HapticV1, PascalFrancis, Corpus, bibRecord, 000006

Strain differences of the effect of enucleation and anophthalmia on the size and growth of sensory cortices in mice

Identifieur interne : 000006 ( PascalFrancis/Corpus ); précédent : 000005; suivant : 000007

Strain differences of the effect of enucleation and anophthalmia on the size and growth of sensory cortices in mice

Auteurs : Ian O. Masse ; Sonia Guillemette ; Marie-Eve Laramie ; Gilles Bronchti ; Denis Boire

Source :

Brain research [ 0006-8993 ] ; 2014.

RBID : Pascal:15-0019049

Descripteurs français

Pascal (Inist)
- Enucléation, Croissance, Vision, Perception intermodale, Audition, Plasticité, Thalamus, Cécité, Souris, Animal.

English descriptors

KwdEn :
- Animal, Blindness, Enucleation, Growth, Hearing, Intermodal perception, Mouse, Plasticity, Thalamus, Vision.

Abstract

Anophthalmia is a condition in which the eye does not develop from the early embryonic period. Early blindness induces cross-modal plastic modifications in the brain such as auditory and haptic activations of the visual cortex and also leads to a greater solicitation of the somatosensory and auditory cortices. The visual cortex is activated by auditory stimuli in anophthalmic mice and activity is known to alter the growth pattern of the cerebral cortex. The size of the primary visual, auditory and somatosensory cortices and of the corresponding specific sensory thalamic nuclei were measured in intact and enucleated C57Bl/6J mice and in ZRDCT anophthalmic mice (ZRDCT/An) to evaluate the contribution of cross-modal activity on the growth of the cerebral cortex. In addition, the size of these structures were compared in intact, enucleated and anophthalmic fourth generation backcrossed hybrid C57Bl/6J × ZRDCT/An mice to parse out the effects of mouse strains and of the different visual deprivations. The visual cortex was smaller in the anophthalmic ZRDCT/An than in the intact and enucleated C57Bl/6J mice. Also the auditory cortex was larger and the somatosensory cortex smaller in the ZRDCT/An than in the intact and enucleated C57Bl/6J mice. The size differences of sensory cortices between the enucleated and anophthalmic mice were no longer present in the hybrid mice, showing specific genetic differences between C57Bl/6J and ZRDCT mice. The post natal size increase of the visual cortex was less in the enucleated than in the anophthalmic and intact hybrid mice. This suggests differences in the activity of the visual cortex between enucleated and anophthalmic mice and that early in-utero spontaneous neural activity in the visual system contributes to the shaping of functional properties of cortical networks.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C01	`01`		`ENG`	@0 Anophthalmia is a condition in which the eye does not develop from the early embryonic period. Early blindness induces cross-modal plastic modifications in the brain such as auditory and haptic activations of the visual cortex and also leads to a greater solicitation of the somatosensory and auditory cortices. The visual cortex is activated by auditory stimuli in anophthalmic mice and activity is known to alter the growth pattern of the cerebral cortex. The size of the primary visual, auditory and somatosensory cortices and of the corresponding specific sensory thalamic nuclei were measured in intact and enucleated C57Bl/6J mice and in ZRDCT anophthalmic mice (ZRDCT/An) to evaluate the contribution of cross-modal activity on the growth of the cerebral cortex. In addition, the size of these structures were compared in intact, enucleated and anophthalmic fourth generation backcrossed hybrid C57Bl/6J × ZRDCT/An mice to parse out the effects of mouse strains and of the different visual deprivations. The visual cortex was smaller in the anophthalmic ZRDCT/An than in the intact and enucleated C57Bl/6J mice. Also the auditory cortex was larger and the somatosensory cortex smaller in the ZRDCT/An than in the intact and enucleated C57Bl/6J mice. The size differences of sensory cortices between the enucleated and anophthalmic mice were no longer present in the hybrid mice, showing specific genetic differences between C57Bl/6J and ZRDCT mice. The post natal size increase of the visual cortex was less in the enucleated than in the anophthalmic and intact hybrid mice. This suggests differences in the activity of the visual cortex between enucleated and anophthalmic mice and that early in-utero spontaneous neural activity in the visual system contributes to the shaping of functional properties of cortical networks.
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Format Inist (serveur)

