Rise and Demise of Bioinformatics? Promise and Progress
Identifieur interne : 000309 ( Ncbi/Merge ); précédent : 000308; suivant : 000310Rise and Demise of Bioinformatics? Promise and Progress
Auteurs : Christos A. Ouzounis [Grèce, Canada]Source :
- PLoS Computational Biology [ 1553-734X ] ; 2012.
Abstract
The field of bioinformatics and computational biology has gone through a number of transformations during the past 15 years, establishing itself as a key component of new biology. This spectacular growth has been challenged by a number of disruptive changes in science and technology. Despite the apparent fatigue of the linguistic use of the term itself, bioinformatics has grown perhaps to a point beyond recognition. We explore both historical aspects and future trends and argue that as the field expands, key questions remain unanswered and acquire new meaning while at the same time the range of applications is widening to cover an ever increasing number of biological disciplines. These trends appear to be pointing to a redefinition of certain objectives, milestones, and possibly the field itself.
Url:
DOI: 10.1371/journal.pcbi.1002487
PubMed: 22570600
PubMed Central: 3343106
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000595
- to stream Pmc, to step Curation: 000595
- to stream Pmc, to step Checkpoint: 000382
Links to Exploration step
PMC:3343106Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Rise and Demise of Bioinformatics? Promise and Progress</title>
<author><name sortKey="Ouzounis, Christos A" sort="Ouzounis, Christos A" uniqKey="Ouzounis C" first="Christos A." last="Ouzounis">Christos A. Ouzounis</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Agrobiotechnology, Centre for Research & Technology Hellas (CERTH), Thessaloniki, Greece</addr-line>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Institute of Agrobiotechnology, Centre for Research & Technology Hellas (CERTH), Thessaloniki</wicri:regionArea>
<wicri:noRegion>Thessaloniki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Ontario, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22570600</idno>
<idno type="pmc">3343106</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343106</idno>
<idno type="RBID">PMC:3343106</idno>
<idno type="doi">10.1371/journal.pcbi.1002487</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">000595</idno>
<idno type="wicri:Area/Pmc/Curation">000595</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000382</idno>
<idno type="wicri:Area/Ncbi/Merge">000309</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Rise and Demise of Bioinformatics? Promise and Progress</title>
<author><name sortKey="Ouzounis, Christos A" sort="Ouzounis, Christos A" uniqKey="Ouzounis C" first="Christos A." last="Ouzounis">Christos A. Ouzounis</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Agrobiotechnology, Centre for Research & Technology Hellas (CERTH), Thessaloniki, Greece</addr-line>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Institute of Agrobiotechnology, Centre for Research & Technology Hellas (CERTH), Thessaloniki</wicri:regionArea>
<wicri:noRegion>Thessaloniki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Ontario, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS Computational Biology</title>
<idno type="ISSN">1553-734X</idno>
<idno type="eISSN">1553-7358</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The field of bioinformatics and computational biology has gone through a number of transformations during the past 15 years, establishing itself as a key component of new biology. This spectacular growth has been challenged by a number of disruptive changes in science and technology. Despite the apparent fatigue of the linguistic use of the term itself, bioinformatics has grown perhaps to a point beyond recognition. We explore both historical aspects and future trends and argue that as the field expands, key questions remain unanswered and acquire new meaning while at the same time the range of applications is widening to cover an ever increasing number of biological disciplines. These trends appear to be pointing to a redefinition of certain objectives, milestones, and possibly the field itself.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ouzounis, Ca" uniqKey="Ouzounis C">CA Ouzounis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ouzounis, C" uniqKey="Ouzounis C">C Ouzounis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ouzounis, C" uniqKey="Ouzounis C">C Ouzounis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ouzounis, Ca" uniqKey="Ouzounis C">CA Ouzounis</name>
