Linear IgA disease and ulcerative colitis
Identifieur interne : 000E68 ( Istex/Curation ); précédent : 000E67; suivant : 000E69Linear IgA disease and ulcerative colitis
Auteurs : D. G. Paige [Royaume-Uni] ; J. N. Leonard [Royaume-Uni] ; F. Wojnarowska [Royaume-Uni] ; L. Fry [Royaume-Uni]Source :
- British Journal of Dermatology [ 0007-0963 ] ; 1997-05.
Abstract
Seventy adult patients with linear IgA disease were studied. Five (7.1%) also suffered from ulcerative colitis (the prevalence of ulcerative colitis in the U.K. is 0.05%). A further three patients with this association, from other British centres were also reviewed. In all cases, ulcerative colitis preceded the onset of skin disease, by a median of 6.5 years. The reason for this association remains unclear but the abnormalities in colonic mucosal B cells and mucosal IgA1 production reported in patients with ulcerative colitis may be important in the subsequent development of IgA1 mediated linear IgA disease.
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DOI: 10.1046/j.1365-2133.1997.6751622.x
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<front><div type="abstract" xml:lang="en">Seventy adult patients with linear IgA disease were studied. Five (7.1%) also suffered from ulcerative colitis (the prevalence of ulcerative colitis in the U.K. is 0.05%). A further three patients with this association, from other British centres were also reviewed. In all cases, ulcerative colitis preceded the onset of skin disease, by a median of 6.5 years. The reason for this association remains unclear but the abnormalities in colonic mucosal B cells and mucosal IgA1 production reported in patients with ulcerative colitis may be important in the subsequent development of IgA1 mediated linear IgA disease.</div>
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