Effect of mitomycin-C on posterior capsule opacification in rabbit eyes
Identifieur interne : 007E54 ( Main/Exploration ); précédent : 007E53; suivant : 007E55Effect of mitomycin-C on posterior capsule opacification in rabbit eyes
Auteurs : Hak S. Chung [États-Unis, Corée du Sud] ; Seung J. Lim [Corée du Sud] ; Hong B. Kim [Corée du Sud]Source :
- Journal of Cataract & Refractive Surgery [ 0886-3350 ] ; 2000.
Abstract
Purpose To determine whether mitomycin-C can inhibit posterior capsule opacification (PCO) without causing ocular toxicity.Setting Yonsei Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.Methods Mitomycin-C dissolved in sodium hyaluronate (0.2 cc of 0.2 mg/mL) was injected into the empty capsular bag for 3 minutes after endocapsular phacoemulsification in rabbit eyes. Three months after surgery, the obstruction rate of visible light caused by PCO was measured using an optical power meter.Results The mean obstruction rate of visible light was 81.0% ± 8.3% (SD) in the control group in which sodium hyaluronate without mitomycin-C was used, 30.5% ± 10.1% in the group in which mitomycin-C was dissolved in sodium hyaluronate, and 71.9% ± 6.8% in the group in which mitomycin-C was dissolved in a balanced salt solution. Statistically significant differences were found among all 3 groups.Conclusion Our results suggest that the application of mitomycin-C dissolved in sodium hyaluronate effectively reduces PCO in rabbit eyes.
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DOI: 10.1016/S0886-3350(00)00309-6
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Chung</name><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Yonsei Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lim, Seung J" sort="Lim, Seung J" uniqKey="Lim S" first="Seung J" last="Lim">Seung J. Lim</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Yonsei Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Hong B" sort="Kim, Hong B" uniqKey="Kim H" first="Hong B" last="Kim">Hong B. Kim</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Yonsei Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Cataract & Refractive Surgery</title><title level="j" type="abbrev">JCRS</title><idno type="ISSN">0886-3350</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1537">1537</biblScope><biblScope unit="page" to="1542">1542</biblScope></imprint><idno type="ISSN">0886-3350</idno></series><idno type="istex">1DC13C16747BEE1AEC05B4B821959E54A18EFC46</idno><idno type="DOI">10.1016/S0886-3350(00)00309-6</idno><idno type="PII">S0886-3350(00)00309-6</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0886-3350</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose To determine whether mitomycin-C can inhibit posterior capsule opacification (PCO) without causing ocular toxicity.Setting Yonsei Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.Methods Mitomycin-C dissolved in sodium hyaluronate (0.2 cc of 0.2 mg/mL) was injected into the empty capsular bag for 3 minutes after endocapsular phacoemulsification in rabbit eyes. Three months after surgery, the obstruction rate of visible light caused by PCO was measured using an optical power meter.Results The mean obstruction rate of visible light was 81.0% ± 8.3% (SD) in the control group in which sodium hyaluronate without mitomycin-C was used, 30.5% ± 10.1% in the group in which mitomycin-C was dissolved in sodium hyaluronate, and 71.9% ± 6.8% in the group in which mitomycin-C was dissolved in a balanced salt solution. Statistically significant differences were found among all 3 groups.Conclusion Our results suggest that the application of mitomycin-C dissolved in sodium hyaluronate effectively reduces PCO in rabbit eyes.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>États-Unis</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="États-Unis"><noRegion><name sortKey="Chung, Hak S" sort="Chung, Hak S" uniqKey="Chung H" first="Hak S" last="Chung">Hak S. Chung</name></noRegion></country><country name="Corée du Sud"><noRegion><name sortKey="Chung, Hak S" sort="Chung, Hak S" uniqKey="Chung H" first="Hak S" last="Chung">Hak S. Chung</name></noRegion><name sortKey="Kim, Hong B" sort="Kim, Hong B" uniqKey="Kim H" first="Hong B" last="Kim">Hong B. Kim</name><name sortKey="Lim, Seung J" sort="Lim, Seung J" uniqKey="Lim S" first="Seung J" last="Lim">Seung J. Lim</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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