Rosuvastatin may stabilize atherosclerotic aortic plaque: transesophageal echocardiographic study in the EPISTEME trial.
Identifieur interne : 000007 ( PubMed/Checkpoint ); précédent : 000006; suivant : 000008Rosuvastatin may stabilize atherosclerotic aortic plaque: transesophageal echocardiographic study in the EPISTEME trial.
Auteurs : Yuji Ueno [Japon] ; Kazuo Yamashiro [Japon] ; Yasutaka Tanaka [Japon] ; Masao Watanabe [Japon] ; Nobukazu Miyamoto [Japon] ; Yoshiaki Shimada [Japon] ; Takuma Kuroki [Japon] ; Ryota Tanaka [Japon] ; Katsumi Miyauchi [Japon] ; Hiroyuki Daida [Japon] ; Nobutaka Hattori [Japon] ; Takao Urabe [Japon]Source :
- Atherosclerosis [ 1879-1484 ] ; 2015.
Descripteurs français
- KwdFr :
- Accident vasculaire cérébral (), Accident vasculaire cérébral (diagnostic), Accident vasculaire cérébral (étiologie), Adulte d'âge moyen, Aorte thoracique (), Aorte thoracique (métabolisme), Athérosclérose (), Athérosclérose (sang), Athérosclérose (traitement médicamenteux), Cholestérol LDL (sang), Embolie intracrânienne (), Embolie intracrânienne (diagnostic), Embolie intracrânienne (étiologie), Encéphalopathie ischémique (), Encéphalopathie ischémique (diagnostic), Encéphalopathie ischémique (étiologie), Facteurs temps, Femelle, Humains, Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (usage thérapeutique), Japon, Loi du khi-deux, Maladies de l'aorte (), Maladies de l'aorte (sang), Maladies de l'aorte (traitement médicamenteux), Marqueurs biologiques (sang), Modèles linéaires, Mâle, Plaque d'athérosclérose, Rosuvastatine de calcium (usage thérapeutique), Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Valeur prédictive des tests, Échocardiographie transoesophagienne, Études prospectives.
- MESH :
- diagnostic : Accident vasculaire cérébral, Embolie intracrânienne, Encéphalopathie ischémique.
- métabolisme : Aorte thoracique.
- sang : Athérosclérose, Cholestérol LDL, Maladies de l'aorte, Marqueurs biologiques.
- traitement médicamenteux : Athérosclérose, Maladies de l'aorte.
- usage thérapeutique : Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase, Rosuvastatine de calcium.
- étiologie : Accident vasculaire cérébral, Embolie intracrânienne, Encéphalopathie ischémique.
- Accident vasculaire cérébral, Adulte d'âge moyen, Aorte thoracique, Athérosclérose, Embolie intracrânienne, Encéphalopathie ischémique, Facteurs temps, Femelle, Humains, Japon, Loi du khi-deux, Maladies de l'aorte, Modèles linéaires, Mâle, Plaque d'athérosclérose, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Valeur prédictive des tests, Échocardiographie transoesophagienne, Études prospectives.
- Wicri :
- geographic : Japon.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Aorta, Thoracic (metabolism), Aorta, Thoracic (ultrasonography), Aortic Diseases (blood), Aortic Diseases (complications), Aortic Diseases (drug therapy), Aortic Diseases (ultrasonography), Atherosclerosis (blood), Atherosclerosis (complications), Atherosclerosis (drug therapy), Atherosclerosis (ultrasonography), Biomarkers (blood), Brain Ischemia (diagnosis), Brain Ischemia (etiology), Brain Ischemia (prevention & control), Chi-Square Distribution, Cholesterol, LDL (blood), Echocardiography, Transesophageal, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use), Intracranial Embolism (diagnosis), Intracranial Embolism (etiology), Intracranial Embolism (prevention & control), Japan, Linear Models, Male, Middle Aged, Plaque, Atherosclerotic, Predictive Value of Tests, Prospective Studies, Rosuvastatin Calcium (therapeutic use), Stroke (diagnosis), Stroke (etiology), Stroke (prevention & control), Time Factors, Treatment Outcome.
