How local is the local field potential?
Identifieur interne : 001D13 ( Ncbi/Curation ); précédent : 001D12; suivant : 001D14How local is the local field potential?
Auteurs : Yoshinao Kajikawa ; Charles E. SchroederSource :
- Neuron [ 0896-6273 ] ; 2011.
Abstract
Local field potentials (LFPs) are of growing importance in neurophysiological investigations. LFPs supplement action potential recordings by indexing activity relevant to EEG, MEG and hemodynamic (fMRI) signals. Recent reports suggest that LFPs reflect activity within very small domains of several hundred microns. We examined this conclusion by comparing LFP, current source density (CSD), and multiunit activity (MUA) signals in macaque auditory cortex. Estimated by frequency tuning bandwidths, these signals' “listening areas” differ systematically with an order of: MUA < CSD < LFP. Computational analyses confirm that observed LFPs receive non-local contributions. Direct measurements indicate passive spread of LFPs to sites more than a centimeter from their origins. These findings appear to be independent of the frequency content of the LFP. Our results challenge the idea that LFP recordings
Url:
DOI: 10.1016/j.neuron.2011.09.029
PubMed: 22153379
PubMed Central: 3240862
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<author><name sortKey="Kajikawa, Yoshinao" sort="Kajikawa, Yoshinao" uniqKey="Kajikawa Y" first="Yoshinao" last="Kajikawa">Yoshinao Kajikawa</name>
<affiliation><nlm:aff id="A1">Cognitive Neuroscience and Schizophrenia Program Nathan S. Kline Institute for Psychiatric Research And Department of Psychiatry</nlm:aff>
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<author><name sortKey="Schroeder, Charles E" sort="Schroeder, Charles E" uniqKey="Schroeder C" first="Charles E." last="Schroeder">Charles E. Schroeder</name>
<affiliation><nlm:aff id="A1">Cognitive Neuroscience and Schizophrenia Program Nathan S. Kline Institute for Psychiatric Research And Department of Psychiatry</nlm:aff>
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<affiliation><nlm:aff id="A2">Columbia University College of Physicians and Surgeons</nlm:aff>
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<author><name sortKey="Schroeder, Charles E" sort="Schroeder, Charles E" uniqKey="Schroeder C" first="Charles E." last="Schroeder">Charles E. Schroeder</name>
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<series><title level="j">Neuron</title>
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p id="P1">Local field potentials (LFPs) are of growing importance in neurophysiological investigations. LFPs supplement action potential recordings by indexing activity relevant to EEG, MEG and hemodynamic (fMRI) signals. Recent reports suggest that LFPs reflect activity within very small domains of several hundred microns. We examined this conclusion by comparing LFP, current source density (CSD), and multiunit activity (MUA) signals in macaque auditory cortex. Estimated by frequency tuning bandwidths, these signals' “listening areas” differ systematically with an order of: MUA < CSD < LFP. Computational analyses confirm that observed LFPs receive non-local contributions. Direct measurements indicate passive spread of LFPs to sites more than a centimeter from their origins. These findings appear to be independent of the frequency content of the LFP. Our results challenge the idea that LFP recordings <italic>typically</italic>
integrate over extremely circumscribed local domains. Rather, LFPs appear as a mixture of local potentials with “volume conducted” potentials from distant sites.</p>
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