HapticV1, PascalFrancis, Curation, bibRecord, 000586

Posterior capsule opacification in rabbit eyes implanted with hydrophilic acrylic intraocular lenses with enhanced square edge

Identifieur interne : 000586 ( PascalFrancis/Curation ); précédent : 000585; suivant : 000587

Posterior capsule opacification in rabbit eyes implanted with hydrophilic acrylic intraocular lenses with enhanced square edge

Auteurs : Liliana Werner [États-Unis] ; Nick Mamalis [États-Unis] ; Suresh K. Pandey [États-Unis] ; Andrea M. Izak [États-Unis] ; Christian D. Nilson [États-Unis] ; Brandon L. Davis [États-Unis] ; Christopher Weight [États-Unis] ; David J. Apple [États-Unis]

Source :

Journal of cataract and refractive surgery [ 0886-3350 ] ; 2004.

RBID : Pascal:05-0001728

Descripteurs français

Pascal (Inist)
- Postérieur, Capsule, Gélule, Opacification, Animal, Lapin, Oeil, Ophtalmologie, Implant, Hydrophilie, Lentille intraoculaire, Bord, Chirurgie, Traitement.
Wicri :
- topic : Lapin, Chirurgie.

English descriptors

KwdEn :
- Animal, Capsule, Edge, Eye, Hard capsule, Hydrophily, Implant, Intraocular lens, Opacification, Ophthalmology, Posterior, Rabbit, Surgery, Treatment.

Abstract

Purpose: To evaluate the development of posterior capsule opacification (PCO) after implantation of single-piece hydrophilic acrylic intraocular lenses (lOLs) with an enhanced square edge. Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Methods: The standard 570H Centerflex (Rayner Ltd.) design was compared to 2 new designs with enhanced square edges: the 570E and the 570C. Ten lOLs of each type were implanted in a randomized manner by the same surgeon in 15 pigmented rabbits. After a follow-up of 3 weeks, the rabbits were killed and the eyes were analyzed from the posterior view. The intensity of central PCO, peripheral PCO, and Soemmering's ring formation was graded from 0 to 4. The area of Soemmering's ring was graded from 0 to 4 based on the number of quadrants involved. Other parameters analyzed were capsulorhexis coverage of the IOL edge and IOL centration and fixation. Results from the posterior view were complemented by histopathological evaluation. Results: Posterior capsule opacification was lowest in the 570C group, highest in the 570H group, and intermediate in the 570E group. There was a statistically significant difference between the 3 groups in peripheral PCO (P = .039). No significant difference was found between the groups in the other parameters analyzed. When cell ingrowth occurred with the 570H, it started at the optic-haptic junctions, as observed during the clinical follow-up and confirmed by gross and histopathological analyses. Conclusions: The square optic edge is the most important IOL design feature for PCO prevention. However, it should be present for 360 degrees around the IOL optic to provide an effective barrier effect.

