Comparative analysis of virus-host interactomes with a mammalian high- throughput protein complementation assay based on Gaussia princeps luciferase
Identifieur interne : 000262 ( Main/Curation ); précédent : 000261; suivant : 000263Comparative analysis of virus-host interactomes with a mammalian high- throughput protein complementation assay based on Gaussia princeps luciferase
Auteurs : Grégory Neveu ; Patricia Cassonnet ; Pierre-Olivier Vidalain ; Caroline Rolloy ; José Mendoza ; Louis Jones [France] ; Frédéric Tangy ; Mandy Muller ; Caroline Demeret ; Lionel Tafforeau [France] ; Vincent Lotteau [France] ; Chantal Rabourdin-Combe [France] ; Gilles Travé [France] ; Amélie Dricot [États-Unis] ; David E. Hill [États-Unis] ; Marc Vidal [États-Unis] ; Michel Favre ; Yves JacobSource :
- Methods (San Diego, Calif.) [ 1046-2023 ] ; 2012.
Abstract
Comparative interactomics is a strategy for inferring potential interactions among orthologous proteins or “iginterologs”. Herein we focus, in contrast to standard homology-based inference, on the divergence of protein interaction profiles among closely related organisms, showing that the approach can correlate specific traits to phenotypic differences. As a model, this new comparative interactomic approach was applied at a large scale to human papillomaviruses (HPVs) proteins. The oncogenic potential of HPVs is mainly determined by the E6 and E7 early proteins. We have mapped and overlapped the virus-host protein interaction networks of E6 and E7 proteins from 11 distinct HPV genotypes, selected for their different tropisms and pathologies. We generated robust and comprehensive datasets by combining two orthogonal protein interation assays: yeast two-hybrid (Y2H), and our recently described “High-Throughput
Url:
DOI: 10.1016/j.ymeth.2012.07.029
PubMed: 22898364
PubMed Central: 3546263
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000111
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000111
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000093
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000167
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000167
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000167
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :000257
Links to Exploration step
PMC:3546263Curation
No country items
Grégory Neveu<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparative analysis of virus-host interactomes with a mammalian high- throughput protein complementation assay based on <italic>Gaussia princeps</italic>
luciferase</title>
<author><name sortKey="Neveu, Gregory" sort="Neveu, Gregory" uniqKey="Neveu G" first="Grégory" last="Neveu">Grégory Neveu</name>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Cassonnet, Patricia" sort="Cassonnet, Patricia" uniqKey="Cassonnet P" first="Patricia" last="Cassonnet">Patricia Cassonnet</name>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Vidalain, Pierre Olivier" sort="Vidalain, Pierre Olivier" uniqKey="Vidalain P" first="Pierre-Olivier" last="Vidalain">Pierre-Olivier Vidalain</name>
<affiliation><nlm:aff id="A2">Unité de Génomique Virale et Vaccination (G2V)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rolloy, Caroline" sort="Rolloy, Caroline" uniqKey="Rolloy C" first="Caroline" last="Rolloy">Caroline Rolloy</name>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mendoza, Jose" sort="Mendoza, Jose" uniqKey="Mendoza J" first="José" last="Mendoza">José Mendoza</name>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jones, Louis" sort="Jones, Louis" uniqKey="Jones L" first="Louis" last="Jones">Louis Jones</name>
<affiliation wicri:level="3"><nlm:aff id="A3">Groupe Logiciels et Banques de données, Institut Pasteur, 25 rue du Docteur Roux, Paris 75015, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Groupe Logiciels et Banques de données, Institut Pasteur, 25 rue du Docteur Roux, Paris 75015</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tangy, Frederic" sort="Tangy, Frederic" uniqKey="Tangy F" first="Frédéric" last="Tangy">Frédéric Tangy</name>
<affiliation><nlm:aff id="A2">Unité de Génomique Virale et Vaccination (G2V)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Muller, Mandy" sort="Muller, Mandy" uniqKey="Muller M" first="Mandy" last="Muller">Mandy Muller</name>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Demeret, Caroline" sort="Demeret, Caroline" uniqKey="Demeret C" first="Caroline" last="Demeret">Caroline Demeret</name>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Tafforeau, Lionel" sort="Tafforeau, Lionel" uniqKey="Tafforeau L" first="Lionel" last="Tafforeau">Lionel Tafforeau</name>
<affiliation wicri:level="3"><nlm:aff id="A4">IMAP Team, IFR-128 BioSciences, 21 Av T. Garnier, Lyon 69007, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>IMAP Team, IFR-128 BioSciences, 21 Av T. Garnier, Lyon 69007</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lotteau, Vincent" sort="Lotteau, Vincent" uniqKey="Lotteau V" first="Vincent" last="Lotteau">Vincent Lotteau</name>
