Anterior capsule opacification
Identifieur interne : 004390 ( Istex/Corpus ); précédent : 004389; suivant : 004391Anterior capsule opacification
Auteurs : Liliana Werner ; Suresh K. Pandey ; Marcela Escobar-Gomez ; Nithi Visessook ; Qun Peng ; David J. AppleSource :
- Ophthalmology [ 0161-6420 ] ; 1999.
Abstract
Objective To compare the degree of anterior capsule opacification (ACO) in human eyes obtained postmortem containing various rigid and foldable posterior chamber intraocular lens (PC-IOL) designs.Design Comparative autopsy tissue study with clinicopathologic correlations.Materials Four hundred sixty human globes containing the following PC-IOL styles were analyzed: (1) one-piece polymethylmethacrylate (PMMA) optic-PMMA haptic (n = 50), (2) one-piece silicone-plate IOL, large hole (n = 40), (3) one-piece silicone-plate IOL, small hole (n = 67), (4) three-piece PMMA optic-PMMA/Prolene haptic (n = 51), (5) three-piece acrylic optic-PMMA haptic (n = 96), (6) three-piece silicone optic-PMMA haptic (n = 24), (7) three-piece silicone optic-polyimide haptic (n = 40), and (8) three-piece silicone optic-prolene haptic (n = 92).Testing The globes were sectioned in the equatorial plane for gross examination and then processed through paraffin; sectioned, and stained with hematoxylin–eosin, periodic acid–Schiff, and Masson’s trichrome stains; and examined by light microscopy.Main outcome measures Anterior capsule opacification was scored in each eye by grading the histologic sections from 0 to III, according to the amount (thickness) of proliferative tissue and cells measured in sagittal sections on the inner surface of the anterior capsule at the capsulorhexis margin.Results The difference among the eight groups was significant (P < 0.0001). Mean ACO scores were highest with the large and small hole one-piece silicone-plate lenses (1.77 ± 0.86 and 1.28 ± 0.77, respectively). The lowest mean score was observed in the group of three-piece acrylic optic-PMMA haptics lenses (0.51 ± 0.52).Conclusions Our results confirm previous clinical observations that the rate of ACO is relatively high with plate-haptic silicone IOLs. The lowest rate was noted with the three-piece acrylic optic-PMMA haptic IOL. The IOL design and IOL material are significant factors in the development of ACO.
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DOI: 10.1016/S0161-6420(99)00088-3
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anterior capsule opacification</title><author><name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Pandey, Suresh K" sort="Pandey, Suresh K" uniqKey="Pandey S" first="Suresh K" last="Pandey">Suresh K. Pandey</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Escobar Gomez, Marcela" sort="Escobar Gomez, Marcela" uniqKey="Escobar Gomez M" first="Marcela" last="Escobar-Gomez">Marcela Escobar-Gomez</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Visessook, Nithi" sort="Visessook, Nithi" uniqKey="Visessook N" first="Nithi" last="Visessook">Nithi Visessook</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Peng, Qun" sort="Peng, Qun" uniqKey="Peng Q" first="Qun" last="Peng">Qun Peng</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Apple, David J" sort="Apple, David J" uniqKey="Apple D" first="David J" last="Apple">David J. Apple</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F1E95DF54E00FB49DF70783663EA9930D5026B76</idno><date when="2000" year="2000">2000</date><idno type="doi">10.1016/S0161-6420(99)00088-3</idno><idno type="url">https://api.istex.fr/document/F1E95DF54E00FB49DF70783663EA9930D5026B76/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">004390</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Anterior capsule opacification</title><author><name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Pandey, Suresh K" sort="Pandey, Suresh K" uniqKey="Pandey S" first="Suresh K" last="Pandey">Suresh K. Pandey</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Escobar Gomez, Marcela" sort="Escobar Gomez, Marcela" uniqKey="Escobar Gomez M" first="Marcela" last="Escobar-Gomez">Marcela Escobar-Gomez</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Visessook, Nithi" sort="Visessook, Nithi" uniqKey="Visessook N" first="Nithi" last="Visessook">Nithi Visessook</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Peng, Qun" sort="Peng, Qun" uniqKey="Peng Q" first="Qun" last="Peng">Qun Peng</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Apple, David J" sort="Apple, David J" uniqKey="Apple D" first="David J" last="Apple">David J. Apple</name><affiliation><mods:affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Ophthalmology</title><title level="j" type="abbrev">OPHTHA</title><idno type="ISSN">0161-6420</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">107</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="463">463</biblScope><biblScope unit="page" to="471">471</biblScope></imprint><idno type="ISSN">0161-6420</idno></series><idno type="istex">F1E95DF54E00FB49DF70783663EA9930D5026B76</idno><idno type="DOI">10.1016/S0161-6420(99)00088-3</idno><idno type="PII">S0161-6420(99)00088-3</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0161-6420</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective To compare the degree of anterior capsule opacification (ACO) in human eyes obtained postmortem containing various rigid and foldable posterior chamber intraocular lens (PC-IOL) designs.Design Comparative autopsy tissue study with clinicopathologic correlations.Materials Four hundred sixty human globes containing the following PC-IOL styles were analyzed: (1) one-piece polymethylmethacrylate (PMMA) optic-PMMA haptic (n = 50), (2) one-piece silicone-plate IOL, large hole (n = 40), (3) one-piece silicone-plate IOL, small hole (n = 67), (4) three-piece PMMA optic-PMMA/Prolene haptic (n = 51), (5) three-piece acrylic optic-PMMA haptic (n = 96), (6) three-piece silicone optic-PMMA haptic (n = 24), (7) three-piece silicone optic-polyimide haptic (n = 40), and (8) three-piece silicone optic-prolene haptic (n = 92).Testing The globes were sectioned in the equatorial plane for gross examination and then processed through paraffin; sectioned, and stained with hematoxylin–eosin, periodic acid–Schiff, and Masson’s trichrome stains; and examined by light microscopy.Main outcome measures Anterior capsule opacification was scored in each eye by grading the histologic sections from 0 to III, according to the amount (thickness) of proliferative tissue and cells measured in sagittal sections on the inner surface of the anterior capsule at the capsulorhexis margin.Results The difference among the eight groups was significant (P < 0.0001). Mean ACO scores were highest with the large and small hole one-piece silicone-plate lenses (1.77 ± 0.86 and 1.28 ± 0.77, respectively). The lowest mean score was observed in the group of three-piece acrylic optic-PMMA haptics lenses (0.51 ± 0.52).Conclusions Our results confirm previous clinical observations that the rate of ACO is relatively high with plate-haptic silicone IOLs. The lowest rate was noted with the three-piece acrylic optic-PMMA haptic IOL. The IOL design and IOL material are significant factors in the development of ACO.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Liliana Werner MD, PhD</name><affiliations><json:string>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</json:string></affiliations></json:item><json:item><name>Suresh K Pandey MD</name><affiliations><json:string>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</json:string></affiliations></json:item><json:item><name>Marcela Escobar-Gomez MD</name><affiliations><json:string>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</json:string></affiliations></json:item><json:item><name>Nithi Visessook MD</name><affiliations><json:string>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</json:string></affiliations></json:item><json:item><name>Qun Peng MD</name><affiliations><json:string>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</json:string></affiliations></json:item><json:item><name>David J Apple MD</name><affiliations><json:string>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</json:string></affiliations></json:item></author><language><json:string>eng</json:string></language><abstract>Objective To compare the degree of anterior capsule opacification (ACO) in human eyes obtained postmortem containing various rigid and foldable posterior chamber intraocular lens (PC-IOL) designs.Design Comparative autopsy tissue study with clinicopathologic correlations.Materials Four hundred sixty human globes containing the following PC-IOL styles were analyzed: (1) one-piece polymethylmethacrylate (PMMA) optic-PMMA haptic (n = 50), (2) one-piece silicone-plate IOL, large hole (n = 40), (3) one-piece silicone-plate IOL, small hole (n = 67), (4) three-piece PMMA optic-PMMA/Prolene haptic (n = 51), (5) three-piece acrylic optic-PMMA haptic (n = 96), (6) three-piece silicone optic-PMMA haptic (n = 24), (7) three-piece silicone optic-polyimide haptic (n = 40), and (8) three-piece silicone optic-prolene haptic (n = 92).Testing The globes were sectioned in the equatorial plane for gross examination and then processed through paraffin; sectioned, and stained with hematoxylin–eosin, periodic acid–Schiff, and Masson’s trichrome stains; and examined by light microscopy.Main outcome measures Anterior capsule opacification was scored in each eye by grading the histologic sections from 0 to III, according to the amount (thickness) of proliferative tissue and cells measured in sagittal sections on the inner surface of the anterior capsule at the capsulorhexis margin.Results The difference among the eight groups was significant (P > 0.0001). Mean ACO scores were highest with the large and small hole one-piece silicone-plate lenses (1.77 ± 0.86 and 1.28 ± 0.77, respectively). The lowest mean score was observed in the group of three-piece acrylic optic-PMMA haptics lenses (0.51 ± 0.52).Conclusions Our results confirm previous clinical observations that the rate of ACO is relatively high with plate-haptic silicone IOLs. The lowest rate was noted with the three-piece acrylic optic-PMMA haptic IOL. The IOL design and IOL material are significant factors in the development of ACO.</abstract><qualityIndicators><score>7.131</score><pdfVersion>1.2</pdfVersion><pdfPageSize>586 x 786 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1997</abstractCharCount><pdfWordCount>4131</pdfWordCount><pdfCharCount>26997</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>285</abstractWordCount></qualityIndicators><title>Anterior capsule opacification</title><pii><json:string>S0161-6420(99)00088-3</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>107</volume><pii><json:string>S0161-6420(00)X0003-6</json:string></pii><pages><last>471</last><first>463</first></pages><issn><json:string>0161-6420</json:string></issn><issue>3</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Ophthalmology</title><publicationDate>2000</publicationDate></host><categories><wos><json:string>OPHTHALMOLOGY</json:string></wos></categories><publicationDate>1999</publicationDate><copyrightDate>2000</copyrightDate><doi><json:string>10.1016/S0161-6420(99)00088-3</json:string></doi><id>F1E95DF54E00FB49DF70783663EA9930D5026B76</id><score>1</score><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/F1E95DF54E00FB49DF70783663EA9930D5026B76/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/F1E95DF54E00FB49DF70783663EA9930D5026B76/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/F1E95DF54E00FB49DF70783663EA9930D5026B76/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/F1E95DF54E00FB49DF70783663EA9930D5026B76/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Anterior capsule opacification</title><title level="a" type="sub" xml:lang="en">A histopathological study comparing different IOL styles</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>2000</date></publicationStmt><notesStmt><note>Supported in part by an unrestricted grant from Research to Prevent Blindness, Inc, New York, New York.</note><note>Manuscript no. 99314.</note><note>The authors have no financial or proprietary interest in any product mentioned in this paper.</note><note type="content">Section title: Original Articles</note><note type="content">Figure 1: Gross photographs of a pseudophakic human globe obtained postmortem, showing an example of a clear anterior capsule. A, Anterior (surgeon’s) view. B, Miyake-Apple posterior view.</note><note type="content">Figure 2: Gross photographs of a pseudophakic human globe obtained postmortem, showing opacification of the anterior capsule. Note that this eye has also been treated with a Nd:YAG laser posterior capsulotomy (central orifice), not to be confused with the anterior circular edge of the CCC. A, Anterior (surgeon’s) view. B, Miyake-Apple posterior view.</note><note type="content">Figure 3: Photomicrographs taken at the CCC margin of pseudophakic human globes obtained postmortem. A, Masson’s trichrome stain; anterior capsule fibrosis grade 0. B, Same case as Figure 3A, periodic acid–Schiff (PAS) stain; anterior capsule fibrosis grade 0. C, Masson’s trichrome stain; anterior capsule fibrosis grade I. D, Same case as Figure 3C, PAS stain; anterior capsule fibrosis grade I. E, Masson’s trichrome stain; anterior capsule fibrosis grade II. F, Same case as Figure 3E, PAS stain; anterior capsule fibrosis grade II. G, Masson’s trichrome stain; anterior capsule fibrosis grade III. H, Same case as Figure 3G, PAS stain; anterior capsule fibrosis grade III. (A to H, original magnification, ×400.)