</author>
<author><name sortKey="Valencia, A" uniqKey="Valencia A">A Valencia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Robbins, Rj" uniqKey="Robbins R">RJ Robbins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gavaghan, H" uniqKey="Gavaghan H">H Gavaghan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Altman, Rb" uniqKey="Altman R">RB Altman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kafatos, Fc" uniqKey="Kafatos F">FC Kafatos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thornton, Jm" uniqKey="Thornton J">JM Thornton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sobral, Bws" uniqKey="Sobral B">BWS Sobral</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Attwood, Tk" uniqKey="Attwood T">TK Attwood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hatzimanikatis, V" uniqKey="Hatzimanikatis V">V Hatzimanikatis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Palsson, B" uniqKey="Palsson B">B Palsson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="O Donnell, Cj" uniqKey="O Donnell C">CJ O'Donnell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reed, J" uniqKey="Reed J">J Reed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wada, A" uniqKey="Wada A">A Wada</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aldridge, S" uniqKey="Aldridge S">S Aldridge</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Butte, Aj" uniqKey="Butte A">AJ Butte</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roos, Ds" uniqKey="Roos D">DS Roos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maschio, T" uniqKey="Maschio T">T Maschio</name>
</author>
<author><name sortKey="Kowalski, T" uniqKey="Kowalski T">T Kowalski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sander, C" uniqKey="Sander C">C Sander</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Harvey, M" uniqKey="Harvey M">M Harvey</name>
</author>
<author><name sortKey="Mcmeekin, A" uniqKey="Mcmeekin A">A McMeekin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fuchs, R" uniqKey="Fuchs R">R Fuchs</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roy, D" uniqKey="Roy D">D Roy</name>
</author>
<author><name sortKey="Forster, T" uniqKey="Forster T">T Forster</name>
</author>
<author><name sortKey="Mcgeever, S" uniqKey="Mcgeever S">S McGeever</name>
</author>
<author><name sortKey="Robertson, K" uniqKey="Robertson K">K Robertson</name>
</author>
<author><name sortKey="Ghazal, P" uniqKey="Ghazal P">P Ghazal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Slepchenko, Bm" uniqKey="Slepchenko B">BM Slepchenko</name>
</author>
<author><name sortKey="Schaff, Jc" uniqKey="Schaff J">JC Schaff</name>
</author>
<author><name sortKey="Carson, Jh" uniqKey="Carson J">JH Carson</name>
</author>
<author><name sortKey="Loew, Lm" uniqKey="Loew L">LM Loew</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chain, P" uniqKey="Chain P">P Chain</name>
</author>
<author><name sortKey="Kurtz, S" uniqKey="Kurtz S">S Kurtz</name>
</author>
<author><name sortKey="Ohlebusch, E" uniqKey="Ohlebusch E">E Ohlebusch</name>
</author>
<author><name sortKey="Slezak, T" uniqKey="Slezak T">T Slezak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Godzik, A" uniqKey="Godzik A">A Godzik</name>
</author>
<author><name sortKey="Canaves, J" uniqKey="Canaves J">J Canaves</name>
</author>
<author><name sortKey="Grzechnik, S" uniqKey="Grzechnik S">S Grzechnik</name>
</author>
<author><name sortKey="Jaroszewski, L" uniqKey="Jaroszewski L">L Jaroszewski</name>
</author>
<author><name sortKey="Morse, A" uniqKey="Morse A">A Morse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kanehisa, M" uniqKey="Kanehisa M">M Kanehisa</name>
</author>
<author><name sortKey="Bork, P" uniqKey="Bork P">P Bork</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="See Kiong, N" uniqKey="See Kiong N">N See-Kiong</name>
