A multiscale model for the study of cardiac biomechanics in single-ventricle surgeries: a clinical case
Identifieur interne : 003814 ( Ncbi/Merge ); précédent : 003813; suivant : 003815A multiscale model for the study of cardiac biomechanics in single-ventricle surgeries: a clinical case
Auteurs : Alessio Meoli [Italie] ; Elena Cutrì [Italie] ; Adarsh Krishnamurthy [États-Unis] ; Gabriele Dubini [Italie] ; Francesco Migliavacca [Italie] ; Tain-Yen Hsia [Royaume-Uni] ; Giancarlo Pennati [Italie]Source :
- Interface Focus [ 2042-8898 ] ; 2015.
Abstract
Complex congenital heart disease characterized by the underdevelopment of one ventricular chamber (single ventricle (SV) circulation) is normally treated with a three-stage surgical repair. This study aims at developing a multiscale computational framework able to couple a patient-specific three-dimensional finite-element model of the SV to a patient-specific lumped parameter (LP) model of the whole circulation, in a closed-loop fashion. A sequential approach was carried out: (i) cardiocirculatory parameters were estimated by using a fully LP model; (ii) ventricular material parameters and unloaded geometry were identified by means of the stand-alone, three-dimensional model of the SV; and (iii) the three-dimensional model of SV was coupled to the LP model of the circulation, thus closing the loop and creating a multiscale model. Once the patient-specific multiscale model was set using pre-operative clinical data, the virtual surgery was performed, and the post-operative conditions were simulated. This approach allows the analysis of local information on ventricular function as well as global parameters of the cardiovascular system. This methodology is generally applicable to patients suffering from SV disease for surgical planning at different stages of treatment. As an example, a clinical case from stage 1 to stage 2 is considered here.
Url:
DOI: 10.1098/rsfs.2014.0079
PubMed: 25844151
PubMed Central: 4342947
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<front><div type="abstract" xml:lang="en"><p>Complex congenital heart disease characterized by the underdevelopment of one ventricular chamber (single ventricle (SV) circulation) is normally treated with a three-stage surgical repair. This study aims at developing a multiscale computational framework able to couple a patient-specific three-dimensional finite-element model of the SV to a patient-specific lumped parameter (LP) model of the whole circulation, in a closed-loop fashion. A sequential approach was carried out: (i) cardiocirculatory parameters were estimated by using a fully LP model; (ii) ventricular material parameters and unloaded geometry were identified by means of the stand-alone, three-dimensional model of the SV; and (iii) the three-dimensional model of SV was coupled to the LP model of the circulation, thus closing the loop and creating a multiscale model. Once the patient-specific multiscale model was set using pre-operative clinical data, the virtual surgery was performed, and the post-operative conditions were simulated. This approach allows the analysis of local information on ventricular function as well as global parameters of the cardiovascular system. This methodology is generally applicable to patients suffering from SV disease for surgical planning at different stages of treatment. As an example, a clinical case from stage 1 to stage 2 is considered here.</p>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Interface Focus</journal-id>
<journal-id journal-id-type="iso-abbrev">Interface Focus</journal-id>
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<article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>1004</subject>
<subject>25</subject>
</subj-group>
<subj-group subj-group-type="heading"><subject>Articles</subject>
</subj-group>
<subj-group subj-group-type="leader"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>A multiscale model for the study of cardiac biomechanics in single-ventricle surgeries: a clinical case</article-title>
<alt-title alt-title-type="short">Multiscale model of single-ventricle</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Meoli</surname>
<given-names>Alessio</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cutrì</surname>
<given-names>Elena</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Krishnamurthy</surname>
<given-names>Adarsh</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dubini</surname>
<given-names>Gabriele</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Migliavacca</surname>
<given-names>Francesco</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hsia</surname>
<given-names>Tain-Yen</given-names>
</name>
<xref ref-type="aff" rid="af3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pennati</surname>
<given-names>Giancarlo</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="corresp" rid="cor1"></xref>
<on-behalf-of>the Modeling of Congenital Hearts Alliance (MOCHA) Investigators</on-behalf-of>
<xref ref-type="author-notes" rid="AN2">†</xref>
</contrib>
</contrib-group>
<contrib-group><contrib contrib-type="author"><collab>Modeling of Congenital Hearts Alliance (MOCHA) Group</collab>
</contrib>
<contrib contrib-type="author"><name><surname>Taylor</surname>
<given-names>Andrew</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Giardini</surname>
<given-names>Alessandro</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Khambadkone</surname>
<given-names>Sachin</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Schievano</surname>