</note><note type="content">Figure 4: Photomicrographs taken at the CCC margin of pseudophakic human globes obtained postmortem, implanted with one-piece silicone-plate large-hole IOLs (mean score, 1.77, Table 2). A, Anterior capsule fibrosis grade II. B, Anterior capsule fibrosis grade III. (A and B, Masson’s trichrome stain; original magnification, ×400.)</note><note type="content">Figure 5: Photomicrographs taken at the CCC margin of pseudophakic human globes obtained postmortem, implanted with one-piece silicone-plate small-hole IOLs (mean score, 1.28, Table 2). A, Anterior capsule fibrosis grade I. B, Anterior capsule fibrosis grade II. (A and B, Masson’s trichrome stain; original magnification, ×400.)</note><note type="content">Figure 6: Photomicrographs taken at the CCC margin of pseudophakic human globes obtained postmortem, implanted with 3-piece silicone optic-PMMA haptics IOLs (mean score, 1.21, Table 2). A, Anterior capsule fibrosis grade I. B, Anterior capsule fibrosis grade II. (A and B, Masson’s trichrome stain; original magnification, ×400.)</note><note type="content">Figure 7: Photomicrographs taken at the CCC margin of pseudophakic human globes obtained postmortem, implanted with 3-piece silicone optic-prolene haptics IOLs (mean score, 1.09, Table 2). A, Anterior capsule fibrosis grade I. B, Anterior capsule fibrosis grade II. (A and B, Masson’s trichrome stain; original magnification, ×400.)</note><note type="content">Figure 8: Photomicrographs taken at the CCC margin of pseudophakic human globes obtained postmortem. A, Globe implanted with a three-piece PMMA optic-PMMA/Prolene haptics IOL; anterior capsule fibrosis grade I (mean score, 1.07, Table 2). B, Globe implanted with a one-piece PMMA optic-PMMA haptics IOL; anterior capsule fibrosis grade I (mean score, 0.94, Table 2). C, Globe implanted with a three-piece silicone optic-polyimide haptics IOL; anterior capsule fibrosis grade I (mean score, 0.92, Table 2). (A to C, Masson trichrome stain; original magnification, ×400.)</note><note type="content">Figure 9: Photomicrographs taken at the CCC margin of pseudophakic human globes obtained postmortem, implanted with three-piece acrylic optic-PMMA haptics IOLs (mean score, 0.51, Table 2). A, Anterior capsule fibrosis grade 0. B, Anterior capsule fibrosis grade I. (A and B, Masson trichrome stain; original magnification, ×400.)</note><note type="content">Figure 10: Gross photograph (anterior or surgeon’s view) of a pseudophakic human globe obtained postmortem, implanted with a three-piece silicone optic-prolene haptic IOL. This is an example of extreme, eccentric constriction of the CCC opening (capsular contraction syndrome, capsular phimosis).</note><note type="content">Table 1: IOL Styles Included in this Study. The Specimens are Human Globes Obtained Postmortem, Accessed Between January 1995 and January 1999.legend</note><note type="content">Table 2: Histopathologic Scoring of ACO (from grade 0 to III) in Human Globes Obtained Postmortem, January 1995 to January 1999legend</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Anterior capsule opacification</title><title level="a" type="sub" xml:lang="en">A histopathological study comparing different IOL styles</title><author><persName><forename type="first">Liliana</forename><surname>Werner</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation></author><author><persName><forename type="first">Suresh K</forename><surname>Pandey</surname></persName><roleName type="degree">MD</roleName><affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation></author><author><persName><forename type="first">Marcela</forename><surname>Escobar-Gomez</surname></persName><roleName type="degree">MD</roleName><affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation></author><author><persName><forename type="first">Nithi</forename><surname>Visessook</surname></persName><roleName type="degree">MD</roleName><affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation></author><author><persName><forename type="first">Qun</forename><surname>Peng</surname></persName><roleName type="degree">MD</roleName><affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation></author><author><persName><forename type="first">David J</forename><surname>Apple</surname></persName><roleName type="degree">MD</roleName><note type="biography">Reprint requests to David J. Apple, MD, Storm Eye Institute, Department of Ophthalmology, Medical University of South Carolina, 167 Ashley Ave, PO Box 250676, Charleston, SC</note><affiliation>Reprint requests to David J. Apple, MD, Storm