Functional connectivity of visual cortex in the blind follows retinotopic organization principles
Identifieur interne : 003841 ( Ncbi/Merge ); précédent : 003840; suivant : 003842Functional connectivity of visual cortex in the blind follows retinotopic organization principles
Auteurs : Ella Striem-Amit [Israël, États-Unis] ; Smadar Ovadia-Caro [Allemagne] ; Alfonso Caramazza [États-Unis, Italie] ; Daniel S. Margulies [Allemagne] ; Arno Villringer [Allemagne] ; Amir Amedi [Israël, France]Source :
- Brain [ 0006-8950 ] ; 2015.
Abstract
Although early visual experience is essential for the proper development of visual cortex, Striem-Amit
Url:
DOI: 10.1093/brain/awv083
PubMed: 25869851
PubMed Central: 4614142
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This basic organisational principle emerges independently of visual input and persists despite lifelong experience-dependent plasticity.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ackman, Jb" uniqKey="Ackman J">JB Ackman</name></author><author><name sortKey="Crair, Mc" uniqKey="Crair M">MC Crair</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amedi, A" uniqKey="Amedi A">A Amedi</name></author><author><name sortKey="Floel, A" uniqKey="Floel A">A Floel</name></author><author><name sortKey="Knecht, S" uniqKey="Knecht S">S Knecht</name></author><author><name sortKey="Zohary, E" uniqKey="Zohary E">E Zohary</name></author><author><name sortKey="Cohen, Lg" uniqKey="Cohen L">LG Cohen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amedi, A" uniqKey="Amedi A">A Amedi</name></author><author><name sortKey="Raz, N" uniqKey="Raz N">N Raz</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Brain</journal-id><journal-id journal-id-type="iso-abbrev">Brain</journal-id><journal-id journal-id-type="publisher-id">brainj</journal-id><journal-id journal-id-type="hwp">brain</journal-id><journal-title-group><journal-title>Brain</journal-title></journal-title-group><issn pub-type="ppub">0006-8950</issn><issn pub-type="epub">1460-2156</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25869851</article-id><article-id pub-id-type="pmc">4614142</article-id><article-id pub-id-type="doi">10.1093/brain/awv083</article-id><article-id pub-id-type="publisher-id">awv083</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Functional connectivity of visual cortex in the blind follows retinotopic organization principles</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Striem-Amit</surname><given-names>Ella</given-names></name><xref ref-type="aff" rid="awv083-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="awv083-AFF2"><sup>2</sup></xref><xref ref-type="author-notes" rid="awv083-FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Ovadia-Caro</surname><given-names>Smadar</given-names></name><xref ref-type="aff" rid="awv083-AFF3"><sup>3</sup></xref><xref ref-type="aff" rid="awv083-AFF4"><sup>4</sup></xref><xref ref-type="author-notes" rid="awv083-FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Caramazza</surname><given-names>Alfonso</given-names></name><xref ref-type="aff" rid="awv083-AFF2"><sup>2</sup></xref><xref ref-type="aff" rid="awv083-AFF5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Margulies</surname><given-names>Daniel S.</given-names></name><xref ref-type="aff" rid="awv083-AFF3"><sup>3</sup></xref><xref ref-type="aff" rid="awv083-AFF4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Villringer</surname><given-names>Arno</given-names></name><xref ref-type="aff" rid="awv083-AFF3"><sup>3</sup></xref><xref ref-type="aff" rid="awv083-AFF4"><sup>4</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Amedi</surname><given-names>Amir</given-names></name><xref ref-type="aff" rid="awv083-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="awv083-AFF6"><sup>6</sup></xref><xref ref-type="aff" rid="awv083-AFF7"><sup>7</sup></xref><xref ref-type="aff" rid="awv083-AFF8"><sup>8</sup></xref></contrib><aff id="awv083-AFF1">1 Department of Medical Neurobiology, The Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91220, Israel</aff><aff id="awv083-AFF2">2 Department of Psychology, Harvard University, Cambridge, MA 02138 USA</aff><aff id="awv083-AFF3">3 Mind and Brain Institute, Berlin School of Mind and Brain, Humboldt University, Berlin, Germany</aff><aff id="awv083-AFF4">4 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany</aff><aff id="awv083-AFF5">5 Centre for Mind/Brain Sciences, Università degli Studi di Trento, Polo di Rovereto, Italy</aff><aff id="awv083-AFF6">6 The Edmond and Lily Safra Centre for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Jerusalem 91220, Israel</aff><aff id="awv083-AFF7">7 Cognitive Sciences Program, The Hebrew University of Jerusalem, Jerusalem 91220, Israel</aff><aff id="awv083-AFF8">8 Sorbonne Universités, UPMC Univ Paris 06, Institut de la Vision, UMR_S 968, Paris, F-75012, France</aff></contrib-group><author-notes><corresp id="awv083-COR1">Correspondence to: Ella Striem-Amit, 33 Kirkland St. Cambridge MA 02138, USA E-mail: <email>striemamit@fas.harvard.edu</email></corresp><corresp id="awv083-COR2">Correspondence may also be addressed to: Amir Amedi, Department of Medical Neurobiology, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91220, Israel E-mail: <email>amira@ekmd.huji.ac.il</email></corresp><fn id="awv083-FN1"><p>*<bold>These authors contributed equally to this work.</bold></p></fn></author-notes><pub-date pub-type="ppub"><month>6</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>10</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>10</day><month>4</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>138</volume><issue>6</issue><fpage>1679</fpage><lpage>1695</lpage><history><date date-type="received"><day>18</day><month>9</month><year>2014</year></date><date date-type="rev-recd"><day>15</day><month>1</month><year>2015</year></date><date date-type="accepted"><day>01</day><month>2</month><year>2015</year></date></history><permissions><copyright-statement>© The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain.</copyright-statement><copyright-year>2015</copyright-year><license xlink:href="http://creativecommons.org/licenses/by-nc/4.0/" license-type="creative-commons"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com</license-p></license></permissions><abstract abstract-type="precis"><p>Although early visual experience is essential for the proper development of visual cortex, Striem-Amit <italic>et al.</italic> show that the underlying connectivity structure of retinotopic mapping is retained even in congenitally blind individuals. This basic organisational principle emerges independently of visual input and persists despite lifelong experience-dependent plasticity.</p></abstract><abstract abstract-type="graphical"><p><fig id="fig1g" fig-type="featured" position="float"><caption><p>Although early visual experience is essential for the proper development of visual cortex, Striem-Amit <italic>et al.</italic> show that the underlying connectivity structure of retinotopic mapping is retained even in congenitally blind individuals. This basic organisational principle emerges independently of visual input and persists despite lifelong experience-dependent plasticity.</p></caption><graphic xlink:href="awv083fig1g"></graphic></fig></p></abstract><abstract><p>Is visual input during critical periods of development crucial for the emergence of the fundamental topographical mapping of the visual cortex? And would this structure be retained throughout life-long blindness or would it fade as a result of plastic, use-based reorganization? We used functional connectivity magnetic resonance imaging based on intrinsic blood oxygen level-dependent fluctuations to investigate whether significant traces of topographical mapping of the visual scene in the form of retinotopic organization, could be found in congenitally blind adults. A group of 11 fully and congenitally blind subjects and 18 sighted controls were studied. The blind demonstrated an intact functional connectivity network structural organization of the three main retinotopic mapping axes: eccentricity (centre-periphery), laterality (left-right), and elevation (upper-lower) throughout the retinotopic cortex extending to high-level ventral and dorsal streams, including characteristic eccentricity biases in face- and house-selective areas. Functional connectivity-based topographic organization in the visual cortex was indistinguishable from the normally sighted retinotopic functional connectivity structure as indicated by clustering analysis, and was found even in participants who did not have a typical retinal development <italic>in utero</italic> (microphthalmics). While the internal structural organization of the visual cortex was strikingly similar, the blind exhibited profound differences in functional connectivity to other (non-visual) brain regions as compared to the sighted, which were specific to portions of V1. Central V1 was more connected to language areas but peripheral V1 to spatial attention and control networks. These findings suggest that current accounts of critical periods and experience-dependent development should be revisited even for primary sensory areas, in that the connectivity basis for visual cortex large-scale topographical organization can develop without any visual experience and be retained through life-long experience-dependent plasticity. Furthermore, retinotopic divisions of labour, such as that between the visual cortex regions normally representing the fovea and periphery, also form the basis for topographically-unique plastic changes in the blind.</p></abstract><kwd-group kwd-group-type="keywords"><kwd>blindness</kwd><kwd>development</kwd><kwd>plasticity</kwd><kwd>vision</kwd></kwd-group><counts><page-count count="17"></page-count></counts></article-meta></front><body><sec sec-type="intro"><title>Introduction</title><p>Ever since Hubel and Wiesel’s Nobel prize-winning work (<xref rid="awv083-B108" ref-type="bibr">Wiesel and Hubel, 1963</xref>, <xref rid="awv083-B109" ref-type="bibr">1965</xref>) it has been clear that the maturation process and resulting characteristics of the core retinotopic areas of the human brain, in particular the primary and early visual areas, are extremely sensitive to visual input during certain (critical or sensitive) developmental periods. Abolition of visual input in animals during a critical period after birth can result in permanently impaired vision due to deficient development of visual processing in the brain. For instance, lack of input from one eye will render the ocular dominance columns of that eye nearly extinct and sight will never properly recover even if visual input is restored. Similar phenomena have also been reported in humans (<xref rid="awv083-B47" ref-type="bibr">Lewis and Maurer, 2005</xref>; <xref rid="awv083-B71" ref-type="bibr">Maurer <italic>et al.