- MESH :
- chemical , blood : Biomarkers, Cholesterol, LDL.
- chemical , therapeutic use : Rosuvastatin Calcium.
- geographic : Japan.
- blood : Aortic Diseases, Atherosclerosis.
- complications : Aortic Diseases, Atherosclerosis.
- diagnosis : Brain Ischemia, Intracranial Embolism, Stroke.
- drug therapy : Aortic Diseases, Atherosclerosis.
- etiology : Brain Ischemia, Intracranial Embolism, Stroke.
- metabolism : Aorta, Thoracic.
- prevention & control : Brain Ischemia, Intracranial Embolism, Stroke.
- chemical , therapeutic use : Hydroxymethylglutaryl-CoA Reductase Inhibitors.
- ultrasonography : Aorta, Thoracic, Aortic Diseases, Atherosclerosis.
- Aged, Aged, 80 and over, Chi-Square Distribution, Echocardiography, Transesophageal, Female, Humans, Linear Models, Male, Middle Aged, Plaque, Atherosclerotic, Predictive Value of Tests, Prospective Studies, Time Factors, Treatment Outcome.
Abstract
Large atheromatous aortic plaques (AAPs) have been associated with ischemic stroke. There is little evidence to guide the therapeutic strategy for ischemic stroke associated with large AAPs. This study sought to analyze the temporal profile of AAPs after rosuvastatin therapy in Japanese patients with acute ischemic stroke.
DOI: 10.1016/j.atherosclerosis.2015.02.021
PubMed: 25702618
Affiliations:
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Urayasu Hospital, Japan; Department of Neurology, Juntendo University School of Medicine, Japan. Electronic address: yuji-u@juntendo.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University Urayasu Hospital, Japan; Department of Neurology, Juntendo University School of Medicine</wicri:regionArea><wicri:noRegion>Juntendo University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Yamashiro, Kazuo" sort="Yamashiro, Kazuo" uniqKey="Yamashiro K" first="Kazuo" last="Yamashiro">Kazuo Yamashiro</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University School of Medicine</wicri:regionArea><wicri:noRegion>Juntendo University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Tanaka, Yasutaka" sort="Tanaka, Yasutaka" uniqKey="Tanaka Y" first="Yasutaka" last="Tanaka">Yasutaka Tanaka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University Urayasu Hospital</wicri:regionArea><wicri:noRegion>Juntendo University Urayasu Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Watanabe, Masao" sort="Watanabe, Masao" uniqKey="Watanabe M" first="Masao" last="Watanabe">Masao Watanabe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University Urayasu Hospital</wicri:regionArea><wicri:noRegion>Juntendo University Urayasu Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Miyamoto, Nobukazu" sort="Miyamoto, Nobukazu" uniqKey="Miyamoto N" first="Nobukazu" last="Miyamoto">Nobukazu Miyamoto</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University Urayasu Hospital</wicri:regionArea><wicri:noRegion>Juntendo University Urayasu Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Shimada, Yoshiaki" sort="Shimada, Yoshiaki" uniqKey="Shimada Y" first="Yoshiaki" last="Shimada">Yoshiaki Shimada</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University School of Medicine</wicri:regionArea><wicri:noRegion>Juntendo University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Kuroki, Takuma" sort="Kuroki, Takuma" uniqKey="Kuroki T" first="Takuma" last="Kuroki">Takuma Kuroki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University School of Medicine</wicri:regionArea><wicri:noRegion>Juntendo University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Tanaka, Ryota" sort="Tanaka, Ryota" uniqKey="Tanaka R" first="Ryota" last="Tanaka">Ryota Tanaka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University School of Medicine</wicri:regionArea><wicri:noRegion>Juntendo University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Miyauchi, Katsumi" sort="Miyauchi, Katsumi" uniqKey="Miyauchi K" first="Katsumi" last="Miyauchi">Katsumi Miyauchi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Juntendo University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiology, Juntendo University School of Medicine</wicri:regionArea><wicri:noRegion>Juntendo University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Daida, Hiroyuki" sort="Daida, Hiroyuki" uniqKey="Daida H" first="Hiroyuki" last="Daida">Hiroyuki Daida</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Juntendo University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiology, Juntendo University School of Medicine</wicri:regionArea><wicri:noRegion>Juntendo University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University School of Medicine</wicri:regionArea><wicri:noRegion>Juntendo University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Urabe, Takao" sort="Urabe, Takao" uniqKey="Urabe T" first="Takao" last="Urabe">Takao Urabe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Juntendo University Urayasu