Computer-Aided Patient-Specific Coronary Artery Graft Design Improvements Using CFD Coupled Shape Optimizer
Identifieur interne : 001F60 ( Ncbi/Checkpoint ); précédent : 001F59; suivant : 001F61Computer-Aided Patient-Specific Coronary Artery Graft Design Improvements Using CFD Coupled Shape Optimizer
Auteurs : Onur Dur [États-Unis] ; Sinan Tolga Coskun [Allemagne] ; Kasim Oguz Coskun [Allemagne] ; David Frakes [États-Unis] ; Levent Burak Kara [États-Unis] ; Kerem Pekkan [États-Unis]Source :
- Cardiovascular Engineering and Technology [ 1869-408X ] ; 2010.
Abstract
This study aims to (i) demonstrate the efficacy of a new surgical planning framework for complex cardiovascular reconstructions, (ii) develop a computational fluid dynamics (CFD) coupled multi-dimensional shape optimization method to aid patient-specific coronary artery by-pass graft (CABG) design and, (iii) compare the hemodynamic efficiency of the sequential CABG, i.e., raising a daughter parallel branch from the parent CABG in patient-specific 3D settings. Hemodynamic efficiency of patient-specific complete revascularization scenarios for right coronary artery (RCA), left anterior descending artery (LAD), and left circumflex artery (LCX) bypasses were investigated in comparison to the stenosis condition. Multivariate 2D constraint optimization was applied on the left internal mammary artery (LIMA) graft, which was parameterized based on actual surgical settings extracted from 2D CT slices. The objective function was set to minimize the local variation of wall shear stress (WSS) and other hemodynamic indices (energy dissipation, flow deviation angle, average WSS, and vorticity) that correlate with performance of the graft and risk of re-stenosis at the anastomosis zone. Once the optimized 2D graft shape was obtained, it was translated to 3D using an in-house “sketch-based” interactive anatomical editing tool. The final graft design was evaluated using an experimentally validated second-order non-Newtonian CFD solver incorporating resistance based outlet boundary conditions. 3D patient-specific simulations for the healthy coronary anatomy produced realistic coronary flows. All revascularization techniques restored coronary perfusions to the healthy baseline. Multi-scale evaluation of the optimized LIMA graft enabled significant wall shear stress gradient (WSSG) relief (~34%). In comparison to original LIMA graft, sequential graft also lowered the WSSG by 15% proximal to LAD and diagonal bifurcation. The proposed sketch-based surgical planning paradigm evaluated the selected coronary bypass surgery procedures based on acute hemodynamic readjustments of aorta-CA flow. This methodology may provide a rational to aid surgical decision making in time-critical, patient-specific CA bypass operations before
Url:
DOI: 10.1007/s13239-010-0029-z
PubMed: 22448203
PubMed Central: 3291828
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000778
- to stream Pmc, to step Curation: 000778
- to stream Pmc, to step Checkpoint: 001F37
- to stream Ncbi, to step Merge: 001F60
- to stream Ncbi, to step Curation: 001F60
Links to Exploration step
PMC:3291828Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Computer-Aided Patient-Specific Coronary Artery Graft Design Improvements Using CFD Coupled Shape Optimizer</title><author><name sortKey="Dur, Onur" sort="Dur, Onur" uniqKey="Dur O" first="Onur" last="Dur">Onur Dur</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Biomedical Engineering, Carnegie Mellon University, 700 Technology Dr., Pittsburgh, PA 15219 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biomedical Engineering, Carnegie Mellon University, 700 Technology Dr., Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Coskun, Sinan Tolga" sort="Coskun, Sinan Tolga" uniqKey="Coskun S" first="Sinan Tolga" last="Coskun">Sinan Tolga Coskun</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Vascular Surgery, Horst Schmidt Kliniken, Wiesbaden, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Vascular Surgery, Horst Schmidt Kliniken, Wiesbaden</wicri:regionArea><wicri:noRegion>Wiesbaden</wicri:noRegion><wicri:noRegion>Wiesbaden</wicri:noRegion><wicri:noRegion>Wiesbaden</wicri:noRegion></affiliation></author><author><name sortKey="Coskun, Kasim Oguz" sort="Coskun, Kasim Oguz" uniqKey="Coskun K" first="Kasim Oguz" last="Coskun">Kasim Oguz Coskun</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Department of Thoracic Cardiovascular Surgery, University of Göttingen, Göttingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Thoracic Cardiovascular Surgery, University of