</italic>, 2005</xref>; <xref rid="awv083-B10" ref-type="bibr">Birch <italic>et al.</italic>, 2009</xref>; <xref rid="awv083-B22" ref-type="bibr">Chan <italic>et al.</italic>, 2012</xref>; <xref rid="awv083-B29" ref-type="bibr">Dormal <italic>et al.</italic>, 2012</xref> although see also <xref rid="awv083-B54" ref-type="bibr">Kalia <italic>et al.</italic>, 2014</xref>), and the common consensus is that lack of visual input will cause irreparable damage to the organization of the visual cortex. Furthermore, full visual deprivation causes visual areas to reorganize to process other inputs and sensory modalities (<xref rid="awv083-B72" ref-type="bibr">Merabet and Pascual-Leone, 2010</xref>; <xref rid="awv083-B100" ref-type="bibr">Voss and Zatorre, 2012</xref>). The reorganization of the primary visual cortex of the congenitally blind is thought to be so extreme as to result in its recruitment for language and memory tasks (<xref rid="awv083-B88" ref-type="bibr">Sadato <italic>et al.</italic>, 1996</xref>; <xref rid="awv083-B2" ref-type="bibr">Amedi <italic>et al.</italic>, 2003</xref>, <xref rid="awv083-B3" ref-type="bibr">2004</xref>; <xref rid="awv083-B15" ref-type="bibr">Burton <italic>et al.</italic>, 2003</xref>; <xref rid="awv083-B6" ref-type="bibr">Bedny <italic>et al.</italic>, 2011</xref>). This has engendered the common belief that sight restoration should not be attempted on people fully blind from birth, because their brains cannot develop or retain the organization needed for processing vision.</p><p>However, one of the fundamental issues as regards brain organization, which may have important bearings on brain plasticity and potential practical implications for future sight restoration efforts, has yet to be thoroughly explored. It is currently not known to what extent the visual cortex can develop and retain its fundamental large-scale organizational principle—the topographic organization of the visual scene, also known as retinotopic mapping (<xref rid="awv083-B102" ref-type="bibr">Wandell <italic>et al.</italic>, 2007<italic>a</italic></xref>)—without any visual input. Further, even if such maps do develop without visual experience, can they be retained throughout life-long blindness, or do they dwindle as an outcome of the well-known usage-induced, experience-dependent, compensatory plasticity (<xref rid="awv083-B83" ref-type="bibr">Raz <italic>et al.</italic>, 2007</xref>; <xref rid="awv083-B59" ref-type="bibr">Kupers and Ptito, 2013</xref>)?</p><p>Two recent studies have investigated the existence of traces of topographical organization in the blind’s striate cortex (the anatomical location of the primary visual cortex; in a mixed group of congenital and acquired blindness individuals; <xref rid="awv083-B18" ref-type="bibr">Butt <italic>et al.</italic>, 2013</xref>) and its bilateral anatomical connections via the corpus callosum (<xref rid="awv083-B13" ref-type="bibr">Bock <italic>et al.</italic>, 2013</xref>). The findings showed that in fact the earliest station of the visual cortical hierarchy retains aspects of its architecture patterns in blindness.</p><p>Here we explored whether this pattern is limited to the very first station of cortex, or whether this organization, which is the major organizing principle of the entire visual cortex (<xref rid="awv083-B102" ref-type="bibr">Wandell <italic>et al.</italic>, 2007<italic>a</italic></xref>), is dependent on visual experience for its creation and/or maintenance throughout life. This was studied using functional connectivity analysis based on intrinsic slow (<0.1 Hz) blood oxygen level-dependent fluctuations in 11 congenitally, fully blind subjects (<ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Table 1</ext-link>) and 18 sighted controls. Functional connectivity MRI (<xref rid="awv083-B11" ref-type="bibr">Biswal <italic>et al.</italic>, 1995</xref>) in the absence of a task shows similar spatial patterns to those evident during a task (<xref rid="awv083-B37" ref-type="bibr">Fox and Raichle, 2007</xref>; <xref rid="awv083-B91" ref-type="bibr">Smith <italic>et al.</italic>, 2009</xref>; <xref rid="awv083-B28" ref-type="bibr">Deco <italic>et al.</italic>, 2011</xref>), and is highly correlated with underlying structural connectivity (<xref rid="awv083-B26" ref-type="bibr">Damoiseaux and Greicius, 2009</xref>), including not only direct but also indirect (<xref rid="awv083-B49" ref-type="bibr">Honey <italic>et al.</italic>, 2009</xref>) and polysynaptic connectivity (<xref rid="awv083-B98" ref-type="bibr">Vincent <italic>et al.</italic>, 2007</xref>). Importantly, resting-state functional connectivity also correlates with functional and structural anatomy changes due to brain plasticity (<xref rid="awv083-B41" ref-type="bibr">Guerra-Carrillo <italic>et al.</italic>, 2014</xref>), and usage, reflecting ongoing developmental changes in network engagement (<xref rid="awv083-B117" ref-type="bibr">Dosenbach <italic>et al.</italic>, 2007</xref>; <xref rid="awv083-B36" ref-type="bibr">Fair <italic>et al.</italic>, 2007</xref>). Thus, functional connectivity is a sensitive measure to investigate both stable anatomical connectivity as well as plastic changes throughout life, in normal conditions, atypical development, and disease. These findings reinforce the validity of this approach to the study of the organization of the visual cortex without visual input, which is critical for studying neural networks that are not otherwise accessible, such as the retinotopic organization in the fully blind. We thus studied the segregation of visual functional networks in congenitally blind subjects based on the three retinotopic mapping principles of the intact visual cortex: eccentricity, laterality and elevation, which together constitute the complete mapping of the visual field.</p></sec><sec sec-type="materials|methods"><title>Material and methods</title><sec sec-type="subjects"><title>Participants</title><p>Eleven congenitally blind individuals with no light perception (<ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Table 1</ext-link>) and 18 normally sighted healthy controls (with normal or corrected-to-normal vision; no age difference between the groups; <italic>P</italic> > 0.2) participated in the study. The age of the subjects ranged from 23 to 54 years. None had neurological or psychiatric conditions. The Tel-Aviv Sourasky Medical Centre Ethics Committee approved the experimental procedure, and written informed consent was obtained from each subject.</p></sec><sec><title>Functional imaging</title><p>Functional MRI data were obtained during a 9.1-min (182 volumes) resting-state scan (i.e. spontaneous blood oxygen level-dependent fluctuations) using a 3-T General Electric scanner with an InVivo 8-channel head coil. During the scan, subjects lay supine in the scanner with no external stimulation or explicit task. The sighted subjects were blindfolded and had their eyes shut for the duration of the scan. Two-dimensional functional images using blood oxygen level-dependent contrast were obtained with an Echo Planar Imaging sequence (repetition time = 3000 ms, echo time = 30 ms, 29–46 slices to obtain full-brain coverage, voxel size 3 × 3 × 4 mm, flip angle 90°). T<sub>1</sub>-weighted anatomical images were acquired using a 3D MPRAGE sequence (repetition time = 8.9 ms, echo time = 3.5 ms, inversion time = 450, 158 slices, voxel size 1 × 1 × 1 mm, flip angle 13°).</p></sec><sec><title>Functional MRI preprocessing</title><p>Data analysis was performed using the Brain Voyager QX 2.2 software package (Brain Innovation, Maastricht, The Netherlands) and complementary in-house preprocessing in MATLAB (MathWorks) using standard preprocessing procedures. The first two images of each scan were excluded from the analysis due to non-steady state magnetization. Preprocessing of functional scans included 3D motion correction, slice scan time correction, band-pass filtering (0.01–0.1 Hz), regression of spurious signals from the ventricles and white matter regions defined using a grow-region function embedded in Brain Voyager on the individual level and spatial smoothing with a 4 mm full-width at half-maximum Gaussian kernel. No head motions exceeded 2 mm in any given axis, or had spike-like motion of more than 1 mm in any direction. Data were then normalized to standard Talairach space (<xref rid="awv083-B96" ref-type="bibr">Talairach and Tournoux, 1988</xref>).</p></sec><sec><title>Defining <italic>a priori</italic> retinotopic regions of interest</title><p>To define the primary visual cortex seeds for functional connectivity MRI analysis we scanned 14 normally sighted subjects using a standard phase-encoded retinotopic mapping protocol, with eccentricity and polar mapping of ring and wedge stimuli, respectively, to measure visual retinotopic mapping (<xref rid="awv083-B33" ref-type="bibr">Engel <italic>et al.</italic>, 1994</xref>; <xref rid="awv083-B89" ref-type="bibr">Sereno <italic>et al.</italic>, 1995</xref>; <xref rid="awv083-B103" ref-type="bibr">Wandell <italic>et al.</italic>, 2007<italic>b</italic></xref>; <xref rid="awv083-B104" ref-type="bibr">Wandell and Winawer, 2011</xref>), delivered during two separate experiments. The stimuli were projected by an LCD projector onto a tangent screen positioned over the subject’s forehead and viewed through a tilted mirror. In Experiment 1 an expanding annulus was presented, expanding from 0° to 34° of the subject’s visual field in 30 s, repeated 10 times. Experiment 2 presented a wedge with a polar angle of 22.5° that rotated around the fixation point, completing a full cycle in 30 s, repeated 20 times. Both the annulus in Experiment 1 and the wedge in Experiment 2 contained a flickering (6 Hz) radial checkerboard pattern according to standard retinotopic procedures (<xref rid="awv083-B33" ref-type="bibr">Engel <italic>et al.</italic>, 1994</xref>) for field map mapping. In both cases there was a 30-s period of baseline (fixation) before and after the visual stimulus for baseline. Group phase analysis was conducted on the two experiments as done in other studies (<xref rid="awv083-B48" ref-type="bibr">Hertz and Amedi, 2010</xref>; <xref rid="awv083-B95" ref-type="bibr">Striem-Amit <italic>et al.</italic>, 2011</xref>) resulting in group maps depicting the eccentricity and angle mapping. Angle mapping was then used to define the borders of V1 and V2, and the two maps were used to segregate them according to eccentricity (centre of visual field and periphery; <xref ref-type="fig" rid="awv083-F1">Fig. 1</xref>A), laterality (right/left visual field responses; <xref ref-type="fig" rid="awv083-F1">Fig. 1</xref>A) and elevation (lower and upper visual field responses; <xref ref-type="fig" rid="awv083-F1">Fig. 1</xref>A), thus creating the seeds used for functional connectivity MRI analyses.
