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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Human Papillomavirus 18 Genetic Variation and Cervical Cancer Risk Worldwide</title>
<author><name sortKey="Chen, Alyce A" sort="Chen, Alyce A" uniqKey="Chen A" first="Alyce A." last="Chen">Alyce A. Chen</name>
</author>
<author><name sortKey="Gheit, Tarik" sort="Gheit, Tarik" uniqKey="Gheit T" first="Tarik" last="Gheit">Tarik Gheit</name>
</author>
<author><name sortKey="Franceschi, Silvia" sort="Franceschi, Silvia" uniqKey="Franceschi S" first="Silvia" last="Franceschi">Silvia Franceschi</name>
</author>
<author><name sortKey="Tommasino, Massimo" sort="Tommasino, Massimo" uniqKey="Tommasino M" first="Massimo" last="Tommasino">Massimo Tommasino</name>
</author>
<author><name sortKey="Clifford, Gary M" sort="Clifford, Gary M" uniqKey="Clifford G" first="Gary M." last="Clifford">Gary M. Clifford</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26269181</idno>
<idno type="pmc">4580183</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580183</idno>
<idno type="RBID">PMC:4580183</idno>
<idno type="doi">10.1128/JVI.01747-15</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000004</idno>
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</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Human Papillomavirus 18 Genetic Variation and Cervical Cancer Risk Worldwide</title>
<author><name sortKey="Chen, Alyce A" sort="Chen, Alyce A" uniqKey="Chen A" first="Alyce A." last="Chen">Alyce A. Chen</name>
</author>
<author><name sortKey="Gheit, Tarik" sort="Gheit, Tarik" uniqKey="Gheit T" first="Tarik" last="Gheit">Tarik Gheit</name>
</author>
<author><name sortKey="Franceschi, Silvia" sort="Franceschi, Silvia" uniqKey="Franceschi S" first="Silvia" last="Franceschi">Silvia Franceschi</name>
</author>
<author><name sortKey="Tommasino, Massimo" sort="Tommasino, Massimo" uniqKey="Tommasino M" first="Massimo" last="Tommasino">Massimo Tommasino</name>
</author>
<author><name sortKey="Clifford, Gary M" sort="Clifford, Gary M" uniqKey="Clifford G" first="Gary M." last="Clifford">Gary M. Clifford</name>
</author>
</analytic>
<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>Human papillomavirus 18 (HPV18) is the second most carcinogenic HPV type, after HPV16, and it accounts for approximately 12% of squamous cell carcinoma (SCC) as well as 37% of adenocarcinoma (ADC) of the cervix worldwide. We aimed to evaluate the worldwide diversity and carcinogenicity of HPV18 genetic variants by sequencing the entire long control region (LCR) and the E6 open reading frame of 711 HPV18-positive cervical samples from 39 countries, taking advantage of the International Agency for Research on Cancer biobank. A total of 209 unique HPV18 sequence variants were identified that formed three phylogenetic lineages (A, B, and C). A and B lineages each divided into four sublineages, including a newly identified candidate B4 sublineage. The distribution of lineages varied by geographical region, with B and C lineages found principally in Africa. HPV18 (sub)lineages were compared between 453 cancer cases and 236 controls, as well as between 81 ADC and 160 matched SCC cases. In region-stratified analyses, there were no significant differences in the distribution of HPV18 variant lineages between cervical cancer cases and controls or between ADC and SCC. In conclusion, our findings do not support the role of HPV18 (sub)lineages for discriminating cancer risk or explaining why HPV18 is more strongly linked with ADC than SCC.</p>
<p><bold>IMPORTANCE</bold>
This is the largest and most geographically/ethnically diverse study of the genetic variation of HPV18 to date, providing a comprehensive reference for phylogenetic classification of HPV18 sublineages for epidemiological and biological studies.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Virol</journal-id>
<journal-id journal-id-type="hwp">jvi</journal-id>
<journal-id journal-id-type="pmc">jvi</journal-id>
<journal-id journal-id-type="publisher-id">JVI</journal-id>
<journal-title-group><journal-title>Journal of Virology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0022-538X</issn>
<issn pub-type="epub">1098-5514</issn>
<publisher><publisher-name>American Society for Microbiology</publisher-name>
<publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26269181</article-id>
<article-id pub-id-type="pmc">4580183</article-id>
<article-id pub-id-type="publisher-id">01747-15</article-id>
<article-id pub-id-type="doi">10.1128/JVI.01747-15</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Genetic Diversity and Evolution</subject>