</author>
<author><name sortKey="Limsoon, W" uniqKey="Limsoon W">W Limsoon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miller, Cj" uniqKey="Miller C">CJ Miller</name>
</author>
<author><name sortKey="Attwood, Tk" uniqKey="Attwood T">TK Attwood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gurwitz, D" uniqKey="Gurwitz D">D Gurwitz</name>
</author>
<author><name sortKey="Lunshof, Je" uniqKey="Lunshof J">JE Lunshof</name>
</author>
<author><name sortKey="Altman, Rb" uniqKey="Altman R">RB Altman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Molidor, R" uniqKey="Molidor R">R Molidor</name>
</author>
<author><name sortKey="Sturn, A" uniqKey="Sturn A">A Sturn</name>
</author>
<author><name sortKey="Maurer, M" uniqKey="Maurer M">M Maurer</name>
</author>
<author><name sortKey="Trajanoski, Z" uniqKey="Trajanoski Z">Z Trajanoski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Lorenzo, V" uniqKey="De Lorenzo V">V de Lorenzo</name>
</author>
<author><name sortKey="Serrano, L" uniqKey="Serrano L">L Serrano</name>
</author>
<author><name sortKey="Valencia, A" uniqKey="Valencia A">A Valencia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barker, J" uniqKey="Barker J">J Barker</name>
</author>
<author><name sortKey="Thornton, J" uniqKey="Thornton J">J Thornton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Blake, Ja" uniqKey="Blake J">JA Blake</name>
</author>
<author><name sortKey="Bult, Cj" uniqKey="Bult C">CJ Bult</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Buckingham, S" uniqKey="Buckingham S">S Buckingham</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Blanchard, Jl" uniqKey="Blanchard J">JL Blanchard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Volpin, H" uniqKey="Volpin H">H Volpin</name>
</author>
<author><name sortKey="Koltai, H" uniqKey="Koltai H">H Koltai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rhee, Sy" uniqKey="Rhee S">SY Rhee</name>
</author>
<author><name sortKey="Dickerson, J" uniqKey="Dickerson J">J Dickerson</name>
</author>
<author><name sortKey="Xu, D" uniqKey="Xu D">D Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ilyin, Se" uniqKey="Ilyin S">SE Ilyin</name>
</author>
<author><name sortKey="Bernal, A" uniqKey="Bernal A">A Bernal</name>
</author>
<author><name sortKey="Horowitz, D" uniqKey="Horowitz D">D Horowitz</name>
</author>
<author><name sortKey="Derian, Ck" uniqKey="Derian C">CK Derian</name>
</author>
<author><name sortKey="Xin, H" uniqKey="Xin H">H Xin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ritchie, Md" uniqKey="Ritchie M">MD Ritchie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tarczy Hornoch, P" uniqKey="Tarczy Hornoch P">P Tarczy-Hornoch</name>
</author>
<author><name sortKey="Minie, M" uniqKey="Minie M">M Minie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maojo, V" uniqKey="Maojo V">V Maojo</name>
</author>
<author><name sortKey="Martin Sanchez, F" uniqKey="Martin Sanchez F">F Martin-Sanchez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Da Fontoura Costa, L" uniqKey="Da Fontoura Costa L">L da Fontoura Costa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nightingale, P" uniqKey="Nightingale P">P Nightingale</name>
</author>
<author><name sortKey="Martin, P" uniqKey="Martin P">P Martin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ranganathan, S" uniqKey="Ranganathan S">S Ranganathan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hack, C" uniqKey="Hack C">C Hack</name>
</author>
<author><name sortKey="Kendall, G" uniqKey="Kendall G">G Kendall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eisenberg, D" uniqKey="Eisenberg D">D Eisenberg</name>
</author>
<author><name sortKey="Marcotte, E" uniqKey="Marcotte E">E Marcotte</name>
</author>
<author><name sortKey="Mclachlan, Ad" uniqKey="Mclachlan A">AD McLachlan</name>
</author>
<author><name sortKey="Pellegrini, M" uniqKey="Pellegrini M">M Pellegrini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perez Iratxeta, C" uniqKey="Perez Iratxeta C">C Perez-Iratxeta</name>
</author>
<author><name sortKey="Andrade Navarro, Ma" uniqKey="Andrade Navarro M">MA Andrade-Navarro</name>
</author>