<fig id="awv083-F1" position="float"><label>Figure 1</label><caption><p><bold>Resting-state functional connectivity MRI retinotopic organization in congenitally fully blind participants.</bold> (<bold>A</bold>) Retinotopic functional connectivity MRI seeds separating the primary visual cortex according to the three fundamental topographical mapping principles of eccentricity (<italic>left</italic>: central and peripheral visual fields), laterality (<italic>middle</italic>: left and right visual fields) and elevation (<italic>right</italic>: top and bottom visual fields). The seeds were generated from an external retinotopic mapping experiment, and are displayed on brain slices and unfolded cortical sheets along with a circle depicting the corresponding parts in the visual fields. (<bold>B</bold>) Functional connectivity MRI retinotopic organization maps of a group of normally sighted controls (GLM random effect analysis, corrected for multiple comparisons) shows that visual field mapping principles can indeed be observed using resting-state functional connectivity MRI covering a large extent of the visual cortex from the seeds in the primary visual cortex to areas encompassing high-order ventral and dorsal visual streams. The circles depict the approximate corresponding areas in the visual field for both seeds in each colour map. (<bold>C</bold>) The group of participants fully blind from birth showed a similar arrangement of resting-state functional connectivity MRI topographic organization as seen in the sighted (GLM random effect analysis, corrected for multiple comparisons), replicating the known retinotopic organization pattern in the absence of visual experience. cVF = visual field; pVF = peripheral visual field; lVF = left visual field; rVF = right visual field; tVF = top visual field; bVF = bottom visual field.</p></caption><graphic xlink:href="awv083f1p"></graphic></fig></p></sec><sec><title>Analysis of functional connectivity</title><p>Functional connectivity was computed for <italic>a priori</italic> defined seed regions of interest located in the primary visual cortex (V1), dividing it according to eccentricity, laterality, and elevation using a separate task-based retinotopic mapping external localizer from normally-sighted controls (see details above). Individual average time courses from each seed region of interest were sampled and <italic>z</italic>-normalized at the individual level. Partial correlation analysis (<xref rid="awv083-B113" ref-type="bibr">Zhang <italic>et al.</italic>, 2008</xref>; <xref rid="awv083-B119" ref-type="bibr">Margulies <italic>et al.</italic>, 2010</xref>) was performed in the following manner: for each seed, the time course was used as an individual predictor in a separate group analysis using a General Linear Model (GLM) in a hierarchical random effects (RFX) analysis (<xref rid="awv083-B38" ref-type="bibr">Friston <italic>et al.</italic>, 1999</xref>), while regressing out the time course of the complementary visual field component to discard the shared variance and remain solely with the unique variance attributed to the seed (see <ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 1</ext-link> for illustration). This analysis resulted in a group map for each of the six regions of interest. The two maps from each two complementary seeds in V1 (i.e. the group maps for central and peripheral visual fields in <xref ref-type="fig" rid="awv083-F1">Fig. 1</xref>B) were overlaid to reveal the pattern across this axis. The minimum significance level of the results for the full group sizes (<italic>n =</italic> 11 for the blind, <italic>n =</italic> 18 for the sighted) was set to <italic>P <</italic> 0.05 corrected for multiple comparisons, using the spatial extent method based on the theory of Gaussian random fields (<xref rid="awv083-B39" ref-type="bibr">Friston <italic>et al.</italic>, 1993</xref>), a set-level statistical inference correction. This was done based on the Monte Carlo stimulation approach extended to 3D data sets using the threshold size plug-in for BrainVoyager QX. Mapping the boundary of V1 and V2 (<xref ref-type="fig" rid="awv083-F6">Fig. 6</xref>) was done in a comparable manner, using seeds within the left ventral (lower) V1 and V2, on both sides of the border between them, which refer to similar visual field locations in both areas. Group comparisons (<xref ref-type="fig" rid="awv083-F5">Fig. 5</xref> and <ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 6</ext-link>) were created using standard seed functional connectivity analysis, without using partial correlations (without regressing out the time course of another seed).</p></sec><sec><title>Analysis of blind subgroups</title><p>Since the blind varied in their aetiologies, this enabled us to investigate subgroups of the blind with differing prenatal visual development. Specifically, we investigated the retinotopic organization in subjects (<italic>n =</italic> 5) whose blindness resulted from retinopathy of prematurity (caused in these cases by oxygen treatment to premature infants), who prenatally had an intact visual system, and in subjects (<italic>n =</italic> 5) whose blindness resulted from microphthalmia, a developmental condition in which the eyes do not develop to their normal size (in this case, also causing full blindness), whose peripheral visual system was also deficient prenatally. For the subgroup analysis we applied a fixed effect GLM analysis at a highly significant threshold (<italic>P <</italic> 0.001 with false discovery rate correction; <xref rid="awv083-B40" ref-type="bibr">Genovese <italic>et al.</italic>, 2002</xref>).</p></sec><sec><title>Analysis of spatial consistency</title><p>In addition to canonical group analyses (e.g. random effect GLM), we applied three different complementary analyses to examine the spatial consistency of retinotopic networks in the blind: (i) we plotted the overlap probability maps across all the blind subjects; (ii) we used an independent k-means clustering analysis to qualitatively assess the similarity between the maps of the blind and sighted subjects; and (iii) we quantified the similarity between the maps of the blind and sighted subjects using a concordance correlation coefficient.
<list list-type="roman-lower"><list-item><p>Overlap probability maps across subjects (<xref ref-type="fig" rid="awv083-F2">Fig. 2</xref>A and <ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 3</ext-link>) were derived from single-subject activation contrast maps at a threshold of <italic>P <</italic> 0.05, corrected for multiple comparisons using the spatial extent method. The individual-level maps were overlaid and the overlap probability across the subjects was calculated on a voxel-by-voxel basis. Probability maps are shown at a minimal threshold of >50%, such that the smallest ratio of subjects showing activation in each presented voxel was 6 of 11 participants (although most voxels had a higher ratio, as indicated by the colour scale).</p></list-item><list-item><p>To capture the spatial similarity between the maps obtained for sighted and blind subjects, we performed a k-means clustering analysis. K-means is designed to partition <italic>n</italic> observations (in our case <italic>n =</italic> 29, data of all the blind and sighted individual subjects) into k clusters (in our case k = 2) in which each observation is assigned to the cluster with the nearest mean in an iterative converging analysis (1000 iterations), so as to minimize the within-cluster sum of squares (<xref rid="awv083-B65" ref-type="bibr">MacKay, 2003</xref>). The observations entered in the analysis were the concatenated retinotopic functional connectivity GLM statistical parametric maps of each subject from all 29 individual subjects, 18 sighted and 11 blind. Individual statistical parametric maps were masked by a visual cortex mask obtained with a retinotopic mapping rotating-wedge stimulus versus baseline contrast (see details on the localizer below). This mask was created at lenient threshold (<italic>P <</italic> 0.05 corrected for multiple comparisons, covering 149 404 mm<sup>3</sup>), so as to cover to the largest extent the visually-responsive cortex. Individual statistical parametric maps from each of the six V1 seeds (centre, periphery, left, right, top and bottom visual field) were concatenated and used as input for the k-means clustering analysis to test whether the clustering algorithm could tell the different groups apart. In a control analysis, the maps of each pair of complementing seeds for each subject (not concatenated; i.e. a statistical parametric map from the central visual field and a statistical parametric map from the peripheral visual field) were analysed, resulting in a clustering according to the seed rather than according to the group.</p></list-item><list-item><p>To quantify the spatial similarity between the sighted and blind group maps, we computed a concordance correlation coefficient (<xref rid="awv083-B63" ref-type="bibr">Lin, 1989</xref>) using in-house software written in MATLAB (MathWorks). Concordance correlation coefficient values range from 1 (perfect spatial similarity) to −1 (perfect spatial dissimilarity), and were computed for each seed between the group maps (e.g. between the central visual field map of the blind and that of the sighted). A mask of the visually-responsive cortex (also used for the k-means analysis) was used to compute the similarity between the group maps only for the relevant regions. The significance level was obtained using a permutation test while randomly shuffling voxels from one group map, and was corrected for multiple comparisons using the Bonferroni correction. We found a significant high spatial similarity between the group maps of the blind subjects and the sighted subjects for all seed regions of interest (<ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Table 2</ext-link>).