Eye Institute, Department of Ophthalmology, Medical University of South Carolina, 167 Ashley Ave, PO Box 250676, Charleston, SC</affiliation><affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation></author></analytic><monogr><title level="j">Ophthalmology</title><title level="j" type="abbrev">OPHTHA</title><idno type="pISSN">0161-6420</idno><idno type="PII">S0161-6420(00)X0003-6</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999"></date><biblScope unit="volume">107</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="463">463</biblScope><biblScope unit="page" to="471">471</biblScope></imprint></monogr><idno type="istex">F1E95DF54E00FB49DF70783663EA9930D5026B76</idno><idno type="DOI">10.1016/S0161-6420(99)00088-3</idno><idno type="PII">S0161-6420(99)00088-3</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2000</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Objective To compare the degree of anterior capsule opacification (ACO) in human eyes obtained postmortem containing various rigid and foldable posterior chamber intraocular lens (PC-IOL) designs.Design Comparative autopsy tissue study with clinicopathologic correlations.Materials Four hundred sixty human globes containing the following PC-IOL styles were analyzed: (1) one-piece polymethylmethacrylate (PMMA) optic-PMMA haptic (n = 50), (2) one-piece silicone-plate IOL, large hole (n = 40), (3) one-piece silicone-plate IOL, small hole (n = 67), (4) three-piece PMMA optic-PMMA/Prolene haptic (n = 51), (5) three-piece acrylic optic-PMMA haptic (n = 96), (6) three-piece silicone optic-PMMA haptic (n = 24), (7) three-piece silicone optic-polyimide haptic (n = 40), and (8) three-piece silicone optic-prolene haptic (n = 92).Testing The globes were sectioned in the equatorial plane for gross examination and then processed through paraffin; sectioned, and stained with hematoxylin–eosin, periodic acid–Schiff, and Masson’s trichrome stains; and examined by light microscopy.Main outcome measures Anterior capsule opacification was scored in each eye by grading the histologic sections from 0 to III, according to the amount (thickness) of proliferative tissue and cells measured in sagittal sections on the inner surface of the anterior capsule at the capsulorhexis margin.Results The difference among the eight groups was significant (P < 0.0001). Mean ACO scores were highest with the large and small hole one-piece silicone-plate lenses (1.77 ± 0.86 and 1.28 ± 0.77, respectively). The lowest mean score was observed in the group of three-piece acrylic optic-PMMA haptics lenses (0.51 ± 0.52).Conclusions Our results confirm previous clinical observations that the rate of ACO is relatively high with plate-haptic silicone IOLs. The lowest rate was noted with the three-piece acrylic optic-PMMA haptic IOL. The IOL design and IOL material are significant factors in the development of ACO.</p></abstract></profileDesc><revisionDesc><change when="1999-10-13">Registration</change><change when="1999">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="GR1"></istex:entity><istex:entity SYSTEM="gr2" NDATA="IMAGE" name="GR2"></istex:entity><istex:entity SYSTEM="gr3" NDATA="IMAGE" name="GR3"></istex:entity><istex:entity SYSTEM="gr4" NDATA="IMAGE" name="GR4"></istex:entity><istex:entity SYSTEM="gr5" NDATA="IMAGE" name="GR5"></istex:entity><istex:entity SYSTEM="gr6" NDATA="IMAGE" name="GR6"></istex:entity><istex:entity SYSTEM="gr7" NDATA="IMAGE" name="GR7"></istex:entity><istex:entity SYSTEM="gr8" NDATA="IMAGE" name="GR8"></istex:entity><istex:entity SYSTEM="gr9" NDATA="IMAGE" name="GR9"></istex:entity><istex:entity SYSTEM="gr10" NDATA="IMAGE" name="GR10"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>OPHTHA</jid><aid>87</aid><ce:pii>S0161-6420(99)00088-3</ce:pii><ce:doi>10.1016/S0161-6420(99)00088-3</ce:doi><ce:copyright type="society" year="2000">American Academy of Ophthalmology, Inc.</ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>Supported in part by an unrestricted grant from Research to Prevent Blindness, Inc, New York, New York.</ce:note-para></ce:article-footnote><ce:dochead><ce:textfn>Original Articles</ce:textfn></ce:dochead><ce:title>Anterior capsule opacification<ce:cross-ref refid="FN1"><ce:sup>1</ce:sup></ce:cross-ref><ce:footnote id="FN1"><ce:label>1</ce:label><ce:note-para>The authors have no financial or proprietary interest in any product mentioned in this paper.</ce:note-para></ce:footnote></ce:title><ce:subtitle>A histopathological study comparing different IOL styles</ce:subtitle><ce:presented>Presented in part at the American Academy of Ophthalmology annual meeting, Orlando, Florida, October 1999.