</subj-group>
</article-categories>
<title-group><article-title>Human Papillomavirus 18 Genetic Variation and Cervical Cancer Risk Worldwide</article-title>
<alt-title alt-title-type="running-head">HPV18 Variants</alt-title>
<alt-title alt-title-type="short-authors">Chen et al.</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Alyce A.</given-names>
</name>
<xref ref-type="author-notes" rid="fn1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gheit</surname>
<given-names>Tarik</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Franceschi</surname>
<given-names>Silvia</given-names>
</name>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Tommasino</surname>
<given-names>Massimo</given-names>
</name>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Clifford</surname>
<given-names>Gary M.</given-names>
</name>
</contrib>
<on-behalf-of>the IARC HPV Variant Study Group</on-behalf-of>
<aff>International Agency for Research on Cancer, Lyon, France</aff>
</contrib-group>
<contrib-group><contrib contrib-type="editor"><name><surname>Banks</surname>
<given-names>L.</given-names>
</name>
<role>Editor</role>
</contrib>
</contrib-group>
<author-notes><corresp id="cor1">Address correspondence to Massimo Tommasino, <email>tommasinom@iarc.fr</email>
, or Gary M. Clifford, <email>cliffordg@iarc.fr</email>
.</corresp>
<fn id="fn1" fn-type="present-address"><label>*</label>
<p>Present address: Alyce A. Chen, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, USA.</p>
</fn>
<fn fn-type="other"><p><bold>Citation</bold>
Chen AA, Gheit T, Franceschi S, Tommasino M, Clifford GM, IARC HPV Variant Study Group. 2015. Human papillomavirus 18 genetic variation and cervical cancer risk worldwide. J Virol 89:10680–10687. doi:<ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1128/JVI.01747-15">10.1128/JVI.01747-15</ext-link>
.</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>12</day>
<month>8</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><day>15</day>
<month>10</month>
<year>2015</year>
</pub-date>
<volume>89</volume>
<issue>20</issue>
<fpage>10680</fpage>
<lpage>10687</lpage>
<history><date date-type="received"><day>10</day>
<month>7</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>5</day>
<month>8</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2015, American Society for Microbiology. All Rights Reserved.</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder>American Society for Microbiology</copyright-holder>
</permissions>
<self-uri content-type="pdf" xlink:href="zjv02015010680.pdf"></self-uri>
<abstract><title>ABSTRACT</title>
<p>Human papillomavirus 18 (HPV18) is the second most carcinogenic HPV type, after HPV16, and it accounts for approximately 12% of squamous cell carcinoma (SCC) as well as 37% of adenocarcinoma (ADC) of the cervix worldwide. We aimed to evaluate the worldwide diversity and carcinogenicity of HPV18 genetic variants by sequencing the entire long control region (LCR) and the E6 open reading frame of 711 HPV18-positive cervical samples from 39 countries, taking advantage of the International Agency for Research on Cancer biobank. A total of 209 unique HPV18 sequence variants were identified that formed three phylogenetic lineages (A, B, and C). A and B lineages each divided into four sublineages, including a newly identified candidate B4 sublineage. The distribution of lineages varied by geographical region, with B and C lineages found principally in Africa. HPV18 (sub)lineages were compared between 453 cancer cases and 236 controls, as well as between 81 ADC and 160 matched SCC cases. In region-stratified analyses, there were no significant differences in the distribution of HPV18 variant lineages between cervical cancer cases and controls or between ADC and SCC. In conclusion, our findings do not support the role of HPV18 (sub)lineages for discriminating cancer risk or explaining why HPV18 is more strongly linked with ADC than SCC.</p>
<p><bold>IMPORTANCE</bold>
This is the largest and most geographically/ethnically diverse study of the genetic variation of HPV18 to date, providing a comprehensive reference for phylogenetic classification of HPV18 sublineages for epidemiological and biological studies.</p>
</abstract>
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<table-count count="4"></table-count>
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<ref-count count="59"></ref-count>
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</article-meta>
</front>
</pmc>
</record>
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