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Cataract development associated with collagen copolymer posterior chamber phakic intraocular lenses: Clinicopathological correlation

Identifieur interne : 000496 ( PascalFrancis/Checkpoint ); précédent : 000495; suivant : 000497

Cataract development associated with collagen copolymer posterior chamber phakic intraocular lenses: Clinicopathological correlation

Auteurs : Yousuf M. Khalifa [États-Unis] ; Majid Moshirfar [États-Unis] ; Mark D. Mifflin [États-Unis] ; Kandon Kamae [États-Unis] ; Nick Mamalis [États-Unis] ; Liliana Werner [États-Unis]

Source :

RBID : Pascal:10-0489614

Descripteurs français

English descriptors

Abstract

PURPOSE: To assess the histopathology of anterior subcapsular cataract associated with a collagen copolymer posterior chamber phakic intraocular lens (pIOL) (Visian Implantable Collamer Lens) using light microscopy after pIOL explantation and cataract surgery. SETTING: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. DESIGN: Laboratory investigation. METHODS: Pathology specimens related to explanted pIOLs were reviewed and preoperative and postoperative patient data collected. The anterior lens capsules and explanted pIOLs were examined. RESULTS: Four eyes (3 patients) had pIOL explantation for low vault and anterior subcapsular cataract. The explanted pIOLs were the shorter length models (3,12.1 mm; 1,12.6 mm). Anterior segment optical coherence tomography (AS-OCT) confirmed the low pIOL vault before explantation in 2 eyes. Histopathology of the anterior subcapsular cataract showed fibrous metaplasia with a variable number of lens epithelial cell (LEC) layers attached to the inner surface of the anterior capsulorhexis specimens. Light microscopy of the explanted pIOLs showed no pigment on 1 lens, mild pigment deposition on 1 haptic, and pigment deposition throughout the anterior surface of 2 pIOLs. CONCLUSIONS: Anterior subcapsular cataract associated with the pIOLs was caused by low vaulting (confirmed on AS-OCT) and consequent fibrous metaplasia of the anterior LECs. Surgeons should consider the possibility of anterior subcapsular cataract associated with shorter platforms when selecting a pIOL length for appropriate vault. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.


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<div type="abstract" xml:lang="en">PURPOSE: To assess the histopathology of anterior subcapsular cataract associated with a collagen copolymer posterior chamber phakic intraocular lens (pIOL) (Visian Implantable Collamer Lens) using light microscopy after pIOL explantation and cataract surgery. SETTING: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. DESIGN: Laboratory investigation. METHODS: Pathology specimens related to explanted pIOLs were reviewed and preoperative and postoperative patient data collected. The anterior lens capsules and explanted pIOLs were examined. RESULTS: Four eyes (3 patients) had pIOL explantation for low vault and anterior subcapsular cataract. The explanted pIOLs were the shorter length models (3,12.1 mm; 1,12.6 mm). Anterior segment optical coherence tomography (AS-OCT) confirmed the low pIOL vault before explantation in 2 eyes. Histopathology of the anterior subcapsular cataract showed fibrous metaplasia with a variable number of lens epithelial cell (LEC) layers attached to the inner surface of the anterior capsulorhexis specimens. Light microscopy of the explanted pIOLs showed no pigment on 1 lens, mild pigment deposition on 1 haptic, and pigment deposition throughout the anterior surface of 2 pIOLs. CONCLUSIONS: Anterior subcapsular cataract associated with the pIOLs was caused by low vaulting (confirmed on AS-OCT) and consequent fibrous metaplasia of the anterior LECs. Surgeons should consider the possibility of anterior subcapsular cataract associated with shorter platforms when selecting a pIOL length for appropriate vault. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.</div>
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<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Ojo patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Pathologie du segment antérieur</s0>
<s2>NM</s2>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Anterior segment disease</s0>
<s2>NM</s2>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Segmento anterior patología</s0>
<s2>NM</s2>
<s5>39</s5>
</fC07>
<fN21>
<s1>326</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations>
<list>
<country>
<li>États-Unis</li>
</country>
<region>
<li>Utah</li>
<li>État de New York</li>
</region>
</list>
<tree>
<country name="États-Unis">
<region name="État de New York">
<name sortKey="Khalifa, Yousuf M" sort="Khalifa, Yousuf M" uniqKey="Khalifa Y" first="Yousuf M." last="Khalifa">Yousuf M. Khalifa</name>
</region>
<name sortKey="Kamae, Kandon" sort="Kamae, Kandon" uniqKey="Kamae K" first="Kandon" last="Kamae">Kandon Kamae</name>
<name sortKey="Mamalis, Nick" sort="Mamalis, Nick" uniqKey="Mamalis N" first="Nick" last="Mamalis">Nick Mamalis</name>
<name sortKey="Mifflin, Mark D" sort="Mifflin, Mark D" uniqKey="Mifflin M" first="Mark D." last="Mifflin">Mark D. Mifflin</name>
<name sortKey="Moshirfar, Majid" sort="Moshirfar, Majid" uniqKey="Moshirfar M" first="Majid" last="Moshirfar">Majid Moshirfar</name>
<name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name>
</country>
</tree>
</affiliations>
</record>

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