Repetitive Transcranial Magnetic Stimulation-Induced Changes in Sensorimotor Coupling Parallel Improvements of Somatosensation in Humans
Identifieur interne : 005D60 ( Main/Merge ); précédent : 005D59; suivant : 005D61Repetitive Transcranial Magnetic Stimulation-Induced Changes in Sensorimotor Coupling Parallel Improvements of Somatosensation in Humans
Auteurs : Burkhard Pleger [Royaume-Uni] ; Felix Blankenburg [Royaume-Uni] ; Sven Bestmann [Royaume-Uni] ; Christian C. Ruff [Royaume-Uni] ; Katja Wiech [Royaume-Uni] ; Klaas E. Stephan [Royaume-Uni] ; Karl J. Friston [Royaume-Uni] ; Raymond J. Dolan [Royaume-Uni]Source :
- The Journal of neuroscience : the official journal of the Society for Neuroscience [ 0270-6474 ] ; 2006.
Abstract
Repetitive transcranial magnetic stimulation (rTMS) is an established technique for non-invasive stimulation of human cortex. Although studies have shown an influence of rTMS on single cortical regions and on simple behavioral response patterns, its influences on the dynamics of task-related activity in cortical networks have not been characterized. We provide such a characterization by showing that 5 Hz rTMS over primary somatosensory cortex (SI) induces a reconfiguration of activity patterns in a sensorimotor network, comprising the stimulated region and ipsilateral primary motor cortex (MI). These plastic changes endure for up to 120 min and are correlated with behavioral improvement in discrimination. Dynamic causal modeling showed that this reconfiguration could be explained by an rTMS-induced increase in SI excitability (self-connection) and an increase in the effective connectivity from SI to MI. Thus, our data demonstrate that rTMS can temporarily induce behaviorally relevant reorganization within a complex cortical network underlying human somatosensory experience.
Url:
DOI: 10.1523/JNEUROSCI.4097-05.2006
PubMed: 16481426
PubMed Central: 2635564
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001968
- to stream Pmc, to step Curation: 001968
- to stream Pmc, to step Checkpoint: 002521
- to stream Ncbi, to step Merge: 000884
- to stream Ncbi, to step Curation: 000884
- to stream Ncbi, to step Checkpoint: 000884
Links to Exploration step
PMC:2635564Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Repetitive Transcranial Magnetic Stimulation-Induced Changes in Sensorimotor Coupling Parallel Improvements of Somatosensation in Humans</title>
<author><name sortKey="Pleger, Burkhard" sort="Pleger, Burkhard" uniqKey="Pleger B" first="Burkhard" last="Pleger">Burkhard Pleger</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Blankenburg, Felix" sort="Blankenburg, Felix" uniqKey="Blankenburg F" first="Felix" last="Blankenburg">Felix Blankenburg</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bestmann, Sven" sort="Bestmann, Sven" uniqKey="Bestmann S" first="Sven" last="Bestmann">Sven Bestmann</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruff, Christian C" sort="Ruff, Christian C" uniqKey="Ruff C" first="Christian C." last="Ruff">Christian C. Ruff</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Institute of Cognitive Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cognitive Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wiech, Katja" sort="Wiech, Katja" uniqKey="Wiech K" first="Katja" last="Wiech">Katja Wiech</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Human Anatomy and Genetics, Oxford University, Oxford OX1 3QX, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Human Anatomy and Genetics, Oxford University, Oxford OX1 3QX</wicri:regionArea>
<wicri:noRegion>Oxford OX1 3QX</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stephan, Klaas E" sort="Stephan, Klaas E" uniqKey="Stephan K" first="Klaas E." last="Stephan">Klaas E. Stephan</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Friston, Karl J" sort="Friston, Karl J" uniqKey="Friston K" first="Karl J." last="Friston">Karl J. Friston</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dolan, Raymond J" sort="Dolan, Raymond J" uniqKey="Dolan R" first="Raymond J." last="Dolan">Raymond J. Dolan</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">16481426</idno>
<idno type="pmc">2635564</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635564</idno>
<idno type="RBID">PMC:2635564</idno>
<idno type="doi">10.1523/JNEUROSCI.4097-05.2006</idno>
<date when="2006">2006</date>
