Differential effects of BDNF val(66)met in repetitive associative learning paradigms.
Identifieur interne : 000963 ( Main/Merge ); précédent : 000962; suivant : 000964Differential effects of BDNF val(66)met in repetitive associative learning paradigms.
Auteurs : Nils Freundlieb [Allemagne] ; Winifried Backhaus [Allemagne] ; Norbert Brüggemann [Allemagne] ; Christian Gerloff [Allemagne] ; Christine Klein [Allemagne] ; Hans O. Pinnschmidt [Allemagne] ; Friedhelm C. Hummel [Allemagne]Source :
- Neurobiology of learning and memory [ 1095-9564 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Aged, Association Learning (physiology), Auditory Perception (physiology), Brain-Derived Neurotrophic Factor (genetics), Female, Humans, Male, Methionine, Middle Aged, Pattern Recognition, Visual (physiology), Polymorphism, Single Nucleotide, Practice (Psychology), Touch Perception (physiology), Valine, Vocabulary, Young Adult.
- MESH :
- chemical , genetics : Brain-Derived Neurotrophic Factor.
- physiology : Association Learning, Auditory Perception, Pattern Recognition, Visual, Touch Perception.
- Adult, Aged, Female, Humans, Male, Methionine, Middle Aged, Polymorphism, Single Nucleotide, Practice (Psychology), Valine, Vocabulary, Young Adult.
Abstract
In healthy young subjects, the brain derived neurotropic factor (BDNF) val(66)met polymorphism negatively affects behavioural outcome in short-term motor cortex or hippocampus-based learning paradigms. In repetitive training paradigms over several days this effect can be overcome, in tests involving other brain areas even positive effects were found. To further specify the role of this polymorphism in cognitive processes, we used an associative vocabulary learning paradigm over four consecutive days and tested 38 young healthy subjects and 29 healthy elderly subjects. As a control paradigm, we designed a nonverbal haptic Braille letter-learning paradigm based on the same principles. Behavioural outcome was then associated with the BDNF-genotype. In the vocabulary learning task, met carrier (met/val and met/met) benefitted more from the repetitive training than val/val subjects. This was paralleled by a higher reduction of delayed answers during the course of the study, an effect that was also present in the haptic paradigm. However, in a group of healthy elderly subjects, no similar tendency was found. We conclude that the BDNF val(66)met polymorphism alters highly circumscribed answer behaviours in young healthy subjects. This might partly explain the high variability of previously published results.
DOI: 10.1016/j.nlm.2015.04.010
PubMed: 25933507
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<front><div type="abstract" xml:lang="en">In healthy young subjects, the brain derived neurotropic factor (BDNF) val(66)met polymorphism negatively affects behavioural outcome in short-term motor cortex or hippocampus-based learning paradigms. In repetitive training paradigms over several days this effect can be overcome, in tests involving other brain areas even positive effects were found. To further specify the role of this polymorphism in cognitive processes, we used an associative vocabulary learning paradigm over four consecutive days and tested 38 young healthy subjects and 29 healthy elderly subjects. As a control paradigm, we designed a nonverbal haptic Braille letter-learning paradigm based on the same principles. Behavioural outcome was then associated with the BDNF-genotype. In the vocabulary learning task, met carrier (met/val and met/met) benefitted more from the repetitive training than val/val subjects. This was paralleled by a higher reduction of delayed answers during the course of the study, an effect that was also present in the haptic paradigm. However, in a group of healthy elderly subjects, no similar tendency was found. We conclude that the BDNF val(66)met polymorphism alters highly circumscribed answer behaviours in young healthy subjects. This might partly explain the high variability of previously published results.</div>
</front>
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