<affiliation wicri:level="3"><nlm:aff id="A4">IMAP Team, IFR-128 BioSciences, 21 Av T. Garnier, Lyon 69007, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>IMAP Team, IFR-128 BioSciences, 21 Av T. Garnier, Lyon 69007</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rabourdin Combe, Chantal" sort="Rabourdin Combe, Chantal" uniqKey="Rabourdin Combe C" first="Chantal" last="Rabourdin-Combe">Chantal Rabourdin-Combe</name>
<affiliation wicri:level="3"><nlm:aff id="A4">IMAP Team, IFR-128 BioSciences, 21 Av T. Garnier, Lyon 69007, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>IMAP Team, IFR-128 BioSciences, 21 Av T. Garnier, Lyon 69007</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Trave, Gilles" sort="Trave, Gilles" uniqKey="Trave G" first="Gilles" last="Travé">Gilles Travé</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Equipe Oncoprotéines, CNRS-UMR 7175, ESBS, Bd S. Brant, BP10413, Illkirch 67412, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Equipe Oncoprotéines, CNRS-UMR 7175, ESBS, Bd S. Brant, BP10413, Illkirch 67412</wicri:regionArea>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dricot, Amelie" sort="Dricot, Amelie" uniqKey="Dricot A" first="Amélie" last="Dricot">Amélie Dricot</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hill, David E" sort="Hill, David E" uniqKey="Hill D" first="David E." last="Hill">David E. Hill</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vidal, Marc" sort="Vidal, Marc" uniqKey="Vidal M" first="Marc" last="Vidal">Marc Vidal</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Favre, Michel" sort="Favre, Michel" uniqKey="Favre M" first="Michel" last="Favre">Michel Favre</name>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jacob, Yves" sort="Jacob, Yves" uniqKey="Jacob Y" first="Yves" last="Jacob">Yves Jacob</name>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22898364</idno>
<idno type="pmc">3546263</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546263</idno>
<idno type="RBID">PMC:3546263</idno>
<idno type="doi">10.1016/j.ymeth.2012.07.029</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">000111</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000111</idno>
<idno type="wicri:Area/Pmc/Curation">000111</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000111</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000093</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000093</idno>
<idno type="wicri:Area/Ncbi/Merge">000167</idno>
<idno type="wicri:Area/Ncbi/Curation">000167</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000167</idno>
<idno type="wicri:doubleKey">1046-2023:2012:Neveu G:comparative:analysis:of</idno>
<idno type="wicri:Area/Main/Merge">000257</idno>
<idno type="wicri:Area/Main/Curation">000262</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparative analysis of virus-host interactomes with a mammalian high- throughput protein complementation assay based on <italic>Gaussia princeps</italic>
luciferase</title>
<author><name sortKey="Neveu, Gregory" sort="Neveu, Gregory" uniqKey="Neveu G" first="Grégory" last="Neveu">Grégory Neveu</name>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Cassonnet, Patricia" sort="Cassonnet, Patricia" uniqKey="Cassonnet P" first="Patricia" last="Cassonnet">Patricia Cassonnet</name>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Vidalain, Pierre Olivier" sort="Vidalain, Pierre Olivier" uniqKey="Vidalain P" first="Pierre-Olivier" last="Vidalain">Pierre-Olivier Vidalain</name>
<affiliation><nlm:aff id="A2">Unité de Génomique Virale et Vaccination (G2V)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rolloy, Caroline" sort="Rolloy, Caroline" uniqKey="Rolloy C" first="Caroline" last="Rolloy">Caroline Rolloy</name>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mendoza, Jose" sort="Mendoza, Jose" uniqKey="Mendoza J" first="José" last="Mendoza">José Mendoza</name>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jones, Louis" sort="Jones, Louis" uniqKey="Jones L" first="Louis" last="Jones">Louis Jones</name>
<affiliation wicri:level="3"><nlm:aff id="A3">Groupe Logiciels et Banques de données, Institut Pasteur, 25 rue du Docteur Roux, Paris 75015, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Groupe Logiciels et Banques de données, Institut Pasteur, 25 rue du Docteur Roux, Paris 75015</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tangy, Frederic" sort="Tangy, Frederic" uniqKey="Tangy F" first="Frédéric" last="Tangy">Frédéric Tangy</name>
<affiliation><nlm:aff id="A2">Unité de Génomique Virale et Vaccination (G2V)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Muller, Mandy" sort="Muller, Mandy" uniqKey="Muller M" first="Mandy" last="Muller">Mandy Muller</name>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Demeret, Caroline" sort="Demeret, Caroline" uniqKey="Demeret C" first="Caroline" last="Demeret">Caroline Demeret</name>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Tafforeau, Lionel" sort="Tafforeau, Lionel" uniqKey="Tafforeau L" first="Lionel" last="Tafforeau">Lionel Tafforeau</name>