</ce:presented><ce:author-group><ce:author><ce:given-name>Liliana</ce:given-name><ce:surname>Werner</ce:surname><ce:degrees>MD, PhD</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Suresh K</ce:given-name><ce:surname>Pandey</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Marcela</ce:given-name><ce:surname>Escobar-Gomez</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Nithi</ce:given-name><ce:surname>Visessook</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Qun</ce:given-name><ce:surname>Peng</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>David J</ce:given-name><ce:surname>Apple</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="CORR1">*</ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Reprint requests to David J. Apple, MD, Storm Eye Institute, Department of Ophthalmology, Medical University of South Carolina, 167 Ashley Ave, PO Box 250676, Charleston, SC</ce:text></ce:correspondence></ce:author-group><ce:date-received day="16" month="6" year="1999"></ce:date-received><ce:date-accepted day="13" month="10" year="1999"></ce:date-accepted><ce:miscellaneous>Manuscript no. 99314.</ce:miscellaneous><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:section-title>Objective</ce:section-title><ce:simple-para>To compare the degree of anterior capsule opacification (ACO) in human eyes obtained postmortem containing various rigid and foldable posterior chamber intraocular lens (PC-IOL) designs.</ce:simple-para></ce:abstract-sec><ce:abstract-sec><ce:section-title>Design</ce:section-title><ce:simple-para>Comparative autopsy tissue study with clinicopathologic correlations.</ce:simple-para></ce:abstract-sec><ce:abstract-sec><ce:section-title>Materials</ce:section-title><ce:simple-para>Four hundred sixty human globes containing the following PC-IOL styles were analyzed: (1) one-piece polymethylmethacrylate (PMMA) optic-PMMA haptic (<ce:italic>n</ce:italic> = 50), (2) one-piece silicone-plate IOL, large hole (<ce:italic>n</ce:italic> = 40), (3) one-piece silicone-plate IOL, small hole (<ce:italic>n</ce:italic> = 67), (4) three-piece PMMA optic-PMMA/Prolene haptic (<ce:italic>n</ce:italic> = 51), (5) three-piece acrylic optic-PMMA haptic (<ce:italic>n</ce:italic> = 96), (6) three-piece silicone optic-PMMA haptic (<ce:italic>n</ce:italic> = 24), (7) three-piece silicone optic-polyimide haptic (<ce:italic>n</ce:italic> = 40), and (8) three-piece silicone optic-prolene haptic (<ce:italic>n</ce:italic> = 92).</ce:simple-para></ce:abstract-sec><ce:abstract-sec><ce:section-title>Testing</ce:section-title><ce:simple-para>The globes were sectioned in the equatorial plane for gross examination and then processed through paraffin; sectioned, and stained with hematoxylin–eosin, periodic acid–Schiff, and Masson’s trichrome stains; and examined by light microscopy.</ce:simple-para></ce:abstract-sec><ce:abstract-sec><ce:section-title>Main outcome measures</ce:section-title><ce:simple-para>Anterior capsule opacification was scored in each eye by grading the histologic sections from 0 to III, according to the amount (thickness) of proliferative tissue and cells measured in sagittal sections on the inner surface of the anterior capsule at the capsulorhexis margin.</ce:simple-para></ce:abstract-sec><ce:abstract-sec><ce:section-title>Results</ce:section-title><ce:simple-para>The difference among the eight groups was significant (<ce:italic>P</ce:italic> < 0.0001). Mean ACO scores were highest with the large and small hole one-piece silicone-plate lenses (1.77 ± 0.86 and 1.28 ± 0.77, respectively). The lowest mean score was observed in the group of three-piece acrylic optic-PMMA haptics lenses (0.51 ± 0.52).</ce:simple-para></ce:abstract-sec><ce:abstract-sec><ce:section-title>Conclusions</ce:section-title><ce:simple-para>Our results confirm previous clinical observations that the rate of ACO is relatively high with plate-haptic silicone IOLs. The lowest rate was noted with the three-piece acrylic optic-PMMA haptic IOL. The IOL design and IOL material are significant factors in the development of ACO.