Göttingen, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Frakes, David" sort="Frakes, David" uniqKey="Frakes D" first="David" last="Frakes">David Frakes</name><affiliation wicri:level="2"><nlm:aff id="Aff4">School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>School of Biological and Health Systems Engineering, Arizona State University, Tempe</wicri:cityArea></affiliation></author><author><name sortKey="Kara, Levent Burak" sort="Kara, Levent Burak" uniqKey="Kara L" first="Levent Burak" last="Kara">Levent Burak Kara</name><affiliation wicri:level="2"><nlm:aff id="Aff5">Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Pekkan, Kerem" sort="Pekkan, Kerem" uniqKey="Pekkan K" first="Kerem" last="Pekkan">Kerem Pekkan</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Biomedical Engineering, Carnegie Mellon University, 700 Technology Dr., Pittsburgh, PA 15219 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biomedical Engineering, Carnegie Mellon University, 700 Technology Dr., Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff5">Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22448203</idno><idno type="pmc">3291828</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291828</idno><idno type="RBID">PMC:3291828</idno><idno type="doi">10.1007/s13239-010-0029-z</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000778</idno><idno type="wicri:Area/Pmc/Curation">000778</idno><idno type="wicri:Area/Pmc/Checkpoint">001F37</idno><idno type="wicri:Area/Ncbi/Merge">001F60</idno><idno type="wicri:Area/Ncbi/Curation">001F60</idno><idno type="wicri:Area/Ncbi/Checkpoint">001F60</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Computer-Aided Patient-Specific Coronary Artery Graft Design Improvements Using CFD Coupled Shape Optimizer</title><author><name sortKey="Dur, Onur" sort="Dur, Onur" uniqKey="Dur O" first="Onur" last="Dur">Onur Dur</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Biomedical Engineering, Carnegie Mellon University, 700 Technology Dr., Pittsburgh, PA 15219 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biomedical Engineering, Carnegie Mellon University, 700 Technology Dr., Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Coskun, Sinan Tolga" sort="Coskun, Sinan Tolga" uniqKey="Coskun S" first="Sinan Tolga" last="Coskun">Sinan Tolga Coskun</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Vascular Surgery, Horst Schmidt Kliniken, Wiesbaden, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Vascular Surgery, Horst Schmidt Kliniken, Wiesbaden</wicri:regionArea><wicri:noRegion>Wiesbaden</wicri:noRegion><wicri:noRegion>Wiesbaden</wicri:noRegion><wicri:noRegion>Wiesbaden</wicri:noRegion></affiliation></author><author><name sortKey="Coskun, Kasim Oguz" sort="Coskun, Kasim Oguz" uniqKey="Coskun K" first="Kasim Oguz" last="Coskun">Kasim Oguz Coskun</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Department of Thoracic Cardiovascular Surgery, University of Göttingen, Göttingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Thoracic Cardiovascular Surgery, University of Göttingen, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Frakes, David" sort="Frakes, David" uniqKey="Frakes D" first="David" last="Frakes">David Frakes</name><affiliation wicri:level="2"><nlm:aff id="Aff4">School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>School of Biological and Health Systems Engineering, Arizona State University, Tempe</wicri:cityArea></affiliation></author><author><name sortKey="Kara, Levent Burak" sort="Kara, Levent Burak" uniqKey="Kara L" first="Levent Burak" last="Kara">Levent Burak Kara</name><affiliation wicri:level="2"><nlm:aff id="Aff5">Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Pekkan, Kerem" sort="Pekkan, Kerem" uniqKey="Pekkan K" first="Kerem" last="Pekkan">Kerem Pekkan</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Biomedical Engineering, Carnegie Mellon University, 700 Technology Dr., Pittsburgh, PA 15219 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Biomedical Engineering, Carnegie Mellon University, 700 Technology Dr., Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff5">Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh</wicri:cityArea></affiliation></author></analytic><series><title level="j">Cardiovascular Engineering and Technology</title><idno type="ISSN">1869-408X</idno><idno type="eISSN">1869-4098</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>This study aims to (i) demonstrate the efficacy of a new surgical planning framework for complex cardiovascular reconstructions, (ii) develop a computational fluid dynamics (CFD) coupled multi-dimensional shape optimization