<affiliation wicri:level="3"><nlm:aff id="A4">IMAP Team, IFR-128 BioSciences, 21 Av T. Garnier, Lyon 69007, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>IMAP Team, IFR-128 BioSciences, 21 Av T. Garnier, Lyon 69007</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lotteau, Vincent" sort="Lotteau, Vincent" uniqKey="Lotteau V" first="Vincent" last="Lotteau">Vincent Lotteau</name>
<affiliation wicri:level="3"><nlm:aff id="A4">IMAP Team, IFR-128 BioSciences, 21 Av T. Garnier, Lyon 69007, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>IMAP Team, IFR-128 BioSciences, 21 Av T. Garnier, Lyon 69007</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rabourdin Combe, Chantal" sort="Rabourdin Combe, Chantal" uniqKey="Rabourdin Combe C" first="Chantal" last="Rabourdin-Combe">Chantal Rabourdin-Combe</name>
<affiliation wicri:level="3"><nlm:aff id="A4">IMAP Team, IFR-128 BioSciences, 21 Av T. Garnier, Lyon 69007, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>IMAP Team, IFR-128 BioSciences, 21 Av T. Garnier, Lyon 69007</wicri:regionArea>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Trave, Gilles" sort="Trave, Gilles" uniqKey="Trave G" first="Gilles" last="Travé">Gilles Travé</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Equipe Oncoprotéines, CNRS-UMR 7175, ESBS, Bd S. Brant, BP10413, Illkirch 67412, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Equipe Oncoprotéines, CNRS-UMR 7175, ESBS, Bd S. Brant, BP10413, Illkirch 67412</wicri:regionArea>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dricot, Amelie" sort="Dricot, Amelie" uniqKey="Dricot A" first="Amélie" last="Dricot">Amélie Dricot</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hill, David E" sort="Hill, David E" uniqKey="Hill D" first="David E." last="Hill">David E. Hill</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vidal, Marc" sort="Vidal, Marc" uniqKey="Vidal M" first="Marc" last="Vidal">Marc Vidal</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Favre, Michel" sort="Favre, Michel" uniqKey="Favre M" first="Michel" last="Favre">Michel Favre</name>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jacob, Yves" sort="Jacob, Yves" uniqKey="Jacob Y" first="Yves" last="Jacob">Yves Jacob</name>
<affiliation><nlm:aff id="A1">Unité de Génétique, Papillomavirus et Cancer Humain (GPCH)</nlm:aff>
<wicri:noCountry code="subfield">Papillomavirus et Cancer Humain (GPCH)</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Methods (San Diego, Calif.)</title>
<idno type="ISSN">1046-2023</idno>
<idno type="eISSN">1095-9130</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P2">Comparative interactomics is a strategy for inferring potential interactions among orthologous proteins or “iginterologs”. Herein we focus, in contrast to standard homology-based inference, on the divergence of protein interaction profiles among closely related organisms, showing that the approach can correlate specific traits to phenotypic differences. As a model, this new comparative interactomic approach was applied at a large scale to human papillomaviruses (HPVs) proteins. The oncogenic potential of HPVs is mainly determined by the E6 and E7 early proteins. We have mapped and overlapped the virus-host protein interaction networks of E6 and E7 proteins from 11 distinct HPV genotypes, selected for their different tropisms and pathologies. We generated robust and comprehensive datasets by combining two orthogonal protein interation assays: yeast two-hybrid (Y2H), and our recently described “High-Throughput <italic>Gaussia princeps</italic>
Protein Complementation Assay” (HT-GPCA). HT-GPCA detects protein interaction by measuring the interaction-mediated reconstitution of activity of a split <italic>Gaussia princeps</italic>
luciferase. Hierarchical clustering of interaction profiles recapitulated HPV phylogeny and was used to correlate specific virus-host interaction profiles with pathological traits, reflecting the distinct carcinogenic potentials of different HPVs. This comparative interactomics constitutes a reliable and powerful strategy to decipher molecular relationships in virtually any combination of microorganism-host interactions.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/EpistemeV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000262 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000262 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Ticri/CIDE |area= EpistemeV1 |flux= Main |étape= Curation |type= RBID |clé= PMC:3546263 |texte= Comparative analysis of virus-host interactomes with a mammalian high- throughput protein complementation assay based on Gaussia princeps luciferase }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:22898364" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a EpistemeV1
This area was generated with Dilib version V0.6.31. |