NO :	PASCAL 15-0019049 INIST
ET :	Strain differences of the effect of enucleation and anophthalmia on the size and growth of sensory cortices in mice
AU :	MASSE (Ian O.); GUILLEMETTE (Sonia); LARAMIE (Marie-Eve); BRONCHTI (Gilles); BOIRE (Denis)
AF :	Departement d'anatomie, Université du Québec à Trois-Rivières/Québec G9A 5H7/Canada (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.); Ecole d'optométrie, Université de Montréal/Québec H3C 3J7/Canada (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Brain research; ISSN 0006-8993; Coden BRREAP; Pays-Bas; Da. 2014; Vol. 1588; Pp. 113-126; Bibl. 2 p.1/4
LA :	Anglais
EA :	Anophthalmia is a condition in which the eye does not develop from the early embryonic period. Early blindness induces cross-modal plastic modifications in the brain such as auditory and haptic activations of the visual cortex and also leads to a greater solicitation of the somatosensory and auditory cortices. The visual cortex is activated by auditory stimuli in anophthalmic mice and activity is known to alter the growth pattern of the cerebral cortex. The size of the primary visual, auditory and somatosensory cortices and of the corresponding specific sensory thalamic nuclei were measured in intact and enucleated C57Bl/6J mice and in ZRDCT anophthalmic mice (ZRDCT/An) to evaluate the contribution of cross-modal activity on the growth of the cerebral cortex. In addition, the size of these structures were compared in intact, enucleated and anophthalmic fourth generation backcrossed hybrid C57Bl/6J × ZRDCT/An mice to parse out the effects of mouse strains and of the different visual deprivations. The visual cortex was smaller in the anophthalmic ZRDCT/An than in the intact and enucleated C57Bl/6J mice. Also the auditory cortex was larger and the somatosensory cortex smaller in the ZRDCT/An than in the intact and enucleated C57Bl/6J mice. The size differences of sensory cortices between the enucleated and anophthalmic mice were no longer present in the hybrid mice, showing specific genetic differences between C57Bl/6J and ZRDCT mice. The post natal size increase of the visual cortex was less in the enucleated than in the anophthalmic and intact hybrid mice. This suggests differences in the activity of the visual cortex between enucleated and anophthalmic mice and that early in-utero spontaneous neural activity in the visual system contributes to the shaping of functional properties of cortical networks.
CC :	002B09K; 002A25I
FD :	Enucléation; Croissance; Vision; Perception intermodale; Audition; Plasticité; Thalamus; Cécité; Souris; Animal
FG :	Trouble de la vision; Pathologie de l'oeil; Encéphale; Système nerveux central; Rodentia; Mammalia; Vertebrata
ED :	Enucleation; Growth; Vision; Intermodal perception; Hearing; Plasticity; Thalamus; Blindness; Mouse; Animal
EG :	Vision disorder; Eye disease; Encephalon; Central nervous system; Rodentia; Mammalia; Vertebrata
SD :	Enucleación; Crecimiento; Visión; Percepción intermodal; Audición; Plasticidad; Tálamo; Ceguera; Ratón; Animal
LO :	INIST-12895.354000502696210120
ID :	15-0019049

