Cortical and subcortical projections to primary visual cortex in anophthalmic, enucleated and sighted mice.
Identifieur interne : 002127 ( Ncbi/Merge ); précédent : 002126; suivant : 002128Cortical and subcortical projections to primary visual cortex in anophthalmic, enucleated and sighted mice.
Auteurs : Valérie Charbonneau [Canada] ; Marie-Eve Laramée ; Virginie Boucher ; Gilles Bronchti ; Denis BoireSource :
- The European journal of neuroscience [ 1460-9568 ] ; 2012.
English descriptors
- KwdEn :
- Animals, Anophthalmos (physiopathology), Auditory Cortex (physiology), Blindness (physiopathology), Blindness (surgery), Eye Enucleation, Mice, Mice, Inbred C57BL, Neurons (cytology), Neurons (physiology), Somatosensory Cortex (physiology), Visual Cortex (cytology), Visual Cortex (physiology), Visual Cortex (physiopathology), Visual Pathways (cytology), Visual Pathways (physiology), Visual Pathways (physiopathology).
- MESH :
- cytology : Neurons, Visual Cortex, Visual Pathways.
- physiology : Auditory Cortex, Neurons, Somatosensory Cortex, Visual Cortex, Visual Pathways.
- physiopathology : Anophthalmos, Blindness, Visual Cortex, Visual Pathways.
- surgery : Blindness.
- Animals, Eye Enucleation, Mice, Mice, Inbred C57BL.
Abstract
The purpose of this study was to identify and compare the afferent projections to the primary visual cortex in intact and enucleated C57BL/6 mice and in ZRDCT/An anophthalmic mice. Early loss of sensory-driven activity in blind subjects can lead to activations of the primary visual cortex by haptic or auditory stimuli. This intermodal activation following the onset of blindness is believed to arise through either unmasking of already present cortical connections, sprouting of novel cortical connections or enhancement of intermodal cortical connections. Studies in humans have similarly demonstrated heteromodal activation of visual cortex following relatively short periods of blindfolding. This suggests that the primary visual cortex in normal sighted subjects receives afferents, either from multisensory association cortices or from primary sensory cortices dedicated to other modalities. Here cortical afferents to the primary visual cortex were investigated to determine whether the visual cortex receives sensory input from other modalities, and whether differences exist in the quantity and/or the structure of projections found in sighted, enucleated and anophthalmic mice. This study demonstrates extensive direct connections between the primary visual cortex and auditory and somatosensory areas, as well as with motor and association cortices in all three animal groups. This suggests that information from different sensory modalities can be integrated at early cortical stages and that visual cortex activations following visual deprivations can partly be explained by already present intermodal corticocortical connections.
DOI: 10.1111/j.1460-9568.2012.08215.x
PubMed: 22780435
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sort="Boucher, Virginie" uniqKey="Boucher V" first="Virginie" last="Boucher">Virginie Boucher</name></author><author><name sortKey="Bronchti, Gilles" sort="Bronchti, Gilles" uniqKey="Bronchti G" first="Gilles" last="Bronchti">Gilles Bronchti</name></author><author><name sortKey="Boire, Denis" sort="Boire, Denis" uniqKey="Boire D" first="Denis" last="Boire">Denis Boire</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1111/j.1460-9568.2012.08215.x</idno><idno type="RBID">pubmed:22780435</idno><idno type="pmid">22780435</idno><idno type="wicri:Area/PubMed/Corpus">000B71</idno><idno type="wicri:Area/PubMed/Curation">000B71</idno><idno type="wicri:Area/PubMed/Checkpoint">000B72</idno><idno type="wicri:Area/Ncbi/Merge">002127</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cortical and subcortical projections to primary visual cortex in anophthalmic, enucleated and sighted 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xml:lang="en">The purpose of this study was to identify and compare the afferent projections to the primary visual cortex in intact and enucleated C57BL/6 mice and in ZRDCT/An anophthalmic mice. Early loss of sensory-driven activity in blind subjects can lead to activations of the primary visual cortex by haptic or auditory stimuli. This intermodal activation following the onset of blindness is believed to arise through either unmasking of already present cortical connections, sprouting of novel cortical connections or enhancement of intermodal cortical connections. Studies in humans have similarly demonstrated heteromodal activation of visual cortex following relatively short periods of blindfolding. This suggests that the primary visual cortex in normal sighted subjects receives afferents, either from multisensory association cortices or from