Hospital</wicri:regionArea><wicri:noRegion>Juntendo University Urayasu Hospital</wicri:noRegion></affiliation></author></analytic><series><title level="j">Atherosclerosis</title><idno type="eISSN">1879-1484</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Aorta, Thoracic (metabolism)</term><term>Aorta, Thoracic (ultrasonography)</term><term>Aortic Diseases (blood)</term><term>Aortic Diseases (complications)</term><term>Aortic Diseases (drug therapy)</term><term>Aortic Diseases (ultrasonography)</term><term>Atherosclerosis (blood)</term><term>Atherosclerosis (complications)</term><term>Atherosclerosis (drug therapy)</term><term>Atherosclerosis (ultrasonography)</term><term>Biomarkers (blood)</term><term>Brain Ischemia (diagnosis)</term><term>Brain Ischemia (etiology)</term><term>Brain Ischemia (prevention & control)</term><term>Chi-Square Distribution</term><term>Cholesterol, LDL (blood)</term><term>Echocardiography, Transesophageal</term><term>Female</term><term>Humans</term><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)</term><term>Intracranial Embolism (diagnosis)</term><term>Intracranial Embolism (etiology)</term><term>Intracranial Embolism (prevention & control)</term><term>Japan</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Plaque, Atherosclerotic</term><term>Predictive Value of Tests</term><term>Prospective Studies</term><term>Rosuvastatin Calcium (therapeutic use)</term><term>Stroke (diagnosis)</term><term>Stroke (etiology)</term><term>Stroke (prevention & control)</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral ()</term><term>Accident vasculaire cérébral (diagnostic)</term><term>Accident vasculaire cérébral (étiologie)</term><term>Adulte d'âge moyen</term><term>Aorte thoracique ()</term><term>Aorte thoracique (métabolisme)</term><term>Athérosclérose ()</term><term>Athérosclérose (sang)</term><term>Athérosclérose (traitement médicamenteux)</term><term>Cholestérol LDL (sang)</term><term>Embolie intracrânienne ()</term><term>Embolie intracrânienne (diagnostic)</term><term>Embolie intracrânienne (étiologie)</term><term>Encéphalopathie ischémique ()</term><term>Encéphalopathie ischémique (diagnostic)</term><term>Encéphalopathie ischémique (étiologie)</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (usage thérapeutique)</term><term>Japon</term><term>Loi du khi-deux</term><term>Maladies de l'aorte ()</term><term>Maladies de l'aorte (sang)</term><term>Maladies de l'aorte (traitement médicamenteux)</term><term>Marqueurs biologiques (sang)</term><term>Modèles linéaires</term><term>Mâle</term><term>Plaque d'athérosclérose</term><term>Rosuvastatine de calcium (usage thérapeutique)</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Valeur prédictive des tests</term><term>Échocardiographie transoesophagienne</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Cholesterol, LDL</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Rosuvastatin Calcium</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Japan</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Aortic Diseases</term><term>Atherosclerosis</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Aortic Diseases</term><term>Atherosclerosis</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Brain Ischemia</term><term>Intracranial Embolism</term><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Accident vasculaire cérébral</term><term>Embolie intracrânienne</term><term>Encéphalopathie ischémique</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Aortic Diseases</term><term>Atherosclerosis</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Brain Ischemia</term><term>Intracranial Embolism</term><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Aorta, Thoracic</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Aorte thoracique</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Brain Ischemia</term><term>Intracranial Embolism</term><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Athérosclérose</term><term>Cholestérol LDL</term><term>Maladies de l'aorte</term><term>Marqueurs biologiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Athérosclérose</term><term>Maladies de l'aorte</term></keywords><keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Aorta, Thoracic</term><term>Aortic Diseases</term><term>Atherosclerosis</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase</term><term>Rosuvastatine de calcium</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Accident vasculaire cérébral</term><term>Embolie intracrânienne</term><term>Encéphalopathie ischémique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Chi-Square Distribution</term><term>Echocardiography, Transesophageal</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Plaque, Atherosclerotic</term><term>Predictive Value of Tests</term><term>Prospective Studies</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Accident vasculaire cérébral</term><term>Adulte d'âge