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Anterior capsule opacification</title><subTitle>A histopathological study comparing different IOL styles</subTitle></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Anterior capsule opacification</title><subTitle>A histopathological study comparing different IOL styles</subTitle></titleInfo><name type="personal"><namePart type="given">Liliana</namePart><namePart type="family">Werner</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Suresh K</namePart><namePart type="family">Pandey</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marcela</namePart><namePart type="family">Escobar-Gomez</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nithi</namePart><namePart type="family">Visessook</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Qun</namePart><namePart type="family">Peng</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David J</namePart><namePart type="family">Apple</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Research on Ocular Therapeutics and Biodevices (Director: David J. Apple, MD), Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA</affiliation><description>Reprint requests to David J. Apple, MD, Storm Eye Institute, Department of Ophthalmology, Medical University of South Carolina, 167 Ashley Ave, PO Box 250676, Charleston, SC</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued><dateValid encoding="w3cdtf">1999-10-13</dateValid><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Objective To compare the degree of anterior capsule opacification (ACO) in human eyes obtained postmortem containing various rigid and foldable posterior chamber intraocular lens (PC-IOL) designs.Design Comparative autopsy tissue study with clinicopathologic correlations.Materials Four hundred sixty human globes containing the following PC-IOL styles were analyzed: (1) one-piece polymethylmethacrylate (PMMA) optic-PMMA haptic (n = 50), (2) one-piece silicone-plate IOL, large hole (n = 40), (3) one-piece silicone-plate IOL, small hole (n = 67), (4) three-piece PMMA optic-PMMA/Prolene haptic (n = 51), (5) three-piece acrylic optic-PMMA haptic (n = 96), (6) three-piece silicone optic-PMMA haptic (n = 24), (7) three-piece silicone optic-polyimide haptic (n = 40), and (8) three-piece silicone optic-prolene haptic (n = 92).Testing The globes were sectioned in the equatorial plane for gross examination and then processed through paraffin; sectioned, and stained with hematoxylin–eosin, periodic acid–Schiff, and Masson’s trichrome stains; and examined by light microscopy.Main outcome measures Anterior capsule opacification was scored in each eye by grading the histologic sections from 0 to III, according to the amount (thickness) of proliferative tissue and cells measured in sagittal sections on the inner surface of the anterior capsule at the capsulorhexis margin.Results The difference among the eight groups was significant (P < 0.0001). Mean ACO scores were highest with the large and small hole one-piece silicone-plate lenses (1.77 ± 0.86 and 1.28 ± 0.77, respectively). The lowest mean score was observed in the group of three-piece acrylic optic-PMMA haptics lenses (0.51 ± 0.52).Conclusions Our results confirm previous clinical observations that the rate of ACO is relatively high with plate-haptic silicone IOLs. The lowest rate was noted with the three-piece acrylic optic-PMMA haptic IOL. The IOL design and IOL material are significant factors in the development of ACO.</abstract><note>Supported in part by an unrestricted grant from Research to Prevent Blindness, Inc, New York, New York.</note><note>Manuscript no. 99314.</note><note type="footnote">The authors have no financial or proprietary interest in any product mentioned in this paper.</note><note type="content">Section title: Original Articles</note><note type="content">Figure 1: Gross photographs of a pseudophakic human globe obtained postmortem, showing an example of a clear anterior capsule. A, Anterior (surgeon’s) view. B, Miyake-Apple posterior view.</note><note type="content">Figure 2: Gross photographs of a pseudophakic human globe obtained postmortem, showing opacification of the anterior capsule. Note that this eye has also been treated with a Nd:YAG laser posterior capsulotomy (central orifice), not to be confused with the anterior circular edge of the CCC. A, Anterior (surgeon’s) view. B, Miyake-Apple posterior view.</note><note type="content">Figure 3: Photomicrographs taken at the CCC margin of pseudophakic human globes obtained postmortem. A, Masson’s trichrome stain; anterior capsule fibrosis grade 0. B, Same case as Figure 3A, periodic acid–Schiff (PAS) stain; anterior capsule fibrosis grade 0. C, Masson’s trichrome stain; anterior capsule fibrosis grade I. D, Same case as Figure 3C, PAS stain; anterior capsule fibrosis grade I. E, Masson’s trichrome stain; anterior capsule fibrosis grade II. F, Same case as Figure 3E, PAS stain; anterior capsule fibrosis grade II. G, Masson’s trichrome stain; anterior capsule fibrosis grade III. H, Same case as Figure 3G, PAS stain; anterior capsule fibrosis grade III. (A to H, original magnification, ×400.)