Neural and behavioral correlates of drawing in an early blind painter : A case study
Identifieur interne : 005201 ( Main/Curation ); précédent : 005200; suivant : 005202Neural and behavioral correlates of drawing in an early blind painter : A case study
Auteurs : Amir Amedi [États-Unis, Israël] ; Lotfi B. Merabet [États-Unis] ; Joan Camprodon [États-Unis] ; Felix Bermpohl [États-Unis, Allemagne] ; Sharon Fox [États-Unis] ; Itamar Ronen [États-Unis] ; Dae-Shik Kim [États-Unis] ; Alvaro Pascual-Leone [États-Unis]Source :
- Brain research [ 0006-8993 ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Art, Behavior, Behavior (physiology), Blind, Blindness, Brain (physiology), Brain Mapping, Brain plasticity, Case study, Early, Human, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Multisensory integration, Perception, Psychomotor Performance (physiology), Recognition, Tactile sensitivity, Touch Perception (physiology).
- MESH :
Abstract
Humans rely heavily on vision to identify objects in the world and can create mental representations of the objects they encounter. Objects can also be identified and mentally represented through haptic exploration. However, it is unclear whether prior visual experience is necessary to generate these internal representations. Subject EA, an early blind artist, provides insight into this question. Like other blind individuals, EA captures the external world by touch. However, he is also able to reveal his internal representations through highly detailed drawings that are unequivocally understandable by a sighted person. We employed fMRI to investigate the neural correlates associated with EA's ability to transform tactilely explored three-dimensional objects into drawings and contrasted these findings with a series of control conditions (e.g. nonsensical scribbling as a sensory-motor control). Activation during drawing (compared to scribbling) occurred in brain areas normally associated with vision, including the striate cortex along with frontal and parietal cortical regions. Some of these areas showed overlap when EA was asked to mentally imagine the pictures he had to draw (albeit to a lesser anatomical extent and signal magnitude). These results have important implications as regards our understanding of the ways in which tactile information can generate mental representations of shapes and scenes in the absence of normal visual development. Furthermore, these findings suggest the occipital cortex plays a key role in supporting mental representations even without prior visual experience.
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Art</term>
<term>Behavior</term>
<term>Behavior (physiology)</term>
<term>Blind</term>
<term>Blindness</term>
<term>Brain (physiology)</term>
<term>Brain Mapping</term>
<term>Brain plasticity</term>
<term>Case study</term>
<term>Early</term>
<term>Human</term>
<term>Humans</term>
<term>Image Interpretation, Computer-Assisted</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Memory</term>
<term>Middle Aged</term>
<term>Multisensory integration</term>
<term>Perception</term>
<term>Psychomotor Performance (physiology)</term>
<term>Recognition</term>
<term>Tactile sensitivity</term>
<term>Touch Perception (physiology)</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Behavior</term>
<term>Brain</term>
<term>Psychomotor Performance</term>
<term>Touch Perception</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Art</term>
<term>Blindness</term>
<term>Brain Mapping</term>
<term>Humans</term>
<term>Image Interpretation, Computer-Assisted</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Comportement</term>
<term>Précoce</term>
<term>Aveugle</term>
<term>Etude cas</term>
<term>Sensibilité tactile</term>
<term>Perception</term>
<term>Mémoire</term>
<term>Reconnaissance</term>
<term>Cécité</term>
<term>Intégration multisensorielle</term>
<term>Homme</term>
<term>Plasticité cérébrale</term>
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<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
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<front><div type="abstract" xml:lang="en">Humans rely heavily on vision to identify objects in the world and can create mental representations of the objects they encounter. Objects can also be identified and mentally represented through haptic exploration. However, it is unclear whether prior visual experience is necessary to generate these internal representations. Subject EA, an early blind artist, provides insight into this question. Like other blind individuals, EA captures the external world by touch. However, he is also able to reveal his internal representations through highly detailed drawings that are unequivocally understandable by a sighted person. We employed fMRI to investigate the neural correlates associated with EA's ability to transform tactilely explored three-dimensional objects into drawings and contrasted these findings with a series of control conditions (e.g. nonsensical scribbling as a sensory-motor control). Activation during drawing (compared to scribbling) occurred in brain areas normally associated with vision, including the striate cortex along with frontal and parietal cortical regions. Some of these areas showed overlap when EA was asked to mentally imagine the pictures he had to draw (albeit to a lesser anatomical extent and signal magnitude). These results have important implications as regards our understanding of the ways in which tactile information can generate mental representations of shapes and scenes in the absence of normal visual development. Furthermore, these findings suggest the occipital cortex plays a key role in supporting mental representations even without prior visual experience.</div>
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<country>Israël</country>
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<series><title level="j" type="main">Brain research</title>
<title level="j" type="abbreviated">Brain res.</title>
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<imprint><date when="2008">2008</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Behavior</term>
<term>Blind</term>
<term>Blindness</term>
<term>Brain plasticity</term>
<term>Case study</term>
<term>Early</term>
<term>Human</term>
<term>Memory</term>
<term>Multisensory integration</term>
<term>Perception</term>
<term>Recognition</term>
<term>Tactile sensitivity</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Comportement</term>
<term>Précoce</term>
<term>Aveugle</term>
<term>Etude cas</term>
<term>Sensibilité tactile</term>
<term>Perception</term>
<term>Mémoire</term>
<term>Reconnaissance</term>
<term>Cécité</term>
<term>Intégration multisensorielle</term>
<term>Homme</term>