A01	`01`	`1`		`@0 0886-3350`
A02	`01`			`@0 JCSUEV`
A03		`1`		`@0 J. cataract refractive surg.`
A05				`@2 30`
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A08	`01`	`1`	`ENG`	`@1 Posterior capsule opacification in rabbit eyes implanted with hydrophilic acrylic intraocular lenses with enhanced square edge`
A11	`01`	`1`		`@1 WERNER (Liliana)`
A11	`02`	`1`		`@1 MAMALIS (Nick)`
A11	`03`	`1`		`@1 PANDEY (Suresh K.)`
A11	`04`	`1`		`@1 IZAK (Andrea M.)`
A11	`05`	`1`		`@1 NILSON (Christian D.)`
A11	`06`	`1`		`@1 DAVIS (Brandon L.)`
A11	`07`	`1`		`@1 WEIGHT (Christopher)`
A11	`08`	`1`		`@1 APPLE (David J.)`
A14	`01`			`@1 David J. Apple, MD Laboratories for Ophthalmic Devices Research, John A. Moran Eye Center, University of Utah @2 Salt Lake City, Utah @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 8 aut.`
A20				`@1 2403-2409`
A21				`@1 2004`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20937 @5 354000122632170250`
A44				`@0 0000 @1 © 2005 INIST-CNRS. All rights reserved.`
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A64	`01`	`1`		`@0 Journal of cataract and refractive surgery`
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C01	`01`		`ENG`	@0 Purpose: To evaluate the development of posterior capsule opacification (PCO) after implantation of single-piece hydrophilic acrylic intraocular lenses (lOLs) with an enhanced square edge. Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Methods: The standard 570H Centerflex (Rayner Ltd.) design was compared to 2 new designs with enhanced square edges: the 570E and the 570C. Ten lOLs of each type were implanted in a randomized manner by the same surgeon in 15 pigmented rabbits. After a follow-up of 3 weeks, the rabbits were killed and the eyes were analyzed from the posterior view. The intensity of central PCO, peripheral PCO, and Soemmering's ring formation was graded from 0 to 4. The area of Soemmering's ring was graded from 0 to 4 based on the number of quadrants involved. Other parameters analyzed were capsulorhexis coverage of the IOL edge and IOL centration and fixation. Results from the posterior view were complemented by histopathological evaluation. Results: Posterior capsule opacification was lowest in the 570C group, highest in the 570H group, and intermediate in the 570E group. There was a statistically significant difference between the 3 groups in peripheral PCO (P = .039). No significant difference was found between the groups in the other parameters analyzed. When cell ingrowth occurred with the 570H, it started at the optic-haptic junctions, as observed during the clinical follow-up and confirmed by gross and histopathological analyses. Conclusions: The square optic edge is the most important IOL design feature for PCO prevention. However, it should be present for 360 degrees around the IOL optic to provide an effective barrier effect.
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C03	`01`	`X`	`SPA`	`@0 Posterior @5 02`
C03	`02`	`X`	`FRE`	`@0 Capsule @5 03`
C03	`02`	`X`	`ENG`	`@0 Capsule @5 03`
C03	`02`	`X`	`SPA`	`@0 Cápsula @5 03`
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C03	`03`	`X`	`SPA`	`@0 Cápsula dura @5 05`
C03	`04`	`X`	`FRE`	`@0 Opacification @5 06`
C03	`04`	`X`	`ENG`	`@0 Opacification @5 06`
C03	`04`	`X`	`SPA`	`@0 Opacificación @5 06`
C03	`05`	`X`	`FRE`	`@0 Animal @5 08`
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C03	`06`	`X`	`FRE`	`@0 Lapin @5 09`
C03	`06`	`X`	`ENG`	`@0 Rabbit @5 09`
C03	`06`	`X`	`SPA`	`@0 Conejo @5 09`
C03	`07`	`X`	`FRE`	`@0 Oeil @5 11`
C03	`07`	`X`	`ENG`	`@0 Eye @5 11`
C03	`07`	`X`	`SPA`	`@0 Ojo @5 11`
C03	`08`	`X`	`FRE`	`@0 Ophtalmologie @5 12`
C03	`08`	`X`	`ENG`	`@0 Ophthalmology @5 12`
C03	`08`	`X`	`SPA`	`@0 Oftalmología @5 12`
C03	`09`	`X`	`FRE`	`@0 Implant @5 14`
C03	`09`	`X`	`ENG`	`@0 Implant @5 14`
C03	`09`	`X`	`SPA`	`@0 Implante @5 14`
C03	`10`	`X`	`FRE`	`@0 Hydrophilie @5 15`
C03	`10`	`X`	`ENG`	`@0 Hydrophily @5 15`
C03	`10`	`X`	`SPA`	`@0 Hidrofilia @5 15`
C03	`11`	`X`	`FRE`	`@0 Lentille intraoculaire @5 17`
C03	`11`	`X`	`ENG`	`@0 Intraocular lens @5 17`
C03	`11`	`X`	`SPA`	`@0 Lente intraocular @5 17`
C03	`12`	`X`	`FRE`	`@0 Bord @5 18`
C03	`12`	`X`	`ENG`	`@0 Edge @5 18`
C03	`12`	`X`	`SPA`	`@0 Borde @5 18`
C03	`13`	`X`	`FRE`	`@0 Chirurgie @5 19`
C03	`13`	`X`	`ENG`	`@0 Surgery @5 19`
C03	`13`	`X`	`SPA`	`@0 Cirugía @5 19`
C03	`14`	`X`	`FRE`	`@0 Traitement @5 25`
C03	`14`	`X`	`ENG`	`@0 Treatment @5 25`
C03	`14`	`X`	`SPA`	`@0 Tratamiento @5 25`
C07	`01`	`X`	`FRE`	`@0 Lagomorpha @2 NS`
C07	`01`	`X`	`ENG`	`@0 Lagomorpha @2 NS`
C07	`01`	`X`	`SPA`	`@0 Lagomorpha @2 NS`
C07	`02`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`SPA`	`@0 Vertebrata @2 NS`
N21				`@1 004`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Pascal:05-0001728