<idno type="wicri:Area/Pmc/Corpus">001968</idno>
<idno type="wicri:Area/Pmc/Curation">001968</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002521</idno>
<idno type="wicri:Area/Ncbi/Merge">000884</idno>
<idno type="wicri:Area/Ncbi/Curation">000884</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000884</idno>
<idno type="wicri:doubleKey">0270-6474:2006:Pleger B:repetitive:transcranial:magnetic</idno>
<idno type="wicri:Area/Main/Merge">005D60</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Repetitive Transcranial Magnetic Stimulation-Induced Changes in Sensorimotor Coupling Parallel Improvements of Somatosensation in Humans</title>
<author><name sortKey="Pleger, Burkhard" sort="Pleger, Burkhard" uniqKey="Pleger B" first="Burkhard" last="Pleger">Burkhard Pleger</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Blankenburg, Felix" sort="Blankenburg, Felix" uniqKey="Blankenburg F" first="Felix" last="Blankenburg">Felix Blankenburg</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bestmann, Sven" sort="Bestmann, Sven" uniqKey="Bestmann S" first="Sven" last="Bestmann">Sven Bestmann</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruff, Christian C" sort="Ruff, Christian C" uniqKey="Ruff C" first="Christian C." last="Ruff">Christian C. Ruff</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Institute of Cognitive Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cognitive Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wiech, Katja" sort="Wiech, Katja" uniqKey="Wiech K" first="Katja" last="Wiech">Katja Wiech</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Human Anatomy and Genetics, Oxford University, Oxford OX1 3QX, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Human Anatomy and Genetics, Oxford University, Oxford OX1 3QX</wicri:regionArea>
<wicri:noRegion>Oxford OX1 3QX</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stephan, Klaas E" sort="Stephan, Klaas E" uniqKey="Stephan K" first="Klaas E." last="Stephan">Klaas E. Stephan</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Friston, Karl J" sort="Friston, Karl J" uniqKey="Friston K" first="Karl J." last="Friston">Karl J. Friston</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dolan, Raymond J" sort="Dolan, Raymond J" uniqKey="Dolan R" first="Raymond J." last="Dolan">Raymond J. Dolan</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG</wicri:regionArea>
<wicri:noRegion>London WC1N 3BG</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of neuroscience : the official journal of the Society for Neuroscience</title>
<idno type="ISSN">0270-6474</idno>
<idno type="eISSN">1529-2401</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Repetitive transcranial magnetic stimulation (rTMS) is an established technique for non-invasive stimulation of human cortex. Although studies have shown an influence of rTMS on single cortical regions and on simple behavioral response patterns, its influences on the dynamics of task-related activity in cortical networks have not been characterized. We provide such a characterization by showing that 5 Hz rTMS over primary somatosensory cortex (SI) induces a reconfiguration of activity patterns in a sensorimotor network, comprising the stimulated region and ipsilateral primary motor cortex (MI). These plastic changes endure for up to 120 min and are correlated with behavioral improvement in discrimination. Dynamic causal modeling showed that this reconfiguration could be explained by an rTMS-induced increase in SI excitability (self-connection) and an increase in the effective connectivity from SI to MI. Thus, our data demonstrate that rTMS can temporarily induce behaviorally relevant reorganization within a complex cortical network underlying human somatosensory experience.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005D60 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 005D60 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Ticri/CIDE |area= HapticV1 |flux= Main |étape= Merge |type= RBID |clé= PMC:2635564 |texte= Repetitive Transcranial Magnetic Stimulation-Induced Changes in Sensorimotor Coupling Parallel Improvements of Somatosensation in Humans }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:16481426" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a HapticV1
![]() | This area was generated with Dilib version V0.6.23. | ![]() |