</p></list-item></list><fig id="awv083-F2" position="float"><label>Figure 2</label><caption><p><bold>Resting-state functional connectivity MRI retinotopic organization across single blind adult subjects.</bold> (<bold>A</bold>) The spatial reproducibility of the resting-state functional connectivity MRI retinotopic organization in the blind is emphasized by the probability map showing the overlap of the functional connectivity MRI maps across the blind subjects for each seed pair (for a stricter threshold replicating the same effects see <ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 3A</ext-link>). (<bold>B</bold>) The probability map shows the overlap of the functional connectivity MRI maps across the sighted subjects for each seed pair, and indicates comparable spatial reproducibility of the resting-state functional connectivity MRI retinotopic organization in both groups (see also <ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 3B</ext-link> for direct overlay of the two maps). (<bold>C</bold>) Resting-state functional connectivity MRI retinotopic organization maps are shown for four typical congenitally blind (with no light perception) subjects (one of whom, Subject 2, was blind due to micropthalmia), showing the topographic organization robustness even at the single subject level (see <xref ref-type="fig" rid="awv083-F4">Fig. 4</xref> for group analysis of microphthalmic subjects). cVF <bold>=</bold> visual field<bold>;</bold> pVF <bold>=</bold> peripheral visual field<bold>;</bold> lVF <bold>=</bold> left visual field<bold>;</bold> rVF <bold>=</bold> right visual field<bold>;</bold> tVF <bold>=</bold> top visual field<bold>;</bold> bVF <bold>=</bold> bottom visual field; RH = right hemisphere.</p></caption><graphic xlink:href="awv083f2p"></graphic></fig></p></sec><sec><title>Spatial coregistration validation analyses</title><p>As the visual cortex of the blind shows some anatomical differences from that of the sighted in terms of grey matter and white matter integrity (<xref rid="awv083-B75" ref-type="bibr">Noppeney <italic>et al.</italic>, 2005</xref>; <xref rid="awv083-B90" ref-type="bibr">Shimony <italic>et al.</italic>, 2006</xref>; <xref rid="awv083-B76" ref-type="bibr">Pan <italic>et al.</italic>, 2007</xref>), it may vary in size from that of sighted subjects (<xref rid="awv083-B18" ref-type="bibr">Butt <italic>et al.</italic>, 2013</xref>) because of deficient underlying white matter. Thus, to verify that our functional connectivity retinotopic organization findings were not affected by the specific choice of coregistration method, we conducted two additional lines of control analyses: an analysis using stringent spatial smoothing (spatial smoothing of 12 mm full-width at half-maximum Gaussian kernel) to help align the functional data across the subjects (<ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 4</ext-link>), and a surface-based alignment across the subjects according to their cortical curvature (sulcus and gyrus) patterns (<ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 5</ext-link>), which is not affected by white matter volume differences. The curvature alignment across the subjects reached 100% subject overlap for most of the calcarine sulcus as well as other sulci, validating alignment success (<ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 5A</ext-link>). The topographic patterns of the visual cortex organization in the blind were evident in both these control analyses (<ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 5</ext-link> and <ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">6</ext-link>) to similar extents as in the main results.</p></sec><sec><title>Defining the location of category-selective visual areas and region of interest analysis</title><p>To localize the classical face (fusiform face area, FFA; <xref rid="awv083-B55" ref-type="bibr">Kanwisher <italic>et al.</italic>, 1997</xref>) and scene-selective (parahippocampal place area, PPA; <xref rid="awv083-B34" ref-type="bibr">Epstein and Kanwisher, 1998</xref>) visual areas, we conducted an additional visual localizer experiment on a separate group of seven normally sighted participants, using a standard visual localizer experiment (detailed in <xref rid="awv083-B93" ref-type="bibr">Striem-Amit <italic>et al.</italic>, 2012<italic>a</italic></xref>). Twelve images from one visual category were presented in each epoch; each image was presented for 800 ms and was followed by a 200 ms blank screen (similar to standard visual localizer experiments; <xref rid="awv083-B42" ref-type="bibr">Hasson <italic>et al.</italic>, 2003</xref>). The categories of stimuli were faces, houses, objects, letters, and textures. The FFA was defined as the peak group random-effect GLM activation cluster in the fusiform gyrus showing face selectivity when contrasting faces with all the other stimulus categories (<italic>P <</italic> 0.005, corrected). The PPA was similarly defined in the parahippocampal cortex according to the contrast houses versus all other categories (<italic>P <</italic> 0.05, corrected). GLM parameter estimators for the functional connectivity to the central and peripheral V1 were extracted for each of the groups (<xref ref-type="fig" rid="awv083-F3">Fig. 3</xref>). A <italic>t</italic>-test was used to compare GLM parameter estimators for the two V1-subparts within each group (corrected for multiple comparisons), and an overall ANOVA was conducted computing the effects of group, eccentricity hemisphere and region (FFA, PPA) as well as their interactions.
<fig id="awv083-F3" position="float"><label>Figure 3</label><caption><p><bold>Eccentricity bias as an organizing principle for human high-order object areas in the blind.</bold> The eccentricity preference of the FFA (marked in pink on the unfolded cortical sheets) and PPA (marked in blue; both defined using an external visual localizer in a normally sighted group) were computed using the functional connectivity MRI GLM parameter estimator, revealing the known bias for central visual field connectivity (in red bars) in the FFA and peripheral visual field connectivity (in blue bars) in the PPA in the blind. Error bars refer to SEM. LH = left hemisphere; RH = right hemisphere.</p></caption><graphic xlink:href="awv083f3p"></graphic></fig></p></sec></sec><sec sec-type="results"><title>Results</title><p>Functional connectivity was computed for <italic>a priori</italic> defined seed regions of interest located in the primary visual cortex (V1) using a separate standard task-based retinotopic mapping localizer (<xref rid="awv083-B102" ref-type="bibr">Wandell <italic>et al.</italic>, 2007<italic>a</italic></xref>) in a separate group of normally sighted controls (<italic>n =</italic> 14). Regions of interest divided V1 (<xref ref-type="fig" rid="awv083-F1">Fig. 1</xref>A) according to eccentricity (responses to central and peripheral visual fields), laterality (left and right visual fields) and elevation (top and bottom visual fields). Individual average time courses from each seed region of interest were extracted and <italic>z</italic>-normalized. In each complementing pair of visual field parts (e.g. central and peripheral visual field) each time course (e.g. central visual field) was used as an individual predictor in a separate group analysis using a GLM in a hierarchical random effects analysis (<xref rid="awv083-B38" ref-type="bibr">Friston <italic>et al.</italic>, 1999</xref>), while regressing out the time course from the other seed (e.g. peripheral visual field), so as to minimize the common (correlated) components (<ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 1</ext-link>; i.e. partial correlation mapping; <xref rid="awv083-B113" ref-type="bibr">Zhang <italic>et al.</italic>, 2008</xref>; <xref rid="awv083-B119" ref-type="bibr">Margulies <italic>et al.</italic>, 2010</xref>). We then used this approach to investigate retinotopic organization functional connectivity in multiple levels and analyses. These included group random effect GLM analyses (<xref ref-type="fig" rid="awv083-F1">Fig. 1</xref>), single subject analyses and across-subject consistency (<xref ref-type="fig" rid="awv083-F2">Fig. 2</xref>), as well as a quantification of the similarity between the single subjects across the groups using an independent clustering analysis. Analyses were conducted at both the whole-brain level (<xref ref-type="fig" rid="awv083-F1">Figs 1</xref> and <xref ref-type="fig" rid="awv083-F2">2</xref>) and region of interest approaches (<xref ref-type="fig" rid="awv083-F3">Fig. 3</xref>). A separate analysis was done in a subgroup of the blind who had experienced a malfunction in eye development, and who in addition to the absence of post-natal visual experience also did not have typical <italic>in utero</italic> visual development (<xref ref-type="fig" rid="awv083-F4">Fig. 4</xref>). Furthermore, we compared between the groups on a seed-by-seed basis (<xref ref-type="fig" rid="awv083-F5">Fig. 5</xref>).