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Capsule</term>
<term>Edge</term>
<term>Eye</term>
<term>Hard capsule</term>
<term>Hydrophily</term>
<term>Implant</term>
<term>Intraocular lens</term>
<term>Opacification</term>
<term>Ophthalmology</term>
<term>Posterior</term>
<term>Rabbit</term>
<term>Surgery</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Postérieur</term>
<term>Capsule</term>
<term>Gélule</term>
<term>Opacification</term>
<term>Animal</term>
<term>Lapin</term>
<term>Oeil</term>
<term>Ophtalmologie</term>
<term>Implant</term>
<term>Hydrophilie</term>
<term>Lentille intraoculaire</term>
<term>Bord</term>
<term>Chirurgie</term>
<term>Traitement</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Lapin</term>
<term>Chirurgie</term>
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<front><div type="abstract" xml:lang="en">Purpose: To evaluate the development of posterior capsule opacification (PCO) after implantation of single-piece hydrophilic acrylic intraocular lenses (lOLs) with an enhanced square edge. Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Methods: The standard 570H Centerflex (Rayner Ltd.) design was compared to 2 new designs with enhanced square edges: the 570E and the 570C. Ten lOLs of each type were implanted in a randomized manner by the same surgeon in 15 pigmented rabbits. After a follow-up of 3 weeks, the rabbits were killed and the eyes were analyzed from the posterior view. The intensity of central PCO, peripheral PCO, and Soemmering's ring formation was graded from 0 to 4. The area of Soemmering's ring was graded from 0 to 4 based on the number of quadrants involved. Other parameters analyzed were capsulorhexis coverage of the IOL edge and IOL centration and fixation. Results from the posterior view were complemented by histopathological evaluation. Results: Posterior capsule opacification was lowest in the 570C group, highest in the 570H group, and intermediate in the 570E group. There was a statistically significant difference between the 3 groups in peripheral PCO (P = .039). No significant difference was found between the groups in the other parameters analyzed. When cell ingrowth occurred with the 570H, it started at the optic-haptic junctions, as observed during the clinical follow-up and confirmed by gross and histopathological analyses. Conclusions: The square optic edge is the most important IOL design feature for PCO prevention. However, it should be present for 360 degrees around the IOL optic to provide an effective barrier effect.</div>
</front>
</TEI>
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<fA02 i1="01"><s0>JCSUEV</s0>
</fA02>
<fA03 i2="1"><s0>J. cataract refractive surg.</s0>
</fA03>
<fA05><s2>30</s2>
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<fA06><s2>11</s2>
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<fA08 i1="01" i2="1" l="ENG"><s1>Posterior capsule opacification in rabbit eyes implanted with hydrophilic acrylic intraocular lenses with enhanced square edge</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>WERNER (Liliana)</s1>
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<fA11 i1="02" i2="1"><s1>MAMALIS (Nick)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>PANDEY (Suresh K.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>IZAK (Andrea M.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>NILSON (Christian D.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>DAVIS (Brandon L.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>WEIGHT (Christopher)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>APPLE (David J.)</s1>
</fA11>
<fA14 i1="01"><s1>David J. Apple, MD Laboratories for Ophthalmic Devices Research, John A. Moran Eye Center, University of Utah</s1>
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<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
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<fA20><s1>2403-2409</s1>
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<fA61><s0>A</s0>
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<fA64 i1="01" i2="1"><s0>Journal of cataract and refractive surgery</s0>
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<fC01 i1="01" l="ENG"><s0>Purpose: To evaluate the development of posterior capsule opacification (PCO) after implantation of single-piece hydrophilic acrylic intraocular lenses (lOLs) with an enhanced square edge. Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Methods: The standard 570H Centerflex (Rayner Ltd.) design was compared to 2 new designs with enhanced square edges: the 570E and the 570C. Ten lOLs of each type were implanted in a randomized manner by the same surgeon in 15 pigmented rabbits. After a follow-up of 3 weeks, the rabbits were killed and the eyes were analyzed from the posterior view. The intensity of central PCO, peripheral PCO, and Soemmering's ring formation was graded from 0 to 4. The area of Soemmering's ring was graded from 0 to 4 based on the number of quadrants involved. Other parameters analyzed were capsulorhexis coverage of the IOL edge and IOL centration and fixation. Results from the posterior view were complemented by histopathological evaluation. Results: Posterior capsule opacification was lowest in the 570C group, highest in the 570H group, and intermediate in the 570E group. There was a statistically significant difference between the 3 groups in peripheral PCO (P = .039). No significant difference was found between the groups in the other parameters analyzed. When cell ingrowth occurred with the 570H, it started at the optic-haptic junctions, as observed during the clinical follow-up and confirmed by gross and histopathological analyses. Conclusions: The square optic edge is the most important IOL design feature for PCO prevention. However, it should be present for 360 degrees around the IOL optic to provide an effective barrier effect.</s0>
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<fC02 i1="02" i2="X"><s0>002B26B</s0>
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<s5>05</s5>
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<s5>15</s5>
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<s5>17</s5>
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<s5>17</s5>
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<s5>17</s5>
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Posterior capsule opacification in rabbit eyes implanted with hydrophilic acrylic intraocular lenses with enhanced square edge

Posterior capsule opacification in rabbit eyes implanted with hydrophilic acrylic intraocular lenses with enhanced square edge

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