Accommodative Lens Refilling in Rhesus Monkeys
Identifieur interne : 000948 ( Ncbi/Merge ); précédent : 000947; suivant : 000949Accommodative Lens Refilling in Rhesus Monkeys
Auteurs : Steven A. Koopmans [Pays-Bas] ; Thom Terwee [Pays-Bas] ; Adrian Glasser [États-Unis] ; Mark Wendt [États-Unis] ; Abhiram S. Vilipuru [États-Unis] ; Theo G. Van Kooten [Pays-Bas] ; Sverker Norrby [Pays-Bas] ; Henk J. Haitjema [Pays-Bas] ; Aart C. Kooijman [Pays-Bas]Source :
- Investigative ophthalmology & visual science [ 0146-0404 ] ; 2006.
Abstract
Accommodation can be restored to presbyopic human eyes by refilling the capsular bag with a soft polymer. This study was conducted to test whether accommodation, measurable as changes in optical refraction, can be restored with a newly developed refilling polymer in a rhesus monkey model. A specific intra- and postoperative treatment protocol was used to minimize postoperative inflammation and to delay capsular opacification.
Nine adolescent rhesus monkeys underwent refilling of the lens capsular bag with a polymer. In the first four monkeys (group A) the surgical procedure was followed by two weekly subconjunctival injections of corticosteroids. In a second group of five monkeys (group B) a treatment intended to delay the development of capsular opacification was applied during the surgery, and, in the postoperative period, eye drops and two subconjunctival injections of corticosteroids were applied. Accommodation was stimulated with carbachol iontophoresis or pilocarpine and was measured with a Hartinger refractometer at regular times during a follow-up period of 37 weeks in five monkeys. In one monkey, lens thickness changes were measured with A-scan ultrasound.
In group A, refraction measurement was possible in one monkey. In the three other animals in group A, postoperative inflammation and capsular opacification prevented refraction measurements. In group B, the maximum accommodative amplitude of the surgically treated eyes was 6.3 D. In three monkeys the accommodative amplitude decreased to almost 0 D after 37 weeks. In the two other monkeys, the accommodative amplitude remained stable at ±4 D during the follow-up period. In group B, capsular opacification developed in the postoperative period, but refraction measurements could still be performed during the whole follow-up period of 37 weeks.
A certain level of accommodation can be restored after lens refilling in adolescent rhesus monkeys. During the follow-up period refraction measurements were possible in all five monkeys that underwent the treatment designed to prevent inflammation and capsular opacification.
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DOI: 10.1167/iovs.05-1346
PubMed: 16799042
PubMed Central: 2918258
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Koopmans</name><affiliation wicri:level="3"><nlm:aff id="A1"> Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea> Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Terwee, Thom" sort="Terwee, Thom" uniqKey="Terwee T" first="Thom" last="Terwee">Thom Terwee</name><affiliation wicri:level="3"><nlm:aff id="A2"> Advanced Medical Optics Groningen BV, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Advanced Medical Optics Groningen BV, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Glasser, Adrian" sort="Glasser, Adrian" uniqKey="Glasser A" first="Adrian" last="Glasser">Adrian Glasser</name><affiliation wicri:level="2"><nlm:aff id="A3"> College of Optometry, University of Houston, Houston, Texas</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea> College of Optometry, University of Houston, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Wendt, Mark" sort="Wendt, Mark" uniqKey="Wendt M" first="Mark" last="Wendt">Mark Wendt</name><affiliation wicri:level="2"><nlm:aff id="A3"> College of Optometry, University of Houston, Houston, Texas</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea> College of Optometry, University of Houston, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Vilipuru, Abhiram S" sort="Vilipuru, Abhiram S" uniqKey="Vilipuru A" first="Abhiram S." last="Vilipuru">Abhiram S. Vilipuru</name><affiliation wicri:level="2"><nlm:aff id="A3"> College of Optometry, University of Houston, Houston, Texas</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea> College of Optometry, University of Houston, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Van Kooten, Theo G" sort="Van Kooten, Theo G" uniqKey="Van Kooten T" first="Theo G." last="Van Kooten">Theo G. Van Kooten</name><affiliation wicri:level="3"><nlm:aff id="A4"> Institute for Biomedical Engineering, Materials Science, and Application, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea> Institute for