method to aid patient-specific coronary artery by-pass graft (CABG) design and, (iii) compare the hemodynamic efficiency of the sequential CABG, i.e., raising a daughter parallel branch from the parent CABG in patient-specific 3D settings. Hemodynamic efficiency of patient-specific complete revascularization scenarios for right coronary artery (RCA), left anterior descending artery (LAD), and left circumflex artery (LCX) bypasses were investigated in comparison to the stenosis condition. Multivariate 2D constraint optimization was applied on the left internal mammary artery (LIMA) graft, which was parameterized based on actual surgical settings extracted from 2D CT slices. The objective function was set to minimize the local variation of wall shear stress (WSS) and other hemodynamic indices (energy dissipation, flow deviation angle, average WSS, and vorticity) that correlate with performance of the graft and risk of re-stenosis at the anastomosis zone. Once the optimized 2D graft shape was obtained, it was translated to 3D using an in-house “sketch-based” interactive anatomical editing tool. The final graft design was evaluated using an experimentally validated second-order non-Newtonian CFD solver incorporating resistance based outlet boundary conditions. 3D patient-specific simulations for the healthy coronary anatomy produced realistic coronary flows. All revascularization techniques restored coronary perfusions to the healthy baseline. Multi-scale evaluation of the optimized LIMA graft enabled significant wall shear stress gradient (WSSG) relief (~34%). In comparison to original LIMA graft, sequential graft also lowered the WSSG by 15% proximal to LAD and diagonal bifurcation. The proposed sketch-based surgical planning paradigm evaluated the selected coronary bypass surgery procedures based on acute hemodynamic readjustments of aorta-CA flow. This methodology may provide a rational to aid surgical decision making in time-critical, patient-specific CA bypass operations before <italic>in vivo</italic> execution.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abraham, F" uniqKey="Abraham F">F Abraham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agoshkov, V" uniqKey="Agoshkov V">V Agoshkov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brien, To" uniqKey="Brien T">TO Brien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caiati, C" uniqKey="Caiati C">C Caiati</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Canver, Cc" uniqKey="Canver C">CC Canver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chatzizisis, Ys" uniqKey="Chatzizisis Y">YS Chatzizisis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Christenson, Jt" uniqKey="Christenson J">JT Christenson</name></author><author><name sortKey="Schmuziger, M" uniqKey="Schmuziger M">M Schmuziger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dion, R" uniqKey="Dion R">R Dion</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dur, O" uniqKey="Dur O">O Dur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Edelman, Rr" uniqKey="Edelman R">RR Edelman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fei, Dy" uniqKey="Fei D">DY Fei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frakes, Dh" uniqKey="Frakes D">DH Frakes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, Cm" uniqKey="Gibson C">CM Gibson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grundy, Sm" uniqKey="Grundy S">SM Grundy</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kara, Lb" uniqKey="Kara L">LB Kara</name></author><author><name sortKey="Shimada, K" uniqKey="Shimada K">K Shimada</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kasik, D" uniqKey="Kasik D">D Kasik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kute, Sm" uniqKey="Kute S">SM Kute</name></author><author><name sortKey="Vorp, Da" uniqKey="Vorp D">DA Vorp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Sw" uniqKey="Lee S">SW Lee</name></author><author><name sortKey="Steinman, Da" uniqKey="Steinman D">DA Steinman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lei, M" uniqKey="Lei M">M Lei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lei, M" uniqKey="Lei M">M Lei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loth, F" uniqKey="Loth F">F Loth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marsden, A" uniqKey="Marsden A">A Marsden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marsden, Al" uniqKey="Marsden A">AL Marsden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Migliavacca, F" uniqKey="Migliavacca F">F Migliavacca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Myers, Jg" uniqKey="Myers