Differential effects of BDNF val(66)met in repetitive associative learning paradigms.
Identifieur interne : 000963 ( Main/Merge ); précédent : 000962; suivant : 000964Differential effects of BDNF val(66)met in repetitive associative learning paradigms.
Auteurs : Nils Freundlieb [Allemagne] ; Winifried Backhaus [Allemagne] ; Norbert Brüggemann [Allemagne] ; Christian Gerloff [Allemagne] ; Christine Klein [Allemagne] ; Hans O. Pinnschmidt [Allemagne] ; Friedhelm C. Hummel [Allemagne]Source :
- Neurobiology of learning and memory [ 1095-9564 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Aged, Association Learning (physiology), Auditory Perception (physiology), Brain-Derived Neurotrophic Factor (genetics), Female, Humans, Male, Methionine, Middle Aged, Pattern Recognition, Visual (physiology), Polymorphism, Single Nucleotide, Practice (Psychology), Touch Perception (physiology), Valine, Vocabulary, Young Adult.
- MESH :
- chemical , genetics : Brain-Derived Neurotrophic Factor.
- physiology : Association Learning, Auditory Perception, Pattern Recognition, Visual, Touch Perception.
- Adult, Aged, Female, Humans, Male, Methionine, Middle Aged, Polymorphism, Single Nucleotide, Practice (Psychology), Valine, Vocabulary, Young Adult.
Abstract
In healthy young subjects, the brain derived neurotropic factor (BDNF) val(66)met polymorphism negatively affects behavioural outcome in short-term motor cortex or hippocampus-based learning paradigms. In repetitive training paradigms over several days this effect can be overcome, in tests involving other brain areas even positive effects were found. To further specify the role of this polymorphism in cognitive processes, we used an associative vocabulary learning paradigm over four consecutive days and tested 38 young healthy subjects and 29 healthy elderly subjects. As a control paradigm, we designed a nonverbal haptic Braille letter-learning paradigm based on the same principles. Behavioural outcome was then associated with the BDNF-genotype. In the vocabulary learning task, met carrier (met/val and met/met) benefitted more from the repetitive training than val/val subjects. This was paralleled by a higher reduction of delayed answers during the course of the study, an effect that was also present in the haptic paradigm. However, in a group of healthy elderly subjects, no similar tendency was found. We conclude that the BDNF val(66)met polymorphism alters highly circumscribed answer behaviours in young healthy subjects. This might partly explain the high variability of previously published results.
DOI: 10.1016/j.nlm.2015.04.010
PubMed: 25933507
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential effects of BDNF val(66)met in repetitive associative learning paradigms.</title><author><name sortKey="Freundlieb, Nils" sort="Freundlieb, Nils" uniqKey="Freundlieb N" first="Nils" last="Freundlieb">Nils Freundlieb</name><affiliation wicri:level="1"><nlm:affiliation>Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg</wicri:regionArea><wicri:noRegion>20246 Hamburg</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Backhaus, Winifried" sort="Backhaus, Winifried" uniqKey="Backhaus W" first="Winifried" last="Backhaus">Winifried Backhaus</name><affiliation wicri:level="1"><nlm:affiliation>Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg</wicri:regionArea><wicri:noRegion>20246 Hamburg</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Bruggemann, Norbert" sort="Bruggemann, Norbert" uniqKey="Bruggemann N" first="Norbert" last="Brüggemann">Norbert Brüggemann</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany; Department of Neurology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany; Department of Neurology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck</wicri:regionArea><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Gerloff, Christian" sort="Gerloff, Christian" uniqKey="Gerloff C" first="Christian" last="Gerloff">Christian Gerloff</name><affiliation wicri:level="1"><nlm:affiliation>Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg</wicri:regionArea><wicri:noRegion>20246 Hamburg</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck</wicri:regionArea><wicri:noRegion>23562 Lübeck</wicri:noRegion><wicri:noRegion>23562 Lübeck</wicri:noRegion><wicri:noRegion>23562 Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Pinnschmidt, Hans O" sort="Pinnschmidt, Hans O" uniqKey="Pinnschmidt H" first="Hans O" last="Pinnschmidt">Hans O. Pinnschmidt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg</wicri:regionArea><wicri:noRegion>20246 Hamburg</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Hummel, Friedhelm C" sort="Hummel, Friedhelm C" uniqKey="Hummel F" first="Friedhelm C" last="Hummel">Friedhelm C. Hummel</name><affiliation wicri:level="1"><nlm:affiliation>Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg, Germany. Electronic address: f.hummel@uke.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg</wicri:regionArea><wicri:noRegion>20246 Hamburg</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25933507</idno><idno type="pmid">25933507</idno><idno type="doi">10.1016/j.nlm.2015.04.010</idno><idno type="wicri:Area/PubMed/Corpus">000348</idno><idno type="wicri:Area/PubMed/Curation">000348</idno><idno type="wicri:Area/PubMed/Checkpoint">000384</idno><idno type="wicri:Area/Ncbi/Merge">003903</idno><idno type="wicri:Area/Ncbi/Curation">003903</idno><idno type="wicri:Area/Ncbi/Checkpoint">003903</idno><idno type="wicri:Area/Main/Merge">000963</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Differential effects of BDNF val(66)met in repetitive associative learning paradigms.