Biomedical Engineering, Materials Science, and Application, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Norrby, Sverker" sort="Norrby, Sverker" uniqKey="Norrby S" first="Sverker" last="Norrby">Sverker Norrby</name><affiliation wicri:level="3"><nlm:aff id="A2"> Advanced Medical Optics Groningen BV, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Advanced Medical Optics Groningen BV, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Haitjema, Henk J" sort="Haitjema, Henk J" uniqKey="Haitjema H" first="Henk J." last="Haitjema">Henk J. Haitjema</name><affiliation wicri:level="3"><nlm:aff id="A2"> Advanced Medical Optics Groningen BV, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Advanced Medical Optics Groningen BV, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Kooijman, Aart C" sort="Kooijman, Aart C" uniqKey="Kooijman A" first="Aart C." last="Kooijman">Aart C. Kooijman</name><affiliation wicri:level="3"><nlm:aff id="A5"> Laboratory of Experimental Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea> Laboratory of Experimental Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16799042</idno><idno type="pmc">2918258</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918258</idno><idno type="RBID">PMC:2918258</idno><idno type="doi">10.1167/iovs.05-1346</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000F75</idno><idno type="wicri:Area/Pmc/Curation">000F75</idno><idno type="wicri:Area/Pmc/Checkpoint">002556</idno><idno type="wicri:Area/Ncbi/Merge">000948</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Accommodative Lens Refilling in Rhesus Monkeys</title><author><name sortKey="Koopmans, Steven A" sort="Koopmans, Steven A" uniqKey="Koopmans S" first="Steven A." last="Koopmans">Steven A. Koopmans</name><affiliation wicri:level="3"><nlm:aff id="A1"> Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea> Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Terwee, Thom" sort="Terwee, Thom" uniqKey="Terwee T" first="Thom" last="Terwee">Thom Terwee</name><affiliation wicri:level="3"><nlm:aff id="A2"> Advanced Medical Optics Groningen BV, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Advanced Medical Optics Groningen BV, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Glasser, Adrian" sort="Glasser, Adrian" uniqKey="Glasser A" first="Adrian" last="Glasser">Adrian Glasser</name><affiliation wicri:level="2"><nlm:aff id="A3"> College of Optometry, University of Houston, Houston, Texas</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea> College of Optometry, University of Houston, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Wendt, Mark" sort="Wendt, Mark" uniqKey="Wendt M" first="Mark" last="Wendt">Mark Wendt</name><affiliation wicri:level="2"><nlm:aff id="A3"> College of Optometry, University of Houston, Houston, Texas</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea> College of Optometry, University of Houston, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Vilipuru, Abhiram S" sort="Vilipuru, Abhiram S" uniqKey="Vilipuru A" first="Abhiram S." last="Vilipuru">Abhiram S. Vilipuru</name><affiliation wicri:level="2"><nlm:aff id="A3"> College of Optometry, University of Houston, Houston, Texas</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea> College of Optometry, University of Houston, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Van Kooten, Theo G" sort="Van Kooten, Theo G" uniqKey="Van Kooten T" first="Theo G." last="Van Kooten">Theo G. Van Kooten</name><affiliation wicri:level="3"><nlm:aff id="A4"> Institute for Biomedical Engineering, Materials Science, and Application, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea> Institute for Biomedical Engineering, Materials Science, and Application, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Norrby, Sverker" sort="Norrby, Sverker" uniqKey="Norrby S" first="Sverker" last="Norrby">Sverker Norrby</name><affiliation wicri:level="3"><nlm:aff id="A2"> Advanced Medical Optics Groningen BV, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Advanced Medical Optics Groningen BV, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Haitjema, Henk J" sort="Haitjema, Henk J" uniqKey="Haitjema H" first="Henk J." last="Haitjema">Henk J. Haitjema</name><affiliation wicri:level="3"><nlm:aff id="A2"> Advanced Medical Optics Groningen BV, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea> Advanced Medical Optics Groningen BV, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Kooijman, Aart C" sort="Kooijman, Aart C" uniqKey="Kooijman A" first="Aart C." last="Kooijman">Aart C. Kooijman</name><affiliation wicri:level="3"><nlm:aff id="A5"> Laboratory of Experimental Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea> Laboratory of Experimental Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author></analytic><series><title level="j">Investigative ophthalmology & visual science</title><idno type="ISSN">0146-0404</idno><idno type="eISSN">1552-5783</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">Accommodation can be restored to presbyopic human eyes by refilling the capsular bag with a soft polymer. This study was conducted to test whether accommodation, measurable as changes in optical refraction, can be restored with a newly developed refilling polymer in a rhesus monkey model. A specific intra- and postoperative treatment protocol was used to minimize postoperative inflammation and to delay capsular opacification.