<author><name sortKey="Wren, Jd" uniqKey="Wren J">JD Wren</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brewster, C" uniqKey="Brewster C">C Brewster</name>
</author>
<author><name sortKey="O Hara, K" uniqKey="O Hara K">K O'Hara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Faith, Dp" uniqKey="Faith D">DP Faith</name>
</author>
<author><name sortKey="Baker, Am" uniqKey="Baker A">AM Baker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Serrano, L" uniqKey="Serrano L">L Serrano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gatenby, Ra" uniqKey="Gatenby R">RA Gatenby</name>
</author>
<author><name sortKey="Frieden, Br" uniqKey="Frieden B">BR Frieden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scherer, Sw" uniqKey="Scherer S">SW Scherer</name>
</author>
<author><name sortKey="Lee, C" uniqKey="Lee C">C Lee</name>
</author>
<author><name sortKey="Birney, E" uniqKey="Birney E">E Birney</name>
</author>
<author><name sortKey="Altshuler, Dm" uniqKey="Altshuler D">DM Altshuler</name>
</author>
<author><name sortKey="Eichler, Ee" uniqKey="Eichler E">EE Eichler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hanauer, Da" uniqKey="Hanauer D">DA Hanauer</name>
</author>
<author><name sortKey="Rhodes, Dr" uniqKey="Rhodes D">DR Rhodes</name>
</author>
<author><name sortKey="Sinha Kumar, C" uniqKey="Sinha Kumar C">C Sinha-Kumar</name>
</author>
<author><name sortKey="Chinnaiyan, Am" uniqKey="Chinnaiyan A">AM Chinnaiyan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kumar, S" uniqKey="Kumar S">S Kumar</name>
</author>
<author><name sortKey="Dudley, J" uniqKey="Dudley J">J Dudley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Butte, Aj" uniqKey="Butte A">AJ Butte</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pop, M" uniqKey="Pop M">M Pop</name>
</author>
<author><name sortKey="Salzberg, Sl" uniqKey="Salzberg S">SL Salzberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Yp" uniqKey="Chen Y">YP Chen</name>
</author>
<author><name sortKey="Chen, F" uniqKey="Chen F">F Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Simpson, Rj" uniqKey="Simpson R">RJ Simpson</name>
</author>
<author><name sortKey="Bernhard, Ok" uniqKey="Bernhard O">OK Bernhard</name>
</author>
<author><name sortKey="Greening, Dw" uniqKey="Greening D">DW Greening</name>
</author>
<author><name sortKey="Moritz, Rl" uniqKey="Moritz R">RL Moritz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Howe, D" uniqKey="Howe D">D Howe</name>
</author>
<author><name sortKey="Costanzo, M" uniqKey="Costanzo M">M Costanzo</name>
</author>
<author><name sortKey="Fey, P" uniqKey="Fey P">P Fey</name>
</author>
<author><name sortKey="Gojobori, T" uniqKey="Gojobori T">T Gojobori</name>
</author>
<author><name sortKey="Hannick, L" uniqKey="Hannick L">L Hannick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krallinger, M" uniqKey="Krallinger M">M Krallinger</name>
</author>
<author><name sortKey="Valencia, A" uniqKey="Valencia A">A Valencia</name>
</author>
<author><name sortKey="Hirschman, L" uniqKey="Hirschman L">L Hirschman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Craddock, T" uniqKey="Craddock T">T Craddock</name>
</author>
<author><name sortKey="Harwood, Cr" uniqKey="Harwood C">CR Harwood</name>
</author>
<author><name sortKey="Hallinan, J" uniqKey="Hallinan J">J Hallinan</name>
</author>
<author><name sortKey="Wipat, A" uniqKey="Wipat A">A Wipat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stein, Ld" uniqKey="Stein L">LD Stein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Tf" uniqKey="Smith T">TF Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pop, M" uniqKey="Pop M">M Pop</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Suarez, M" uniqKey="Suarez M">M Suarez</name>
</author>
<author><name sortKey="Jaramillo, A" uniqKey="Jaramillo A">A Jaramillo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kyrpides, Nc" uniqKey="Kyrpides N">NC Kyrpides</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Auffray, C" uniqKey="Auffray C">C Auffray</name>
</author>
<author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name>
</author>
<author><name sortKey="Hood, L" uniqKey="Hood L">L Hood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Berglund, Ec" uniqKey="Berglund E">EC Berglund</name>
</author>
<author><name sortKey="Nystedt, B" uniqKey="Nystedt B">B Nystedt</name>
</author>
<author><name sortKey="Andersson, Sg" uniqKey="Andersson S">SG Andersson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thorisson, Ga" uniqKey="Thorisson G">GA Thorisson</name>
</author>
<author><name sortKey="Muilu, J" uniqKey="Muilu J">J Muilu</name>
</author>
<author><name sortKey="Brookes, Aj" uniqKey="Brookes A">AJ Brookes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boden, M" uniqKey="Boden M">M Boden</name>
</author>
<author><name sortKey="Cagnin, C" uniqKey="Cagnin C">C Cagnin</name>
</author>
<author><name sortKey="Carabias, V" uniqKey="Carabias V">V Carabias</name>
</author>
<author><name sortKey="Haegeman, K" uniqKey="Haegeman K">K Haegeman</name>
</author>
<author><name sortKey="K Nn L, T" uniqKey="K Nn L T">T Kønnølå</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Atanassov, A" uniqKey="Atanassov A">A Atanassov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alterovitz, G" uniqKey="Alterovitz G">G Alterovitz</name>
</author>
<author><name sortKey="Muso, T" uniqKey="Muso T">T Muso</name>
</author>
<author><name sortKey="Ramoni, Mf" uniqKey="Ramoni M">MF Ramoni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khalil, As" uniqKey="Khalil A">AS Khalil</name>
</author>
<author><name sortKey="Collins, Jj" uniqKey="Collins J">JJ Collins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pons, C" uniqKey="Pons C">C Pons</name>
</author>
<author><name sortKey="Grosdidier, S" uniqKey="Grosdidier S">S Grosdidier</name>
</author>
<author><name sortKey="Solernou, A" uniqKey="Solernou A">A Solernou</name>
</author>
<author><name sortKey="Perez Cano, L" uniqKey="Perez Cano L">L Perez-Cano</name>
</author>
<author><name sortKey="Fernandez Recio, J" uniqKey="Fernandez Recio J">J Fernandez-Recio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yan, Q" uniqKey="Yan Q">Q Yan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kitano, H" uniqKey="Kitano H">H Kitano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sarkar, In" uniqKey="Sarkar I">IN Sarkar</name>
</author>
<author><name sortKey="Butte, Aj" uniqKey="Butte A">AJ Butte</name>
</author>
<author><name sortKey="Lussier, Ya" uniqKey="Lussier Y">YA Lussier</name>
</author>
<author><name sortKey="Tarczy Hornoch, P" uniqKey="Tarczy Hornoch P">P Tarczy-Hornoch</name>
</author>
<author><name sortKey="Ohno Machado, L" uniqKey="Ohno Machado L">L Ohno-Machado</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fernald, Gh" uniqKey="Fernald G">GH Fernald</name>
</author>
<author><name sortKey="Capriotti, E" uniqKey="Capriotti E">E Capriotti</name>
</author>
<author><name sortKey="Daneshjou, R" uniqKey="Daneshjou R">R Daneshjou</name>
</author>
<author><name sortKey="Karczewski, Kj" uniqKey="Karczewski K">KJ Karczewski</name>
</author>
<author><name sortKey="Altman, Rb" uniqKey="Altman R">RB Altman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moore, Jh" uniqKey="Moore J">JH Moore</name>
</author>
<author><name sortKey="Asselbergs, Fw" uniqKey="Asselbergs F">FW Asselbergs</name>
</author>
<author><name sortKey="Williams, Sm" uniqKey="Williams S">SM Williams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miller, G" uniqKey="Miller G">G Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sleator, Rd" uniqKey="Sleator R">RD Sleator</name>
</author>
<author><name sortKey="Walsh, P" uniqKey="Walsh P">P Walsh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schneider, Mv" uniqKey="Schneider M">MV Schneider</name>
</author>
<author><name sortKey="Watson, J" uniqKey="Watson J">J Watson</name>
</author>
<author><name sortKey="Attwood, T" uniqKey="Attwood T">T Attwood</name>
</author>
<author><name sortKey="Rother, K" uniqKey="Rother K">K Rother</name>
</author>
<author><name sortKey="Budd, A" uniqKey="Budd A">A Budd</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS Comput Biol</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS Comput. Biol</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">ploscomp</journal-id>
<journal-title-group><journal-title>PLoS Computational Biology</journal-title>
</journal-title-group>
<issn pub-type="ppub">1553-734X</issn>
<issn pub-type="epub">1553-7358</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22570600</article-id>
<article-id pub-id-type="pmc">3343106</article-id>
<article-id pub-id-type="publisher-id">PCOMPBIOL-D-11-01776</article-id>
<article-id pub-id-type="doi">10.1371/journal.pcbi.1002487</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Biology</subject>
<subj-group><subject>Computational Biology</subject>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Science Policy</subject>
<subj-group><subject>Research Assessment</subject>
<subj-group><subject>Research Monitoring</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Social and Behavioral Sciences</subject>
<subj-group><subject>Science Education</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Rise and Demise of Bioinformatics? Promise and Progress</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Ouzounis</surname>
<given-names>Christos A.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>*</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<addr-line>Institute of Agrobiotechnology, Centre for Research & Technology Hellas (CERTH), Thessaloniki, Greece</addr-line>
</aff>
<aff id="aff2"><label>2</label>
<addr-line>Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Ontario, Canada</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Bourne</surname>
<given-names>Philip E.</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1">University of California San Diego, United States of America</aff>
<author-notes><corresp id="cor1">* E-mail: <email>ouzounis@certh.gr</email>
</corresp>
</author-notes>
<pub-date pub-type="collection"><month>4</month>
<year>2012</year>
</pub-date>
<pmc-comment> Fake ppub added to accomodate plos workflow change from 03/2008 and 03/2009 </pmc-comment>
<pub-date pub-type="ppub"><month>4</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>26</day>
<month>4</month>
<year>2012</year>
</pub-date>
<volume>8</volume>
<issue>4</issue>
<elocation-id>e1002487</elocation-id>
<permissions><copyright-statement>Christos A. Ouzounis. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</copyright-statement>
<copyright-year>2012</copyright-year>
</permissions>
<abstract><p>The field of bioinformatics and computational biology has gone through a number of transformations during the past 15 years, establishing itself as a key component of new biology. This spectacular growth has been challenged by a number of disruptive changes in science and technology. Despite the apparent fatigue of the linguistic use of the term itself, bioinformatics has grown perhaps to a point beyond recognition. We explore both historical aspects and future trends and argue that as the field expands, key questions remain unanswered and acquire new meaning while at the same time the range of applications is widening to cover an ever increasing number of biological disciplines. These trends appear to be pointing to a redefinition of certain objectives, milestones, and possibly the field itself.</p>
</abstract>
<counts><page-count count="5"></page-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Canada</li>
<li>Grèce</li>
</country>
<region><li>Ontario</li>
</region>
<settlement><li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Grèce"><noRegion><name sortKey="Ouzounis, Christos A" sort="Ouzounis, Christos A" uniqKey="Ouzounis C" first="Christos A." last="Ouzounis">Christos A. Ouzounis</name>
</noRegion>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Ouzounis, Christos A" sort="Ouzounis, Christos A" uniqKey="Ouzounis C" first="Christos A." last="Ouzounis">Christos A. Ouzounis</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/CyberinfraV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000309 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000309 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Ticri/CIDE |area= CyberinfraV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:3343106 |texte= Rise and Demise of Bioinformatics? Promise and Progress }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:22570600" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a CyberinfraV1
![]() | This area was generated with Dilib version V0.6.25. | ![]() |