primary sensory cortices dedicated to other modalities. Here cortical afferents to the primary visual cortex were investigated to determine whether the visual cortex receives sensory input from other modalities, and whether differences exist in the quantity and/or the structure of projections found in sighted, enucleated and anophthalmic mice. This study demonstrates extensive direct connections between the primary visual cortex and auditory and somatosensory areas, as well as with motor and association cortices in all three animal groups. This suggests that information from different sensory modalities can be integrated at early cortical stages and that visual cortex activations following visual deprivations can partly be explained by already present intermodal corticocortical connections.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22780435</PMID><DateCreated><Year>2012</Year><Month>10</Month><Day>02</Day></DateCreated><DateCompleted><Year>2013</Year><Month>02</Month><Day>18</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1460-9568</ISSN><JournalIssue CitedMedium="Internet"><Volume>36</Volume><Issue>7</Issue><PubDate><Year>2012</Year><Month>Oct</Month></PubDate></JournalIssue><Title>The European journal of neuroscience</Title><ISOAbbreviation>Eur. J. Neurosci.</ISOAbbreviation></Journal><ArticleTitle>Cortical and subcortical projections to primary visual cortex in anophthalmic, enucleated and sighted mice.</ArticleTitle><Pagination><MedlinePgn>2949-63</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1460-9568.2012.08215.x</ELocationID><Abstract><AbstractText>The purpose of this study was to identify and compare the afferent projections to the primary visual cortex in intact and enucleated C57BL/6 mice and in ZRDCT/An anophthalmic mice. Early loss of sensory-driven activity in blind subjects can lead to activations of the primary visual cortex by haptic or auditory stimuli. This intermodal activation following the onset of blindness is believed to arise through either unmasking of already present cortical connections, sprouting of novel cortical connections or enhancement of intermodal cortical connections. Studies in humans have similarly demonstrated heteromodal activation of visual cortex following relatively short periods of blindfolding. This suggests that the primary visual cortex in normal sighted subjects receives afferents, either from multisensory association cortices or from primary sensory cortices dedicated to other modalities. Here cortical afferents to the primary visual cortex were investigated to determine whether the visual cortex receives sensory input from other modalities, and whether differences exist in the quantity and/or the structure of projections found in sighted, enucleated and anophthalmic mice. This study demonstrates extensive direct connections between the primary visual cortex and auditory and somatosensory areas, as well as with motor and association cortices in all three animal groups. This suggests that information from different sensory modalities can be integrated at early cortical stages and that visual cortex activations following visual deprivations can partly be explained by already present intermodal corticocortical connections.</AbstractText><CopyrightInformation>© 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Charbonneau</LastName><ForeName>Valérie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Groupe de Recherche en Neurosciences, Département de chimie-biologie, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laramée</LastName><ForeName>Marie-Eve</ForeName><Initials>ME</Initials></Author><Author ValidYN="Y"><LastName>Boucher</LastName><ForeName>Virginie</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Bronchti</LastName><ForeName>Gilles</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Boire</LastName><ForeName>Denis</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType 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Cortex</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000166">cytology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014795">Visual Pathways</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000166">cytology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2012</Year><Month>7</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>7</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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M" first="Marie-Eve" last="Laramée">Marie-Eve Laramée</name></noCountry><country name="Canada"><noRegion><name sortKey="Charbonneau, Valerie" sort="Charbonneau, Valerie" uniqKey="Charbonneau V" first="Valérie" last="Charbonneau">Valérie Charbonneau</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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