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Multimodal interactions between proprioceptive and cutaneous signals in primary somatosensory cortex

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Multimodal interactions between proprioceptive and cutaneous signals in primary somatosensory cortex

Auteurs : Sung Soo Kim [États-Unis] ; Manuel Gomez-Ramirez [États-Unis] ; Pramodsingh H. Thakur [États-Unis] ; Steven S. Hsiao [États-Unis]

Source :

Neuron [ 0896-6273 ] ; 2015.

RBID : PMC:4409561

Abstract

The classical view of somatosensory processing holds that proprioceptive and cutaneous inputs are conveyed to cortex through segregated channels, initially synapsing in modality-specific areas 3a (proprioception) and 3b (cutaneous) of primary somatosensory cortex (SI). These areas relay their signals to areas 1 and 2 where multimodal convergence first emerges. However, proprioceptive and cutaneous maps have traditionally been characterized using unreliable stimulation tools. Here, we employed a mechanical stimulator that reliably positioned animals' hands in different postures and presented tactile stimuli with superb precision. Single-unit recordings in SI revealed that most neurons responded to cutaneous and proprioceptive stimuli, including cells in areas 3a and 3b. Multimodal responses were characterized by linear and nonlinear effects that emerged during early (∼20ms) and latter (>100ms) stages of stimulus processing, respectively. These data are incompatible with the modality specificity model in SI, and provide evidence for distinct mechanisms of multimodal processing in the somatosensory system.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409561

DOI: 10.1016/j.neuron.2015.03.020
PubMed: 25864632
PubMed Central: 4409561

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PMC:4409561

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p id="P1">The classical view of somatosensory processing holds that proprioceptive and cutaneous inputs are conveyed to cortex through segregated channels, initially synapsing in modality-specific areas 3a (proprioception) and 3b (cutaneous) of primary somatosensory cortex (SI). These areas relay their signals to areas 1 and 2 where multimodal convergence first emerges. However, proprioceptive and cutaneous maps have traditionally been characterized using unreliable stimulation tools. Here, we employed a mechanical stimulator that reliably positioned animals' hands in different postures and presented tactile stimuli with superb precision. Single-unit recordings in SI revealed that most neurons responded to cutaneous and proprioceptive stimuli, including cells in areas 3a and 3b. Multimodal responses were characterized by linear and nonlinear effects that emerged during early (∼20ms) and latter (>100ms) stages of stimulus processing, respectively. These data are incompatible with the modality specificity model in SI, and provide evidence for distinct mechanisms of multimodal processing in the somatosensory system.</p>
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Multimodal interactions between proprioceptive and cutaneous signals in primary somatosensory cortex

Multimodal interactions between proprioceptive and cutaneous signals in primary somatosensory cortex

Source :

Abstract

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Links to Exploration step

Le document en format XML

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