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">Nine adolescent rhesus monkeys underwent refilling of the lens capsular bag with a polymer. In the first four monkeys (group A) the surgical procedure was followed by two weekly subconjunctival injections of corticosteroids. In a second group of five monkeys (group B) a treatment intended to delay the development of capsular opacification was applied during the surgery, and, in the postoperative period, eye drops and two subconjunctival injections of corticosteroids were applied. Accommodation was stimulated with carbachol iontophoresis or pilocarpine and was measured with a Hartinger refractometer at regular times during a follow-up period of 37 weeks in five monkeys. In one monkey, lens thickness changes were measured with A-scan ultrasound.</p></sec><sec id="S3"><title>Results</title><p id="P3">In group A, refraction measurement was possible in one monkey. In the three other animals in group A, postoperative inflammation and capsular opacification prevented refraction measurements. In group B, the maximum accommodative amplitude of the surgically treated eyes was 6.3 D. In three monkeys the accommodative amplitude decreased to almost 0 D after 37 weeks. In the two other monkeys, the accommodative amplitude remained stable at ±4 D during the follow-up period. In group B, capsular opacification developed in the postoperative period, but refraction measurements could still be performed during the whole follow-up period of 37 weeks.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">A certain level of accommodation can be restored after lens refilling in adolescent rhesus monkeys. During the follow-up period refraction measurements were possible in all five monkeys that underwent the treatment designed to prevent inflammation and capsular opacification.</p></sec></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7703701</journal-id><journal-id journal-id-type="pubmed-jr-id">4371</journal-id><journal-id journal-id-type="nlm-ta">Invest Ophthalmol Vis Sci</journal-id><journal-title>Investigative ophthalmology & visual science</journal-title><issn pub-type="ppub">0146-0404</issn><issn pub-type="epub">1552-5783</issn></journal-meta><article-meta><article-id pub-id-type="pmid">16799042</article-id><article-id pub-id-type="pmc">2918258</article-id><article-id pub-id-type="doi">10.1167/iovs.05-1346</article-id><article-id pub-id-type="manuscript">NIHMS220958</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Accommodative Lens Refilling in Rhesus Monkeys</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Koopmans</surname><given-names>Steven A.</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Terwee</surname><given-names>Thom</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Glasser</surname><given-names>Adrian</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Wendt</surname><given-names>Mark</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Vilipuru</surname><given-names>Abhiram S.</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>van Kooten</surname><given-names>Theo G.</given-names></name><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Norrby</surname><given-names>Sverker</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Haitjema</surname><given-names>Henk J.</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Kooijman</surname><given-names>Aart C.