<fig id="awv083-F4" position="float"><label>Figure 4</label><caption><p><bold>Resting-state functional connectivity MRI retinotopic organization with abnormal prenatal eye development.</bold> (<bold>A</bold>) Resting-state functional connectivity MRI retinotopic organization is shown in a subgroup of microphthalmic subjects, whose eyes did not develop properly (<italic>n</italic> = 4). This group still shows a similar pattern of visual cortex arrangement, replicating the known retinotopic organization in the absence of normal prenatal visual experience. (<bold>B</bold>) A subgroup of subjects blinded postnatally due to retinopathy of prematurity of similar group size (<italic>n</italic> = 5) showed effects qualitatively comparable to the microphthalmic subjects. cVF <bold>=</bold> visual field<bold>;</bold> pVF <bold>=</bold> peripheral visual field<bold>;</bold> lVF <bold>=</bold> left visual field<bold>;</bold> rVF <bold>=</bold> right visual field<bold>;</bold> tVF <bold>=</bold> top visual field<bold>;</bold> bVF <bold>=</bold> bottom visual field.</p></caption><graphic xlink:href="awv083f4p"></graphic></fig><fig id="awv083-F5" position="float"><label>Figure 5</label><caption><p><bold>Functional connectivity MRI patterns of group differences across V1 retinotopic functional portions.</bold> To study the effect of blindness on the functional connectivity (FC) of different parts of V1, a contrast between the groups is presented for each seed (<bold>A</bold>, central V1; <bold>B</bold>, peripheral V1; without applying partial correlations) along the eccentricity axis (for a similar comparison along laterality and elevation see <ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 6</ext-link>) as well as the overlay of each complementary seed pair (<bold>C</bold>). While the within-visual-cortex pattern is generally similar in both seeds, different parts of V1 of the blind show altered functional connectivity to other non-visual cortices, especially in the frontal lobe, as compared to the sighted. CS = central sulcus; LS = lateral sulcus; STS = superior temporal sulcus; IFG = inferior frontal gyrus.</p></caption><graphic xlink:href="awv083f5p"></graphic></fig></p><sec><title>Group retinotopic organization functional connectivity MRI analysis</title><p>Resting-state funtional connectivity MRI random effect GLM analysis in the sighted control group replicated to a large extent the well-known retinotopic organization observed during task-based retinotopic phase mapping. We found robust connectivity to the central visual field in the occipital pole and the peripheral visual field in the anterior visual cortex extending well beyond V1 (<xref ref-type="fig" rid="awv083-F1">Fig. 1</xref>B). We also found a gross division of the visual cortex into its left and right halves in their connectivity pattern to the right visual field and left visual field, respectively (<xref ref-type="fig" rid="awv083-F1">Fig. 1</xref>B). Furthermore, we found a division to the upper and lower halves of visual cortex in connectivity to the bottom visual field and top visual field, respectively (<xref ref-type="fig" rid="awv083-F1">Fig. 1</xref>B). These results support the validity of using functional connectivity analysis based on external group retinotopic seed regions of interest as a technique to map the organization within the visual cortex in the blind.</p><p>Importantly, the functional connectivity MRI random effect GLM analysis revealed an identical functional division of the visual cortex in the congenitally blind group, replicating the full extent of the visual cortex organization pattern according to the eccentricity, laterality and elevation divisions of labour (<xref ref-type="fig" rid="awv083-F1">Fig. 1</xref>C). This was found despite the known general reduction of functional connectivity of the early visual cortex to other parts of the brain of the blind (see <ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 2</ext-link> depicting a one region of interest seed functional connectivity analysis from the whole V1, as shown previously; <xref rid="awv083-B64" ref-type="bibr">Liu <italic>et al.</italic>, 2007</xref>; <xref rid="awv083-B112" ref-type="bibr">Yu <italic>et al.</italic>, 2008</xref>; <xref rid="awv083-B105" ref-type="bibr">Wang <italic>et al.</italic>, 2013</xref>; <xref rid="awv083-B16" ref-type="bibr">Burton <italic>et al.</italic>, 2014</xref>; <xref rid="awv083-B81" ref-type="bibr">Qin <italic>et al.</italic>, 2014</xref>: reviewed in <xref rid="awv083-B12" ref-type="bibr">Bock and Fine, 2014</xref>). This connectivity-based organization according to retinotopic principles extended from our seed regions of interest in V1 throughout the classical retinotopic cortex and continued to the high-order visual cortex. It extended as far as the intraparietal sulcus in the dorsal stream and the fusiform and parahippocampal gyrus in the ventral stream.</p></sec><sec sec-type="subjects"><title>Cross-subject consistency of retinotopic patterns in the blind</title><p>We further examined the consistency of this visual cortex functional connectivity topographical structure across the blind participants. We computed the functional connectivity statistical parametric map of visual field part activations in each of the subjects and plotted the cross-subject overlap probability map over all the individual subjects in the blind group (<xref ref-type="fig" rid="awv083-F2">Fig. 2</xref>A and <ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 3A</ext-link>) and sighted group (<xref ref-type="fig" rid="awv083-F2">Fig. 2</xref>B and <ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 3B</ext-link>). The retinotopic mapping principles of eccentricity, laterality and elevation in the visual field were also replicated across a large majority of the subjects (see <ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 3</ext-link> for overlaid maps of the blind and sighted), as well as at the individual blind participant level (<xref ref-type="fig" rid="awv083-F2">Fig. 2</xref>C). These findings were also replicated using alignment measures to correct for the potential size difference of the visual cortex of the blind. This included applying stringent spatial smoothing (with a 12 mm full-width at half-maximum Gaussian; <ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 4</ext-link>) to overcome intersubject variability, and aligning the data using cortex-based surface alignment rather than volume alignment (<ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 5</ext-link>).</p><p>Furthermore, we tested for fundamental differences between the blind and sighted subjects’ functional connectivity MRI retinotopic patterns by inspecting whether a k-means clustering analysis (<xref rid="awv083-B65" ref-type="bibr">MacKay, 2003</xref>) could clearly divide the functional connectivity maps of the subjects according to their group (with and without visual experience). First, we examined whether the algorithm would divide the maps according to the seed from which they were computed, or whether it would divide them according to the subjects’ sight status. The algorithm performed perfectly in clustering all the subjects’ eccentricity maps according to seed: it placed all the central visual field maps in one group and all the peripheral visual field in the other, regardless of whether the map belonged to a blind or sighted subject. It similarly flawlessly divided maps according to laterality and elevation principles (each tested separately). Critically, we tested what would happen when the algorithm was presented with the entire data set of maps grouped by subject (i.e. map data vectors from the six different seeds concatenated per subject), in which the only obvious source of grouping would be the visual experience. In this case it generated one cluster combining all the blind subjects with most (all but one) of the sighted subjects, and placed only one sighted subject in the second cluster, rather than generating a distinct cluster for each group. Furthermore, running the clustering analysis without this potential sighted outlier subject, again generated a cluster containing all the blind and most of the sighted in one cluster, and two other sighted subjects in another cluster. Thus, the intersubject variability in the sighted group appears to have been larger than the difference between the groups at the single-subject level, making the retinotopic organization functional connectivity patterns indistinguishable between the blind and sighted.</p><p>To quantify the spatial similarity between the blind and sighted retinotopic organizations we further computed the concordance correlation coefficient between the group maps (<xref rid="awv083-B63" ref-type="bibr">Lin, 1989</xref> and see above). Highly significant concordance values were observed for all the retinotopic division maps (for all maps concordance correlation coefficient > 0.39, <italic>P <</italic> 0.001; see <ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Table 2</ext-link> for details). Thus, the visual retinotopic functional connectivity networks were comparable to those of the sighted, even in the absence of any visual experience or light perception.</p></sec><sec><title>Eccentricity bias in high-order object areas in the blind</title><p>The retinotopic organization in the functional connectivity maps appeared to extend far beyond the early visual cortex. To investigate whether the blind visual cortex functional connectivity MRI retinotopy principles applied in the same way to high-order visual cortex areas, we inspected the eccentricity bias in two areas (localized in a separate visual localizer experiment) (<xref rid="awv083-B93" ref-type="bibr">Striem-Amit <italic>et al.</italic>, 2012<italic>a</italic></xref>; see marked portions in <xref ref-type="fig" rid="awv083-F3">Fig. 3</xref>) which show opposite trends in the sighted according to their visual functional roles. The FFA (<xref rid="awv083-B55" ref-type="bibr">Kanwisher <italic>et al.</italic>, 1997</xref>) normally shows a preference towards foveal representations that is related to the need for high-resolution vision during face processing (<xref rid="awv083-B43" ref-type="bibr">Hasson <italic>et al.</italic>, 2002</xref>), and the PPA (<xref rid="awv083-B34" ref-type="bibr">Epstein and Kanwisher, 1998</xref>) shows peripheral visual field biases (<xref rid="awv083-B61" ref-type="bibr">Levy <italic>et al.</italic>, 2001</xref>), presumably because scenes used in navigation are recognized at a coarser level and require large-scale integration of features. These two areas normally fall on either side of the retinotopic border (<xref rid="awv083-B43" ref-type="bibr">Hasson <italic>et al.