Sustained-Release Celecoxib from Incubated Acrylic Intraocular Lenses Suppresses Lens Epithelial Cell Growth in an Ex Vivo Model of Posterior Capsule Opacity
Identifieur interne : 002182 ( Main/Merge ); précédent : 002181; suivant : 002183Sustained-Release Celecoxib from Incubated Acrylic Intraocular Lenses Suppresses Lens Epithelial Cell Growth in an Ex Vivo Model of Posterior Capsule Opacity
Auteurs : Jennifer L. Davis ; Na Young Yi ; Jacklyn H. Salmon ; Anna N. Charlton ; Carmen M. H. Colitz ; Brian C. GilgerSource :
- Journal of Ocular Pharmacology and Therapeutics [ 1080-7683 ] ; 2012.
Abstract
To determine whether celecoxib (CXB) can be released from incubated intraocular lenses (IOLs) sufficiently to inhibit lens epithelial cell (LEC) growth in an
LEC growth was evaluated for 14 days in canine lens capsules (LCs) that had been exposed to media containing 20 μM CXB for 1–5 days. After the incubation of hydrophilic and hydrophobic IOLs in CXB solution, the determination of the
The treatment of LCs with 20 μM CXB for 4 and 5 days completely inhibited LEC growth. LEC repopulation did not occur after the removal of CXB. IOLs incubated in CXB for 24 h resulted in a sustained release of CXB
A 4-day treatment of LCs with a concentration of 20 μM CXB may effectively prevent PCO. IOLs incubated in CXB for 24 h resulted in a sustained release of CXB
Url:
DOI: 10.1089/jop.2011.0196
PubMed: 22372691
PubMed Central: 3406318
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sustained-Release Celecoxib from Incubated Acrylic Intraocular Lenses Suppresses Lens Epithelial Cell Growth in an <italic>Ex Vivo</italic>
Model of Posterior Capsule Opacity</title>
<author><name sortKey="Davis, Jennifer L" sort="Davis, Jennifer L" uniqKey="Davis J" first="Jennifer L." last="Davis">Jennifer L. Davis</name>
</author>
<author><name sortKey="Yi, Na Young" sort="Yi, Na Young" uniqKey="Yi N" first="Na Young" last="Yi">Na Young Yi</name>
</author>
<author><name sortKey="Salmon, Jacklyn H" sort="Salmon, Jacklyn H" uniqKey="Salmon J" first="Jacklyn H." last="Salmon">Jacklyn H. Salmon</name>
</author>
<author><name sortKey="Charlton, Anna N" sort="Charlton, Anna N" uniqKey="Charlton A" first="Anna N." last="Charlton">Anna N. Charlton</name>
</author>
<author><name sortKey="Colitz, Carmen M H" sort="Colitz, Carmen M H" uniqKey="Colitz C" first="Carmen M. H." last="Colitz">Carmen M. H. Colitz</name>
</author>
<author><name sortKey="Gilger, Brian C" sort="Gilger, Brian C" uniqKey="Gilger B" first="Brian C." last="Gilger">Brian C. Gilger</name>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Sustained-Release Celecoxib from Incubated Acrylic Intraocular Lenses Suppresses Lens Epithelial Cell Growth in an <italic>Ex Vivo</italic>
Model of Posterior Capsule Opacity</title>
<author><name sortKey="Davis, Jennifer L" sort="Davis, Jennifer L" uniqKey="Davis J" first="Jennifer L." last="Davis">Jennifer L. Davis</name>
</author>
<author><name sortKey="Yi, Na Young" sort="Yi, Na Young" uniqKey="Yi N" first="Na Young" last="Yi">Na Young Yi</name>
</author>
<author><name sortKey="Salmon, Jacklyn H" sort="Salmon, Jacklyn H" uniqKey="Salmon J" first="Jacklyn H." last="Salmon">Jacklyn H. Salmon</name>
</author>
<author><name sortKey="Charlton, Anna N" sort="Charlton, Anna N" uniqKey="Charlton A" first="Anna N." last="Charlton">Anna N. Charlton</name>
</author>
<author><name sortKey="Colitz, Carmen M H" sort="Colitz, Carmen M H" uniqKey="Colitz C" first="Carmen M. H." last="Colitz">Carmen M. H. Colitz</name>
</author>
<author><name sortKey="Gilger, Brian C" sort="Gilger, Brian C" uniqKey="Gilger B" first="Brian C." last="Gilger">Brian C. Gilger</name>
</author>
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<series><title level="j">Journal of Ocular Pharmacology and Therapeutics</title>
<idno type="ISSN">1080-7683</idno>
<idno type="eISSN">1557-7732</idno>
<imprint><date when="2012">2012</date>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<sec><title>Purpose</title>
<p>To determine whether celecoxib (CXB) can be released from incubated intraocular lenses (IOLs) sufficiently to inhibit lens epithelial cell (LEC) growth in an <italic>ex vivo</italic>
model of posterior capsule opacification (PCO).</p>
</sec>
<sec><title>Materials</title>
<p>LEC growth was evaluated for 14 days in canine lens capsules (LCs) that had been exposed to media containing 20 μM CXB for 1–5 days. After the incubation of hydrophilic and hydrophobic IOLs in CXB solution, the determination of the <italic>in vitro</italic>
release of CXB from the IOLs was performed for up to 28 days. The incubated and nonincubated IOLs were evaluated in the <italic>ex vivo</italic>
model of PCO, and the rate of LEC growth was evaluated over 28 days.</p>
</sec>
<sec><title>Results</title>
<p>The treatment of LCs with 20 μM CXB for 4 and 5 days completely inhibited LEC growth. LEC repopulation did not occur after the removal of CXB. IOLs incubated in CXB for 24 h resulted in a sustained release of CXB <italic>in vitro</italic>
at levels theoretically sufficient to inhibit PCO. LCs in the <italic>ex vivo</italic>
model of PCO treated with acrylic IOLs incubated in CXB had significantly suppressed LEC ingrowth compared with untreated and IOL-only LCs.</p>
</sec>
<sec><title>Conclusions</title>
<p>A 4-day treatment of LCs with a concentration of 20 μM CXB may effectively prevent PCO. IOLs incubated in CXB for 24 h resulted in a sustained release of CXB <italic>in vitro</italic>
at levels sufficient to inhibit LEC growth in the <italic>ex vivo</italic>
model of PCO. Further studies are needed to determine whether CXB-incubated IOLs can effectively prevent the development of PCO <italic>in vivo</italic>
.</p>
</sec>
</div>
</front>
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