensorimotor cortical activity in healthy and hemiparetic subjects</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Tunik</surname>
<given-names>Eugene</given-names>
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<aff id="A1">University of Medicine and Dentistry of New Jersey, Newark, NJ 07107 USA</aff>
<email>tunikeu@umdnj.edu</email>
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<contrib contrib-type="author"><name><surname>Saleh</surname>
<given-names>Soha</given-names>
</name>
<aff id="A2">University of Medicine and Dentistry of New Jersey, Newark, NJ 07107 USA</aff>
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<contrib contrib-type="author"><name><surname>Adamovich</surname>
<given-names>Sergei V.</given-names>
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<aff id="A3">New Jersey Institute of Technology and the University of Medicine and Dentistry of New Jersey, Newark, NJ 07102 USA</aff>
<email>sergei.adamovich@njit.edu</email>
</contrib>
</contrib-group>
<author-notes><corresp id="FN1">corresponding author: <email>salehsh@umdnj.edu</email>
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<pub-date pub-type="nihms-submitted"><day>16</day>
<month>8</month>
<year>2013</year>
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<pub-date pub-type="epub"><day>09</day>
<month>1</month>
<year>2013</year>
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<pub-date pub-type="ppub"><month>3</month>
<year>2013</year>
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<pub-date pub-type="pmc-release"><day>04</day>
<month>9</month>
<year>2013</year>
</pub-date>
<volume>21</volume>
<issue>2</issue>
<fpage>198</fpage>
<lpage>207</lpage>
<abstract><p id="P1">We investigated neural effects of visuo-motor discordances during visually-guided finger movements. An fMRI-compatible data glove was used to actuate (in real-time) virtual hand models shown on a display in 1<sup>st</sup>
person perspective. In experiment 1, we manipulated virtual hand motion to simulate either hypometric or unintentional (actuation of a mismatched finger) feedback of sequential finger flexion in healthy subjects. Analysis of finger motion revealed no significant differences in movement behavior across conditions, suggesting that between-condition differences in brain activity could only be attributed to varying modes of visual feedback rather than motor output. Activation in the veridical relative to either altered feedback conditions was localized to the ipsilateral motor cortex. Hypometric feedback and mismatched finger feedback (relative to veridical) were associated with distinct activation. Hypometric feedback was associated with activation in the contralateral motor cortex. Mismatched feedback was associated with activation in bilateral ventral premotor, left dorsal premotor and left occipitotemporal cortex. The time it took the subject to evaluate visuomotor discordance was positively correlated with activation in bilateral supplementary motor area, bilateral insula, right postcentral gyrus, bilateral dorsal premotor areas and bilateral posterior parietal lobe. In Experiment 2, we investigated the effects of hypo- and hypermetric visual feedback in three stroke subjects. We observed increased activation of ipsilesional motor cortex in both hypometric and hypermetric feedback conditions. Our data suggest that manipulation of visual feedback of one’s own hand movement may be used to facilitate activity in select brain networks. We suggest that these effects can be exploited in neurorehabilition to enhance the processes of brain reorganization after injury and, specifically, might be useful in aiding recovery of hand function in patients during virtual reality-based training.</p>
</abstract>
<kwd-group><title>Index Terms</title>
<kwd>motor control</kwd>
<kwd>fMRI</kwd>
<kwd>virtual reality</kwd>
<kwd>action observation</kwd>
<kwd>visuomotor</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute of Child Health & Human Development : NICHD</funding-source>
<award-id>K01 HD059983 || HD</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
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<tree><noCountry><name sortKey="Adamovich, Sergei V" sort="Adamovich, Sergei V" uniqKey="Adamovich S" first="Sergei V." last="Adamovich">Sergei V. Adamovich</name>
<name sortKey="Saleh, Soha" sort="Saleh, Soha" uniqKey="Saleh S" first="Soha" last="Saleh">Soha Saleh</name>
<name sortKey="Tunik, Eugene" sort="Tunik, Eugene" uniqKey="Tunik E" first="Eugene" last="Tunik">Eugene Tunik</name>
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