Real-time control of hind limb functional electrical stimulation using feedback from dorsal root ganglia recordings
Identifieur interne : 001911 ( Main/Exploration ); précédent : 001910; suivant : 001912Real-time control of hind limb functional electrical stimulation using feedback from dorsal root ganglia recordings
Auteurs : Tim M. Bruns [États-Unis] ; Joost B. Wagenaar [États-Unis] ; Matthew J. Bauman [États-Unis] ; Robert A. Gaunt [États-Unis] ; Douglas J. Weber [États-Unis]Source :
- Journal of neural engineering [ 1741-2560 ] ; 2013.
Abstract
Functional electrical stimulation (FES) approaches often utilize an open-loop controller to drive state transitions. The addition of sensory feedback may allow for closed-loop control that can respond effectively to perturbations and muscle fatigue.
We evaluated the use of natural sensory nerve signals obtained with penetrating microelectrode arrays in lumbar dorsal root ganglia (DRG) as real-time feedback for closed-loop control of FES-generated hind limb stepping in anesthetized cats.
Leg position feedback was obtained in near real-time at 50 ms intervals by decoding the firing rates of more than 120 DRG neurons recorded simultaneously. Over 5 m of effective linear distance was traversed during closed-loop stepping trials in each of two cats. The controller compensated effectively for perturbations in the stepping path when DRG sensory feedback was provided. The presence of stimulation artifacts and the quality of DRG unit sorting did not significantly affect the accuracy of leg position feedback obtained from the linear decoding model as long as at least 20 DRG units were included in the model.
This work demonstrates the feasibility and utility of closed-loop FES control based on natural neural sensors. Further work is needed to improve the controller and electrode technologies and to evaluate long-term viability.
Url:
DOI: 10.1088/1741-2560/10/2/026020
PubMed: 23503062
PubMed Central: 3640462
Affiliations:
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Bruns</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Wagenaar, Joost B" sort="Wagenaar, Joost B" uniqKey="Wagenaar J" first="Joost B" last="Wagenaar">Joost B. Wagenaar</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Bauman, Matthew J" sort="Bauman, Matthew J" uniqKey="Bauman M" first="Matthew J" last="Bauman">Matthew J. Bauman</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Gaunt, Robert A" sort="Gaunt, Robert A" uniqKey="Gaunt R" first="Robert A" last="Gaunt">Robert A. Gaunt</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Weber, Douglas J" sort="Weber, Douglas J" uniqKey="Weber D" first="Douglas J" last="Weber">Douglas J. Weber</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Veterans Affairs, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veterans Affairs, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j">Journal of neural engineering</title><idno type="ISSN">1741-2560</idno><idno type="eISSN">1741-2552</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">Functional electrical stimulation (FES) approaches often utilize an open-loop controller to drive state transitions. The addition of sensory feedback may allow for closed-loop control that can respond effectively to perturbations and muscle fatigue.</p></sec><sec id="S2"><title>Approach</title><p id="P2">We evaluated the use of natural sensory nerve signals obtained with penetrating microelectrode arrays in lumbar dorsal root ganglia (DRG) as real-time feedback for closed-loop control of FES-generated hind limb stepping in anesthetized cats.</p></sec><sec id="S3"><title>Main results</title><p id="P3">Leg position feedback was obtained in near real-time at 50 ms intervals by decoding the firing rates of more than 120 DRG neurons recorded simultaneously. Over 5 m of effective linear distance was traversed during closed-loop stepping trials in each of two cats. The controller compensated effectively for perturbations in the stepping path when DRG sensory feedback was provided. The presence of stimulation artifacts and the quality of DRG unit sorting did not significantly affect the accuracy of leg position feedback obtained from the linear decoding model as long as at least 20 DRG units were included in the model.</p></sec><sec id="S4"><title>Significance</title><p id="P4">This work demonstrates the feasibility and utility of closed-loop FES control based on natural neural sensors. Further work is needed to improve the controller and electrode technologies and to evaluate long-term viability.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region><orgName><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Bruns, Tim M" sort="Bruns, Tim M" uniqKey="Bruns T" first="Tim M" last="Bruns">Tim M. Bruns</name></region><name sortKey="Bauman, Matthew J" sort="Bauman, Matthew J" uniqKey="Bauman M" first="Matthew J" last="Bauman">Matthew J. Bauman</name><name sortKey="Gaunt, Robert A" sort="Gaunt, Robert A" uniqKey="Gaunt R" first="Robert A" last="Gaunt">Robert A. Gaunt</name><name sortKey="Gaunt, Robert A" sort="Gaunt, Robert A" uniqKey="Gaunt R" first="Robert A" last="Gaunt">Robert A. Gaunt</name><name sortKey="Wagenaar, Joost B" sort="Wagenaar, Joost B" uniqKey="Wagenaar J" first="Joost B" last="Wagenaar">Joost B. Wagenaar</name><name sortKey="Wagenaar, Joost B" sort="Wagenaar, Joost B" uniqKey="Wagenaar J" first="Joost B" last="Wagenaar">Joost B. Wagenaar</name><name sortKey="Weber, Douglas J" sort="Weber, Douglas J" uniqKey="Weber D" first="Douglas J" last="Weber">Douglas J. Weber</name><name sortKey="Weber, Douglas J" sort="Weber, Douglas J" uniqKey="Weber D" first="Douglas J" last="Weber">Douglas J. Weber</name><name sortKey="Weber, Douglas J" sort="Weber, Douglas J" uniqKey="Weber D" first="Douglas J" last="Weber">Douglas J. Weber</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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