</italic>, 2002</xref>); thus their preference can also be used to estimate similarity in retinotopy border locations between groups. The functional connectivity preferences of these regions were assessed using an ANOVA with four main effects: group (blind/sighted), cortical region (FFA/PPA), eccentricity (centre/periphery) and hemisphere (right hemisphere/left hemisphere). Significant effects for cortical region (F = 9.033, <italic>P <</italic> 0.01), eccentricity (F = 5.171, <italic>P <</italic> 0.05) and hemisphere (F = 4.703, <italic>P <</italic> 0.05) were found, as well as significant interactions between cortical region × hemisphere (F = 7.74, <italic>P <</italic> 0.01) and importantly, also between the cortical region × eccentricity (F = 17.97, <italic>P <</italic> 0.001) indicating that indeed the FFA and PPA differ in their eccentricity functional connectivity preferences. Group effects were neither found in the main effect nor in any interaction (<ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Table 3</ext-link>), again suggesting that the blind pattern of functional connectivity was similar to that of the normally sighted. Furthermore, we directly investigated the effects within each region of interest in the blind using <italic>post hoc t</italic>-tests (corrected for multiple comparisons). The functional connectivity between the time courses of the FFA and central V1 was significant (<italic>t</italic> = 3.32 <italic>P <</italic> 0.01 and <italic>t</italic> = 5.18 <italic>P <</italic> 0.0005 for the left and right FFA, respectively), and significantly stronger than the functional connectivity between the peripheral V1 and FFA (<italic>t</italic> = 3.28 <italic>P <</italic> 0.005 and <italic>t</italic> = 4.41 <italic>P <</italic> 0.0005 for the left and right FFA, respectively). The reverse pattern was observed in the PPA, as the functional connectivity between the PPA and peripheral V1 was significant (<italic>t</italic> = 4.66 <italic>P <</italic> 0.001 and <italic>t</italic> = 3.33 <italic>P <</italic> 0.01 for the left and right PPA, respectively; <xref ref-type="fig" rid="awv083-F3">Fig. 3</xref>) and significantly stronger than the PPA-central V1 functional connectivity (<italic>t</italic> = 5.80 <italic>P <</italic> 0.0001 and <italic>t</italic> = 4.79 <italic>P <</italic> 0.0001 for the left and right PPA, respectively). Therefore, the characteristic eccentricity biases pattern for the FFA and PPA were also evident in the absence of vision.</p></sec><sec><title>The role of typical prenatal development in retinotopic organization</title><p>Our results show that post-natal visual experience is not required for the creation and maintenance of macro-scale retinotopic organization. But to what extent is typical pre-natal visual experience necessary? To provide a preliminary investigation, we examined the visual cortex organization in the subgroup of subjects suffering from microphthalmia, a developmental deficiency in eye development that leads to the development of smaller (and in this case non-functional) eyes. Despite the reduced group size (<italic>n =</italic> 4), functional connectivity MRI retinotopy seed analysis indicated retention of the functional division of the cortical visual fields along the eccentricity, laterality and elevation axes throughout large portions of the visual cortex (<xref ref-type="fig" rid="awv083-F4">Fig. 4</xref>A). This organization was not qualitatively different from that of a subgroup of participants suffering from retinopathy of prematurity whose visual system developed typically <italic>in utero</italic> but were injured due to postnatal oxygen treatment, being born prematurely (<xref ref-type="fig" rid="awv083-F4">Fig. 4</xref>B; <italic>n =</italic> 5).</p></sec><sec><title>Plasticity in relation to retinotopic divisions</title><p>Our findings thus suggest that there are surprising similarities in the within-visual cortex organization of the blind and sighted. Are there also significant differences in visual cortex functional connectivity to other parts of the brain, due to life-long blindness, that are specific to retinotopically-defined segments of the visual cortex? Or is the original structure of visual field parts irrelevant to the plasticity pattern later emerging in the visual cortex in blindness? One distinct difference between visual field cortical organizations is found in the visual cortex areas related to the foveal and peripheral visual fields. For example, the peripheral V1 segment in the normally sighted shows anatomical connectivity to the auditory cortices and recruitment due to auditory attention (<xref rid="awv083-B32" ref-type="bibr">Eckert <italic>et al.</italic>, 2008</xref>; <xref rid="awv083-B25" ref-type="bibr">Cate <italic>et al.</italic>, 2009</xref>; <xref rid="awv083-B8" ref-type="bibr">Beer <italic>et al.</italic>, 2011</xref>). Does this lead to different patterns of functional connectivity MRI in the blind? To assess this we compared the functional connectivity MRI of the blind and sighted groups separately in the central visual field seed and peripheral visual field seed (<xref ref-type="fig" rid="awv083-F5">Fig. 5</xref>). We found that group differences within the visual cortex were generally similar across these two V1 segments (see <xref ref-type="fig" rid="awv083-F5">Fig. 5</xref>C and <ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 2</ext-link>). However, different parts of V1 of the blind showed altered functional connectivity to other non-visual cortices, as compared to the sighted. Specifically, both portions of V1 of the blind showed reduced functional connectivity to the somatosensory and auditory cortices and increased connectivity to some portions of the lateral occipito-temporal cortex and inferior frontal lobe, as was previously reported (<xref rid="awv083-B64" ref-type="bibr">Liu <italic>et al.</italic>, 2007</xref>; <xref rid="awv083-B112" ref-type="bibr">Yu <italic>et al.</italic>, 2008</xref>; <xref rid="awv083-B105" ref-type="bibr">Wang <italic>et al.</italic>, 2013</xref>; <xref rid="awv083-B12" ref-type="bibr">Bock and Fine, 2014</xref>; <xref rid="awv083-B16" ref-type="bibr">Burton <italic>et al.</italic>, 2014</xref>). However, the different parts of V1 were functionally connected to different areas within the frontal lobe: the central V1 showed increased functional connectivity to the inferior frontal gyrus (mostly the pars triangularis, stronger on the left, near Broca’s area) whereas the peripheral V1 showed stronger functional connectivity to the dorsolateral prefrontal cortex, in the inferior frontal sulcus and middle frontal gyrus (also strongly left lateralized) and also to the posterior temporal lobe (posterior superior temporal sulcus and middle temporal gyrus). A similar comparison of both the laterality and elevation axes (<ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 6</ext-link>) showed a general pattern of increased segregation between functional networks of complementary parts of the primary visual cortex. Areas showing increased functional connectivity to the left hemisphere V1 as compared to the sighted (e.g. the left inferior frontal sulcus, the left retinotopic areas and the right auditory cortex) showed decreased functional connectivity to the right hemisphere V1 (whereas the reverse pattern was found in the right anterior frontal lobe). Areas showing increased functional connectivity to the upper part of V1 as compared to the sighted showed decreased functional connectivity to the lower part of V1 (both within the visual cortex and beyond it, in the right parietal lobe and left frontal lobe). Therefore, alongside the overall robust similarities between the visual cortex organizations between the two groups, the blind also displayed a pattern of plasticity which was uniquely altered for different portions of the visual cortex.</p></sec><sec><title>Functional connectivity MRI border analysis in the visual cortex of the blind</title><p>Our findings reveal the retention of the supra-areal retinotopic-principle organization (<xref rid="awv083-B14" ref-type="bibr">Buckner and Yeo, 2014</xref>), in which, for example, the eccentricity axis differences span V1 and its neighbouring extrastriate areas with no clear border between visual areas. But can functional connectivity also reveal areal borders in the blind, such as the V1-V2 border, as was recently shown in the sighted (<xref rid="awv083-B107" ref-type="bibr">Wig <italic>et al.</italic>, 2014</xref>)? To test this directly, we compared the connectivity pattern from a seed in V1 with that of a seed in the same visual field in V2 (both in the ventral left central visual areas; <xref ref-type="fig" rid="awv083-F6">Fig. 6</xref>A). Interestingly, while the entire ventral border between V1 and V2 could be constructed using such functional connectivity maps through both group random effect GLM analysis and inter-subject consistency measures, (<xref ref-type="fig" rid="awv083-F6">Fig 6</xref>C and D; compare to Brodmann area definitions <xref ref-type="fig" rid="awv083-F6">Fig. 6</xref>B), the dorsal border was not clearly visible (also when using dorsal V1 and V2 seeds; <ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 7</ext-link>). This may partly correspond to the decreased functional connectivity seen in the blind between the ventral aspect of V1 and the dorsal visual cortices (present in the group differences in the analysis of elevation; <ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 6</ext-link>). Alternatively, this may be ascribed to substantial areal organization differences. Thus, although the supra-areal organization appears to be preserved to a great extent in blindness, the areal borders themselves are not fully retained.
<fig id="awv083-F6" position="float"><label>Figure 6</label><caption><p><bold>Mapping the boundary between Brodmann areas 17 and 18 using functional connectivity MRI in the blind.</bold> (<bold>A</bold>) To reveal the boundary between Brodmann areas 17 and 18 we sampled two seeds, in comparable visual field locations, in ventral areas V1 and V2 defined retinotopically in the sighted group using visual stimuli (see ‘Materials and methods’ section). (<bold>B</bold>) Anatomical Brodmann areas 17 and 18 are displayed confirming our seed locations from an external atlas. (<bold>C</bold>) Group functional connectivity partial correlation analysis in the congenitally blind (random effect GLM) reflected the V1-V2 distinction along the entire ventral areal border. Overlaid black line shows the Brodmann area border. (<bold>D</bold>) Similar findings are shown in the intersubject consistency analysis (probability map showing the overlap of the functional connectivity MRI maps across the blind subjects).</p></caption><graphic xlink:href="awv083f6p"></graphic></fig></p></sec></sec><sec sec-type="discussion"><title>Discussion</title><p>Functional connectivity MRI measures have been used to reveal the effects of visual deprivation (<xref rid="awv083-B64" ref-type="bibr">Liu <italic>et al.</italic>, 2007</xref>; <xref rid="awv083-B112" ref-type="bibr">Yu <italic>et al.</italic>, 2008</xref>; <xref rid="awv083-B18" ref-type="bibr">Butt <italic>et al.</italic>, 2013</xref>; <xref rid="awv083-B105" ref-type="bibr">Wang <italic>et al.</italic>, 2013</xref>; <xref rid="awv083-B16" ref-type="bibr">Burton <italic>et al.</italic>, 2014</xref>; <xref rid="awv083-B81" ref-type="bibr">Qin <italic>et al.</italic>, 2014</xref>) throughout the sensory and multisensory cortices (<xref rid="awv083-B101" ref-type="bibr">Wallace <italic>et al.</italic>, 2006</xref>; <xref rid="awv083-B21" ref-type="bibr">Carriere <italic>et al.