</title><author><name sortKey="Freundlieb, Nils" sort="Freundlieb, Nils" uniqKey="Freundlieb N" first="Nils" last="Freundlieb">Nils Freundlieb</name><affiliation wicri:level="1"><nlm:affiliation>Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg</wicri:regionArea><wicri:noRegion>20246 Hamburg</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Backhaus, Winifried" sort="Backhaus, Winifried" uniqKey="Backhaus W" first="Winifried" last="Backhaus">Winifried Backhaus</name><affiliation wicri:level="1"><nlm:affiliation>Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg</wicri:regionArea><wicri:noRegion>20246 Hamburg</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Bruggemann, Norbert" sort="Bruggemann, Norbert" uniqKey="Bruggemann N" first="Norbert" last="Brüggemann">Norbert Brüggemann</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany; Department of Neurology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany; Department of Neurology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck</wicri:regionArea><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion><wicri:noRegion>23538 Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Gerloff, Christian" sort="Gerloff, Christian" uniqKey="Gerloff C" first="Christian" last="Gerloff">Christian Gerloff</name><affiliation wicri:level="1"><nlm:affiliation>Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg</wicri:regionArea><wicri:noRegion>20246 Hamburg</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck</wicri:regionArea><wicri:noRegion>23562 Lübeck</wicri:noRegion><wicri:noRegion>23562 Lübeck</wicri:noRegion><wicri:noRegion>23562 Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Pinnschmidt, Hans O" sort="Pinnschmidt, Hans O" uniqKey="Pinnschmidt H" first="Hans O" last="Pinnschmidt">Hans O. Pinnschmidt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg</wicri:regionArea><wicri:noRegion>20246 Hamburg</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Hummel, Friedhelm C" sort="Hummel, Friedhelm C" uniqKey="Hummel F" first="Friedhelm C" last="Hummel">Friedhelm C. Hummel</name><affiliation wicri:level="1"><nlm:affiliation>Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg, Germany. Electronic address: f.hummel@uke.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Brain Imaging and Neurostimulation (BINS) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246 Hamburg</wicri:regionArea><wicri:noRegion>20246 Hamburg</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author></analytic><series><title level="j">Neurobiology of learning and memory</title><idno type="eISSN">1095-9564</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Association Learning (physiology)</term><term>Auditory Perception (physiology)</term><term>Brain-Derived Neurotrophic Factor (genetics)</term><term>Female</term><term>Humans</term><term>Male</term><term>Methionine</term><term>Middle Aged</term><term>Pattern Recognition, Visual (physiology)</term><term>Polymorphism, Single Nucleotide</term><term>Practice (Psychology)</term><term>Touch Perception (physiology)</term><term>Valine</term><term>Vocabulary</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Brain-Derived Neurotrophic Factor</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Association Learning</term><term>Auditory Perception</term><term>Pattern Recognition, Visual</term><term>Touch Perception</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Methionine</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Practice (Psychology)</term><term>Valine</term><term>Vocabulary</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In healthy young subjects, the brain derived neurotropic factor (BDNF) val(66)met polymorphism negatively affects behavioural outcome in short-term motor cortex or hippocampus-based learning paradigms. In repetitive training paradigms over several days this effect can be overcome, in tests involving other brain areas even positive effects were found. To further specify the role of this polymorphism in cognitive processes, we used an associative vocabulary learning paradigm over four consecutive days and tested 38 young healthy subjects and 29 healthy elderly subjects. As a control paradigm, we designed a nonverbal haptic Braille letter-learning paradigm based on the same principles. Behavioural outcome was then associated with the BDNF-genotype. In the vocabulary learning task, met carrier (met/val and met/met) benefitted more from the repetitive training than val/val subjects. This was paralleled by a higher reduction of delayed answers during the course of the study, an effect that was also present in the haptic paradigm. However, in a group of healthy elderly subjects, no similar tendency was found. We conclude that the BDNF val(66)met polymorphism alters highly circumscribed answer behaviours in young healthy subjects. This might partly explain the high variability of previously published results.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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