Links to Exploration step

Pascal:15-0019049

Le document en format XML

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<front><div type="abstract" xml:lang="en">Anophthalmia is a condition in which the eye does not develop from the early embryonic period. Early blindness induces cross-modal plastic modifications in the brain such as auditory and haptic activations of the visual cortex and also leads to a greater solicitation of the somatosensory and auditory cortices. The visual cortex is activated by auditory stimuli in anophthalmic mice and activity is known to alter the growth pattern of the cerebral cortex. The size of the primary visual, auditory and somatosensory cortices and of the corresponding specific sensory thalamic nuclei were measured in intact and enucleated C57Bl/6J mice and in ZRDCT anophthalmic mice (ZRDCT/An) to evaluate the contribution of cross-modal activity on the growth of the cerebral cortex. In addition, the size of these structures were compared in intact, enucleated and anophthalmic fourth generation backcrossed hybrid C57Bl/6J × ZRDCT/An mice to parse out the effects of mouse strains and of the different visual deprivations. The visual cortex was smaller in the anophthalmic ZRDCT/An than in the intact and enucleated C57Bl/6J mice. Also the auditory cortex was larger and the somatosensory cortex smaller in the ZRDCT/An than in the intact and enucleated C57Bl/6J mice. The size differences of sensory cortices between the enucleated and anophthalmic mice were no longer present in the hybrid mice, showing specific genetic differences between C57Bl/6J and ZRDCT mice. The post natal size increase of the visual cortex was less in the enucleated than in the anophthalmic and intact hybrid mice. This suggests differences in the activity of the visual cortex between enucleated and anophthalmic mice and that early in-utero spontaneous neural activity in the visual system contributes to the shaping of functional properties of cortical networks.</div>
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<fC01 i1="01" l="ENG"><s0>Anophthalmia is a condition in which the eye does not develop from the early embryonic period. Early blindness induces cross-modal plastic modifications in the brain such as auditory and haptic activations of the visual cortex and also leads to a greater solicitation of the somatosensory and auditory cortices. The visual cortex is activated by auditory stimuli in anophthalmic mice and activity is known to alter the growth pattern of the cerebral cortex. The size of the primary visual, auditory and somatosensory cortices and of the corresponding specific sensory thalamic nuclei were measured in intact and enucleated C57Bl/6J mice and in ZRDCT anophthalmic mice (ZRDCT/An) to evaluate the contribution of cross-modal activity on the growth of the cerebral cortex. In addition, the size of these structures were compared in intact, enucleated and anophthalmic fourth generation backcrossed hybrid C57Bl/6J × ZRDCT/An mice to parse out the effects of mouse strains and of the different visual deprivations. The visual cortex was smaller in the anophthalmic ZRDCT/An than in the intact and enucleated C57Bl/6J mice. Also the auditory cortex was larger and the somatosensory cortex smaller in the ZRDCT/An than in the intact and enucleated C57Bl/6J mice. The size differences of sensory cortices between the enucleated and anophthalmic mice were no longer present in the hybrid mice, showing specific genetic differences between C57Bl/6J and ZRDCT mice. The post natal size increase of the visual cortex was less in the enucleated than in the anophthalmic and intact hybrid mice. This suggests differences in the activity of the visual cortex between enucleated and anophthalmic mice and that early in-utero spontaneous neural activity in the visual system contributes to the shaping of functional properties of cortical networks.</s0>
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<s5>20</s5>
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<s5>21</s5>
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<s5>22</s5>
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<fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>23</s5>
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<fC07 i1="05" i2="X" l="FRE"><s0>Rodentia</s0>
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<s2>NS</s2>
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<fC07 i1="07" i2="X" l="SPA"><s0>Vertebrata</s0>
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<ET>Strain differences of the effect of enucleation and anophthalmia on the size and growth of sensory cortices in mice</ET>
<AU>MASSE (Ian O.); GUILLEMETTE (Sonia); LARAMIE (Marie-Eve); BRONCHTI (Gilles); BOIRE (Denis)</AU>
<AF>Departement d'anatomie, Université du Québec à Trois-Rivières/Québec G9A 5H7/Canada (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.); Ecole d'optométrie, Université de Montréal/Québec H3C 3J7/Canada (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Brain research; ISSN 0006-8993; Coden BRREAP; Pays-Bas; Da. 2014; Vol. 1588; Pp. 113-126; Bibl. 2 p.1/4</SO>
<LA>Anglais</LA>
<EA>Anophthalmia is a condition in which the eye does not develop from the early embryonic period. Early blindness induces cross-modal plastic modifications in the brain such as auditory and haptic activations of the visual cortex and also leads to a greater solicitation of the somatosensory and auditory cortices. The visual cortex is activated by auditory stimuli in anophthalmic mice and activity is known to alter the growth pattern of the cerebral cortex. The size of the primary visual, auditory and somatosensory cortices and of the corresponding specific sensory thalamic nuclei were measured in intact and enucleated C57Bl/6J mice and in ZRDCT anophthalmic mice (ZRDCT/An) to evaluate the contribution of cross-modal activity on the growth of the cerebral cortex. In addition, the size of these structures were compared in intact, enucleated and anophthalmic fourth generation backcrossed hybrid C57Bl/6J × ZRDCT/An mice to parse out the effects of mouse strains and of the different visual deprivations. The visual cortex was smaller in the anophthalmic ZRDCT/An than in the intact and enucleated C57Bl/6J mice. Also the auditory cortex was larger and the somatosensory cortex smaller in the ZRDCT/An than in the intact and enucleated C57Bl/6J mice. The size differences of sensory cortices between the enucleated and anophthalmic mice were no longer present in the hybrid mice, showing specific genetic differences between C57Bl/6J and ZRDCT mice. The post natal size increase of the visual cortex was less in the enucleated than in the anophthalmic and intact hybrid mice. This suggests differences in the activity of the visual cortex between enucleated and anophthalmic mice and that early in-utero spontaneous neural activity in the visual system contributes to the shaping of functional properties of cortical networks.</EA>
<CC>002B09K; 002A25I</CC>
<FD>Enucléation; Croissance; Vision; Perception intermodale; Audition; Plasticité; Thalamus; Cécité; Souris; Animal</FD>
<FG>Trouble de la vision; Pathologie de l'oeil; Encéphale; Système nerveux central; Rodentia; Mammalia; Vertebrata</FG>
<ED>Enucleation; Growth; Vision; Intermodal perception; Hearing; Plasticity; Thalamus; Blindness; Mouse; Animal</ED>
<EG>Vision disorder; Eye disease; Encephalon; Central nervous system; Rodentia; Mammalia; Vertebrata</EG>
<SD>Enucleación; Crecimiento; Visión; Percepción intermodal; Audición; Plasticidad; Tálamo; Ceguera; Ratón; Animal</SD>
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Strain differences of the effect of enucleation and anophthalmia on the size and growth of sensory cortices in mice

Strain differences of the effect of enucleation and anophthalmia on the size and growth of sensory cortices in mice

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