</italic>, 2007</xref>). Here, we largely replicated these results (<ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 2</ext-link>) but crucially, we used the new partial correlation approach with retinotopic-based seeds to investigate the retention of retinotopic organization in the visual cortex of the blind, which is not otherwise accessible non-invasively. Our findings suggest that postnatal visual experience is not necessary for at least certain levels of retinotopic large-scale functional connectivity to emerge, and to be retained throughout life, in humans.</p><sec><title>Retention of functional organization in the visual cortex of the blind</title><p>These results strengthen other findings from our and several other groups in recent years that showed that some high-order areas of visual cortex of the early-onset blind retain the functional organization (for a specific object category or task) of the normally developing visual cortex, albeit via other modalities (<xref rid="awv083-B79" ref-type="bibr">Pietrini <italic>et al.</italic>, 2004</xref>; <xref rid="awv083-B67" ref-type="bibr">Mahon <italic>et al.</italic>, 2009</xref>; <xref rid="awv083-B59" ref-type="bibr">Ptito <italic>et al.</italic>, 2009</xref>; <xref rid="awv083-B86" ref-type="bibr">Renier <italic>et al.</italic>, 2010</xref>; <xref rid="awv083-B23" ref-type="bibr">Collignon <italic>et al.</italic>, 2011, 2013</xref>; <xref rid="awv083-B7" ref-type="bibr">Bedny and Saxe, 2012</xref>; <xref rid="awv083-B84" ref-type="bibr">Reich <italic>et al.</italic>, 2012</xref>; <xref rid="awv083-B93" ref-type="bibr">Striem-Amit <italic>et al.</italic>, 2012<italic>a</italic></xref>, <xref rid="awv083-B94" ref-type="bibr"><italic>b</italic></xref>; <xref rid="awv083-B4" ref-type="bibr">Arnott <italic>et al.</italic>, 2013</xref>; <xref rid="awv083-B44" ref-type="bibr">He <italic>et al.</italic>, 2013</xref>; <xref rid="awv083-B56" ref-type="bibr">Kitada <italic>et al.</italic>, 2013</xref>; <xref rid="awv083-B77" ref-type="bibr">Peelen <italic>et al.</italic>, 2014</xref>; <xref rid="awv083-B92" ref-type="bibr">Striem-Amit and Amedi, 2014</xref>). There have only been a few attempts to investigate whether the general notion of functional organization retention extends to early visual processing stations. One such study reported contralateral activations in a single early-onset blind echo-locating expert (<xref rid="awv083-B97" ref-type="bibr">Thaler <italic>et al.</italic>, 2011</xref>). More recently, two highly relevant studies investigated in depth the fine-scale organization of V1 in blind and sighted subjects; one using resting state connectivity (in a heterogeneous mix of congenital and late-onset, acquired blindness; <xref rid="awv083-B18" ref-type="bibr">Butt <italic>et al.</italic>, 2013</xref>), and the other inspecting the anatomical connectivity in the corpus callosum splenium connecting the bilateral V1 (<xref rid="awv083-B13" ref-type="bibr">Bock <italic>et al.</italic>, 2013</xref>). Both studies found a surprising level of preservation of connectivity patterns in blindness at the level of V1. Remarkably, even anopthalmic subjects (in which the input from the optic nerves to the thalamus and midbrain never existed or only existed temporarily; <xref rid="awv083-B122" ref-type="bibr">Stevenson and Hall, 2005</xref>), the corpus callosum splenium volume, diffusivity and overall topographic organization of fibres connecting bilateral V1 were retained (<xref rid="awv083-B13" ref-type="bibr">Bock <italic>et al.</italic>, 2013</xref>). Our study is consistent in general with these studies, and expands upon them and for the first time reports the functional connectivity preservation of all three axes of retinotopic organization further beyond V1 even in the absence of visual input during early development (and to some extent even without normal prenatal development, in the microphthalmics). We show that these crucial functional properties can be found in the organization of the most critical early stations of the visual cortex hierarchy, and moreover, that these span the entire visual system from early retinotopic areas such as V1/V2 to object-related FFA and PPA. Furthermore, as functional connectivity attests not only to direct anatomical connectivity but is also affected by use-dependent plasticity, it is even more surprising that it retains some form of topographical organization in the full and life-long absence of visual experience and in the presence of cross-modal plasticity.</p></sec><sec><title>Mechanisms contributing to the development of retinotopic maps in the blind</title><p>The emergence of the retinotopic network may be due to a combination of mechanisms that are not experience-dependent, and take place prior to birth. These may be activity-independent topographically specific molecular factors (e.g. the combination of EphA-ephrin-A signalling in the cortex; <xref rid="awv083-B35" ref-type="bibr">Espinosa and Stryker, 2012</xref>) and activity-dependent effects of spontaneous retinal waves, coordinated waves of spontaneous activity, which sweep across the retina pre-natally, causing spatiotemporal patterns of neural activity to propagate forward in the visual system (<xref rid="awv083-B35" ref-type="bibr">Espinosa and Stryker, 2012</xref>). Our findings show that these are sufficient to drive and maintain the organization of macro-scale cortical maps (<xref rid="awv083-B66" ref-type="bibr">McLaughlin <italic>et al.</italic>, 2003</xref>; <xref rid="awv083-B20" ref-type="bibr">Cang <italic>et al.</italic>, 2005</xref>; <xref rid="awv083-B52" ref-type="bibr">Huberman <italic>et al.</italic>, 2008</xref>; <xref rid="awv083-B19" ref-type="bibr">Cang and Feldheim, 2013</xref>; <xref rid="awv083-B1" ref-type="bibr">Ackman and Crair, 2014</xref>) even in the absence of later patterned vision or light perception.</p><p>To what extent is the large-scale retinotopic organization we observed here dependent upon prenatal retinal waves (<xref rid="awv083-B111" ref-type="bibr">Xu <italic>et al.</italic>, 2011</xref>)? Can it develop fully based on other developmental topographically-specific molecular mechanisms that are not functionally or activity-dependent (<xref rid="awv083-B35" ref-type="bibr">Espinosa and Stryker, 2012</xref>; <xref rid="awv083-B85" ref-type="bibr">Reid, 2012</xref>)? It would be interesting to examine retinotopic functional connectivity in anopthalmic patients that do not develop retinas at all in order to address the necessity of this mechanism. In a preliminary attempt to investigate this question, we showed here that a small group of microphthalmic congenitally blind individuals (<italic>n =</italic> 4), who do not develop a full-sized functional retina (and in our case did not develop any functional vision) still possess a relatively retained retinotopic functional connectivity pattern (<xref ref-type="fig" rid="awv083-F4">Fig. 4</xref>). Future studies with larger cohorts of fully anophthalmic blind participants may help assess whether this pattern emerges without any prenatal retinal activity. In any case, our findings of an intact large-scale topographic visual organization are not sufficient in themselves, to allow for functional sight restoration. Large-scale topographic patterns do not imply that finer-scale organization or experience-dependent mechanisms, which are necessary for the development of useful vision, such as those relevant for the creation, maintenance and refinement of binocular ocular dominance organization or orientation selectivity (<xref rid="awv083-B47" ref-type="bibr">Lewis and Maurer, 2005</xref>; <xref rid="awv083-B35" ref-type="bibr">Espinosa and Stryker, 2012</xref>; <xref rid="awv083-B60" ref-type="bibr">Levelt and Hübener, 2012</xref>; <xref rid="awv083-B70" ref-type="bibr">Maurer and Hensch, 2012</xref>; <xref rid="awv083-B85" ref-type="bibr">Reid, 2012</xref>) are present or inducible in the congenitally blind (<xref rid="awv083-B87" ref-type="bibr">Renier <italic>et al.</italic>, 2014</xref>). Such fine-tuning, which is required for functional useful vision, still depends on intact sensory experience and pattern vision during a sequence of hyper-plastic critical developmental periods (<xref rid="awv083-B78" ref-type="bibr">Penn and Shatz, 1999</xref>; <xref rid="awv083-B45" ref-type="bibr">Hensch, 2005</xref>; <xref rid="awv083-B47" ref-type="bibr">Lewis and Maurer, 2005</xref>; <xref rid="awv083-B9" ref-type="bibr">Bengoetxea <italic>et al.</italic>, 2012</xref>; <xref rid="awv083-B35" ref-type="bibr">Espinosa and Stryker, 2012</xref>; <xref rid="awv083-B124" ref-type="bibr">Voss, 2013</xref>; but see also <xref rid="awv083-B54" ref-type="bibr">Kalia <italic>et al.</italic>, 2014</xref>). However, this hyperplasticity may be made possible even in adulthood via molecular manipulations which reopen critical-period development opportunities based on the principles naturally occurring in critical periods and following brain injury (e.g. excitatory-inhibitory balance) (<xref rid="awv083-B5" ref-type="bibr">Bavelier <italic>et al.</italic>, 2010</xref>; <xref rid="awv083-B58" ref-type="bibr">Kuhlman <italic>et al.</italic>, 2013</xref>; <xref rid="awv083-B120" ref-type="bibr">Nahmani and Turrigiano, 2014</xref>). Furthermore, extending the critical period and adult plasticity can also be aided through modifications of sensory input (such as delayed exposure to light) or sensory-motor interactions (<xref rid="awv083-B31" ref-type="bibr">Duffy and Mitchell, 2013</xref>; <xref rid="awv083-B46" ref-type="bibr">Hübener and Bonhoeffer, 2014</xref>), which may also have contributed to recently reported cases of developing pattern vision following early-onset blindness (<xref rid="awv083-B54" ref-type="bibr">Kalia <italic>et al.</italic>, 2014</xref>).</p></sec><sec><title>The balance between plasticity and retained organization in the blind: division of labour within V1?</title><p>Our findings are not contradictory, but rather complementary, to previous findings of reduced overall functional connectivity of the visual cortex of the blind (also replicated in our data, see <ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 2</ext-link>; <xref rid="awv083-B64" ref-type="bibr">Liu <italic>et al.</italic>, 2007</xref>; <xref rid="awv083-B112" ref-type="bibr">Yu <italic>et al.</italic>, 2008</xref>; <xref rid="awv083-B105" ref-type="bibr">Wang <italic>et al.</italic>, 2013</xref>; <xref rid="awv083-B16" ref-type="bibr">Burton <italic>et al.</italic>, 2014</xref>; <xref rid="awv083-B81" ref-type="bibr">Qin <italic>et al.</italic>, 2014</xref>). Partial correlation analysis regresses out the joint variance of visual areas, by systematically ignoring the connectivity changes which are common to all visual areas so as to focus on the internal structural features of the visual cortex. While we found that the internal structural organization of the visual cortex seems intact, its integration with other sensory cortices to form multisensory integration is likely to differ due to the lack of visual input (<xref rid="awv083-B50" ref-type="bibr">Hotting <italic>et al.</italic>, 2004</xref>; <xref rid="awv083-B21" ref-type="bibr">Carriere <italic>et al.