HapticV1, Hal, Corpus, bibRecord, 000342

Interactive Cell Injection Simulation Based on 3D Biomechanical Tensegrity Model

Identifieur interne : 000342 ( Hal/Corpus ); précédent : 000341; suivant : 000343

Interactive Cell Injection Simulation Based on 3D Biomechanical Tensegrity Model

Auteurs : Hamid Ladjal ; Jean-Luc Hanus ; Antoine Ferreira

Source :

RBID : Hal:hal-00653111

Descripteurs français

mix :
- Modélisation biomécanique, Tensegrity, interaction en temps réel, microinjection cellulaire.

Abstract

To facilitate training of biological cell injection operations, we are developing an interactive virtual environment to simulate needle insertion into biological cells. A key challenge of deformable simulation is to satisfy the conflicting requirements of real-time interactivity and physical realism. This paper presents methodologies for dynamic modeling, visual/haptic display and model validation of cell injection. We first investigate the challenging issues in the modeling of the bio-mechanical properties of living cells. We propose a dynamic model to simulate cell deformation and puncture. The developed approach is based on the assumptions that the mechanical response of living cells is mainly determined by the cytoskeleton and that the cytoskeleton is organised as a tensegrity structure including microfilaments, microtubules and intermediate filaments. Equivalent microtubules struts are represented with a linear mass-tensor finite element model and equivalent microfilaments and intermediate filaments with viscoelastic Kelvin-Voigt elements. The virtual environment has been implemented with both graphic and haptic interfaces.

Url:

https://hal.archives-ouvertes.fr/hal-00653111

DOI: 10.1109/IROS.2008.4650973

Links to Exploration step

Hal:hal-00653111

Le document en format XML

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<front><div type="abstract" xml:lang="en">To facilitate training of biological cell injection operations, we are developing an interactive virtual environment to simulate needle insertion into biological cells. A key challenge of deformable simulation is to satisfy the conflicting requirements of real-time interactivity and physical realism. This paper presents methodologies for dynamic modeling, visual/haptic display and model validation of cell injection. We first investigate the challenging issues in the modeling of the bio-mechanical properties of living cells. We propose a dynamic model to simulate cell deformation and puncture. The developed approach is based on the assumptions that the mechanical response of living cells is mainly determined by the cytoskeleton and that the cytoskeleton is organised as a tensegrity structure including microfilaments, microtubules and intermediate filaments. Equivalent microtubules struts are represented with a linear mass-tensor finite element model and equivalent microfilaments and intermediate filaments with viscoelastic Kelvin-Voigt elements. The virtual environment has been implemented with both graphic and haptic interfaces.</div>
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<abstract xml:lang="en">To facilitate training of biological cell injection operations, we are developing an interactive virtual environment to simulate needle insertion into biological cells. A key challenge of deformable simulation is to satisfy the conflicting requirements of real-time interactivity and physical realism. This paper presents methodologies for dynamic modeling, visual/haptic display and model validation of cell injection. We first investigate the challenging issues in the modeling of the bio-mechanical properties of living cells. We propose a dynamic model to simulate cell deformation and puncture. The developed approach is based on the assumptions that the mechanical response of living cells is mainly determined by the cytoskeleton and that the cytoskeleton is organised as a tensegrity structure including microfilaments, microtubules and intermediate filaments. Equivalent microtubules struts are represented with a linear mass-tensor finite element model and equivalent microfilaments and intermediate filaments with viscoelastic Kelvin-Voigt elements. The virtual environment has been implemented with both graphic and haptic interfaces.</abstract>
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Interactive Cell Injection Simulation Based on 3D Biomechanical Tensegrity Model

Interactive Cell Injection Simulation Based on 3D Biomechanical Tensegrity Model

Source :

Descripteurs français

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri