Post-Operative Capsular Opacification: A Review
Identifieur interne : 005523 ( Main/Merge ); précédent : 005522; suivant : 005524Post-Operative Capsular Opacification: A Review
Auteurs : Shetal M. Raj ; Abhay R. Vasavada ; S. R. Kaid Johar ; Vaishali A. Vasavada ; Viraj A. VasavadaSource :
- International Journal of Biomedical Science : IJBS [ 1550-9702 ] ; 2007.
Abstract
Post-operative capsular opacification is a multifactorial physiological consequence of cataract surgery. Opacification involving the central posterior capsule has a significant impact on high and low contrast acuity and low contrast sensitivity. The assessment of Posterior Capsule Opacification (PCO) on cadaver eyes, experimental studies, culture models and in clinical studies has provided an understanding of its pathogenesis. The proliferation, migration and abnormal differentiation of residual lens epithelial cells and fibers in the capsular bag have been implicated in the pathogenesis of PCO. The incidence and severity of PCO correlates to the meticulous use of surgical techniques, IOL optic edge designs and IOL materials. This article summarizes the clinical studies with recommendations for retarding the development of central PCO. It discusses experiments with pharmacological agents broadly categorized as anti-inflammatory, immuno-modulating, antiproliferative, antiadhering, antitransdifferentiating agents for the prevention of PCO. These studies will remain critical for future endeavors undertaken for eradication of PCO.
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PubMed: 23675049
PubMed Central: 3614664
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Post-Operative Capsular Opacification: A Review</title><author><name sortKey="Raj, Shetal M" sort="Raj, Shetal M" uniqKey="Raj S" first="Shetal M." last="Raj">Shetal M. Raj</name></author><author><name sortKey="Vasavada, Abhay R" sort="Vasavada, Abhay R" uniqKey="Vasavada A" first="Abhay R." last="Vasavada">Abhay R. Vasavada</name></author><author><name sortKey="Johar, S R Kaid" sort="Johar, S R Kaid" uniqKey="Johar S" first="S. R. Kaid" last="Johar">S. R. Kaid Johar</name></author><author><name sortKey="Vasavada, Vaishali A" sort="Vasavada, Vaishali A" uniqKey="Vasavada V" first="Vaishali A." last="Vasavada">Vaishali A. Vasavada</name></author><author><name sortKey="Vasavada, Viraj A" sort="Vasavada, Viraj A" uniqKey="Vasavada V" first="Viraj A." last="Vasavada">Viraj A. Vasavada</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23675049</idno><idno type="pmc">3614664</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614664</idno><idno type="RBID">PMC:3614664</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">002758</idno><idno type="wicri:Area/Pmc/Curation">002758</idno><idno type="wicri:Area/Pmc/Checkpoint">002438</idno><idno type="wicri:Area/Ncbi/Merge">002683</idno><idno type="wicri:Area/Ncbi/Curation">002683</idno><idno type="wicri:Area/Ncbi/Checkpoint">002683</idno><idno type="wicri:doubleKey">1550-9702:2007:Raj S:post:operative:capsular</idno><idno type="wicri:Area/Main/Merge">005523</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Post-Operative Capsular Opacification: A Review</title><author><name sortKey="Raj, Shetal M" sort="Raj, Shetal M" uniqKey="Raj S" first="Shetal M." last="Raj">Shetal M. Raj</name></author><author><name sortKey="Vasavada, Abhay R" sort="Vasavada, Abhay R" uniqKey="Vasavada A" first="Abhay R." last="Vasavada">Abhay R. Vasavada</name></author><author><name sortKey="Johar, S R Kaid" sort="Johar, S R Kaid" uniqKey="Johar S" first="S. R. Kaid" last="Johar">S. R. Kaid Johar</name></author><author><name sortKey="Vasavada, Vaishali A" sort="Vasavada, Vaishali A" uniqKey="Vasavada V" first="Vaishali A." last="Vasavada">Vaishali A. Vasavada</name></author><author><name sortKey="Vasavada, Viraj A" sort="Vasavada, Viraj A" uniqKey="Vasavada V" first="Viraj A." last="Vasavada">Viraj A. Vasavada</name></author></analytic><series><title level="j">International Journal of Biomedical Science : IJBS</title><idno type="ISSN">1550-9702</idno><idno type="eISSN">1555-2810</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Post-operative capsular opacification is a multifactorial physiological consequence of cataract surgery. Opacification involving the central posterior capsule has a significant impact on high and low contrast acuity and low contrast sensitivity. The assessment of Posterior Capsule Opacification (PCO) on cadaver eyes, experimental studies, culture models and in clinical studies has provided an understanding of its pathogenesis. The proliferation, migration and abnormal differentiation of residual lens epithelial cells and fibers in the capsular bag have been implicated in the pathogenesis of PCO. The incidence and severity of PCO correlates to the meticulous use of surgical techniques, IOL optic edge designs and IOL materials. This article summarizes the clinical studies with recommendations for retarding the development of central PCO. It discusses experiments with pharmacological agents broadly categorized as anti-inflammatory, immuno-modulating, antiproliferative, antiadhering, antitransdifferentiating agents for the prevention of PCO. These studies will remain critical for future endeavors undertaken for eradication of PCO.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Harding, Jj" uniqKey="Harding J">JJ Harding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Hr" uniqKey="Taylor H">HR Taylor</name></author><author><name sortKey="West, Sk" uniqKey="West S">SK West</name></author><author><name sortKey="Rosenthal, Fs" uniqKey="Rosenthal F">FS Rosenthal</name></author><author><name sortKey="Munoz, B" uniqKey="Munoz B">B Munoz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccarty, Ca" uniqKey="Mccarty C">CA McCarty</name></author><author><name sortKey="Taylor, Hr" uniqKey="Taylor H">HR Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vasavada, Ar" uniqKey="Vasavada A">AR Vasavada</name></author><author><name sortKey="Chauhan, H" 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