<term>Plasticité cérébrale</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Humans rely heavily on vision to identify objects in the world and can create mental representations of the objects they encounter. Objects can also be identified and mentally represented through haptic exploration. However, it is unclear whether prior visual experience is necessary to generate these internal representations. Subject EA, an early blind artist, provides insight into this question. Like other blind individuals, EA captures the external world by touch. However, he is also able to reveal his internal representations through highly detailed drawings that are unequivocally understandable by a sighted person. We employed fMRI to investigate the neural correlates associated with EA's ability to transform tactilely explored three-dimensional objects into drawings and contrasted these findings with a series of control conditions (e.g. nonsensical scribbling as a sensory-motor control). Activation during drawing (compared to scribbling) occurred in brain areas normally associated with vision, including the striate cortex along with frontal and parietal cortical regions. Some of these areas showed overlap when EA was asked to mentally imagine the pictures he had to draw (albeit to a lesser anatomical extent and signal magnitude). These results have important implications as regards our understanding of the ways in which tactile information can generate mental representations of shapes and scenes in the absence of normal visual development. Furthermore, these findings suggest the occipital cortex plays a key role in supporting mental representations even without prior visual experience.</div>
</front>
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<author><name sortKey="Merabet, Lotfi B" sort="Merabet, Lotfi B" uniqKey="Merabet L" first="Lotfi B." last="Merabet">Lotfi B. Merabet</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School. Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School. Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Camprodon, Joan" sort="Camprodon, Joan" uniqKey="Camprodon J" first="Joan" last="Camprodon">Joan Camprodon</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School. Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School. Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bermpohl, Felix" sort="Bermpohl, Felix" uniqKey="Bermpohl F" first="Felix" last="Bermpohl">Felix Bermpohl</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School. Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School. Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">Department of Psychiatry and Psychotherapy, Charité - University Medicine Berlin, Campus Mitte, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, Charité - University Medicine Berlin, Campus Mitte, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fox, Sharon" sort="Fox, Sharon" uniqKey="Fox S" first="Sharon" last="Fox">Sharon Fox</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School. Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School. Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ronen, Itamar" sort="Ronen, Itamar" uniqKey="Ronen I" first="Itamar" last="Ronen">Itamar Ronen</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Center for Biomedical Imaging and Department of Anatomy and Neurobiology, Boston University School of Medicine. Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Biomedical Imaging and Department of Anatomy and Neurobiology, Boston University School of Medicine. Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kim, Dae Shik" sort="Kim, Dae Shik" uniqKey="Kim D" first="Dae-Shik" last="Kim">Dae-Shik Kim</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Center for Biomedical Imaging and Department of Anatomy and Neurobiology, Boston University School of Medicine. Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Biomedical Imaging and Department of Anatomy and Neurobiology, Boston University School of Medicine. Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pascual Leone, Alvaro" sort="Pascual Leone, Alvaro" uniqKey="Pascual Leone A" first="Alvaro" last="Pascual-Leone">Alvaro Pascual-Leone</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School. Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School. Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Brain research</title>
<idno type="ISSN">0006-8993</idno>
<idno type="eISSN">1872-6240</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Art</term>
<term>Behavior (physiology)</term>
<term>Blindness</term>
<term>Brain (physiology)</term>
<term>Brain Mapping</term>
<term>Humans</term>
<term>Image Interpretation, Computer-Assisted</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Psychomotor Performance (physiology)</term>
<term>Touch Perception (physiology)</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Behavior</term>
<term>Brain</term>
<term>Psychomotor Performance</term>
<term>Touch Perception</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Art</term>
<term>Blindness</term>
<term>Brain Mapping</term>
<term>Humans</term>
<term>Image Interpretation, Computer-Assisted</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><p id="P1">Humans rely heavily on vision to identify objects in the world and can create mental representations of the objects they encounter. Objects can also be identified and mentally represented through haptic exploration. However, it is unclear whether prior visual experience is necessary to generate these internal representations. Subject EA, an early blind artist, provides insight into this question. Like other blind individuals, EA captures the external world by touch. However, he is also able to reveal his internal representations through highly detailed drawings that are unequivocally understandable by a sighted person. We employed fMRI to investigate the neural correlates associated with EA's ability to transform tactilely explored three dimensional objects into drawings and contrasted these findings with a series of control conditions (e.g. nonsensical scribbling as a sensory-motor control). Activation during drawing (compared to scribbling) occurred in brain areas normally associated with vision, including the striate cortex along with frontal and parietal cortical regions. Some of these areas showed overlap when EA was asked to mentally imagine the pictures he had to draw (albeit to a lesser anatomical extent and signal magnitude). These results have important implications as regards our understanding of the ways in which tactile information can generate mental representations of shapes and scenes in the absence of normal visual development. Furthermore, these findings suggest the occipital cortex plays a key role in supporting mental representations even without prior visual experience.</p>
</div>
</front>
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