Subcortical Neuronal Ensembles: An Analysis of Motor Task Association, Tremor, Oscillations, and Synchrony in Human Patients
Identifieur interne : 002092 ( Ncbi/Checkpoint ); précédent : 002091; suivant : 002093Subcortical Neuronal Ensembles: An Analysis of Motor Task Association, Tremor, Oscillations, and Synchrony in Human Patients
Auteurs : Timothy L. Hanson [États-Unis] ; Andrew M. Fuller [États-Unis] ; Mikhail A. Lebedev [États-Unis] ; Dennis A. Turner [États-Unis] ; Miguel A. L. Nicolelis [États-Unis, Brésil]Source :
- The Journal of neuroscience : the official journal of the Society for Neuroscience [ 0270-6474 ] ; 2012.
English descriptors
- KwdEn :
- Algorithms, Biomechanical Phenomena, Brain (physiopathology), Cortical Synchronization, Deep Brain Stimulation, Electrodes, Implanted, Electroencephalography, Electromyography, Electrophysiological Phenomena, Essential Tremor (physiopathology), Essential Tremor (therapy), Female, Functional Laterality (physiology), Hand (physiology), Humans, Male, Movement (physiology), Nerve Net (physiopathology), Neurons (physiology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Psychomotor Performance (physiology), Subthalamic Nucleus (physiology), Thalamus (physiology), Tremor (physiopathology), Tremor (psychology), Tremor (therapy).
- MESH :
- physiology : Functional Laterality, Hand, Movement, Neurons, Psychomotor Performance, Subthalamic Nucleus, Thalamus.
- physiopathology : Brain, Essential Tremor, Nerve Net, Parkinson Disease, Tremor.
- psychology : Tremor.
- therapy : Essential Tremor, Parkinson Disease, Tremor.
- Algorithms, Biomechanical Phenomena, Cortical Synchronization, Deep Brain Stimulation, Electrodes, Implanted, Electroencephalography, Electromyography, Electrophysiological Phenomena, Female, Humans, Male.
Abstract
Deep brain stimulation (DBS) has expanded as an effective treatment for motor disorders, providing a valuable opportunity for intraoperative recording of the spiking activity of subcortical neurons. The properties of these neurons and their potential utility in neuroprosthetic applications are not completely understood. During DBS surgeries in 25 human patients with either essential tremor or Parkinson’s disease, we acutely recorded the single-unit activity of 274 ventral intermediate/ventral oralis posterior motor thalamus (Vim/Vop) neurons and 123 subthalamic nucleus (STN) neurons. These subcortical neuronal ensembles (up to 23 neurons sampled simultaneously) were recorded while the patients performed a target-tracking motor task using a cursor controlled by a haptic glove. We observed that modulations in firing rate of a substantial number of neurons in both Vim/Vop and STN represented target onset, movement onset/direction, and hand tremor. Neurons in both areas exhibited rhythmic oscillations and pairwise synchrony. Notably, all tremor-associated neurons exhibited synchrony within the ensemble. The data further indicate that oscillatory (likely pathological) neurons and behaviorally tuned neurons are not distinct but rather form overlapping sets. Whereas previous studies have reported a linear relationship between power spectra of neuronal oscillations and hand tremor, we report a nonlinear relationship suggestive of complex encoding schemes. Even in the presence of this pathological activity, linear models were able to extract motor parameters from ensemble discharges. Based on these findings, we propose that chronic multielectrode recordings from Vim/Vop and STN could prove useful for further studying, monitoring, and even treating motor disorders.
Url:
DOI: 10.1523/JNEUROSCI.0750-12.2012
PubMed: 22723703
PubMed Central: 3502028
Affiliations:
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<term>Deep Brain Stimulation</term>
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<front><div type="abstract" xml:lang="en"><p id="P2">Deep brain stimulation (DBS) has expanded as an effective treatment for motor disorders, providing a valuable opportunity for intraoperative recording of the spiking activity of subcortical neurons. The properties of these neurons and their potential utility in neuroprosthetic applications are not completely understood. During DBS surgeries in 25 human patients with either essential tremor or Parkinson’s disease, we acutely recorded the single-unit activity of 274 ventral intermediate/ventral oralis posterior motor thalamus (Vim/Vop) neurons and 123 subthalamic nucleus (STN) neurons. These subcortical neuronal ensembles (up to 23 neurons sampled simultaneously) were recorded while the patients performed a target-tracking motor task using a cursor controlled by a haptic glove. We observed that modulations in firing rate of a substantial number of neurons in both Vim/Vop and STN represented target onset, movement onset/direction, and hand tremor. Neurons in both areas exhibited rhythmic oscillations and pairwise synchrony. Notably, all tremor-associated neurons exhibited synchrony within the ensemble. The data further indicate that oscillatory (likely pathological) neurons and behaviorally tuned neurons are not distinct but rather form overlapping sets. Whereas previous studies have reported a linear relationship between power spectra of neuronal oscillations and hand tremor, we report a nonlinear relationship suggestive of complex encoding schemes. Even in the presence of this pathological activity, linear models were able to extract motor parameters from ensemble discharges. Based on these findings, we propose that chronic multielectrode recordings from Vim/Vop and STN could prove useful for further studying, monitoring, and even treating motor disorders.</p>
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