Role and implications of nanodiagnostics in the changing trends of clinical diagnosis
Identifieur interne : 002D63 ( Ncbi/Merge ); précédent : 002D62; suivant : 002D64Role and implications of nanodiagnostics in the changing trends of clinical diagnosis
Auteurs : Khalid Khalaf Alharbi ; Yazeed A. Al-SheikhSource :
- Saudi Journal of Biological Sciences [ 1319-562X ] ; 2013.
Abstract
Nanodiagnostics is the term used for the application of nanobiotechnology in molecular diagnosis, which is important for developing personalized cancer therapy. It is usually based on pharmacogenetics, pharmacogenomics, and pharmacoproteomic information but also takes into consideration environmental factors that influence response to therapy. Nanotechnology in medicine involves applications of nanoparticles currently under development, as well as longer range research that involves the use of manufactured nano-robots to make repairs at the cellular level. Nanodiagnostic technologies are also being used to refine the discovery of biomarkers, as nanoparticles offer advantages of high volume/surface ratio and multifunctionality. Biomarkers are important basic components of personalized medicine and are applicable to the management of cancer as well. The field of nano diagnostics raises certain ethical concerns related with the testing of blood. With advances in diagnostic technologies, doctors will be able to give patients complete health checks quickly and routinely. If any medication is required this will be tailored specifically to the individual based on their genetic makeup, thus preventing unwanted side-effects.
Url:
DOI: 10.1016/j.sjbs.2013.11.001
PubMed: 24600302
PubMed Central: 3942856
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role and implications of nanodiagnostics in the changing trends of clinical diagnosis</title><author><name sortKey="Alharbi, Khalid Khalaf" sort="Alharbi, Khalid Khalaf" uniqKey="Alharbi K" first="Khalid Khalaf" last="Alharbi">Khalid Khalaf Alharbi</name></author><author><name sortKey="Al Sheikh, Yazeed A" sort="Al Sheikh, Yazeed A" uniqKey="Al Sheikh Y" first="Yazeed A." last="Al-Sheikh">Yazeed A. Al-Sheikh</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24600302</idno><idno type="pmc">3942856</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942856</idno><idno type="RBID">PMC:3942856</idno><idno type="doi">10.1016/j.sjbs.2013.11.001</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002621</idno><idno type="wicri:Area/Pmc/Curation">002621</idno><idno type="wicri:Area/Pmc/Checkpoint">001029</idno><idno type="wicri:Area/Ncbi/Merge">002D63</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Role and implications of nanodiagnostics in the changing trends of clinical diagnosis</title><author><name sortKey="Alharbi, Khalid Khalaf" sort="Alharbi, Khalid Khalaf" uniqKey="Alharbi K" first="Khalid Khalaf" last="Alharbi">Khalid Khalaf Alharbi</name></author><author><name sortKey="Al Sheikh, Yazeed A" sort="Al Sheikh, Yazeed A" uniqKey="Al Sheikh Y" first="Yazeed A." last="Al-Sheikh">Yazeed A. Al-Sheikh</name></author></analytic><series><title level="j">Saudi Journal of Biological Sciences</title><idno type="ISSN">1319-562X</idno><idno type="eISSN">2213-7106</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Nanodiagnostics is the term used for the application of nanobiotechnology in molecular diagnosis, which is important for developing personalized cancer therapy. It is usually based on pharmacogenetics, pharmacogenomics, and pharmacoproteomic information but also takes into consideration environmental factors that influence response to therapy. Nanotechnology in medicine involves applications of nanoparticles currently under development, as well as longer range research that involves the use of manufactured nano-robots to make repairs at the cellular level. Nanodiagnostic technologies are also being used to refine the discovery of biomarkers, as nanoparticles offer advantages of high volume/surface ratio and multifunctionality. Biomarkers are important basic components of personalized medicine and are applicable to the management of cancer as well. The field of nano diagnostics raises certain ethical concerns related with the testing of blood. With advances in diagnostic technologies, doctors will be able to give patients complete health checks quickly and routinely. If any medication is required this will be tailored specifically to the individual based on their genetic makeup, thus preventing unwanted side-effects.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Saudi J Biol Sci</journal-id><journal-title-group><journal-title>Saudi Journal of Biological Sciences</journal-title></journal-title-group><issn pub-type="ppub">1319-562X</issn><issn pub-type="epub">2213-7106</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24600302</article-id><article-id pub-id-type="pmc">3942856</article-id><article-id pub-id-type="publisher-id">S1319-562X(13)00096-X</article-id><article-id pub-id-type="doi">10.1016/j.sjbs.2013.11.001</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Role and implications of nanodiagnostics in the changing trends of clinical diagnosis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Alharbi</surname><given-names>Khalid Khalaf</given-names></name><email>kharbi@ksu.edu.sa</email><xref rid="cor1" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author"><name><surname>Al-sheikh</surname><given-names>Yazeed A.</given-names></name></contrib></contrib-group><aff id="af005">Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia</aff><author-notes><corresp id="cor1"><label>⁎</label>Corresponding author. Tel.: +966 567288142; fax: +966 114693630. <email>kharbi@ksu.edu.sa</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>19</day><month>11</month><year>2013</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was
based on .</pmc-comment>
<pub-date pub-type="epub"><day>19</day><month>11</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2014</year></pub-date><volume>21</volume><issue>2</issue><fpage>109</fpage><lpage>117</lpage><history><date date-type="received"><day>16</day><month>9</month><year>2013</year></date><date date-type="rev-recd"><day>3</day><month>11</month><year>2013</year></date><date date-type="accepted"><day>3</day><month>11</month><year>2013</year></date></history><permissions><copyright-statement>© 2014 King Saud University. Production and Hosting by Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder></copyright-holder></permissions><abstract><p>Nanodiagnostics is the term used for the application of nanobiotechnology in molecular diagnosis, which is important for developing personalized cancer therapy. It is usually based on pharmacogenetics, pharmacogenomics, and pharmacoproteomic information but also takes into consideration environmental factors that influence response to therapy. Nanotechnology in medicine involves applications of nanoparticles currently under development, as well as longer range research that involves the use of manufactured nano-robots to make repairs at the cellular level. Nanodiagnostic technologies are also being used to refine the discovery of biomarkers, as nanoparticles offer advantages of high volume/surface ratio and multifunctionality. Biomarkers are important basic components of personalized medicine and are applicable to the management of cancer as well. The field of nano diagnostics raises certain ethical concerns related with the testing of blood. With advances in diagnostic technologies, doctors will be able to give patients complete health checks quickly and routinely. If any medication is required this will be tailored specifically to the individual based on their genetic makeup, thus preventing unwanted side-effects.</p></abstract><kwd-group><title>Keywords</title><kwd>Nanodiagnostics</kwd><kwd>PCR</kwd><kwd>DNA sequencing</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Al Sheikh, Yazeed A" sort="Al Sheikh, Yazeed A" uniqKey="Al Sheikh Y" first="Yazeed A." last="Al-Sheikh">Yazeed A. Al-Sheikh</name><name sortKey="Alharbi, Khalid Khalaf" sort="Alharbi, Khalid Khalaf" uniqKey="Alharbi K" first="Khalid Khalaf" last="Alharbi">Khalid Khalaf Alharbi</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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