moyen</term><term>Aorte thoracique</term><term>Athérosclérose</term><term>Embolie intracrânienne</term><term>Encéphalopathie ischémique</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Japon</term><term>Loi du khi-deux</term><term>Maladies de l'aorte</term><term>Modèles linéaires</term><term>Mâle</term><term>Plaque d'athérosclérose</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Valeur prédictive des tests</term><term>Échocardiographie transoesophagienne</term><term>Études prospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Japon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Large atheromatous aortic plaques (AAPs) have been associated with ischemic stroke. There is little evidence to guide the therapeutic strategy for ischemic stroke associated with large AAPs. This study sought to analyze the temporal profile of AAPs after rosuvastatin therapy in Japanese patients with acute ischemic stroke.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">25702618</PMID><DateCreated><Year>2015</Year><Month>03</Month><Day>16</Day></DateCreated><DateCompleted><Year>2015</Year><Month>12</Month><Day>14</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1484</ISSN><JournalIssue CitedMedium="Internet"><Volume>239</Volume><Issue>2</Issue><PubDate><Year>2015</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Atherosclerosis</Title><ISOAbbreviation>Atherosclerosis</ISOAbbreviation></Journal><ArticleTitle>Rosuvastatin may stabilize atherosclerotic aortic plaque: transesophageal echocardiographic study in the EPISTEME trial.</ArticleTitle><Pagination><MedlinePgn>476-82</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.atherosclerosis.2015.02.021</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0021-9150(15)00111-2</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Large atheromatous aortic plaques (AAPs) have been associated with ischemic stroke. There is little evidence to guide the therapeutic strategy for ischemic stroke associated with large AAPs. This study sought to analyze the temporal profile of AAPs after rosuvastatin therapy in Japanese patients with acute ischemic stroke.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The Efficacy of Post-stroke Intensive Rosuvastatin Treatment for aortogenic Embolic stroke (EPISTEME) trial was a prospective, randomized, open-label study. Acute ischemic stroke patients with dyslipidemia and AAPs ≥4-mm-thick on transesophageal echocardiography (TEE) were enrolled and randomly allocated to either the group treated with 5 mg/day rosuvastatin or the control group. The primary endpoint was the changes in volume and composition of AAPs on repeat TEE after 6 months. High-echoic plaque area was analyzed using binary images.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 24 Japanese patients (rosuvastatin 12; control 12) were included in the primary analysis. Rosuvastatin substantially reduced low-density lipoprotein cholesterol (LDL-C) compared to control (-42.1% vs. 1.4%, P < 0.001). Percent changes of high-echoic plaque areas were significantly increased in the rosuvastatin group, while they were decreased in the control group (65.8% vs -14.7%, P < 0.001). There was a significant linear correlation between percent increase in high-echoic plaque area and LDL-C decrease (r=-0.434, P=0.002).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Treatment with 5-mg rosuvastatin for 6 months might induce atheromatous aortic plaque stabilization together with marked LDL-C reduction in Japanese patients with ischemic stroke, which could provide evidence on which to base the therapeutic strategy for aortogenic brain embolism.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ueno</LastName><ForeName>Yuji</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan; Department of Neurology, Juntendo University School of Medicine, Japan. Electronic address: yuji-u@juntendo.ac.jp.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yamashiro</LastName><ForeName>Kazuo</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tanaka</LastName><ForeName>Yasutaka</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Watanabe</LastName><ForeName>Masao</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miyamoto</LastName><ForeName>Nobukazu</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shimada</LastName><ForeName>Yoshiaki</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuroki</LastName><ForeName>Takuma</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tanaka</LastName><ForeName>Ryota</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miyauchi</LastName><ForeName>Katsumi</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Juntendo University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Daida</LastName><ForeName>Hiroyuki</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Juntendo