</given-names></name><xref rid="A5" ref-type="aff">5</xref></contrib></contrib-group><aff id="A1"><label>1</label> Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A2"><label>2</label> Advanced Medical Optics Groningen BV, Groningen, the Netherlands</aff><aff id="A3"><label>3</label> College of Optometry, University of Houston, Houston, Texas</aff><aff id="A4"><label>4</label> Institute for Biomedical Engineering, Materials Science, and Application, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A5"><label>5</label> Laboratory of Experimental Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><author-notes><corresp id="FN1">Corresponding author: Steven A. Koopmans, Department of Ophthalmology, University, Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands; <email>s.a.koopmans@ohk.azg.nl</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>15</day><month>7</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2006</year></pub-date><pub-date pub-type="pmc-release"><day>9</day><month>8</month><year>2010</year></pub-date><volume>47</volume><issue>7</issue><fpage>2976</fpage><lpage>2984</lpage><related-article journal-id-type="nlm-ta" journal-id="Invest Ophthalmol Vis Sci" related-article-type="correction-forward" vol="47" page="3246" id="N0x20bd870N0x2b873a8" ext-link-type="pmc"></related-article><abstract><sec id="S1"><title>Purpose</title><p id="P1">Accommodation can be restored to presbyopic human eyes by refilling the capsular bag with a soft polymer. This study was conducted to test whether accommodation, measurable as changes in optical refraction, can be restored with a newly developed refilling polymer in a rhesus monkey model. A specific intra- and postoperative treatment protocol was used to minimize postoperative inflammation and to delay capsular opacification.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">Nine adolescent rhesus monkeys underwent refilling of the lens capsular bag with a polymer. In the first four monkeys (group A) the surgical procedure was followed by two weekly subconjunctival injections of corticosteroids. In a second group of five monkeys (group B) a treatment intended to delay the development of capsular opacification was applied during the surgery, and, in the postoperative period, eye drops and two subconjunctival injections of corticosteroids were applied. Accommodation was stimulated with carbachol iontophoresis or pilocarpine and was measured with a Hartinger refractometer at regular times during a follow-up period of 37 weeks in five monkeys. In one monkey, lens thickness changes were measured with A-scan ultrasound.</p></sec><sec id="S3"><title>Results</title><p id="P3">In group A, refraction measurement was possible in one monkey. In the three other animals in group A, postoperative inflammation and capsular opacification prevented refraction measurements. In group B, the maximum accommodative amplitude of the surgically treated eyes was 6.3 D. In three monkeys the accommodative amplitude decreased to almost 0 D after 37 weeks. In the two other monkeys, the accommodative amplitude remained stable at ±4 D during the follow-up period. In group B, capsular opacification developed in the postoperative period, but refraction measurements could still be performed during the whole follow-up period of 37 weeks.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">A certain level of accommodation can be restored after lens refilling in adolescent rhesus monkeys. During the follow-up period refraction measurements were possible in all five monkeys that underwent the treatment designed to prevent inflammation and capsular opacification.</p></sec></abstract><contract-num rid="EY1">R01 EY014651-03
||EY</contract-num><contract-sponsor id="EY1">National Eye Institute : NEI</contract-sponsor></article-meta></front></pmc><affiliations><list><country><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Groningue (province)</li><li>Texas</li></region><settlement><li>Groningue</li></settlement></list><tree><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Koopmans, Steven A" sort="Koopmans, Steven A" uniqKey="Koopmans S" first="Steven A." last="Koopmans">Steven A. Koopmans</name></region><name sortKey="Haitjema, Henk J" sort="Haitjema, Henk J" uniqKey="Haitjema H" first="Henk J." last="Haitjema">Henk J. Haitjema</name><name sortKey="Kooijman, Aart C" sort="Kooijman, Aart C" uniqKey="Kooijman A" first="Aart C." last="Kooijman">Aart C. Kooijman</name><name sortKey="Norrby, Sverker" sort="Norrby, Sverker" uniqKey="Norrby S" first="Sverker" last="Norrby">Sverker Norrby</name><name sortKey="Terwee, Thom" sort="Terwee, Thom" uniqKey="Terwee T" first="Thom" last="Terwee">Thom Terwee</name><name sortKey="Van Kooten, Theo G" sort="Van Kooten, Theo G" uniqKey="Van Kooten T" first="Theo G." last="Van Kooten">Theo G. Van Kooten</name></country><country name="États-Unis"><region name="Texas"><name sortKey="Glasser, Adrian" sort="Glasser, Adrian" uniqKey="Glasser A" first="Adrian" last="Glasser">Adrian Glasser</name></region><name sortKey="Vilipuru, Abhiram S" sort="Vilipuru, Abhiram S" uniqKey="Vilipuru A" first="Abhiram S." last="Vilipuru">Abhiram S. Vilipuru</name><name sortKey="Wendt, Mark" sort="Wendt, Mark" uniqKey="Wendt M" first="Mark" last="Wendt">Mark Wendt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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