</italic>, 2007</xref>). In fact, in a direct comparison of the blind and sighted subjects we found that not only were there differences due to life-long blindness as reported previously (<ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 2</ext-link>), but that blindness affects the central visual field part of V1 differently from the peripheral part (<xref ref-type="fig" rid="awv083-F5">Fig. 5</xref>), where each segment connects more strongly to different areas in the frontal and temporal cortices. Central V1 showed increased functional connectivity to the left-lateralized inferior frontal gyrus pars triangularis near Broca’s area whereas peripheral V1 showed stronger functional connectivity to the dorsolateral prefrontal cortex, and also to the posterior temporal lobe. These differences might be related to the two apparently conflicting roles generally attributed to the early visual cortex of the congenitally blind: high-order cognitive functions such as language processing on one hand (<xref rid="awv083-B15" ref-type="bibr">Burton <italic>et al.</italic>, 2003</xref>; <xref rid="awv083-B2" ref-type="bibr">Amedi <italic>et al.</italic>, 2004</xref>; <xref rid="awv083-B6" ref-type="bibr">Bedny <italic>et al.</italic>, 2011</xref>) and non-visual spatial (and also non-spatial) attention on the other (<xref rid="awv083-B116" ref-type="bibr">Gougoux <italic>et al.</italic>, 2005</xref>; <xref rid="awv083-B115" ref-type="bibr">Garg <italic>et al.</italic>, 2007</xref>; <xref rid="awv083-B23" ref-type="bibr">Collignon <italic>et al.</italic>, 2011, 2013</xref>). This conflict also manifested in the seemingly counterintuitive functional connectivity pattern of enhanced functional connectivity to multiple unrelated areas of the frontal lobe with no apparent selectivity when larger seed areas of visual cortex are considered in the blind (<xref rid="awv083-B12" ref-type="bibr">Bock and Fine, 2014</xref>) despite the task-selective responses shown in multiple visual areas (<xref rid="awv083-B84" ref-type="bibr">Reich <italic>et al.</italic>, 2012</xref>). These two different functional roles may simply be accounted for by two different segments of V1, which differ in the plasticity of their network properties as shown here. Such differences may also be carried over to higher order areas depending on their eccentricity biases, such as the lateral occipital cortex, which was also shown to be functionally connected to frontal language regions in the blind (<xref rid="awv083-B6" ref-type="bibr">Bedny <italic>et al.</italic>, 2011</xref>; <xref rid="awv083-B106" ref-type="bibr">Watkins <italic>et al.</italic>, 2012</xref>). While direct connectivity between language areas and V1 in normally sighted people is not evident normally in adulthood, functional connectivity may reflect indirect connections existing in the sighted as well, or connectivity patterns unique to the blind (<xref rid="awv083-B3" ref-type="bibr">Amedi <italic>et al.</italic>, 2003</xref>; <xref rid="awv083-B6" ref-type="bibr">Bedny <italic>et al.</italic>, 2011</xref>). In contrast, there is ample evidence that peripheral V1 is also connected to non-visual cortices and responds to auditory information and attention in sighted people (<xref rid="awv083-B32" ref-type="bibr">Eckert <italic>et al.</italic>, 2008</xref>; <xref rid="awv083-B25" ref-type="bibr">Cate <italic>et al.</italic>, 2009</xref>; <xref rid="awv083-B8" ref-type="bibr">Beer <italic>et al.</italic>, 2011</xref>; <xref rid="awv083-B121" ref-type="bibr">Spierer <italic>et al.</italic>, 2013</xref>; <xref rid="awv083-B123" ref-type="bibr">Vetter <italic>et al.</italic>, 2014</xref>). Furthermore, previous studies have shown that the visual cortex is more strongly functionally connected to the fronto-parietal control network and ‘salience network’ in the blind (<xref rid="awv083-B105" ref-type="bibr">Wang <italic>et al.</italic>, 2013</xref>; <xref rid="awv083-B16" ref-type="bibr">Burton <italic>et al.</italic>, 2014</xref>). Here such changes were limited to the peripheral V1, possibly driving cross-modal attention plasticity. Thus, the division of V1 functional connectivity into segments according to eccentricity may help explain several non-converging lines of evidence regarding visual cortex organization and plasticity in the blind. The differences between the right and left hemispheres is consistent with previous findings of a functional connectivity disconnection between the two hemispheres (<xref rid="awv083-B18" ref-type="bibr">Butt <italic>et al.</italic>, 2013</xref>; <xref rid="awv083-B16" ref-type="bibr">Burton <italic>et al.</italic>, 2014</xref>), which may, as previously suggested, account for the greater spatial discrimination accuracy between non-visual inputs from the two sides of the sensory environment (<xref rid="awv083-B16" ref-type="bibr">Burton <italic>et al.</italic>, 2014</xref>). The significance of the differences between the upper and lower sections of the V1 hemispheres is harder to interpret, but may relate to the cross-modal use by the blind of the dorsal part for non-visual tasks (<xref rid="awv083-B29" ref-type="bibr">Dormal <italic>et al.</italic>, 2012</xref>), and the preference of the lower visual field and accordingly the upper visual cortex in such tasks (<xref rid="awv083-B27" ref-type="bibr">Danckert and Goodale, 2001</xref>). Relatedly, our finding of the retention of the V1-V2 areal border in the blind solely in the ventral aspect (<xref ref-type="fig" rid="awv083-F6">Fig. 6</xref>) may result from the decreased functional connectivity found in the blind between the ventral aspect of V1 and the dorsal visual cortices (<ext-link ext-link-type="uri" xlink:href="http://brain.oxfordjournals.org/lookup/suppl/doi:10.1093/brain/awv083/-/DC1">Supplementary Fig. 6</ext-link>). More speculatively, it may relate to a different areal organization in the blind, as has been shown in animal blindness models (<xref rid="awv083-B82" ref-type="bibr">Rakic <italic>et al.</italic>, 1991</xref>; <xref rid="awv083-B53" ref-type="bibr">Kahn and Krubitzer, 2002</xref>). Hence, our findings suggest that there is a balance between plasticity and retained organization in the visual cortex of the blind. During development, spontaneous activity within the visual system may create the inner visual structure and sustain it sufficiently despite the absence of functionally significant retinotopically-organized input. However, the differential connectivity of parts of the retinotopically organized visual cortex also corresponds, and may relay unique patterns of plasticity and reorganization in the absence of sight, due to usage-dependent plasticity (<xref rid="awv083-B117" ref-type="bibr">Dosenbach <italic>et al.</italic>, 2007</xref>; <xref rid="awv083-B36" ref-type="bibr">Fair <italic>et al.</italic>, 2007</xref>). Therefore, even the robust plasticity in the blind builds on the bases of the visually-derived organization and connectivity pattern, in that it is specific to portions of V1 divided according to retinotopic principles.</p><p>Overall, these findings suggest that the balance of experience-independence and critical developmental periods should be further tested and revisited, for both the early and higher-order sensory areas. This is reported here for the case of vision, and may apply also to other sensory modalities and domains, including hearing and language capabilities, as well as multisensory processes, which also represent a balance between experience-dependent and independent developmental processes (<xref rid="awv083-B73" ref-type="bibr">Moore and Shannon, 2009</xref>; <xref rid="awv083-B114" ref-type="bibr">Butler and Lomber, 2013</xref>; <xref rid="awv083-B57" ref-type="bibr">Kral, 2013</xref>; <xref rid="awv083-B62" ref-type="bibr">Lewkowicz, 2014</xref>). These findings stress the relevance of anatomical connectivity patterns and innate developmental constraints (<xref rid="awv083-B68" ref-type="bibr">Mahon and Caramazza, 2011</xref>) for even the most robust plasticity: that of the central V1 of the blind for language processes.</p></sec></sec></body><back><ack><title>Acknowledgements</title><p>We thank Sami Abboud, Uri Hertz, Fatma Imamoglu and Chris Filo Gorgolewski for helpful discussions.</p></ack><sec><title>Funding</title><p>This work was supported by a <funding-source>European Research Council</funding-source> grant (grant number <award-id>310809</award-id>; A.A.), <funding-source>The Gatsby Charitable Foundation</funding-source> (A.A.), <funding-source>The James S. McDonnell Foundation</funding-source> scholar award (grant number <award-id>220020284</award-id>; A.A.), <funding-source>The Israel Science Foundation</funding-source> (grant number <award-id>ISF 1684/08</award-id>; A.A.), <funding-source>The Edmond and Lily Safra Center for Brain Sciences (ELSC) Vision center</funding-source> grant (A.A.), the support of the <funding-source>Maratier family</funding-source> (A.A.), and the <funding-source>German Excellence Initiative Grant to the Berlin School of Mind and Brain</funding-source> (A.V.). 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(Land)</li><li>Île-de-France</li></region><settlement><li>Berlin</li><li>Leipzig</li></settlement></list><tree><country name="Israël"><noRegion><name sortKey="Striem Amit, Ella" sort="Striem Amit, Ella" uniqKey="Striem Amit E" first="Ella" last="Striem-Amit">Ella Striem-Amit</name></noRegion><name sortKey="Amedi, Amir" sort="Amedi, Amir" uniqKey="Amedi A" first="Amir" last="Amedi">Amir Amedi</name><name sortKey="Amedi, Amir" sort="Amedi, Amir" uniqKey="Amedi A" first="Amir" last="Amedi">Amir Amedi</name><name sortKey="Amedi, Amir" sort="Amedi, Amir" uniqKey="Amedi A" first="Amir" last="Amedi">Amir Amedi</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Striem Amit, Ella" sort="Striem Amit, Ella" uniqKey="Striem Amit E" first="Ella" last="Striem-Amit">Ella Striem-Amit</name></region><name sortKey="Caramazza, Alfonso" sort="Caramazza, Alfonso" uniqKey="Caramazza A" first="Alfonso" last="Caramazza">Alfonso Caramazza</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Ovadia Caro, Smadar" sort="Ovadia Caro, Smadar" uniqKey="Ovadia Caro S" first="Smadar" last="Ovadia-Caro">Smadar Ovadia-Caro</name></region><name sortKey="Margulies, Daniel S" sort="Margulies, Daniel S" uniqKey="Margulies D" first="Daniel S." last="Margulies">Daniel S. Margulies</name><name sortKey="Margulies, Daniel S" sort="Margulies, Daniel S" uniqKey="Margulies D" first="Daniel S." last="Margulies">Daniel S. Margulies</name><name sortKey="Ovadia Caro, Smadar" sort="Ovadia Caro, Smadar" uniqKey="Ovadia Caro S" first="Smadar" last="Ovadia-Caro">Smadar Ovadia-Caro</name><name sortKey="Villringer, Arno" sort="Villringer, Arno" uniqKey="Villringer A" first="Arno" last="Villringer">Arno Villringer</name><name sortKey="Villringer, Arno" sort="Villringer, Arno" uniqKey="Villringer A" first="Arno" last="Villringer">Arno Villringer</name></country><country name="Italie"><noRegion><name sortKey="Caramazza, Alfonso" sort="Caramazza, Alfonso" uniqKey="Caramazza A" first="Alfonso" last="Caramazza">Alfonso Caramazza</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Amedi, Amir" sort="Amedi, Amir" uniqKey="Amedi A" first="Amir" last="Amedi">Amir Amedi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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