<given-names>Silvia</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>de Leval</surname>
<given-names>Marc</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hsia</surname>
<given-names>T. -Y.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Bove</surname>
<given-names>Edward</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Dorfman</surname>
<given-names>Adam</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Baker</surname>
<given-names>G. Hamilton</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hlavacek</surname>
<given-names>Anthony</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Migliavacca</surname>
<given-names>Francesco</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Pennati</surname>
<given-names>Giancarlo</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Dubini</surname>
<given-names>Gabriele</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Marsden</surname>
<given-names>Alison</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Feinstein</surname>
<given-names>Jeffrey</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Vignon-Clementel</surname>
<given-names>Irene</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Figliola</surname>
<given-names>Richard</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>McGregor</surname>
<given-names>John</given-names>
</name>
</contrib>
</contrib-group>
<aff id="af1"><label>1</label>
<addr-line>Laboratory of Biological Structure Mechanics, Chemistry, Materials and Chemical Engineering Department ‘Giulio Natta’, Politecnico di Milano, Milan</addr-line>
,<country>Italy</country>
</aff>
<aff id="af2"><label>2</label>
<institution>Laboratory of Mechanics Iowa State University</institution>
,<addr-line>Ames, IA 50011</addr-line>
,<country>USA</country>
</aff>
<aff id="af3"><label>3</label>
<addr-line>Department of Cardiothoracic Surgery</addr-line>
,<institution>Great Ormond Street Hospital for Children, NHS Foundation Trust</institution>
,<addr-line>London WC1N 3JH</addr-line>
,<country>UK</country>
</aff>
<author-notes><corresp id="cor1">e-mail: <email>giancarlo.pennati@polimit.it</email>
</corresp>
<fn id="AN2"><label>†</label>
<p>Modeling of Congenital Hearts Alliance (MOCHA) Group: Andrew Taylor, Alessandro Giardini, Sachin Khambadkone, Silvia Schievano, Marc de Leval and T. -Y. Hsia (Institute of Cardiovascular Science, UCL, London, UK); Edward Bove and Adam Dorfman (University of Michigan, Ann Arbor, MI, USA); G. Hamilton Baker and Anthony Hlavacek (Medical University of South Carolina, Charleston, SC, USA); Francesco Migliavacca, Giancarlo Pennati and Gabriele Dubini (Politecnico di Milano, Milan, Italy); Alison Marsden (University of California, San Diego, CA, USA); Jeffrey Feinstein (Stanford University, Stanford, CA, USA); Irene Vignon-Clementel (INRIA, Paris, France); Richard Figliola and John McGregor (Clemson University, Clemson, SC, USA).</p>
</fn>
<fn fn-type="other"><p>One contribution of 11 to a theme issue ‘<ext-link ext-link-type="uri" xlink:href="http://rsfs.royalsocietypublishing.org/content/5/2.toc">Multiscale modelling in biomechanics: theoretical, computational and translational challenges</ext-link>
’.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>6</day>
<month>4</month>
<year>2015</year>
</pub-date>
<volume>5</volume>
<issue>2</issue>
<issue-title>Theme issue ‘Multiscale modelling in biomechanics: theoretical, computational and translational challenges’ organized by Marco Viceconti, Ahmet Erdemir, Merryn Tawhai and Jay Humphrey</issue-title>
<elocation-id>20140079</elocation-id>
<permissions><copyright-statement>© 2015 The Author(s) Published by the Royal Society. All rights reserved.</copyright-statement>
<copyright-year>2015</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="rsfs20140079.pdf"></self-uri>
<abstract><p>Complex congenital heart disease characterized by the underdevelopment of one ventricular chamber (single ventricle (SV) circulation) is normally treated with a three-stage surgical repair. This study aims at developing a multiscale computational framework able to couple a patient-specific three-dimensional finite-element model of the SV to a patient-specific lumped parameter (LP) model of the whole circulation, in a closed-loop fashion. A sequential approach was carried out: (i) cardiocirculatory parameters were estimated by using a fully LP model; (ii) ventricular material parameters and unloaded geometry were identified by means of the stand-alone, three-dimensional model of the SV; and (iii) the three-dimensional model of SV was coupled to the LP model of the circulation, thus closing the loop and creating a multiscale model. Once the patient-specific multiscale model was set using pre-operative clinical data, the virtual surgery was performed, and the post-operative conditions were simulated. This approach allows the analysis of local information on ventricular function as well as global parameters of the cardiovascular system. This methodology is generally applicable to patients suffering from SV disease for surgical planning at different stages of treatment. As an example, a clinical case from stage 1 to stage 2 is considered here.</p>
</abstract>
<kwd-group><kwd>single ventricle heart</kwd>
<kwd>multiscale coupling</kwd>
<kwd>finite-element method</kwd>
<kwd>lumped parameter model</kwd>
<kwd>virtual surgery</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>cover-date</meta-name>
<meta-value>April 6, 2015</meta-value>
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<affiliations><list><country><li>Italie</li>
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