</note><note type="content">Figure 4: Photomicrographs taken at the CCC margin of pseudophakic human globes obtained postmortem, implanted with one-piece silicone-plate large-hole IOLs (mean score, 1.77, Table 2). A, Anterior capsule fibrosis grade II. B, Anterior capsule fibrosis grade III. (A and B, Masson’s trichrome stain; original magnification, ×400.)</note><note type="content">Figure 5: Photomicrographs taken at the CCC margin of pseudophakic human globes obtained postmortem, implanted with one-piece silicone-plate small-hole IOLs (mean score, 1.28, Table 2). A, Anterior capsule fibrosis grade I. B, Anterior capsule fibrosis grade II. (A and B, Masson’s trichrome stain; original magnification, ×400.)</note><note type="content">Figure 6: Photomicrographs taken at the CCC margin of pseudophakic human globes obtained postmortem, implanted with 3-piece silicone optic-PMMA haptics IOLs (mean score, 1.21, Table 2). A, Anterior capsule fibrosis grade I. B, Anterior capsule fibrosis grade II. (A and B, Masson’s trichrome stain; original magnification, ×400.)</note><note type="content">Figure 7: Photomicrographs taken at the CCC margin of pseudophakic human globes obtained postmortem, implanted with 3-piece silicone optic-prolene haptics IOLs (mean score, 1.09, Table 2). A, Anterior capsule fibrosis grade I. B, Anterior capsule fibrosis grade II. (A and B, Masson’s trichrome stain; original magnification, ×400.)</note><note type="content">Figure 8: Photomicrographs taken at the CCC margin of pseudophakic human globes obtained postmortem. A, Globe implanted with a three-piece PMMA optic-PMMA/Prolene haptics IOL; anterior capsule fibrosis grade I (mean score, 1.07, Table 2). B, Globe implanted with a one-piece PMMA optic-PMMA haptics IOL; anterior capsule fibrosis grade I (mean score, 0.94, Table 2). C, Globe implanted with a three-piece silicone optic-polyimide haptics IOL; anterior capsule fibrosis grade I (mean score, 0.92, Table 2). (A to C, Masson trichrome stain; original magnification, ×400.)</note><note type="content">Figure 9: Photomicrographs taken at the CCC margin of pseudophakic human globes obtained postmortem, implanted with three-piece acrylic optic-PMMA haptics IOLs (mean score, 0.51, Table 2). A, Anterior capsule fibrosis grade 0. B, Anterior capsule fibrosis grade I. (A and B, Masson trichrome stain; original magnification, ×400.)</note><note type="content">Figure 10: Gross photograph (anterior or surgeon’s view) of a pseudophakic human globe obtained postmortem, implanted with a three-piece silicone optic-prolene haptic IOL. This is an example of extreme, eccentric constriction of the CCC opening (capsular contraction syndrome, capsular phimosis).</note><note type="content">Table 1: IOL Styles Included in this Study. The Specimens are Human Globes Obtained Postmortem, Accessed Between January 1995 and January 1999.legend</note><note type="content">Table 2: Histopathologic Scoring of ACO (from grade 0 to III) in Human Globes Obtained Postmortem, January 1995 to January 1999legend</note><relatedItem type="host"><titleInfo><title>Ophthalmology</title></titleInfo><titleInfo type="abbreviated"><title>OPHTHA</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">200003</dateIssued></originInfo><identifier type="ISSN">0161-6420</identifier><identifier type="PII">S0161-6420(00)X0003-6</identifier><part><date>200003</date><detail type="volume"><number>107</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue pages"><start>A1</start><end>A52</end></extent><extent unit="issue pages"><start>407</start><end>618</end></extent><extent unit="pages"><start>463</start><end>471</end></extent></part></relatedItem><identifier type="istex">F1E95DF54E00FB49DF70783663EA9930D5026B76</identifier><identifier type="DOI">10.1016/S0161-6420(99)00088-3</identifier><identifier type="PII">S0161-6420(99)00088-3</identifier><accessCondition type="use and reproduction" contentType="">© 2000American Academy of Ophthalmology, Inc.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>American Academy of Ophthalmology, Inc., ©2000</recordOrigin></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/F1E95DF54E00FB49DF70783663EA9930D5026B76/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">OPHTHALMOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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