J">JG Myers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nishida, H" uniqKey="Nishida H">H Nishida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Eill, Mj" uniqKey="O Eill M">MJ O’Neill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Papaharilaou, Y" uniqKey="Papaharilaou Y">Y Papaharilaou</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Pekkan, K" uniqKey="Pekkan K">K Pekkan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pekkan, K" uniqKey="Pekkan K">K Pekkan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pekkan, K" uniqKey="Pekkan K">K Pekkan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pekkan, K" uniqKey="Pekkan K">K Pekkan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pekkan, K" uniqKey="Pekkan K">K Pekkan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pietrabissa, R" uniqKey="Pietrabissa R">R Pietrabissa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quarteroni, A" uniqKey="Quarteroni A">A Quarteroni</name></author><author><name sortKey="Rozza, G" uniqKey="Rozza G">G Rozza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raghavan, Ml" uniqKey="Raghavan M">ML Raghavan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raja, Sg" uniqKey="Raja S">SG Raja</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosamond, W" uniqKey="Rosamond W">W Rosamond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rozza, G" uniqKey="Rozza G">G Rozza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ryu, K" uniqKey="Ryu K">K Ryu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sankaranarayanan, M" uniqKey="Sankaranarayanan M">M Sankaranarayanan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schittowski, K" uniqKey="Schittowski K">K Schittowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sherwin, Sj" uniqKey="Sherwin S">SJ Sherwin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soulis, Jv" uniqKey="Soulis J">JV Soulis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sundareswaran, Ks" uniqKey="Sundareswaran K">KS Sundareswaran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Ca" uniqKey="Taylor C">CA Taylor</name></author><author><name sortKey="Figueroa, Ca" uniqKey="Figueroa C">CA Figueroa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Torii, R" uniqKey="Torii R">R Torii</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vural, Km" uniqKey="Vural K">KM Vural</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walsh, Mt" uniqKey="Walsh M">MT Walsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wieneke, H" uniqKey="Wieneke H">H Wieneke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wootton, Dm" uniqKey="Wootton D">DM Wootton</name></author><author><name sortKey="Ku, Dn" uniqKey="Ku D">DN Ku</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zarins, Ck" uniqKey="Zarins C">CK Zarins</name></author><author><name sortKey="Taylor, Ca" uniqKey="Taylor C">CA Taylor</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>États-Unis</li></country><region><li>Arizona</li><li>Basse-Saxe</li><li>Pennsylvanie</li></region><settlement><li>Göttingen</li></settlement></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Dur, Onur" sort="Dur, Onur" uniqKey="Dur O" first="Onur" last="Dur">Onur Dur</name></region><name sortKey="Frakes, David" sort="Frakes, David" uniqKey="Frakes D" first="David" last="Frakes">David Frakes</name><name sortKey="Kara, Levent Burak" sort="Kara, Levent Burak" uniqKey="Kara L" first="Levent Burak" last="Kara">Levent Burak Kara</name><name sortKey="Pekkan, Kerem" sort="Pekkan, Kerem" uniqKey="Pekkan K" first="Kerem" last="Pekkan">Kerem Pekkan</name><name sortKey="Pekkan, Kerem" sort="Pekkan, Kerem" uniqKey="Pekkan K" first="Kerem" last="Pekkan">Kerem Pekkan</name></country><country name="Allemagne"><noRegion><name sortKey="Coskun, Sinan Tolga" sort="Coskun, Sinan Tolga" uniqKey="Coskun S" first="Sinan Tolga" last="Coskun">Sinan Tolga Coskun</name></noRegion><name sortKey="Coskun, Kasim Oguz" sort="Coskun, Kasim Oguz" uniqKey="Coskun K" first="Kasim Oguz" last="Coskun">Kasim Oguz Coskun</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F60 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 001F60 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Ticri/CIDE
|area= HapticV1
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= PMC:3291828
|texte= Computer-Aided Patient-Specific Coronary Artery Graft Design Improvements Using CFD Coupled Shape Optimizer
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:22448203" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a HapticV1
| This area was generated with Dilib version V0.6.23. |  |