University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hattori</LastName><ForeName>Nobutaka</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Urabe</LastName><ForeName>Takao</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>02</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>Atherosclerosis</MedlineTA><NlmUniqueID>0242543</NlmUniqueID><ISSNLinking>0021-9150</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008078">Cholesterol, LDL</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019161">Hydroxymethylglutaryl-CoA Reductase Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>83MVU38M7Q</RegistryNumber><NameOfSubstance UI="D000068718">Rosuvastatin Calcium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001013">Aorta, Thoracic</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000736">ultrasonography</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001018">Aortic Diseases</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="N" UI="Q000736">ultrasonography</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D050197">Atherosclerosis</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="N" UI="Q000736">ultrasonography</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015415">Biomarkers</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002545">Brain Ischemia</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000517">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016009">Chi-Square Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008078">Cholesterol, LDL</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D017548">Echocardiography, Transesophageal</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019161">Hydroxymethylglutaryl-CoA Reductase Inhibitors</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020766">Intracranial Embolism</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000517">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic" UI="D007564">Japan</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016014">Linear Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D058226">Plaque, Atherosclerotic</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011237">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011446">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000068718">Rosuvastatin Calcium</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020521">Stroke</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000517">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013997">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016896">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Aortogenic brain embolism</Keyword><Keyword MajorTopicYN="N">Atheromatous aortic plaque</Keyword><Keyword MajorTopicYN="N">Rosuvastatin</Keyword><Keyword MajorTopicYN="N">Stroke</Keyword><Keyword MajorTopicYN="N">Transesophageal echocardiography</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>12</Month><Day>3</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>1</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>2</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2015</Year><Month>2</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>2</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>2</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25702618</ArticleId><ArticleId IdType="pii">S0021-9150(15)00111-2</ArticleId><ArticleId IdType="doi">10.1016/j.atherosclerosis.2015.02.021</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Ueno, Yuji" sort="Ueno, Yuji" uniqKey="Ueno Y" first="Yuji" last="Ueno">Yuji Ueno</name></noRegion><name sortKey="Daida, Hiroyuki" sort="Daida, Hiroyuki" uniqKey="Daida H" first="Hiroyuki" last="Daida">Hiroyuki Daida</name><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><name sortKey="Kuroki, Takuma" sort="Kuroki, Takuma" uniqKey="Kuroki T" first="Takuma" last="Kuroki">Takuma Kuroki</name><name sortKey="Miyamoto, Nobukazu" sort="Miyamoto, Nobukazu" uniqKey="Miyamoto N" first="Nobukazu" last="Miyamoto">Nobukazu Miyamoto</name><name sortKey="Miyauchi, Katsumi" sort="Miyauchi, Katsumi" uniqKey="Miyauchi K" first="Katsumi" last="Miyauchi">Katsumi Miyauchi</name><name sortKey="Shimada, Yoshiaki" sort="Shimada, Yoshiaki" uniqKey="Shimada Y" first="Yoshiaki" last="Shimada">Yoshiaki Shimada</name><name sortKey="Tanaka, Ryota" sort="Tanaka, Ryota" uniqKey="Tanaka R" first="Ryota" last="Tanaka">Ryota Tanaka</name><name sortKey="Tanaka, Yasutaka" sort="Tanaka, Yasutaka" uniqKey="Tanaka Y" first="Yasutaka" last="Tanaka">Yasutaka Tanaka</name><name sortKey="Urabe, Takao" sort="Urabe, Takao" uniqKey="Urabe T" first="Takao" last="Urabe">Takao Urabe</name><name sortKey="Watanabe, Masao" sort="Watanabe, Masao" uniqKey="Watanabe M" first="Masao" last="Watanabe">Masao Watanabe</name><name sortKey="Yamashiro, Kazuo" sort="Yamashiro, Kazuo" uniqKey="Yamashiro K" first="Kazuo" last="Yamashiro">Kazuo Yamashiro</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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